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Jean-Charles Soria
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Journal Articles

Comprehensive Genome Profiling in Patients With Metastatic Non–Small Cell Lung Cancer: The Precision Medicine Phase II Randomized SAFIR02-Lung/IFCT 1301 Trial

Fabrice Barlesi, Pascale Tomasini, Maryam Karimi, Stefan Michiels, Judith Raimbourg, Catherine Daniel, Henri Janicot, Anne Madroszyk, Clarisse Audigier-Valette, Elisabeth Quoix, Julien Mazieres, Denis Moro-Sibilot, Eric Dansin, Olivier Molinier, Hugues Morel, Eric Pichon, Alexis Cortot, Josiane Otto, François Chomy, Pierre-Jean Souquet, Nicolas Cloarec, Etienne Giroux-Leprieur, Ivan Bieche, Ludovic Lacroix, Sandrine Boyault, Valery Attignon, Isabelle Soubeyran, Alain Morel, Alicia Tran-Dien, Alexandra Jacquet, Filippo Gustavo Dall'Olio, Marta Jimenez, Jean-Charles Soria, Benjamin Besse
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (18): 4018–4026.
https://doi.org/10.1158/1078-0432.CCR-22-0371
Published: 15 September 2022
View article titled, Comprehensive Genome Profiling in Patients With Metastatic Non–Small Cell Lung Cancer: The Precision Medicine Phase II Randomized SAFIR02-Lung/IFCT 1301 Trial
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Includes: Supplementary data
Journal Articles

Ceralasertib (AZD6738), an Oral ATR Kinase Inhibitor, in Combination with Carboplatin in Patients with Advanced Solid Tumors: A Phase I Study

Timothy A. Yap, Matthew G. Krebs, Sophie Postel-Vinay, Anthony El-Khouiery, Jean-Charles Soria, Juanita Lopez, Alienor Berges, S.Y. Amy Cheung, Itziar Irurzun-Arana, Andrew Goldwin, Brunella Felicetti, Gemma N. Jones, Alan Lau, Paul Frewer, Andrew J. Pierce, Glen Clack, Christine Stephens, Simon A. Smith, Emma Dean, Simon J. Hollingsworth
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (19): 5213–5224.
https://doi.org/10.1158/1078-0432.CCR-21-1032
Published: 01 October 2021
View article titled, Ceralasertib (AZD6738), an Oral ATR Kinase Inhibitor, in Combination with Carboplatin in Patients with Advanced Solid Tumors: A Phase I Study
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Journal Articles

Interventional Radiology for Local Immunotherapy in Oncology

Lambros Tselikas, Stephane Champiat, Rahul A. Sheth, Steve Yevich, Samy Ammari, Frederic Deschamps, Siham Farhane, Charles Roux, Sandrine Susini, Severine Mouraud, Alexandre Delpla, Thibault Raoult, Caroline Robert, Christophe Massard, Fabrice Barlesi, Jean-Charles Soria, Aurélien Marabelle, Thierry de Baere
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (10): 2698–2705.
https://doi.org/10.1158/1078-0432.CCR-19-4073
Published: 15 May 2021
View article titled, Interventional Radiology for Local Immunotherapy in Oncology
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Includes: Multimedia, Supplementary data
Journal Articles

Circulating T-cell Immunosenescence in Patients with Advanced Non–small Cell Lung Cancer Treated with Single-agent PD-1/PD-L1 Inhibitors or Platinum-based Chemotherapy

Roberto Ferrara, Marie Naigeon, Edouard Auclin, Boris Duchemann, Lydie Cassard, Jean-Mehdi Jouniaux, Lisa Boselli, Jonathan Grivel, Aude Desnoyer, Laura Mezquita, Matthieu Texier, Caroline Caramella, Lizza Hendriks, David Planchard, Jordi Remon, Sabina Sangaletti, Claudia Proto, Marina C. Garassino, Jean-Charles Soria, Aurelien Marabelle, Anne-Laure Voisin, Siham Farhane, Benjamin Besse, Nathalie Chaput
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (2): 492–503.
https://doi.org/10.1158/1078-0432.CCR-20-1420
Published: 19 January 2021
View article titled, Circulating T-cell Immunosenescence in Patients with Advanced Non–small Cell Lung Cancer Treated with Single-agent PD-1/PD-L1 Inhibitors or Platinum-based Chemotherapy
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Includes: Supplementary data
Journal Articles

Abstract PO-030: Outcome of older cancer patients infected with Covid19 at Gustave Roussy Cancer Center

Mathilde Hauchecorne, Capucine Baldini, Stéphanie Foulon, Arnaud Bayle, Bertrand Gachot, Fanny Pommeret, Helene Vincent, Tina Lamy, Celine Nagera, Christophe Willekens, Franck Griscelli, Florence Netzer, Corinne Balleyguier, Samy Ammari, Fabrice André, Florian Scotte, Benjamin Besse, Jean-Charles Soria, Fabrice Barlési, Laurence Albigès
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (18_Supplement): PO-030.
https://doi.org/10.1158/1557-3265.COVID-19-PO-030
Published: 15 September 2020
View article titled, Abstract PO-030: Outcome of older cancer patients infected with Covid19 at Gustave Roussy Cancer Center
Journal Articles

Methodological Development of Combination Drug and Radiotherapy in Basic and Clinical Research

Cyrus Chargari, Antonin Levy, Xavier Paoletti, Jean-Charles Soria, Christophe Massard, Ralph R. Weichselbaum, Eric Deutsch
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (18): 4723–4736.
https://doi.org/10.1158/1078-0432.CCR-19-4155
Published: 15 September 2020
View article titled, Methodological Development of Combination Drug and Radiotherapy in Basic and Clinical Research
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Journal Articles

A First-in-Human Phase I Study to Evaluate the ERK1/2 Inhibitor GDC-0994 in Patients with Advanced Solid Tumors

Andrea Varga, Jean-Charles Soria, Antoine Hollebecque, Patricia LoRusso, Johanna Bendell, Shih-Min A. Huang, Marie-Claire Wagle, Kwame Okrah, Lichuan Liu, Elaine Murray, Sandra M. Sanabria-Bohorquez, Michael Tagen, Hatem Dokainish, Lars Mueller, Howard Burris
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (6): 1229–1236.
https://doi.org/10.1158/1078-0432.CCR-19-2574
Published: 13 March 2020
View article titled, A First-in-Human Phase I Study to Evaluate the ERK1/2 Inhibitor GDC-0994 in Patients with Advanced Solid Tumors
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Includes: Supplementary data
Journal Articles

Diverse Resistance Mechanisms to the Third-Generation ALK Inhibitor Lorlatinib in ALK-Rearranged Lung Cancer

Gonzalo Recondo, Laura Mezquita, Francesco Facchinetti, David Planchard, Anas Gazzah, Ludovic Bigot, Ahsan Z. Rizvi, Rosa L. Frias, Jean Paul Thiery, Jean-Yves Scoazec, Tony Sourisseau, Karen Howarth, Olivier Deas, Dariia Samofalova, Justine Galissant, Pauline Tesson, Floriane Braye, Charles Naltet, Pernelle Lavaud, Linda Mahjoubi, Aurélie Abou Lovergne, Gilles Vassal, Rastilav Bahleda, Antoine Hollebecque, Claudio Nicotra, Maud Ngo-Camus, Stefan Michiels, Ludovic Lacroix, Catherine Richon, Nathalie Auger, Thierry De Baere, Lambros Tselikas, Eric Solary, Eric Angevin, Alexander M. Eggermont, Fabrice Andre, Christophe Massard, Ken A. Olaussen, Jean-Charles Soria, Benjamin Besse, Luc Friboulet
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (1): 242–255.
https://doi.org/10.1158/1078-0432.CCR-19-1104
Published: 03 January 2020
View article titled, Diverse Resistance Mechanisms to the Third-Generation ALK Inhibitor Lorlatinib in ALK-Rearranged Lung Cancer
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Includes: Supplementary data
Journal Articles

Antibody–Drug Conjugates: Future Directions in Clinical and Translational Strategies to Improve the Therapeutic Index

Steven Coats, Marna Williams, Benjamin Kebble, Rakesh Dixit, Leo Tseng, Nai-Shun Yao, David A. Tice, Jean-Charles Soria
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (18): 5441–5448.
https://doi.org/10.1158/1078-0432.CCR-19-0272
Published: 13 September 2019
View article titled, Antibody–Drug Conjugates: Future Directions in Clinical and Translational Strategies to Improve the Therapeutic Index
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Journal Articles

Immunotherapy for the First-Line Treatment of Patients with Metastatic Non–Small Cell Lung Cancer

Pablo Martinez, Solange Peters, Timothy Stammers, Jean-Charles Soria
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (9): 2691–2698.
https://doi.org/10.1158/1078-0432.CCR-18-3904
Published: 01 May 2019
View article titled, Immunotherapy for the First-Line Treatment of Patients with Metastatic Non–Small Cell Lung Cancer
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Journal Articles

The “Guardian of the Genome”—An Old Key to Unlock the ERCC1 Issue

Luc Friboulet, Jean-Charles Soria, Ken André Olaussen
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (8): 2369–2371.
https://doi.org/10.1158/1078-0432.CCR-18-4123
Published: 15 April 2019
View article titled, The “Guardian of the Genome”—An Old Key to Unlock the ERCC1 Issue
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Journal Articles

Long-Term Survival in Patients Responding to Anti–PD-1/PD-L1 Therapy and Disease Outcome upon Treatment Discontinuation

Marie-Léa Gauci, Emilie Lanoy, Stéphane Champiat, Caroline Caramella, Samy Ammari, Sandrine Aspeslagh, Andrea Varga, Capucine Baldini, Rastilav Bahleda, Anas Gazzah, Jean-Marie Michot, Sophie Postel-Vinay, Eric Angevin, Vincent Ribrag, Antoine Hollebecque, Jean-Charles Soria, Caroline Robert, Christophe Massard, Aurélien Marabelle
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (3): 946–956.
https://doi.org/10.1158/1078-0432.CCR-18-0793
Published: 01 February 2019
View article titled, Long-Term Survival in Patients Responding to Anti–PD-1/PD-L1 Therapy and Disease Outcome upon Treatment Discontinuation
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Includes: Supplementary data
Journal Articles

A Model of Overall Survival Predicts Treatment Outcomes with Atezolizumab versus Chemotherapy in Non–Small Cell Lung Cancer Based on Early Tumor Kinetics

Laurent Claret, Jin Y. Jin, Charles Ferté, Helen Winter, Sandhya Girish, Mark Stroh, Pei He, Marcus Ballinger, Alan Sandler, Amita Joshi, Achim Rittmeyer, David Gandara, Jean-Charles Soria, René Bruno
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (14): 3292–3298.
https://doi.org/10.1158/1078-0432.CCR-17-3662
Published: 15 July 2018
View article titled, A Model of Overall Survival Predicts Treatment Outcomes with Atezolizumab versus Chemotherapy in Non–Small Cell Lung Cancer Based on Early Tumor Kinetics
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Includes: Supplementary data
Journal Articles

Phase I Dose-Escalation Study of the Anti-CD70 Antibody ARGX-110 in Advanced Malignancies

Philippe Aftimos, Christian Rolfo, Sylvie Rottey, Fritz Offner, Dominique Bron, Marie Maerevoet, Jean-Charles Soria, Mahan Moshir, Torsten Dreier, Luc Van Rompaey, Jean-Marie Michot, Karen Silence, Anna Hultberg, Domenica Gandini, Hans de Haard, Vincent Ribrag, Marc Peeters, Alain Thibault, Nicolas Leupin, Ahmad Awada
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (21): 6411–6420.
https://doi.org/10.1158/1078-0432.CCR-17-0613
Published: 31 October 2017
View article titled, Phase I Dose-Escalation Study of the Anti-CD70 Antibody ARGX-110 in Advanced Malignancies
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Includes: Supplementary data
Journal Articles

Molecular Screening for Cancer Treatment Optimization (MOSCATO-01) in Pediatric Patients: A Single-Institutional Prospective Molecular Stratification Trial

Anne C. Harttrampf, Ludovic Lacroix, Marc Deloger, Frederic Deschamps, Stephanie Puget, Nathalie Auger, Philippe Vielh, Pascale Varlet, Zsofia Balogh, Samuel Abbou, Adrien Allorant, Dominique Valteau-Couanet, Sabine Sarnacki, Louise Gamiche-Rolland, Guillaume Meurice, Veronique Minard-Colin, Jacques Grill, Laurence Brugieres, Christelle Dufour, Nathalie Gaspar, Stefan Michiels, Gilles Vassal, Jean-Charles Soria, Birgit Geoerger
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (20): 6101–6112.
https://doi.org/10.1158/1078-0432.CCR-17-0381
Published: 12 October 2017
View article titled, Molecular Screening for Cancer Treatment Optimization (MOSCATO-01) in Pediatric Patients: A Single-Institutional Prospective Molecular Stratification Trial
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Includes: Supplementary data
Journal Articles

A Phase Ib Open-Label Multicenter Study of AZD4547 in Patients with Advanced Squamous Cell Lung Cancers

Paul K. Paik, Ronglai Shen, Michael F. Berger, David Ferry, Jean-Charles Soria, Alastair Mathewson, Claire Rooney, Neil R. Smith, Marie Cullberg, Elaine Kilgour, Donal Landers, Paul Frewer, Nigel Brooks, Fabrice André
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (18): 5366–5373.
https://doi.org/10.1158/1078-0432.CCR-17-0645
Published: 14 September 2017
View article titled, A Phase Ib Open-Label Multicenter Study of AZD4547 in Patients with Advanced Squamous Cell Lung Cancers
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Includes: Supplementary data
Journal Articles

Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors

Jeffrey R. Infante, Antoine Hollebecque, Sophie Postel-Vinay, Todd M. Bauer, Elizabeth M. Blackwood, Marie Evangelista, Sami Mahrus, Franklin V. Peale, Xuyang Lu, Srikumar Sahasranaman, Rui Zhu, Yuan Chen, Xiao Ding, Elaine R. Murray, Jennifer L. Schutzman, Jennifer O. Lauchle, Jean-Charles Soria, Patricia M. LoRusso
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (10): 2423–2432.
https://doi.org/10.1158/1078-0432.CCR-16-1782
Published: 14 May 2017
View article titled, Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors
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Includes: Supplementary data
Journal Articles

Hyperprogressive Disease Is a New Pattern of Progression in Cancer Patients Treated by Anti-PD-1/PD-L1

Stéphane Champiat, Laurent Dercle, Samy Ammari, Christophe Massard, Antoine Hollebecque, Sophie Postel-Vinay, Nathalie Chaput, Alexander Eggermont, Aurélien Marabelle, Jean-Charles Soria, Charles Ferté
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (8): 1920–1928.
https://doi.org/10.1158/1078-0432.CCR-16-1741
Published: 13 April 2017
View article titled, Hyperprogressive Disease Is a New Pattern of Progression in Cancer Patients Treated by Anti-PD-1/PD-L1
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Includes: Supplementary data
Journal Articles

A Phase I Clinical Trial and Independent Patient-Derived Xenograft Study of Combined Targeted Treatment with Dacomitinib and Figitumumab in Advanced Solid Tumors

Emiliano Calvo, Jean-Charles Soria, Wen Wee Ma, Tao Wang, Rastilav Bahleda, Anthony W. Tolcher, Diana Gernhardt, Joseph O'Connell, Robert Millham, Nagdeep Giri, Michael J. Wick, Alex A. Adjei, Manuel Hidalgo
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (5): 1177–1185.
https://doi.org/10.1158/1078-0432.CCR-15-2301
Published: 28 February 2017
View article titled, A Phase I Clinical Trial and Independent Patient-Derived Xenograft Study of Combined Targeted Treatment with Dacomitinib and Figitumumab in Advanced Solid Tumors
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Includes: Supplementary data
Journal Articles

First-in-Human Study Testing a New Radioenhancer Using Nanoparticles (NBTXR3) Activated by Radiation Therapy in Patients with Locally Advanced Soft Tissue Sarcomas

Sylvie Bonvalot, Cécile Le Pechoux, Thierry De Baere, Guy Kantor, Xavier Buy, Eberhard Stoeckle, Philippe Terrier, Paul Sargos, Jean Michel Coindre, Nathalie Lassau, Rafik Ait Sarkouh, Mikaela Dimitriu, Elsa Borghi, Laurent Levy, Eric Deutsch, Jean-Charles Soria
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (4): 908–917.
https://doi.org/10.1158/1078-0432.CCR-16-1297
Published: 14 February 2017
View article titled, First-in-Human Study Testing a New Radioenhancer Using Nanoparticles (NBTXR3) Activated by Radiation Therapy in Patients with Locally Advanced Soft Tissue Sarcomas
Open the PDF for First-in-Human Study Testing a New Radioenhancer Using Nanoparticles (NBTXR3) Activated by Radiation Therapy in Patients with Locally Advanced Soft Tissue Sarcomas in another window
Includes: Multimedia, Supplementary data