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Journal Articles

Phase II Study to Determine the Antitumor Activity and Safety of Simlukafusp Alfa (FAP-IL2v) Combined with Atezolizumab in Esophageal Cancer

Hans Prenen, Sanjeev Deva, Bhumsuk Keam, Colin R. Lindsay, Iwona Lugowska, James C. Yang, Federico Longo, Maria de Miguel, Mariano Ponz-Sarvise, Myung-Ju Ahn, Mahmut Gumus, Stephane Champiat, Antoine Italiano, Sébastien Salas, Ruth Perets, Cagatay Arslan, Byoung C. Cho, Stefan Evers, Christophe Boetsch, Daniel Marbach, David Dejardin, Nassim Sleiman, Caroline Ardeshir, Muriel Richard, Jehad Charo, Anton Kraxner, Nino Keshelava, Volker Teichgräber, Victor Moreno
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (14): 2945–2953.
https://doi.org/10.1158/1078-0432.CCR-23-2677
Published: 15 July 2024
View article titled, Phase II Study to Determine the Antitumor Activity and Safety of Simlukafusp Alfa (FAP-IL2v) Combined with Atezolizumab in Esophageal Cancer
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Includes: Supplementary data
Journal Articles

Neoantigen Identification and Response to Adoptive Cell Transfer in Anti–PD-1 Naïve and Experienced Patients with Metastatic Melanoma

Shoshana T. Levi, Amy R. Copeland, Shirley Nah, Jessica S. Crystal, Gabriel D. Ivey, Almin Lalani, Mohammad Jafferji, Bradley S. White, Neilesh B. Parikh, Vid Leko, Sri Krishna, Frank Lowery, Todd D. Prickett, Jared J. Gartner, Li Jia, Yong F. Li, Abraham Sachs, Sivasish Sindiri, Welles Robinson, Billel Gasmi, James C. Yang, Stephanie L. Goff, Steven A. Rosenberg, Paul F. Robbins
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (14): 3042–3052.
https://doi.org/10.1158/1078-0432.CCR-21-4499
Published: 15 July 2022
View article titled, Neoantigen Identification and Response to Adoptive Cell Transfer in Anti–PD-1 Naïve and Experienced Patients with Metastatic Melanoma
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Includes: Supplementary data
Journal Articles

Impact of Prior Treatment on the Efficacy of Adoptive Transfer of Tumor-Infiltrating Lymphocytes in Patients with Metastatic Melanoma

Samantha J. Seitter, Richard M. Sherry, James C. Yang, Paul F. Robbins, Mackenzie L. Shindorf, Amy R. Copeland, Christine T. McGowan, Monica Epstein, Thomas E. Shelton, Michelle M. Langhan, Zulmarie Franco, David N. Danforth, Donald E. White, Steven A. Rosenberg, Stephanie L. Goff
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (19): 5289–5298.
https://doi.org/10.1158/1078-0432.CCR-21-1171
Published: 01 October 2021
View article titled, Impact of Prior Treatment on the Efficacy of Adoptive Transfer of Tumor-Infiltrating Lymphocytes in Patients with Metastatic Melanoma
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Includes: Supplementary data
Journal Articles

Mutated RAS: Targeting the “Untargetable” with T Cells

Praveen D. Chatani, James C. Yang
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (3): 537–544.
https://doi.org/10.1158/1078-0432.CCR-19-2138
Published: 03 February 2020
View article titled, Mutated RAS: Targeting the “Untargetable” with T Cells
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Journal Articles

A Phase II Study of Tumor-infiltrating Lymphocyte Therapy for Human Papillomavirus–associated Epithelial Cancers

Sanja Stevanović, Sarah R. Helman, John R. Wunderlich, Michelle M. Langhan, Stacey L. Doran, Mei Li M. Kwong, Robert P.T. Somerville, Christopher A. Klebanoff, Udai S. Kammula, Richard M. Sherry, James C. Yang, Steven A. Rosenberg, Christian S. Hinrichs
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (5): 1486–1493.
https://doi.org/10.1158/1078-0432.CCR-18-2722
Published: 01 March 2019
View article titled, A Phase II Study of Tumor-infiltrating Lymphocyte Therapy for Human Papillomavirus–associated Epithelial Cancers
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Includes: Supplementary data
Journal Articles

Preclinical Evaluation of Chimeric Antigen Receptors Targeting CD70-Expressing Cancers

Qiong J. Wang, Zhiya Yu, Ken-ichi Hanada, Krishna Patel, David Kleiner, Nicholas P. Restifo, James C. Yang
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (9): 2267–2276.
https://doi.org/10.1158/1078-0432.CCR-16-1421
Published: 30 April 2017
View article titled, Preclinical Evaluation of Chimeric Antigen Receptors Targeting CD70-Expressing Cancers
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Includes: Supplementary data
Journal Articles

The Immunotherapy Roadmap

James C. Yang
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (2): 275–276.
https://doi.org/10.1158/1078-0432.CCR-15-2144
Published: 14 January 2016
View article titled, The Immunotherapy Roadmap
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Journal Articles

Tumor-Infiltrating Lymphocytes Genetically Engineered with an Inducible Gene Encoding Interleukin-12 for the Immunotherapy of Metastatic Melanoma

Ling Zhang, Richard A. Morgan, Joal D. Beane, Zhili Zheng, Mark E. Dudley, Sadik H. Kassim, Azam V. Nahvi, Lien T. Ngo, Richard M. Sherry, Giao Q. Phan, Marybeth S. Hughes, Udai S. Kammula, Steven A. Feldman, Mary Ann Toomey, Sid P. Kerkar, Nicholas P. Restifo, James C. Yang, Steven A. Rosenberg
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (10): 2278–2288.
https://doi.org/10.1158/1078-0432.CCR-14-2085
Published: 14 May 2015
View article titled, Tumor-Infiltrating Lymphocytes Genetically Engineered with an Inducible Gene Encoding Interleukin-12 for the Immunotherapy of Metastatic Melanoma
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Includes: Supplementary data
Journal Articles

A Pilot Trial Using Lymphocytes Genetically Engineered with an NY-ESO-1–Reactive T-cell Receptor: Long-term Follow-up and Correlates with Response

Paul F. Robbins, Sadik H. Kassim, Thai L.N. Tran, Jessica S. Crystal, Richard A. Morgan, Steven A. Feldman, James C. Yang, Mark E. Dudley, John R. Wunderlich, Richard M. Sherry, Udai S. Kammula, Marybeth S. Hughes, Nicholas P. Restifo, Mark Raffeld, Chyi-Chia R. Lee, Yong F. Li, Mona El-Gamil, Steven A. Rosenberg
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (5): 1019–1027.
https://doi.org/10.1158/1078-0432.CCR-14-2708
Published: 01 March 2015
View article titled, A Pilot Trial Using Lymphocytes Genetically Engineered with an NY-ESO-1–Reactive T-cell Receptor: Long-term Follow-up and Correlates with Response
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Includes: Supplementary data
Journal Articles

Persistence of CTL Clones Targeting Melanocyte Differentiation Antigens Was Insufficient to Mediate Significant Melanoma Regression in Humans

Smita S. Chandran, Biman C. Paria, Abhishek K. Srivastava, Luke D. Rothermel, Daniel J. Stephens, Mark E. Dudley, Robert Somerville, John R. Wunderlich, Richard M. Sherry, James C. Yang, Steven A. Rosenberg, Udai S. Kammula
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (3): 534–543.
https://doi.org/10.1158/1078-0432.CCR-14-2208
Published: 01 February 2015
View article titled, Persistence of CTL Clones Targeting Melanocyte Differentiation Antigens Was Insufficient to Mediate Significant Melanoma Regression in Humans
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Includes: Supplementary data
Journal Articles

Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions

Yong-Chen Lu, Xin Yao, Jessica S. Crystal, Yong F. Li, Mona El-Gamil, Colin Gross, Lindy Davis, Mark E. Dudley, James C. Yang, Yardena Samuels, Steven A. Rosenberg, Paul F. Robbins
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (13): 3401–3410.
https://doi.org/10.1158/1078-0432.CCR-14-0433
Published: 30 June 2014
View article titled, Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions
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Includes: Supplementary data
Journal Articles

Adoptive T-cell Transfer Therapy and Oncogene-Targeted Therapy for Melanoma: The Search for Synergy

Mei Li M. Kwong, Bart Neyns, James C. Yang
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (19): 5292–5299.
https://doi.org/10.1158/1078-0432.CCR-13-0261
Published: 01 October 2013
View article titled, Adoptive T-cell Transfer Therapy and Oncogene-Targeted Therapy for Melanoma: The Search for Synergy
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Journal Articles

CTLA-4 Blockade with Ipilimumab: Long-term Follow-up of 177 Patients with Metastatic Melanoma

Peter A. Prieto, James C. Yang, Richard M. Sherry, Marybeth S. Hughes, Udai S. Kammula, Donald E. White, Catherine L. Levy, Steven A. Rosenberg, Giao Q. Phan
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (7): 2039–2047.
https://doi.org/10.1158/1078-0432.CCR-11-1823
Published: 01 April 2012
View article titled, CTLA-4 Blockade with Ipilimumab: Long-term Follow-up of 177 Patients with Metastatic Melanoma
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Includes: Supplementary data
Journal Articles

Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy

Steven A. Rosenberg, James C. Yang, Richard M. Sherry, Udai S. Kammula, Marybeth S. Hughes, Giao Q. Phan, Deborah E. Citrin, Nicholas P. Restifo, Paul F. Robbins, John R. Wunderlich, Kathleen E. Morton, Carolyn M. Laurencot, Seth M. Steinberg, Donald E. White, Mark E. Dudley
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (13): 4550–4557.
https://doi.org/10.1158/1078-0432.CCR-11-0116
Published: 05 July 2011
View article titled, Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy
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Includes: Supplementary data
Journal Articles

CD8+ Enriched “Young” Tumor Infiltrating Lymphocytes Can Mediate Regression of Metastatic Melanoma

Mark E. Dudley, Colin A. Gross, Michelle M. Langhan, Marcos R. Garcia, Richard M. Sherry, James C. Yang, Giao Q. Phan, Udai S. Kammula, Marybeth S. Hughes, Deborah E. Citrin, Nicholas P. Restifo, John R. Wunderlich, Peter A. Prieto, Jenny J. Hong, Russell C. Langan, Daniel A. Zlott, Kathleen E. Morton, Donald E. White, Carolyn M. Laurencot, Steven A. Rosenberg
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (24): 6122–6131.
https://doi.org/10.1158/1078-0432.CCR-10-1297
Published: 16 December 2010
View article titled, CD8+ Enriched “Young” Tumor Infiltrating Lymphocytes Can Mediate Regression of Metastatic Melanoma
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Includes: Supplementary data
Journal Articles

Successful Treatment of Melanoma Brain Metastases with Adoptive Cell Therapy

Jenny J. Hong, Steven A. Rosenberg, Mark E. Dudley, James C. Yang, Donald E. White, John A. Butman, Richard M. Sherry
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (19): 4892–4898.
https://doi.org/10.1158/1078-0432.CCR-10-1507
Published: 29 September 2010
View article titled, Successful Treatment of Melanoma Brain Metastases with Adoptive Cell Therapy
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Journal Articles

Treatment of Metastatic Melanoma Using Interleukin-2 Alone or in Conjunction with Vaccines

Franz O. Smith, Stephanie G. Downey, Jacob A. Klapper, James C. Yang, Richard M. Sherry, Richard E. Royal, Udai S. Kammula, Marybeth S. Hughes, Nicholas P. Restifo, Catherine L. Levy, Donald E. White, Seth M. Steinberg, Steven A. Rosenberg
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (17): 5610–5618.
https://doi.org/10.1158/1078-0432.CCR-08-0116
Published: 02 September 2008
View article titled, Treatment of Metastatic Melanoma Using Interleukin-2 Alone or in Conjunction with Vaccines
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Journal Articles

Prognostic Factors Related to Clinical Response in Patients with Metastatic Melanoma Treated by CTL-Associated Antigen-4 Blockade

Stephanie G. Downey, Jacob A. Klapper, Franz O. Smith, James C. Yang, Richard M. Sherry, Richard E. Royal, Udai S. Kammula, Marybeth S. Hughes, Tamika E. Allen, Catherine L. Levy, Michael Yellin, Geoffrey Nichol, Donald E. White, Seth M. Steinberg, Steven A. Rosenberg
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (22): 6681–6688.
https://doi.org/10.1158/1078-0432.CCR-07-0187
Published: 15 November 2007
View article titled, Prognostic Factors Related to Clinical Response in Patients with Metastatic Melanoma Treated by CTL-Associated Antigen-4 Blockade
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Journal Articles

A Phase I Study on Adoptive Immunotherapy Using Gene-Modified T Cells for Ovarian Cancer

Michael H. Kershaw, Jennifer A. Westwood, Linda L. Parker, Gang Wang, Zelig Eshhar, Sharon A. Mavroukakis, Donald E. White, John R. Wunderlich, Silvana Canevari, Linda Rogers-Freezer, Clara C. Chen, James C. Yang, Steven A. Rosenberg, Patrick Hwu
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (20): 6106–6115.
https://doi.org/10.1158/1078-0432.CCR-06-1183
Published: 24 October 2006
View article titled, A Phase I Study on Adoptive Immunotherapy Using Gene-Modified T Cells for Ovarian Cancer
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Journal Articles

Innovations and Challenges in Renal Cancer: Consensus Statement from the First International Conference

Michael B. Atkins, David E. Avigan, Ronald M. Bukowski, Richard W. Childs, Janice P. Dutcher, Tim G. Eisen, Robert A. Figlin, James H. Finke, Robert C. Flanigan, Daniel J. George, S. Nahum Goldberg, Michael S. Gordon, Othon Iliopoulos, William G. Kaelin, Jr., W. Marston Linehan, Allan Lipton, Robert J. Motzer, Andrew C. Novick, Walter M. Stadler, Bin Tean Teh, James C. Yang, Laura King
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (18): 6277S–6281S.
https://doi.org/10.1158/1078-0432.CCR-040720
Published: 15 September 2004
View article titled, Innovations and Challenges in Renal Cancer: <subtitle>Consensus Statement from the First International Conference</subtitle>
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