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Jann N. Sarkaria
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Journal Articles

Preclinical Characterization of AZD9574, a Blood-Brain Barrier Penetrant Inhibitor of PARP1

Anna D. Staniszewska, Domenic Pilger, Sonja J. Gill, Kunzah Jamal, Natacha Bohin, Sofia Guzzetti, Jacob Gordon, Gregory Hamm, Gill Mundin, Giuditta Illuzzi, Andy Pike, Lisa McWilliams, Gareth Maglennon, Jonathan Rose, Glen Hawthorne, Miguel Cortes Gonzalez, Christer Halldin, Peter Johnström, Magnus Schou, Susan E. Critchlow, Stephen Fawell, Jeffrey W. Johannes, Elisabetta Leo, Barry R. Davies, Sabina Cosulich, Jann N. Sarkaria, Mark J. O'Connor, Petra Hamerlik
Journal: Clinical Cancer Research
Clin Cancer Res (2023)
https://doi.org/10.1158/1078-0432.CCR-23-2094
Published: 15 November 2023
View article titled, Preclinical Characterization of AZD9574, a Blood-Brain Barrier Penetrant Inhibitor of PARP1
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Includes: Supplementary data
Journal Articles

Magnetic Resonance Imaging of Iron Metabolism with T2* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM

Michael S. Petronek, Varun Monga, Kellie L. Bodeker, Michael Kwofie, Chu-Yu Lee, Kranti A. Mapuskar, Jeffrey M. Stolwijk, Amira Zaher, Brett A. Wagner, Mark C. Smith, Sandy Vollstedt, Heather Brown, Meghan L. Chandler, Amanda C. Lorack, Jared S. Wulfekuhle, Jann N. Sarkaria, Ryan T. Flynn, Jeremy D.W. Greenlee, Matthew A. Howard, Brian J. Smith, Karra A. Jones, Garry R. Buettner, Joseph J. Cullen, Joel St-Aubin, John M. Buatti, Vincent A. Magnotta, Douglas R. Spitz, Bryan G. Allen
Journal: Clinical Cancer Research
Clin Cancer Res OF1–OF11.
https://doi.org/10.1158/1078-0432.CCR-22-3952
Published: 13 October 2023
View article titled, Magnetic Resonance Imaging of Iron Metabolism with T<sub>2</sub>* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM
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Includes: Supplementary data
Journal Articles

TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas

Edgar Gonzalez-Buendia, Junfei Zhao, Lu Wang, Subhas Mukherjee, Daniel Zhang, Víctor A. Arrieta, Eric Feldstein, J. Robert Kane, Seong Jae Kang, Catalina Lee-Chang, Aayushi Mahajan, Li Chen, Ronald Realubit, Charles Karan, Lisa Magnuson, Craig Horbinski, Stacy A. Marshall, Jann N. Sarkaria, Ahmed Mohyeldin, Ichiro Nakano, Mukesh Bansal, Charles D. James, Daniel J. Brat, Atique Ahmed, Peter Canoll, Raul Rabadan, Ali Shilatifard, Adam M. Sonabend
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (20): 5669–5680.
https://doi.org/10.1158/1078-0432.CCR-21-0312
Published: 15 October 2021
View article titled, TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas
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Journal Articles

Genomic and Phenotypic Characterization of a Broad Panel of Patient-Derived Xenografts Reflects the Diversity of Glioblastoma

Rachael A. Vaubel, Shulan Tian, Dioval Remonde, Mark A. Schroeder, Ann C. Mladek, Gaspar J. Kitange, Alissa Caron, Thomas M. Kollmeyer, Rebecca Grove, Sen Peng, Brett L. Carlson, Daniel J. Ma, Gobinda Sarkar, Lisa Evers, Paul A. Decker, Huihuang Yan, Harshil D. Dhruv, Michael E. Berens, Qianghu Wang, Bianca M. Marin, Eric W. Klee, Andrea Califano, Daniel H. LaChance, Jeanette E. Eckel-Passow, Roel G. Verhaak, Erik P. Sulman, Terry C. Burns, Fredrick B. Meyer, Brian P. O'Neill, Nhan L. Tran, Caterina Giannini, Robert B. Jenkins, Ian F. Parney, Jann N. Sarkaria
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (5): 1094–1104.
https://doi.org/10.1158/1078-0432.CCR-19-0909
Published: 02 March 2020
View article titled, Genomic and Phenotypic Characterization of a Broad Panel of Patient-Derived Xenografts Reflects the Diversity of Glioblastoma
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Includes: Supplementary data
Journal Articles

Methylation-dependent Tissue Factor Suppression Contributes to the Reduced Malignancy of IDH1-mutant Gliomas

Dusten Unruh, Snezana Mirkov, Brian Wray, Michael Drumm, Jonathan Lamano, Yuping D. Li, Qazi F. Haider, Rodrigo Javier, Kathleen McCortney, Amanda Saratsis, Denise M. Scholtens, Jann N. Sarkaria, C. David James, Craig Horbinski
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (2): 747–759.
https://doi.org/10.1158/1078-0432.CCR-18-1222
Published: 15 January 2019
View article titled, Methylation-dependent Tissue Factor Suppression Contributes to the Reduced Malignancy of IDH1-mutant Gliomas
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Includes: Supplementary data
Journal Articles

CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma

Tony Avril, Amandine Etcheverry, Raphaël Pineau, Joanna Obacz, Gwénaële Jegou, Florence Jouan, Pierre-Jean Le Reste, Masumeh Hatami, Rivka R. Colen, Brett L. Carlson, Paul A. Decker, Jann N. Sarkaria, Elodie Vauléon, Dan Cristian Chiforeanu, Anne Clavreul, Jean Mosser, Eric Chevet, Véronique Quillien
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (23): 7360–7374.
https://doi.org/10.1158/1078-0432.CCR-17-1549
Published: 30 November 2017
View article titled, CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma
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Includes: Supplementary data
Journal Articles

Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival

Gaëlle Müller-Greven, Cathleen R. Carlin, Monica E. Burgett, Manmeet S. Ahluwalia, Adam Lauko, Amy S. Nowacki, Cameron J. Herting, Maha A. Qadan, Markus Bredel, Steven A. Toms, Justin D. Lathia, Dolores Hambardzumyan, Jann N. Sarkaria, Petra Hamerlik, Candece L. Gladson
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (22): 7059–7071.
https://doi.org/10.1158/1078-0432.CCR-17-0249
Published: 14 November 2017
View article titled, Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival
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Includes: Supplementary data
Journal Articles

Abstract B25: The critical importance of the blood-brain barrier in modulating the response to otherwise highly effective targeted therapies in patient-derived orthotopic glioblastoma xenografts

Jann N. Sarkaria, David Calligaris, Daniel Ma, Karen Parrish, Ann C. Mladek, Janice Laramy, Minjee Kim, Shuangling Zhang, Mark Schroeder, Brett L. Carlson, Katrina Bakken, Aaron Johnson, Nathalie Agar, William Elmquist
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16_Supplement): B25.
https://doi.org/10.1158/1557-3265.PDX16-B25
Published: 15 August 2016
View article titled, Abstract B25: The critical importance of the blood-brain barrier in modulating the response to otherwise highly effective targeted therapies in patient-derived orthotopic glioblastoma xenografts
Journal Articles

InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma

Yufang Ma, Nan Tang, Reid C. Thompson, Bret C. Mobley, Steven W. Clark, Jann N. Sarkaria, Jialiang Wang
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (7): 1767–1776.
https://doi.org/10.1158/1078-0432.CCR-15-1677
Published: 31 March 2016
View article titled, InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma
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Includes: Supplementary data
Journal Articles

The Efficacy of the Wee1 Inhibitor MK-1775 Combined with Temozolomide Is Limited by Heterogeneous Distribution across the Blood–Brain Barrier in Glioblastoma

Jenny L. Pokorny, David Calligaris, Shiv K. Gupta, Dennis O. Iyekegbe, Jr, Dustin Mueller, Katrina K. Bakken, Brett L. Carlson, Mark A. Schroeder, Debra L. Evans, Zhenkun Lou, Paul A. Decker, Jeanette E. Eckel-Passow, Vincenzo Pucci, Bennett Ma, Stuart D. Shumway, William F. Elmquist, Nathalie Y.R. Agar, Jann N. Sarkaria
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (8): 1916–1924.
https://doi.org/10.1158/1078-0432.CCR-14-2588
Published: 14 April 2015
View article titled, The Efficacy of the Wee1 Inhibitor MK-1775 Combined with Temozolomide Is Limited by Heterogeneous Distribution across the Blood–Brain Barrier in Glioblastoma
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Includes: Supplementary data
Journal Articles

Discordant In Vitro and In Vivo Chemopotentiating Effects of the PARP Inhibitor Veliparib in Temozolomide-Sensitive versus -Resistant Glioblastoma Multiforme Xenografts

Shiv K. Gupta, Ann C. Mladek, Brett L. Carlson, Felix Boakye-Agyeman, Katrina K. Bakken, Sani H. Kizilbash, Mark A. Schroeder, Joel Reid, Jann N. Sarkaria
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (14): 3730–3741.
https://doi.org/10.1158/1078-0432.CCR-13-3446
Published: 14 July 2014
View article titled, Discordant <em>In Vitro</em> and <em>In Vivo</em> Chemopotentiating Effects of the PARP Inhibitor Veliparib in Temozolomide-Sensitive versus -Resistant Glioblastoma Multiforme Xenografts
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Includes: Supplementary data
Journal Articles

Tumorgrafts as In Vivo Surrogates for Women with Ovarian Cancer

S. John Weroha, Marc A. Becker, Sergio Enderica-Gonzalez, Sean C. Harrington, Ann L. Oberg, Matthew J. Maurer, Sarah E. Perkins, Mariam AlHilli, Kristina A. Butler, Sarah McKinstry, Stephanie Fink, Robert B. Jenkins, Xiaonan Hou, Kimberly R. Kalli, Karin M. Goodman, Jann N. Sarkaria, Beth Y. Karlan, Amanika Kumar, Scott H. Kaufmann, Lynn C. Hartmann, Paul Haluska
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2014) 20 (5): 1288–1297.
https://doi.org/10.1158/1078-0432.CCR-13-2611
Published: 02 March 2014
View article titled, Tumorgrafts as <em>In Vivo</em> Surrogates for Women with Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Impairment of Glioma Stem Cell Survival and Growth by a Novel Inhibitor for Survivin–Ran Protein Complex

Hacer Guvenc, Marat S. Pavlyukov, Kaushal Joshi, Habibe Kurt, Yeshavanth K. Banasavadi-Siddegowda, Ping Mao, Christopher Hong, Ryosuke Yamada, Chang-Hyuk Kwon, Deepak Bhasin, Somsundaram Chettiar, Gaspar Kitange, In-Hee Park, Jann N. Sarkaria, Chenglong Li, Mihail I. Shakhparonov, Ichiro Nakano
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (3): 631–642.
https://doi.org/10.1158/1078-0432.CCR-12-0647
Published: 31 January 2013
View article titled, Impairment of Glioma Stem Cell Survival and Growth by a Novel Inhibitor for Survivin–Ran Protein Complex
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Includes: Supplementary data
Journal Articles

Targeting the PI3K Pathway in the Brain—Efficacy of a PI3K Inhibitor Optimized to Cross the Blood–Brain Barrier

Laurent Salphati, Timothy P. Heffron, Bruno Alicke, Merry Nishimura, Kai Barck, Richard A. Carano, Jonathan Cheong, Kyle A. Edgar, Joan Greve, Samir Kharbanda, Hartmut Koeppen, Shari Lau, Leslie B. Lee, Jodie Pang, Emile G. Plise, Jenny L. Pokorny, Hani Bou Reslan, Jann N. Sarkaria, Jeffrey J. Wallin, Xiaolin Zhang, Stephen E. Gould, Alan G. Olivero, Heidi S. Phillips
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (22): 6239–6248.
https://doi.org/10.1158/1078-0432.CCR-12-0720
Published: 14 November 2012
View article titled, Targeting the PI3K Pathway in the Brain—Efficacy of a PI3K Inhibitor Optimized to Cross the Blood–Brain Barrier
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Includes: Supplementary data
Journal Articles

Inhibition of Histone Deacetylation Potentiates the Evolution of Acquired Temozolomide Resistance Linked to MGMT Upregulation in Glioblastoma Xenografts

Gaspar J. Kitange, Ann C. Mladek, Brett L. Carlson, Mark A. Schroeder, Jenny L. Pokorny, Ling Cen, Paul A. Decker, Wenting Wu, Gwen A. Lomberk, Shiv K. Gupta, Raul A. Urrutia, Jann N. Sarkaria
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (15): 4070–4079.
https://doi.org/10.1158/1078-0432.CCR-12-0560
Published: 30 July 2012
View article titled, Inhibition of Histone Deacetylation Potentiates the Evolution of Acquired Temozolomide Resistance Linked to MGMT Upregulation in Glioblastoma Xenografts
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Includes: Supplementary data
Journal Articles

Combination of Temsirolimus (CCI-779) with Chemoradiation in Newly Diagnosed Glioblastoma Multiforme (GBM) (NCCTG trial N027D) Is Associated with Increased Infectious Risks

Jann N. Sarkaria, Eva Galanis, Wenting Wu, Allan B. Dietz, Timothy J. Kaufmann, Michael P. Gustafson, Paul D. Brown, Joon H. Uhm, Ravi D. Rao, Laurence Doyle, Caterina Giannini, Kurt A. Jaeckle, Jan C. Buckner
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (22): 5573–5580.
https://doi.org/10.1158/1078-0432.CCR-10-1453
Published: 14 November 2010
View article titled, Combination of Temsirolimus (CCI-779) with Chemoradiation in Newly Diagnosed Glioblastoma Multiforme (GBM) (NCCTG trial N027D) Is Associated with Increased Infectious Risks
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Journal Articles

PTEN Loss Does Not Predict for Response to RAD001 (Everolimus) in a Glioblastoma Orthotopic Xenograft Test Panel

Lin Yang, Michelle J. Clarke, Brett L. Carlson, Ann C. Mladek, Mark A. Schroeder, Paul Decker, Wenting Wu, Gaspar J. Kitange, Patrick T. Grogan, Jennie M. Goble, Joon Uhm, Evanthia Galanis, Caterina Giannini, Heidi A. Lane, C. David James, Jann N. Sarkaria
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (12): 3993–4001.
https://doi.org/10.1158/1078-0432.CCR-07-4152
Published: 16 June 2008
View article titled, PTEN Loss Does Not Predict for Response to RAD001 (Everolimus) in a Glioblastoma Orthotopic Xenograft Test Panel
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Journal Articles

Mechanisms of Chemoresistance to Alkylating Agents in Malignant Glioma

Jann N. Sarkaria, Gaspar J. Kitange, C. David James, Ruth Plummer, Hilary Calvert, Michael Weller, Wolfgang Wick
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (10): 2900–2908.
https://doi.org/10.1158/1078-0432.CCR-07-1719
Published: 15 May 2008
View article titled, Mechanisms of Chemoresistance to Alkylating Agents in Malignant Glioma
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Journal Articles

Combination of Measles Virus Virotherapy and Radiation Therapy Has Synergistic Activity in the Treatment of Glioblastoma Multiforme

Chunsheng Liu, Jann N. Sarkaria, Cory A. Petell, Georgia Paraskevakou, Paula J. Zollman, Mark Schroeder, Brett Carlson, Paul A. Decker, Wenting Wu, C. David James, Stephen J. Russell, Evanthia Galanis
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (23): 7155–7165.
https://doi.org/10.1158/1078-0432.CCR-07-1306
Published: 03 December 2007
View article titled, Combination of Measles Virus Virotherapy and Radiation Therapy Has Synergistic Activity in the Treatment of Glioblastoma Multiforme
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Journal Articles

Use of an Orthotopic Xenograft Model for Assessing the Effect of Epidermal Growth Factor Receptor Amplification on Glioblastoma Radiation Response

Jann N. Sarkaria, Brett L. Carlson, Mark A. Schroeder, Patrick Grogan, Paul D. Brown, Caterina Giannini, Karla V. Ballman, Gaspar J. Kitange, Abjahit Guha, Ajay Pandita, C. David James
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (7): 2264–2271.
https://doi.org/10.1158/1078-0432.CCR-05-2510
Published: 11 April 2006
View article titled, Use of an Orthotopic Xenograft Model for Assessing the Effect of Epidermal Growth Factor Receptor Amplification on Glioblastoma Radiation Response
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