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James W. Smithy
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Journal Articles

Early On-Treatment Assessment of T Cells, Cytokines, and Tumor DNA with Adaptively Dosed Nivolumab + Ipilimumab: Final Results from the Phase 2 ADAPT-IT Study

James W. Smithy, Hannah L. Kalvin, Fiona D. Ehrich, Ronak Shah, Matthew Adamow, Vladislav Raber, Collen A. Maher, Jenna Kleman, Deborah A.G. McIntyre, Alexander N. Shoushtari, Allison Betof Warner, Margaret K. Callahan, Parisa Momtaz, Omar Eton, Suresh Nair, Jedd D. Wolchok, Paul B. Chapman, Michael F. Berger, Katherine S. Panageas, Michael A. Postow
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (16): 3407–3415.
https://doi.org/10.1158/1078-0432.CCR-23-3643
Published: 15 August 2024
View article titled, Early On-Treatment Assessment of T Cells, Cytokines, and Tumor DNA with Adaptively Dosed Nivolumab + Ipilimumab: Final Results from the Phase 2 ADAPT-IT Study
Open the PDF for Early On-Treatment Assessment of T Cells, Cytokines, and Tumor DNA with Adaptively Dosed Nivolumab + Ipilimumab: Final Results from the Phase 2 ADAPT-IT Study in another window
Includes: Supplementary data
Journal Articles

CD16+ Macrophages: An Emerging Biomarker for Combined CTLA-4 and PD-1 Blockade

James W. Smithy, Jason J. Luke
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (13): 2345–2347.
https://doi.org/10.1158/1078-0432.CCR-23-0490
Published: 05 July 2023
View article titled, CD16<sup>+</sup> Macrophages: An Emerging Biomarker for Combined CTLA-4 and PD-1 Blockade
Open the PDF for CD16<sup>+</sup> Macrophages: An Emerging Biomarker for Combined CTLA-4 and PD-1 Blockade in another window
Journal Articles

Facts and Hopes in Prediction, Diagnosis, and Treatment of Immune-Related Adverse Events

James W. Smithy, David M. Faleck, Michael A. Postow
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (7): 1250–1257.
https://doi.org/10.1158/1078-0432.CCR-21-1240
Published: 01 April 2022
View article titled, Facts and Hopes in Prediction, Diagnosis, and Treatment of Immune-Related Adverse Events
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Journal Articles

High-Plex Predictive Marker Discovery for Melanoma Immunotherapy–Treated Patients Using Digital Spatial Profiling

Maria I. Toki, Christopher R. Merritt, Pok Fai Wong, James W. Smithy, Harriet M. Kluger, Konstantinos N. Syrigos, Giang T. Ong, Sarah E. Warren, Joseph M. Beechem, David L. Rimm
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (18): 5503–5512.
https://doi.org/10.1158/1078-0432.CCR-19-0104
Published: 13 September 2019
View article titled, High-Plex Predictive Marker Discovery for Melanoma Immunotherapy–Treated Patients Using Digital Spatial Profiling
Open the PDF for High-Plex Predictive Marker Discovery for Melanoma Immunotherapy–Treated Patients Using Digital Spatial Profiling in another window
Includes: Supplementary data
Journal Articles

Multiplex Quantitative Analysis of Tumor-Infiltrating Lymphocytes and Immunotherapy Outcome in Metastatic Melanoma

Pok Fai Wong, Wei Wei, James W. Smithy, Balazs Acs, Maria I. Toki, Kim R.M. Blenman, Daniel Zelterman, Harriet M. Kluger, David L. Rimm
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (8): 2442–2449.
https://doi.org/10.1158/1078-0432.CCR-18-2652
Published: 15 April 2019
View article titled, Multiplex Quantitative Analysis of Tumor-Infiltrating Lymphocytes and Immunotherapy Outcome in Metastatic Melanoma
Open the PDF for Multiplex Quantitative Analysis of Tumor-Infiltrating Lymphocytes and Immunotherapy Outcome in Metastatic Melanoma in another window
Includes: Supplementary data