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Journal Articles

Mechanistic Insights of an Immunological Adverse Event Induced by an Anti-KIT Antibody Drug Conjugate and Mitigation Strategies

Lawrence L'Italien, Olivia Orozco, Tinya Abrams, Lisa Cantagallo, Anu Connor, Jayesh Desai, Hilmar Ebersbach, Hans Gelderblom, Keith Hoffmaster, Emma Lees, Heiko Maacke, Siew Schleyer, Darko Skegro, Si Tuen Lee-Hoeflich
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (14): 3465–3474.
DOI: https://doi.org/10.1158/1078-0432.CCR-17-3786
Published: 15 July 2018
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Girdin (GIV) Expression as a Prognostic Marker of Recurrence in Mismatch Repair–Proficient Stage II Colon Cancer

Pradipta Ghosh, Jeanne Tie, Andrea Muranyi, Shalini Singh, Patrick Brunhoeber, Katherine Leith, Rebecca Bowermaster, Zhiming Liao, Yifei Zhu, Bonnie LaFleur, Ben Tran, Jayesh Desai, Ian Jones, Matthew Croxford, Rodrigo Jover, Ajay Goel, Paul Waring, Song Hu, Volker Teichgraber, Ulrich-Peter Rohr, Ruediger Ridder, Kandavel Shanmugam, Peter Gibbs
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (14): 3488–3498.
DOI: https://doi.org/10.1158/1078-0432.CCR-15-2290
Published: 14 July 2016
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Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma

Ankita Gupte, Emma K. Baker, Soo-San Wan, Elizabeth Stewart, Amos Loh, Anang A. Shelat, Cathryn M. Gould, Alistair M. Chalk, Scott Taylor, Kurt Lackovic, Åsa Karlström, Anthony J. Mutsaers, Jayesh Desai, Piyush B. Madhamshettiwar, Andrew C.W. Zannettino, Chris Burns, David C.S. Huang, Michael A. Dyer, Kaylene J. Simpson, Carl R. Walkley
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (14): 3216–3229.
DOI: https://doi.org/10.1158/1078-0432.CCR-14-3026
Published: 14 July 2015
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PIK3CA and PTEN Gene and Exon Mutation-Specific Clinicopathologic and Molecular Associations in Colorectal Cancer

Fiona L. Day, Robert N. Jorissen, Lara Lipton, Dmitri Mouradov, Anuratha Sakthianandeswaren, Michael Christie, Shan Li, Cary Tsui, Jeannie Tie, Jayesh Desai, Zheng-Zhou Xu, Peter Molloy, Vicki Whitehall, Barbara A. Leggett, Ian T. Jones, Stephen McLaughlin, Robyn L. Ward, Nicholas J. Hawkins, Andrew R. Ruszkiewicz, James Moore, Dana Busam, Qi Zhao, Robert L. Strausberg, Peter Gibbs, Oliver M. Sieber
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (12): 3285–3296.
DOI: https://doi.org/10.1158/1078-0432.CCR-12-3614
Published: 13 June 2013
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Resistance to BRAF Inhibition in BRAF-Mutant Colon Cancer Can Be Overcome with PI3K Inhibition or Demethylating Agents

Muling Mao, Feng Tian, John M. Mariadason, Chun C. Tsao, Robert Lemos, Jr, Farshid Dayyani, Y.N. Vashisht Gopal, Zhi-Qin Jiang, Ignacio I. Wistuba, Xi M. Tang, William G. Bornman, Gideon Bollag, Gordon B. Mills, Garth Powis, Jayesh Desai, Gary E. Gallick, Michael A. Davies, Scott Kopetz
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (3): 657–667.
DOI: https://doi.org/10.1158/1078-0432.CCR-11-1446
Published: 31 January 2013
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Includes: Supplementary data
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Clinical, Pharmacodynamic, and Pharmacokinetic Evaluation of BNC105P: A Phase I Trial of a Novel Vascular Disrupting Agent and Inhibitor of Cancer Cell Proliferation

Danny Rischin, David C. Bibby, Geoff Chong, Gabriel Kremmidiotis, Annabell F. Leske, Clayton A. Matthews, Shirley S. Wong, Mark A. Rosen, Jayesh Desai
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (15): 5152–5160.
DOI: https://doi.org/10.1158/1078-0432.CCR-11-0937
Published: 31 July 2011
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Includes: Supplementary data
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KRAS Mutation Is Associated with Lung Metastasis in Patients with Curatively Resected Colorectal Cancer

Jeanne Tie, Lara Lipton, Jayesh Desai, Peter Gibbs, Robert N. Jorissen, Michael Christie, Katharine J. Drummond, Benjamin N.J. Thomson, Valery Usatoff, Peter M. Evans, Adrian W. Pick, Simon Knight, Peter W.G. Carne, Roger Berry, Adrian Polglase, Paul McMurrick, Qi Zhao, Dana Busam, Robert L. Strausberg, Enric Domingo, Ian P.M. Tomlinson, Rachel Midgley, David Kerr, Oliver M. Sieber
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (5): 1122–1130.
DOI: https://doi.org/10.1158/1078-0432.CCR-10-1720
Published: 01 March 2011
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Comprehensive Mapping of p53 Pathway Alterations Reveals an Apparent Role for Both SNP309 and MDM2 Amplification in Sarcomagenesis

Moriko Ito, Louise Barys, Terence O'Reilly, Sophie Young, Bella Gorbatcheva, John Monahan, Sabine Zumstein-Mecker, Peter F. Choong, Ian Dickinson, Philip Crowe, Christine Hemmings, Jayesh Desai, David M. Thomas, Joanna Lisztwan
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (3): 416–426.
DOI: https://doi.org/10.1158/1078-0432.CCR-10-2050
Published: 01 February 2011
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Journal Articles

Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer

Robert N. Jorissen, Peter Gibbs, Michael Christie, Saurabh Prakash, Lara Lipton, Jayesh Desai, David Kerr, Lauri A. Aaltonen, Diego Arango, Mogens Kruhøffer, Torben F. Ørntoft, Claus Lindbjerg Andersen, Mike Gruidl, Vidya P. Kamath, Steven Eschrich, Timothy J. Yeatman, Oliver M. Sieber
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (24): 7642–7651.
DOI: https://doi.org/10.1158/1078-0432.CCR-09-1431
Published: 14 December 2009
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DNA Copy-Number Alterations Underlie Gene Expression Differences between Microsatellite Stable and Unstable Colorectal Cancers

Robert N. Jorissen, Lara Lipton, Peter Gibbs, Matthew Chapman, Jayesh Desai, Ian T. Jones, Timothy J. Yeatman, Philip East, Ian P.M. Tomlinson, Hein W. Verspaget, Lauri A. Aaltonen, Mogens Kruhøffer, Torben F. Ørntoft, Claus Lindbjerg Andersen, Oliver M. Sieber
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (24): 8061–8069.
DOI: https://doi.org/10.1158/1078-0432.CCR-08-1431
Published: 15 December 2008
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Journal Articles

Clonal Evolution of Resistance to Imatinib in Patients with Metastatic Gastrointestinal Stromal Tumors

Jayesh Desai, Sridhar Shankar, Michael C. Heinrich, Jonathan A. Fletcher, Christopher D. Fletcher, Judi Manola, Jeffrey A. Morgan, Christopher L. Corless, Suzanne George, Kemal Tuncali, Stuart G. Silverman, Annick D. Van den Abbeele, Eric van Sonnenberg, George D. Demetri
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (18): 5398–5405.
DOI: https://doi.org/10.1158/1078-0432.CCR-06-0858
Published: 17 September 2007
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Journal Articles

Blood-Based Biomarkers of SU11248 Activity and Clinical Outcome in Patients with Metastatic Imatinib-Resistant Gastrointestinal Stromal Tumor

Anat Norden-Zfoni, Jayesh Desai, Judith Manola, Paul Beaudry, Jeremy Force, Robert Maki, Judah Folkman, Carlo Bello, Charles Baum, Sam E. DePrimo, David R. Shalinsky, Goerge D. Demetri, John V. Heymach
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (9): 2643–2650.
DOI: https://doi.org/10.1158/1078-0432.CCR-06-0919
Published: 01 May 2007
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Journal Articles

Phase II Study of the Antiangiogenic Agent SU5416 in Patients with Advanced Soft Tissue Sarcomas

John V. Heymach, Jayesh Desai, Judith Manola, Darren W. Davis, David J. McConkey, David Harmon, David P. Ryan, Geraldine Goss, Travis Quigley, Annick D. Van den Abbeele, Stuart G. Silverman, Susan Connors, Judah Folkman, Christopher D. M. Fletcher, George D. Demetri
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (17): 5732–5740.
DOI: https://doi.org/10.1158/1078-0432.CCR-04-0157
Published: 08 September 2004
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