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James L. Gulley
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Journal Articles

Cooperative Armoring of CAR and TCR T Cells by T Cell–Restricted IL15 and IL21 Universally Enhances Solid Tumor Efficacy

Rosa Nguyen, Ekaterina Doubrovina, Charlotte M. Mousset, Benjamin Y. Jin, Reona Okada, Xiyuan Zhang, Arina Clavel, Jeyshka M. Reyes-Gonzalez, Vadim Dyomin, Louis Diaz, Ling Zhang, Shahroze Abbas, Ming Sun, Chao-Ming Hsieh, Mitchell Ho, Jack F. Shern, James L. Gulley, Christian S. Hinrichs
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (8): 1555–1566.
https://doi.org/10.1158/1078-0432.CCR-23-1872
Published: 15 April 2024
View articletitled, Cooperative Armoring of CAR and TCR T Cells by T Cell–Restricted IL15 and IL21 Universally Enhances Solid Tumor Efficacy
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Includes: Supplementary data
Journal Articles

Molecular Pathways and Mechanisms of TGFβ in Cancer Therapy

Mary Helen Barcellos-Hoff, James L. Gulley
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (11): 2025–2033.
https://doi.org/10.1158/1078-0432.CCR-21-3750
Published: 01 June 2023
View articletitled, Molecular Pathways and Mechanisms of TGFβ in Cancer Therapy
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Journal Articles

Circulating Tumor Cell Subtypes and T-cell Populations as Prognostic Biomarkers to Combination Immunotherapy in Patients with Metastatic Genitourinary Cancer

Heather J. Chalfin, Tiziano Pramparo, Amir Mortazavi, Scot A. Niglio, Joseph D. Schonhoft, Adam Jendrisak, Yen-Lin Chu, Robin Richardson, Rachel Krupa, Amanda K.L. Anderson, Yipeng Wang, Ryan Dittamore, Sumanta K. Pal, Primo N. Lara, Mark N. Stein, David I. Quinn, Seth M. Steinberg, Lisa M. Cordes, Lisa Ley, Marissa Mallek, Olena Sierra Ortiz, Rene Costello, Jacqueline Cadena, Carlos Diaz, James L. Gulley, William L. Dahut, Howard Streicher, John J. Wright, Jane B. Trepel, Donald P. Bottaro, Andrea B. Apolo
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (5): 1391–1398.
https://doi.org/10.1158/1078-0432.CCR-20-2891
Published: 01 March 2021
View articletitled, Circulating Tumor Cell Subtypes and T-cell Populations as Prognostic Biomarkers to Combination Immunotherapy in Patients with Metastatic Genitourinary Cancer
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Includes: Supplementary data
Journal Articles

Sequential Prostate Magnetic Resonance Imaging in Newly Diagnosed High-risk Prostate Cancer Treated with Neoadjuvant Enzalutamide is Predictive of Therapeutic Response

Fatima Karzai, Stephanie M. Walker, Scott Wilkinson, Ravi A. Madan, Joanna H. Shih, Maria J. Merino, Stephanie A. Harmon, David J. VanderWeele, Lisa M. Cordes, Nicole V. Carrabba, John R. Bright, Nicolas T. Terrigino, Guinevere Chun, Marijo Bilusic, Anna Couvillon, Amy Hankin, Monique N. Williams, Rosina T. Lis, Huihui Ye, Peter L. Choyke, James L. Gulley, Adam G. Sowalsky, Baris Turkbey, Peter A. Pinto, William L. Dahut
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (2): 429–437.
https://doi.org/10.1158/1078-0432.CCR-20-2344
Published: 19 January 2021
View articletitled, Sequential Prostate Magnetic Resonance Imaging in Newly Diagnosed High-risk Prostate Cancer Treated with Neoadjuvant Enzalutamide is Predictive of Therapeutic Response
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Includes: Supplementary data
Journal Articles

The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance

Himisha Beltran, Andrew Hruszkewycz, Howard I. Scher, Jeffrey Hildesheim, Jennifer Isaacs, Evan Y. Yu, Kathleen Kelly, Daniel Lin, Adam Dicker, Julia Arnold, Toby Hecht, Max Wicha, Rosalie Sears, David Rowley, Richard White, James L. Gulley, John Lee, Maria Diaz Meco, Eric J. Small, Michael Shen, Karen Knudsen, David W. Goodrich, Tamara Lotan, Amina Zoubeidi, Charles L. Sawyers, Charles M. Rudin, Massimo Loda, Timothy Thompson, Mark A. Rubin, Abdul Tawab-Amiri, William Dahut, Peter S. Nelson
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (23): 6916–6924.
https://doi.org/10.1158/1078-0432.CCR-19-1423
Published: 02 December 2019
View articletitled, The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance
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Includes: Supplementary data
Journal Articles

A Phase I Dose-Escalation Trial of BN-CV301, a Recombinant Poxviral Vaccine Targeting MUC1 and CEA with Costimulatory Molecules

Margaret E. Gatti-Mays, Julius Strauss, Renee N. Donahue, Claudia Palena, Jaydira Del Rivero, Jason M. Redman, Ravi A. Madan, Jennifer L. Marté, Lisa M. Cordes, Elizabeth Lamping, Alanvin Orpia, Andrea Burmeister, Eva Wagner, Cesar Pico Navarro, Christopher R. Heery, Jeffrey Schlom, James L. Gulley
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (16): 4933–4944.
https://doi.org/10.1158/1078-0432.CCR-19-0183
Published: 15 August 2019
View articletitled, A Phase I Dose-Escalation Trial of BN-CV301, a Recombinant Poxviral Vaccine Targeting MUC1 and CEA with Costimulatory Molecules
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Includes: Supplementary data
Journal Articles

First-in-Human Phase I Trial of a Tumor-Targeted Cytokine (NHS-IL12) in Subjects with Metastatic Solid Tumors

Julius Strauss, Christopher R. Heery, Joseph W. Kim, Caroline Jochems, Renee N. Donahue, Agnes S. Montgomery, Sheri McMahon, Elizabeth Lamping, Jennifer L. Marté, Ravi A. Madan, Marijo Bilusic, Matthew R. Silver, Elisa Bertotti, Jeffrey Schlom, James L. Gulley
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (1): 99–109.
https://doi.org/10.1158/1078-0432.CCR-18-1512
Published: 03 January 2019
View articletitled, First-in-Human Phase I Trial of a Tumor-Targeted Cytokine (NHS-IL12) in Subjects with Metastatic Solid Tumors
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Includes: Supplementary data
Journal Articles

Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, in Advanced Solid Tumors

Julius Strauss, Christopher R. Heery, Jeffrey Schlom, Ravi A. Madan, Liang Cao, Zhigang Kang, Elizabeth Lamping, Jennifer L. Marté, Renee N. Donahue, Italia Grenga, Lisa Cordes, Olaf Christensen, Lisa Mahnke, Christoph Helwig, James L. Gulley
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (6): 1287–1295.
https://doi.org/10.1158/1078-0432.CCR-17-2653
Published: 14 March 2018
View articletitled, Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, in Advanced Solid Tumors
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Includes: Supplementary data
Journal Articles

Phase I Study of a Poxviral TRICOM-Based Vaccine Directed Against the Transcription Factor Brachyury

Christopher R. Heery, Claudia Palena, Sheri McMahon, Renee N. Donahue, Lauren M. Lepone, Italia Grenga, Ulrike Dirmeier, Lisa Cordes, Jenn Marté, William Dahut, Harpreet Singh, Ravi A. Madan, Romaine I. Fernando, Duane H. Hamilton, Jeffrey Schlom, James L. Gulley
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (22): 6833–6845.
https://doi.org/10.1158/1078-0432.CCR-17-1087
Published: 14 November 2017
View articletitled, Phase I Study of a Poxviral TRICOM-Based Vaccine Directed Against the Transcription Factor Brachyury
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Includes: Supplementary data
Journal Articles

Immunotherapy of Prostate Cancer: Facts and Hopes

Marijo Bilusic, Ravi A. Madan, James L. Gulley
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (22): 6764–6770.
https://doi.org/10.1158/1078-0432.CCR-17-0019
Published: 14 November 2017
View articletitled, Immunotherapy of Prostate Cancer: Facts and Hopes
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Journal Articles

Serum Antibodies to Blood Group A Predict Survival on PROSTVAC-VF

Christopher T. Campbell, James L. Gulley, Oyindasola Oyelaran, James W. Hodge, Jeffrey Schlom, Jeffrey C. Gildersleeve
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (5): 1290–1299.
https://doi.org/10.1158/1078-0432.CCR-12-2478
Published: 03 March 2013
View articletitled, Serum Antibodies to Blood Group A Predict Survival on PROSTVAC-VF
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Includes: Supplementary data
Journal Articles

A Pilot Study of MUC-1/CEA/TRICOM Poxviral-Based Vaccine in Patients with Metastatic Breast and Ovarian Cancer

Mahsa Mohebtash, Kwong-Yok Tsang, Ravi A. Madan, Ngar-Yee Huen, Diane J. Poole, Caroline Jochems, Jacquin Jones, Theresa Ferrara, Christopher R. Heery, Philip M. Arlen, Seth M. Steinberg, Mary Pazdur, Myrna Rauckhorst, Elizabeth C. Jones, William L. Dahut, Jeffrey Schlom, James L. Gulley
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (22): 7164–7173.
https://doi.org/10.1158/1078-0432.CCR-11-0649
Published: 14 November 2011
View articletitled, A Pilot Study of MUC-1/CEA/TRICOM Poxviral-Based Vaccine in Patients with Metastatic Breast and Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Prostate Cancer Immunotherapy

Kenneth F. May, Jr., James L. Gulley, Charles G. Drake, Glenn Dranoff, Philip W. Kantoff
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (16): 5233–5238.
https://doi.org/10.1158/1078-0432.CCR-10-3402
Published: 14 August 2011
View articletitled, Prostate Cancer Immunotherapy
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Journal Articles

Immunotherapy for Prostate Cancer: Recent Advances, Lessons Learned, and Areas for Further Research

James L. Gulley, Charles G. Drake
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (12): 3884–3891.
https://doi.org/10.1158/1078-0432.CCR-10-2656
Published: 15 June 2011
View articletitled, Immunotherapy for Prostate Cancer: Recent Advances, Lessons Learned, and Areas for Further Research
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Journal Articles

Tumor Regression and Growth Rates Determined in Five Intramural NCI Prostate Cancer Trials: The Growth Rate Constant as an Indicator of Therapeutic Efficacy

Wilfred D. Stein, James L. Gulley, Jeff Schlom, Ravi A. Madan, William Dahut, William D. Figg, Yang-min Ning, Phil M. Arlen, Doug Price, Susan E. Bates, Tito Fojo
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (4): 907–917.
https://doi.org/10.1158/1078-0432.CCR-10-1762
Published: 15 February 2011
View articletitled, Tumor Regression and Growth Rates Determined in Five Intramural NCI Prostate Cancer Trials: The Growth Rate Constant as an Indicator of Therapeutic Efficacy
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Includes: Supplementary data
Journal Articles

A Viral Vaccine Encoding Prostate-Specific Antigen Induces Antigen Spreading to a Common Set of Self-Proteins in Prostate Cancer Patients

Nancy J. Nesslinger, Alvin Ng, Kwong-Yok Tsang, Theresa Ferrara, Jeffrey Schlom, James L. Gulley, Brad H. Nelson
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (15): 4046–4056.
https://doi.org/10.1158/1078-0432.CCR-10-0948
Published: 28 July 2010
View articletitled, A Viral Vaccine Encoding Prostate-Specific Antigen Induces Antigen Spreading to a Common Set of Self-Proteins in Prostate Cancer Patients
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Includes: Supplementary data
Journal Articles

Safety and Immunologic Response of a Viral Vaccine to Prostate-Specific Antigen in Combination with Radiation Therapy when Metronomic-Dose Interleukin 2 Is Used as an Adjuvant

Robert J. Lechleider, Philip M. Arlen, Kwong-Yok Tsang, Seth M. Steinberg, Junko Yokokawa, Vittore Cereda, Kevin Camphausen, Jeffrey Schlom, William L. Dahut, James L. Gulley
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (16): 5284–5291.
https://doi.org/10.1158/1078-0432.CCR-07-5162
Published: 12 August 2008
View articletitled, Safety and Immunologic Response of a Viral Vaccine to Prostate-Specific Antigen in Combination with Radiation Therapy when Metronomic-Dose Interleukin 2 Is Used as an Adjuvant
Open the PDF for Safety and Immunologic Response of a Viral Vaccine to Prostate-Specific Antigen in Combination with Radiation Therapy when Metronomic-Dose Interleukin 2 Is Used as an Adjuvant in another window
Journal Articles

Analysis of Overall Survival in Patients with Nonmetastatic Castration-Resistant Prostate Cancer Treated with Vaccine, Nilutamide, and Combination Therapy

Ravi A. Madan, James L. Gulley, Jeffrey Schlom, Seth M. Steinberg, David J. Liewehr, William L. Dahut, Philip M. Arlen
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (14): 4526–4531.
https://doi.org/10.1158/1078-0432.CCR-07-5048
Published: 15 July 2008
View articletitled, Analysis of Overall Survival in Patients with Nonmetastatic Castration-Resistant Prostate Cancer Treated with Vaccine, Nilutamide, and Combination Therapy
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Journal Articles

Pilot Study of Vaccination with Recombinant CEA-MUC-1-TRICOM Poxviral-Based Vaccines in Patients with Metastatic Carcinoma

James L. Gulley, Philip M. Arlen, Kwong-Yok Tsang, Junko Yokokawa, Claudia Palena, Diane J. Poole, Cinzia Remondo, Vittore Cereda, Jacquin L. Jones, Mary P. Pazdur, Jack P. Higgins, James W. Hodge, Seth M. Steinberg, Herbert Kotz, William L. Dahut, Jeffrey Schlom
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (10): 3060–3069.
https://doi.org/10.1158/1078-0432.CCR-08-0126
Published: 15 May 2008
View articletitled, Pilot Study of Vaccination with Recombinant CEA-MUC-1-TRICOM Poxviral-Based Vaccines in Patients with Metastatic Carcinoma
Open the PDF for Pilot Study of Vaccination with Recombinant CEA-MUC-1-TRICOM Poxviral-Based Vaccines in Patients with Metastatic Carcinoma in another window
Includes: Supplementary data
Journal Articles

Enhanced Functionality of CD4+CD25highFoxP3+ Regulatory T Cells in the Peripheral Blood of Patients with Prostate Cancer

Junko Yokokawa, Vittore Cereda, Cinzia Remondo, James L. Gulley, Philip M. Arlen, Jeffrey Schlom, Kwong Y. Tsang
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (4): 1032–1040.
https://doi.org/10.1158/1078-0432.CCR-07-2056
Published: 15 February 2008
View articletitled, Enhanced Functionality of CD4+CD25highFoxP3+ Regulatory T Cells in the Peripheral Blood of Patients with Prostate Cancer
Open the PDF for Enhanced Functionality of CD4+CD25highFoxP3+ Regulatory T Cells in the Peripheral Blood of Patients with Prostate Cancer in another window