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Jane B. Trepel
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Journal Articles

Cabozantinib plus Nivolumab Phase I Expansion Study in Patients with Metastatic Urothelial Carcinoma Refractory to Immune Checkpoint Inhibitor Therapy

Daniel M. Girardi, Scot A. Niglio, Amir Mortazavi, Rosa Nadal, Primo Lara, Sumanta K. Pal, Biren Saraiya, Lisa Cordes, Lisa Ley, Olena Sierra Ortiz, Jacqueline Cadena, Carlos Diaz, Hadi Bagheri, Bernadette Redd, Seth M. Steinberg, Rene Costello, Keith S. Chan, Min-Jung Lee, Sunmin Lee, Yunkai Yu, Sandeep Gurram, Heather J. Chalfin, Vladimir Valera, William D. Figg, Maria Merino, Antoun Toubaji, Howard Streicher, John J. Wright, Elad Sharon, Howard L. Parnes, Yang-Min Ning, Donald P. Bottaro, Liang Cao, Jane B. Trepel, Andrea B. Apolo
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (7): 1353–1362.
https://doi.org/10.1158/1078-0432.CCR-21-3726
Published: 01 April 2022
View article titled, Cabozantinib plus Nivolumab Phase I Expansion Study in Patients with Metastatic Urothelial Carcinoma Refractory to Immune Checkpoint Inhibitor Therapy
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Includes: Supplementary data
Journal Articles

Circulating Tumor Cell Subtypes and T-cell Populations as Prognostic Biomarkers to Combination Immunotherapy in Patients with Metastatic Genitourinary Cancer

Heather J. Chalfin, Tiziano Pramparo, Amir Mortazavi, Scot A. Niglio, Joseph D. Schonhoft, Adam Jendrisak, Yen-Lin Chu, Robin Richardson, Rachel Krupa, Amanda K.L. Anderson, Yipeng Wang, Ryan Dittamore, Sumanta K. Pal, Primo N. Lara, Mark N. Stein, David I. Quinn, Seth M. Steinberg, Lisa M. Cordes, Lisa Ley, Marissa Mallek, Olena Sierra Ortiz, Rene Costello, Jacqueline Cadena, Carlos Diaz, James L. Gulley, William L. Dahut, Howard Streicher, John J. Wright, Jane B. Trepel, Donald P. Bottaro, Andrea B. Apolo
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (5): 1391–1398.
https://doi.org/10.1158/1078-0432.CCR-20-2891
Published: 01 March 2021
View article titled, Circulating Tumor Cell Subtypes and T-cell Populations as Prognostic Biomarkers to Combination Immunotherapy in Patients with Metastatic Genitourinary Cancer
Open the PDF for Circulating Tumor Cell Subtypes and T-cell Populations as Prognostic Biomarkers to Combination Immunotherapy in Patients with Metastatic Genitourinary Cancer in another window
Includes: Supplementary data
Journal Articles

Entinostat plus Pembrolizumab in Patients with Metastatic NSCLC Previously Treated with Anti–PD-(L)1 Therapy

Matthew D. Hellmann, Pasi A. Jänne, Mateusz Opyrchal, Navid Hafez, Luis E. Raez, Dmitry I. Gabrilovich, Fang Wang, Jane B. Trepel, Min-Jung Lee, Akira Yuno, Sunmin Lee, Susan Brouwer, Serap Sankoh, Lei Wang, David Tamang, Emmett V. Schmidt, Michael L. Meyers, Suresh S. Ramalingam, Elaine Shum, Peter Ordentlich
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (4): 1019–1028.
https://doi.org/10.1158/1078-0432.CCR-20-3305
Published: 15 February 2021
View article titled, Entinostat plus Pembrolizumab in Patients with Metastatic NSCLC Previously Treated with Anti–PD-(L)1 Therapy
Open the PDF for Entinostat plus Pembrolizumab in Patients with Metastatic NSCLC Previously Treated with Anti–PD-(L)1 Therapy in another window
Includes: Supplementary data
Journal Articles

Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study

Michael J. Burke, Rumen Kostadinov, Richard Sposto, Lia Gore, Shannon M. Kelley, Cara Rabik, Jane B. Trepel, Min-Jung Lee, Akira Yuno, Sunmin Lee, Deepa Bhojwani, Sima Jeha, Bill H. Chang, Maria Luisa Sulis, Michelle L. Hermiston, Paul Gaynon, Van Huynh, Anupam Verma, Rebecca Gardner, Kenneth M. Heym, Robyn M. Dennis, David S. Ziegler, Theodore W. Laetsch, Javier E. Oesterheld, Steven G. Dubois, Jessica A. Pollard, Julia Glade-Bender, Todd M. Cooper, Joel A. Kaplan, Midhat S. Farooqi, Byunggil Yoo, Erin Guest, Alan S. Wayne, Patrick A. Brown
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (10): 2297–2307.
https://doi.org/10.1158/1078-0432.CCR-19-1251
Published: 15 May 2020
View article titled, Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study
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Includes: Supplementary data
Journal Articles

Phase I/II Study of the Mesothelin-targeted Immunotoxin LMB-100 with Nab-Paclitaxel for Patients with Advanced Pancreatic Adenocarcinoma

Christine Alewine, Mehwish Ahmad, Cody J. Peer, Zishuo I. Hu, Min-Jung Lee, Akira Yuno, Jessica D. Kindrick, Anish Thomas, Seth M. Steinberg, Jane B. Trepel, William D. Figg, Raffit Hassan, Ira Pastan
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (4): 828–836.
https://doi.org/10.1158/1078-0432.CCR-19-2586
Published: 14 February 2020
View article titled, Phase I/II Study of the Mesothelin-targeted Immunotoxin LMB-100 with Nab-Paclitaxel for Patients with Advanced Pancreatic Adenocarcinoma
Open the PDF for Phase I/II Study of the Mesothelin-targeted Immunotoxin LMB-100 with Nab-Paclitaxel for Patients with Advanced Pancreatic Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation

Alex M. Jaeger, Lauren Stopfer, Sunmin Lee, Giorgio Gaglia, Demi Sandel, Sandro Santagata, Nancy U. Lin, Jane B. Trepel, Forest White, Tyler Jacks, Susan Lindquist, Luke Whitesell
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (21): 6392–6405.
https://doi.org/10.1158/1078-0432.CCR-19-0596
Published: 01 November 2019
View article titled, Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation
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Includes: Supplementary data
Journal Articles

Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 (SLFN11) Expression with Class I Histone Deacetylase Inhibitors

Sai-Wen Tang, Anish Thomas, Junko Murai, Jane B. Trepel, Susan E. Bates, Vinodh N. Rajapakse, Yves Pommier
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (8): 1944–1953.
https://doi.org/10.1158/1078-0432.CCR-17-0443
Published: 12 April 2018
View article titled, Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 (<em>SLFN11)</em> Expression with Class I Histone Deacetylase Inhibitors
Open the PDF for Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 (<em>SLFN11)</em> Expression with Class I Histone Deacetylase Inhibitors in another window
Includes: Supplementary data
Journal Articles

A Phase I/II Trial of Belinostat in Combination with Cisplatin, Doxorubicin, and Cyclophosphamide in Thymic Epithelial Tumors: A Clinical and Translational Study

Anish Thomas, Arun Rajan, Eva Szabo, Yusuke Tomita, Corey A. Carter, Barbara Scepura, Ariel Lopez-Chavez, Min-Jung Lee, Christophe E. Redon, Ari Frosch, Cody J. Peer, Yuanbin Chen, Richard Piekarz, Seth M. Steinberg, Jane B. Trepel, William D. Figg, David S. Schrump, Giuseppe Giaccone
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (21): 5392–5402.
https://doi.org/10.1158/1078-0432.CCR-14-0968
Published: 30 October 2014
View article titled, A Phase I/II Trial of Belinostat in Combination with Cisplatin, Doxorubicin, and Cyclophosphamide in Thymic Epithelial Tumors: A Clinical and Translational Study
Open the PDF for A Phase I/II Trial of Belinostat in Combination with Cisplatin, Doxorubicin, and Cyclophosphamide in Thymic Epithelial Tumors: A Clinical and Translational Study in another window
Includes: Supplementary data
Journal Articles

Stressing the Development of Small Molecules Targeting HSP90

Len Neckers, Jane B. Trepel
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (2): 275–277.
https://doi.org/10.1158/1078-0432.CCR-13-2571
Published: 16 January 2014
View article titled, Stressing the Development of Small Molecules Targeting HSP90
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Includes: Supplementary data
Journal Articles

A Phase I Study of PF-04929113 (SNX-5422), an Orally Bioavailable Heat Shock Protein 90 Inhibitor, in Patients with Refractory Solid Tumor Malignancies and Lymphomas

Arun Rajan, Ronan J. Kelly, Jane B. Trepel, Yeong Sang Kim, Sylvia V. Alarcon, Shivaani Kummar, Martin Gutierrez, Sonja Crandon, Wadih M. Zein, Lokesh Jain, Baskar Mannargudi, William D. Figg, Brett E. Houk, Michael Shnaidman, Nicoletta Brega, Giuseppe Giaccone
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (21): 6831–6839.
https://doi.org/10.1158/1078-0432.CCR-11-0821
Published: 31 October 2011
View article titled, A Phase I Study of PF-04929113 (SNX-5422), an Orally Bioavailable Heat Shock Protein 90 Inhibitor, in Patients with Refractory Solid Tumor Malignancies and Lymphomas
Open the PDF for A Phase I Study of PF-04929113 (SNX-5422), an Orally Bioavailable Heat Shock Protein 90 Inhibitor, in Patients with Refractory Solid Tumor Malignancies and Lymphomas in another window
Includes: Supplementary data
Journal Articles

Phase I Trial of MS-275, a Histone Deacetylase Inhibitor, Administered Weekly in Refractory Solid Tumors and Lymphoid Malignancies

Shivaani Kummar, Martin Gutierrez, Erin R. Gardner, Erin Donovan, Kyunghwa Hwang, Eun Joo Chung, Min-Jung Lee, Kim Maynard, Mikhail Kalnitskiy, Alice Chen, Giovanni Melillo, Qin C. Ryan, Barbara Conley, William D. Figg, Jane B. Trepel, James Zwiebel, James H. Doroshow, Anthony J. Murgo
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (18): 5411–5417.
https://doi.org/10.1158/1078-0432.CCR-07-0791
Published: 17 September 2007
View article titled, Phase I Trial of MS-275, a Histone Deacetylase Inhibitor, Administered Weekly in Refractory Solid Tumors and Lymphoid Malignancies
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Journal Articles

Abrogation of p21 Expression by Flavopiridol Enhances Depsipeptide-Mediated Apoptosis in Malignant Pleural Mesothelioma Cells

Dao M. Nguyen, William D. Schrump, G. Aaron Chen, Wilson Tsai, Phuongmai Nguyen, Jane B. Trepel, David S. Schrump
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (5): 1813–1825.
https://doi.org/10.1158/1078-0432.CCR-0901-3
Published: 10 March 2004
View article titled, Abrogation of p21 Expression by Flavopiridol Enhances Depsipeptide-Mediated Apoptosis in Malignant Pleural Mesothelioma Cells
Open the PDF for Abrogation of p21 Expression by Flavopiridol Enhances Depsipeptide-Mediated Apoptosis in Malignant Pleural Mesothelioma Cells in another window