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Jakob Dupont
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Journal Articles

A First-in-Human Phase I Study of the Anticancer Stem Cell Agent Ipafricept (OMP-54F28), a Decoy Receptor for Wnt Ligands, in Patients with Advanced Solid Tumors

Antonio Jimeno, Michael Gordon, Rashmi Chugh, Wells Messersmith, David Mendelson, Jakob Dupont, Robert Stagg, Ann M. Kapoun, Lu Xu, Shailaja Uttamsingh, Rainer K. Brachmann, David C. Smith
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (24): 7490–7497.
https://doi.org/10.1158/1078-0432.CCR-17-2157
Published: 14 December 2017
View article titled, A First-in-Human Phase I Study of the Anticancer Stem Cell Agent Ipafricept (OMP-54F28), a Decoy Receptor for Wnt Ligands, in Patients with Advanced Solid Tumors
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Journal Articles

Abstract A42: Using a PDX tumor bank to screen for cancer stem cell therapies

James Evans, Chun Zhang, Angie InKyung Park, Alayne Brunner, Min Wang, Cristina Dee-Hoskins, Roger Lopez, Xiaomei Song, Kellie Pickell, Wan-Cheng Yen, Marcus Fischer, Raymond Tam, Gilbert O'Young, Jakob Dupont, Lei Zhou, Austin Gurney, John Lewicki, Tim Hoey, Ann M. Kapoun, Belinda Cancilla
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16_Supplement): A42.
https://doi.org/10.1158/1557-3265.PDX16-A42
Published: 15 August 2016
View article titled, Abstract A42: Using a PDX tumor bank to screen for cancer stem cell therapies
Journal Articles

Abstract A41: Use of patient-derived tumor xenografts (PDX) for discovery and development of an anti-Notch2/3 monoclonal antibody targeting cancer stem cells

Marcus M. Fischer, Wan-Ching Yen, Fumiko Axelrod, Christopher Bond, Jennifer Cain, Belinda Cancilla, Randall Henner, Rene Meisner, Aaron Sato, Jalpa Shaw, Tracy Tang, Breanna Wallace, Min Wang, Chun Zhang, Ann Kapoun, Lei Zhou, Jakob Dupont, John Lewicki, Austin Gurney, Tim Hoey
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16_Supplement): A41.
https://doi.org/10.1158/1557-3265.PDX16-A41
Published: 15 August 2016
View article titled, Abstract A41: Use of patient-derived tumor xenografts (PDX) for discovery and development of an anti-Notch2/3 monoclonal antibody targeting cancer stem cells
Journal Articles

A Phase I Dose Escalation and Expansion Study of the Anticancer Stem Cell Agent Demcizumab (Anti-DLL4) in Patients with Previously Treated Solid Tumors

David C. Smith, Peter D. Eisenberg, Georgy Manikhas, Rashmi Chugh, Matthew A. Gubens, Robert J. Stagg, Ann M. Kapoun, Lu Xu, Jakob Dupont, Branimir Sikic
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2014) 20 (24): 6295–6303.
https://doi.org/10.1158/1078-0432.CCR-14-1373
Published: 14 December 2014
View article titled, A Phase I Dose Escalation and Expansion Study of the Anticancer Stem Cell Agent Demcizumab (Anti-DLL4) in Patients with Previously Treated Solid Tumors
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Includes: Supplementary data
Journal Articles

Phase 1 Study of Aflibercept Administered Subcutaneously to Patients with Advanced Solid Tumors

William P. Tew, Michael Gordon, John Murren, Jakob Dupont, Sandra Pezzulli, Carol Aghajanian, Paul Sabbatini, David Mendelson, Lawrence Schwartz, Scott Gettinger, Amanda Psyrri, Jesse M. Cedarbaum, David R. Spriggs
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (1): 358–366.
https://doi.org/10.1158/1078-0432.CCR-09-2103
Published: 04 January 2010
View article titled, Phase 1 Study of Aflibercept Administered Subcutaneously to Patients with Advanced Solid Tumors
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Journal Articles

Safety and Immunogenicity Study of NY-ESO-1b Peptide and Montanide ISA-51 Vaccination of Patients with Epithelial Ovarian Cancer in High-Risk First Remission

Catherine S.M. Diefenbach, Sacha Gnjatic, Paul Sabbatini, Carol Aghajanian, Martee L. Hensley, David R. Spriggs, Alexia Iasonos, Helen Lee, Bo Dupont, Sandra Pezzulli, Achim A. Jungbluth, Lloyd J. Old, Jakob Dupont
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (9): 2740–2748.
https://doi.org/10.1158/1078-0432.CCR-07-4619
Published: 01 May 2008
View article titled, Safety and Immunogenicity Study of NY-ESO-1b Peptide and Montanide ISA-51 Vaccination of Patients with Epithelial Ovarian Cancer in High-Risk First Remission
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Journal Articles

Vascular Endothelial Growth Factor-Trap Overcomes Defects in Dendritic Cell Differentiation but Does Not Improve Antigen-Specific Immune Responses

Ingo Fricke, Noweeda Mirza, Jakob Dupont, Craig Lockhart, Autumn Jackson, Ji-Hyun Lee, Jeffrey A. Sosman, Dmitry I. Gabrilovich
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (16): 4840–4848.
https://doi.org/10.1158/1078-0432.CCR-07-0409
Published: 15 August 2007
View article titled, Vascular Endothelial Growth Factor-Trap Overcomes Defects in Dendritic Cell Differentiation but Does Not Improve Antigen-Specific Immune Responses
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Journal Articles

The Activity of Sunitinib against Gastrointestinal Stromal Tumor Seems to be Distinct from Its Antiangiogenic Effects

Marco Seandel, Jinru Shia, Irina Linkov, Robert G. Maki, Cristina R. Antonescu, Jakob Dupont
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (20): 6203–6204.
https://doi.org/10.1158/1078-0432.CCR-06-1292
Published: 24 October 2006
View article titled, The Activity of Sunitinib against Gastrointestinal Stromal Tumor Seems to be Distinct from Its Antiangiogenic Effects
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Journal Articles

Phase I Study of Abagovomab in Patients with Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Paul Sabbatini, Jakob Dupont, Carol Aghajanian, Felicia Derosa, Elizabeth Poynor, Sybil Anderson, Martee Hensley, Phillip Livingston, Alexia Iasonos, David Spriggs, William McGuire, Silke Reinartz, Sally Schneider, Cathy Grande, Shashikant Lele, Kerry Rodabaugh, James Kepner, Soldano Ferrone, Kunle Odunsi
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (18): 5503–5510.
https://doi.org/10.1158/1078-0432.CCR-05-2670
Published: 25 September 2006
View article titled, Phase I Study of Abagovomab in Patients with Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
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Journal Articles

Intraperitoneal Cisplatin with Intraperitoneal Gemcitabine in Patients with Epithelial Ovarian Cancer: Results of a Phase I/II Trial

Paul Sabbatini, Carol Aghajanian, Mario Leitao, Ennapadam Venkatraman, Sybil Anderson, Jakob Dupont, Don Dizon, Catherine O’Flaherty, Jeffrey Bloss, Dennis Chi, David Spriggs
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (9): 2962–2967.
https://doi.org/10.1158/1078-0432.CCR-03-0486
Published: 06 May 2004
View article titled, Intraperitoneal Cisplatin with Intraperitoneal Gemcitabine in Patients with Epithelial Ovarian Cancer: <subtitle>Results of a Phase I/II Trial</subtitle>
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