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Jaffer A. Ajani
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Journal Articles

Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers

Timothy P. DiPeri, Kurt W. Evans, Maria Gabriela Raso, Ming Zhao, Yasmeen Q. Rizvi, Xiaofeng Zheng, Bailiang Wang, Bryce P. Kirby, Kathleen Kong, Michael Kahle, Timothy A. Yap, Ecaterina E. Dumbrava, Jaffer A. Ajani, Siqing Fu, Khandan Keyomarsi, Funda Meric-Bernstam
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (21): 4385–4398.
https://doi.org/10.1158/1078-0432.CCR-23-0103
Published: 01 November 2023
View article titled, Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers
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Includes: Supplementary data
Journal Articles

ARID1A Mutation May Define an Immunologically Active Subgroup in Patients with Microsatellite Stable Colorectal Cancer

Amir Mehrvarz Sarshekeh, Jumanah Alshenaifi, Jason Roszik, Ganiraju C. Manyam, Shailesh M. Advani, Riham Katkhuda, Anuj Verma, Michael Lam, Jason Willis, John Paul Shen, Jeffrey Morris, Jennifer S. Davis, Jonathan M. Loree, Hey Min Lee, Jaffer A. Ajani, Dipen M. Maru, Michael J. Overman, Scott Kopetz
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (6): 1663–1670.
https://doi.org/10.1158/1078-0432.CCR-20-2404
Published: 15 March 2021
View article titled, ARID1A Mutation May Define an Immunologically Active Subgroup in Patients with Microsatellite Stable Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Ushering in Liquid Biopsy for the Microsatellite Status: Advantages and Caveats

Linghua Wang, Jaffer A. Ajani
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (23): 6887–6889.
https://doi.org/10.1158/1078-0432.CCR-19-2585
Published: 02 December 2019
View article titled, Ushering in Liquid Biopsy for the Microsatellite Status: Advantages and Caveats
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Journal Articles

YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer – Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer

Fan Li, Yan Xu, Bovey Liu, Pankaj Kumar Singh, Wei Zhao, Jiankang Jin, Guangchun Han, Ailing W. Scott, Xiaochuan Dong, Longfei Huo, Lang Ma, Melissa Pool Pizzi, Ying Wang, Yuan Li, Kazuto Harada, Min Xie, Heath D. Skinner, Sheng Ding, Linghua Wang, Sunil Krishnan, Randy L. Johnson, Shumei Song, Jaffer A. Ajani
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (7): 2264–2277.
https://doi.org/10.1158/1078-0432.CCR-18-1029
Published: 01 April 2019
View article titled, YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer – Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer
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Includes: Supplementary data
Journal Articles

Efficacy of Sequential Ipilimumab Monotherapy versus Best Supportive Care for Unresectable Locally Advanced/Metastatic Gastric or Gastroesophageal Junction Cancer

Yung-Jue Bang, Jae Yong Cho, Yeul Hong Kim, Jin Won Kim, Maria Di Bartolomeo, Jaffer A. Ajani, Kensei Yamaguchi, Agnes Balogh, Teresa Sanchez, Markus Moehler
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (19): 5671–5678.
https://doi.org/10.1158/1078-0432.CCR-17-0025
Published: 01 October 2017
View article titled, Efficacy of Sequential Ipilimumab Monotherapy versus Best Supportive Care for Unresectable Locally Advanced/Metastatic Gastric or Gastroesophageal Junction Cancer
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Includes: Supplementary data
Journal Articles

Clinical Significance of Four Molecular Subtypes of Gastric Cancer Identified by The Cancer Genome Atlas Project

Bo Hwa Sohn, Jun-Eul Hwang, Hee-Jin Jang, Hyun-Sung Lee, Sang Cheul Oh, Jae-Jun Shim, Keun-Wook Lee, Eui Hyun Kim, Sun Young Yim, Sang Ho Lee, Jae-Ho Cheong, Woojin Jeong, Jae Yong Cho, Joohee Kim, Jungsoo Chae, Jeeyun Lee, Won Ki Kang, Sung Kim, Sung Hoon Noh, Jaffer A. Ajani, Ju-Seog Lee
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (15): 4441–4449.
https://doi.org/10.1158/1078-0432.CCR-16-2211
Published: 01 August 2017
View article titled, Clinical Significance of Four Molecular Subtypes of Gastric Cancer Identified by The Cancer Genome Atlas Project
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Includes: Supplementary data
Journal Articles

Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer

Keun-Wook Lee, Sung Sook Lee, Jun-Eul Hwang, Hee-Jin Jang, Hyun-Sung Lee, Sang Cheul Oh, Sang Ho Lee, Bo Hwa Sohn, Sang Bae Kim, Jae-Jun Shim, Woojin Jeong, Minse Cha, Jae-Ho Cheong, Jae Yong Cho, Jae Yun Lim, Eun Sung Park, Sang Cheol Kim, Yoon-Koo Kang, Sung Hoon Noh, Jaffer A. Ajani, Ju-Seog Lee
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (24): 6228–6235.
https://doi.org/10.1158/1078-0432.CCR-15-2468
Published: 15 December 2016
View article titled, Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
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Includes: Supplementary data
Journal Articles

The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer

Shumei Song, Soichiro Honjo, Jiankang Jin, Shih-Shin Chang, Ailing W. Scott, Qiongrong Chen, Neda Kalhor, Arlene M. Correa, Wayne L. Hofstetter, Constance T. Albarracin, Tsung-Teh Wu, Randy L. Johnson, Mien-Chie Hung, Jaffer A. Ajani
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (11): 2580–2590.
https://doi.org/10.1158/1078-0432.CCR-14-2191
Published: 31 May 2015
View article titled, The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer
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Includes: Supplementary data
Journal Articles

Constitutive short chromosome-specific telomere length of 17p and 12q, but not XpYp, 11q and 2p is associated with increased esophageal cancer risk

Jinliang Xing, Jaffer A Ajani, Meng Chen, Julie Izzo, Xifeng Wu
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (19_Supplement): A10.
Published: 15 August 2014
View article titled, Constitutive short chromosome-specific telomere length of 17p and 12q, but not XpYp, 11q and 2p is associated with increased esophageal cancer risk
Journal Articles

Gene Expression Signature–Based Prognostic Risk Score in Gastric Cancer

Jae Yong Cho, Jae Yun Lim, Jae Ho Cheong, Yun-Yong Park, Se-Lyun Yoon, Soo Mi Kim, Sang-Bae Kim, Hoguen Kim, Soon Won Hong, Young Nyun Park, Sung Hoon Noh, Eun Sung Park, In-Sun Chu, Waun Ki Hong, Jaffer A. Ajani, Ju-Seog Lee
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (7): 1850–1857.
https://doi.org/10.1158/1078-0432.CCR-10-2180
Published: 31 March 2011
View article titled, Gene Expression Signature–Based Prognostic Risk Score in Gastric Cancer
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Includes: Supplementary data
Journal Articles

MicroRNA Expression Signatures in Barrett's Esophagus and Esophageal Adenocarcinoma

Hushan Yang, Jian Gu, Kenneth K. Wang, Wei Zhang, Jinliang Xing, Zhinan Chen, Jaffer A. Ajani, Xifeng Wu
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (18): 5744–5752.
https://doi.org/10.1158/1078-0432.CCR-09-0385
Published: 14 September 2009
View article titled, MicroRNA Expression Signatures in Barrett's Esophagus and Esophageal Adenocarcinoma
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Includes: Supplementary data
Journal Articles

Decreased Expression of Gene Cluster at Chromosome 1q21 Defines Molecular Subgroups of Chemoradiotherapy Response in Esophageal Cancers

Madan G. Luthra, Jaffer A. Ajani, Julie Izzo, Joe Ensor, Tsung-Teh Wu, Asif Rashid, Li Zhang, Alexandria Phan, Norio Fukami, Rajyalakshmi Luthra
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (3): 912–919.
https://doi.org/10.1158/1078-0432.CCR-06-1577
Published: 08 February 2007
View article titled, Decreased Expression of Gene Cluster at Chromosome 1q21 Defines Molecular Subgroups of Chemoradiotherapy Response in Esophageal Cancers
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Journal Articles

Clinical and In vitro Studies of Imatinib in Advanced Carcinoid Tumors

James C. Yao, Jun X. Zhang, Asif Rashid, Sai-Ching J. Yeung, Janio Szklaruk, Kenneth Hess, Keping Xie, Lee Ellis, James L. Abbruzzese, Jaffer A. Ajani
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (1): 234–240.
https://doi.org/10.1158/1078-0432.CCR-06-1618
Published: 02 January 2007
View article titled, Clinical and <em>In vitro</em> Studies of Imatinib in Advanced Carcinoid Tumors
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Journal Articles

Early Detection of Chemoradioresponse in Esophageal Carcinoma by 3′-Deoxy-3′-3H-Fluorothymidine Using Preclinical Tumor Models

Smith Apisarnthanarax, Mian M. Alauddin, Firas Mourtada, Hisanori Ariga, Uma Raju, Osama Mawlawi, Dongmei Han, William G. Bornmann, Jaffer A. Ajani, Luka Milas, Juri G. Gelovani, K.S. Clifford Chao
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (15): 4590–4597.
https://doi.org/10.1158/1078-0432.CCR-05-2720
Published: 09 August 2006
View article titled, Early Detection of Chemoradioresponse in Esophageal Carcinoma by 3′-Deoxy-3′-<sup>3</sup>H-Fluorothymidine Using Preclinical Tumor Models
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Journal Articles

Expression of Annexin A1 in Esophageal and Esophagogastric Junction Adenocarcinomas: Association with Poor Outcome

Kim L. Wang, Tsung-Teh Wu, Erika Resetkova, Huamin Wang, Arlene M. Correa, Wayne L. Hofstetter, Stephen G. Swisher, Jaffer A. Ajani, Asif Rashid, Stanley R. Hamilton, Constance T. Albarracin
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (15): 4598–4604.
https://doi.org/10.1158/1078-0432.CCR-06-0483
Published: 09 August 2006
View article titled, Expression of Annexin A1 in Esophageal and Esophagogastric Junction Adenocarcinomas: Association with Poor Outcome
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Journal Articles

Signet-Ring Cell or Mucinous Histology after Preoperative Chemoradiation and Survival in Patients with Esophageal or Esophagogastric Junction Adenocarcinoma

Lucian R. Chirieac, Stephen G. Swisher, Arlene M. Correa, Jaffer A. Ajani, Ritsuko R. Komaki, Asif Rashid, Stanley R. Hamilton, Tsung-Teh Wu
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (6): 2229–2236.
https://doi.org/10.1158/1078-0432.CCR-04-1840
Published: 23 March 2005
View article titled, Signet-Ring Cell or Mucinous Histology after Preoperative Chemoradiation and Survival in Patients with Esophageal or Esophagogastric Junction Adenocarcinoma
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Journal Articles

Expression of Activated Signal Transducer and Activator of Transcription 3 Predicts Expression of Vascular Endothelial Growth Factor in and Angiogenic Phenotype of Human Gastric Cancer

Weida Gong, Liwei Wang, James C. Yao, Jaffer A. Ajani, Daoyan Wei, Kenneth D. Aldape, Keping Xie, Raymond Sawaya, Suyun Huang
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (4): 1386–1393.
https://doi.org/10.1158/1078-0432.CCR-04-0487
Published: 02 March 2005
View article titled, Expression of Activated Signal Transducer and Activator of Transcription 3 Predicts Expression of Vascular Endothelial Growth Factor in and Angiogenic Phenotype of Human Gastric Cancer
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Journal Articles

Prognostic Significance of CpG Island Methylator Phenotype and Microsatellite Instability in Gastric Carcinoma

Changhyeok An, In-Seon Choi, James C. Yao, Samidha Worah, Keping Xie, Paul F. Mansfield, Jaffer A. Ajani, Asif Rashid, Stanley R. Hamilton, Tsung-Teh Wu
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (2): 656–663.
https://doi.org/10.1158/1078-0432.656.11.2
Published: 08 February 2005
View article titled, Prognostic Significance of CpG Island Methylator Phenotype and Microsatellite Instability in Gastric Carcinoma
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Journal Articles

Phase I Study with Pharmacokinetics of S-1 on an Oral Daily Schedule for 28 Days in Patients with Solid Tumors

Paulo M. Hoff, Everardo D. Saad, Jaffer A. Ajani, Yvonne Lassere, Cynthia Wenske, Diana Medgyesy, Sunita Dwivedy, Mark Russo, Richard Pazdur
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (1): 134–142.
Published: 01 January 2003
View article titled, Phase I Study with Pharmacokinetics of S-1 on an Oral Daily Schedule for 28 Days in Patients with Solid Tumors
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