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Jaclyn F. Hechtman
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Journal Articles

Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer

Steven B. Maron, Walid Chatila, Henry Walch, Joanne F. Chou, Nicholas Ceglia, Ryan Ptashkin, Richard Kinh Gian Do, Viktoriya Paroder, Neeta Pandit-Taskar, Jason S. Lewis, Tiago Biachi De Castria, Shalom Sabwa, Fiona Socolow, Lara Feder, Jasmine Thomas, Isabell Schulze, Kwanghee Kim, Arijh Elzein, Viktoria Bojilova, Matthew Zatzman, Umesh Bhanot, Rebecca J. Nagy, Jeeyun Lee, Marc Simmons, Michal Segal, Geoffrey Yuyat Ku, David H. Ilson, Marinela Capanu, Jaclyn F. Hechtman, Taha Merghoub, Sohrab Shah, Nikolaus Schultz, David B. Solit, Yelena Y. Janjigian
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (18): 3633–3640.
https://doi.org/10.1158/1078-0432.CCR-22-3769
Published: 15 September 2023
View article titled, Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
Open the PDF for Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer in another window
Includes: Supplementary data
Journal Articles

A Performance Comparison of Commonly Used Assays to Detect RET Fusions

Soo-Ryum Yang, Umut Aypar, Ezra Y. Rosen, Douglas A. Mata, Ryma Benayed, Kerry Mullaney, Gowtham Jayakumaran, Yanming Zhang, Denise Frosina, Alexander Drilon, Marc Ladanyi, Achim A. Jungbluth, Natasha Rekhtman, Jaclyn F. Hechtman
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (5): 1316–1328.
https://doi.org/10.1158/1078-0432.CCR-20-3208
Published: 01 March 2021
View article titled, A Performance Comparison of Commonly Used Assays to Detect RET Fusions
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Includes: Supplementary data
Journal Articles

Characterization and Clinical Outcomes of DNA Mismatch Repair–deficient Small Bowel Adenocarcinoma

Alicia Latham, Jinru Shia, Zalak Patel, Diane L. Reidy-Lagunes, Neil H. Segal, Rona Yaeger, Karuna Ganesh, Louise Connell, Nancy E. Kemeny, David P. Kelsen, Jaclyn F. Hechtman, Garrett M. Nash, Philip B. Paty, Ahmet Zehir, Kaitlin A. Tkachuk, Rania Sheikh, Arnold J. Markowitz, Diana Mandelker, Kenneth Offit, Michael F. Berger, Andrea Cercek, Julio Garcia-Aguilar, Leonard B. Saltz, Martin R. Weiser, Zsofia K. Stadler
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (5): 1429–1437.
https://doi.org/10.1158/1078-0432.CCR-20-2892
Published: 01 March 2021
View article titled, Characterization and Clinical Outcomes of DNA Mismatch Repair–deficient Small Bowel Adenocarcinoma
Open the PDF for Characterization and Clinical Outcomes of DNA Mismatch Repair–deficient Small Bowel Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion–Positive Lung Cancer by Combining Selpercatinib with Crizotinib

Ezra Y. Rosen, Melissa L. Johnson, Sarah E. Clifford, Romel Somwar, Jennifer F. Kherani, Jieun Son, Arrien A. Bertram, Monika A. Davare, Eric Gladstone, Elena V. Ivanova, Dahlia N. Henry, Elaine M. Kelley, Mika Lin, Marina S.D. Milan, Binoj C. Nair, Elizabeth A. Olek, Jenna E. Scanlon, Morana Vojnic, Kevin Ebata, Jaclyn F. Hechtman, Bob T. Li, Lynette M. Sholl, Barry S. Taylor, Marc Ladanyi, Pasi A. Jänne, S. Michael Rothenberg, Alexander Drilon, Geoffrey R. Oxnard
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (1): 34–42.
https://doi.org/10.1158/1078-0432.CCR-20-2278
Published: 04 January 2021
View article titled, Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion–Positive Lung Cancer by Combining Selpercatinib with Crizotinib
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Includes: Supplementary data
Journal Articles

Abstract 16: Landscape and outcome of TRK fusion-positive Cancers

Ezra Y. Rosen, Debra A. Goldman, Jaclyn F. Hechtman, Ryma Benayed, Alison M. Schram, Emiliano Cocco, Sophie Shifman, Yixiao Gong, Ritika Kundra, James P. Solomon, Alberto Bardelli, Maurizio Scaltriti, Alexander Drilon, Alexia Iasonos, Barry S. Taylor, David M. Hyman
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (12_Supplement_1): 16.
https://doi.org/10.1158/1557-3265.ADVPRECMED20-16
Published: 15 June 2020
View article titled, Abstract 16: Landscape and outcome of TRK fusion-positive Cancers
Journal Articles

TRK Fusions Are Enriched in Cancers with Uncommon Histologies and the Absence of Canonical Driver Mutations

Ezra Y. Rosen, Debra A. Goldman, Jaclyn F. Hechtman, Ryma Benayed, Alison M. Schram, Emiliano Cocco, Sophie Shifman, Yixiao Gong, Ritika Kundra, James P. Solomon, Alberto Bardelli, Maurizio Scaltriti, Alexander Drilon, Alexia Iasonos, Barry S. Taylor, David M. Hyman
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (7): 1624–1632.
https://doi.org/10.1158/1078-0432.CCR-19-3165
Published: 01 April 2020
View article titled, TRK Fusions Are Enriched in Cancers with Uncommon Histologies and the Absence of Canonical Driver Mutations
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Includes: Supplementary data
Journal Articles

Clinical and Molecular Predictors of Response to Immune Checkpoint Inhibitors in Patients with Advanced Esophagogastric Cancer

Megan Greally, Joanne F. Chou, Walid K. Chatila, Matthew Margolis, Marinela Capanu, Jaclyn F. Hechtman, Yaelle Tuvy, Ritika Kundra, Foysal Daian, Marc Ladanyi, David P. Kelsen, David H. Ilson, Michael F. Berger, Laura H. Tang, David B. Solit, Luis A. Diaz, Jr, Nikolaus Schultz, Yelena Y. Janjigian, Geoffrey Y. Ku
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (20): 6160–6169.
https://doi.org/10.1158/1078-0432.CCR-18-3603
Published: 15 October 2019
View article titled, Clinical and Molecular Predictors of Response to Immune Checkpoint Inhibitors in Patients with Advanced Esophagogastric Cancer
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Includes: Supplementary data
Journal Articles

Efficacy of Combined VEGFR1-3, PDGFα/β, and FGFR1-3 Blockade Using Nintedanib for Esophagogastric Cancer

Elizabeth Won, Azfar Basunia, Walid K. Chatila, Jaclyn F. Hechtman, Joanne F. Chou, Geoffrey Y. Ku, Sree B. Chalasani, Michelle S. Boyar, Zoe Goldberg, Avni M. Desai, Yaelle Tuvy, Michael F. Berger, Laura Tang, David P. Kelsen, Mark Schattner, David H. Ilson, Marinela Capanu, David B. Solit, Nikolaus Schultz, Yelena Y. Janjigian
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (13): 3811–3817.
https://doi.org/10.1158/1078-0432.CCR-18-3789
Published: 01 July 2019
View article titled, Efficacy of Combined VEGFR1-3, PDGFα/β, and FGFR1-3 Blockade Using Nintedanib for Esophagogastric Cancer
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Includes: Supplementary data
Journal Articles

Prospective Genotyping of Hepatocellular Carcinoma: Clinical Implications of Next-Generation Sequencing for Matching Patients to Targeted and Immune Therapies

James J. Harding, Subhiksha Nandakumar, Joshua Armenia, Danny N. Khalil, Melanie Albano, Michele Ly, Jinru Shia, Jaclyn F. Hechtman, Ritika Kundra, Imane El Dika, Richard K. Do, Yichao Sun, T. Peter Kingham, Michael I. D'Angelica, Michael F. Berger, David M. Hyman, William Jarnagin, David S. Klimstra, Yelena Y. Janjigian, David B. Solit, Nikolaus Schultz, Ghassan K. Abou-Alfa
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (7): 2116–2126.
https://doi.org/10.1158/1078-0432.CCR-18-2293
Published: 01 April 2019
View article titled, Prospective Genotyping of Hepatocellular Carcinoma: Clinical Implications of Next-Generation Sequencing for Matching Patients to Targeted and Immune Therapies
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Includes: Supplementary data
Journal Articles

Clonal Relatedness and Mutational Differences between Upper Tract and Bladder Urothelial Carcinoma

François Audenet, Sumit Isharwal, Eugene K. Cha, Mark T.A. Donoghue, Esther N. Drill, Irina Ostrovnaya, Eugene J. Pietzak, John P. Sfakianos, Aditya Bagrodia, Paari Murugan, Guido Dalbagni, Timothy F. Donahue, Jonathan E. Rosenberg, Dean F. Bajorin, Maria E. Arcila, Jaclyn F. Hechtman, Michael F. Berger, Barry S. Taylor, Hikmat Al-Ahmadie, Gopa Iyer, Bernard H. Bochner, Jonathan A. Coleman, David B. Solit
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (3): 967–976.
https://doi.org/10.1158/1078-0432.CCR-18-2039
Published: 01 February 2019
View article titled, Clonal Relatedness and Mutational Differences between Upper Tract and Bladder Urothelial Carcinoma
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Includes: Supplementary data
Journal Articles

Comprehensive Molecular Profiling of Intrahepatic and Extrahepatic Cholangiocarcinomas: Potential Targets for Intervention

Maeve A. Lowery, Ryan Ptashkin, Emmet Jordan, Michael F. Berger, Ahmet Zehir, Marinela Capanu, Nancy E. Kemeny, Eileen M. O'Reilly, Imane El-Dika, William R. Jarnagin, James J. Harding, Michael I. D'Angelica, Andrea Cercek, Jaclyn F. Hechtman, David B. Solit, Nikolaus Schultz, David M. Hyman, David S. Klimstra, Leonard B. Saltz, Ghassan K. Abou-Alfa
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (17): 4154–4161.
https://doi.org/10.1158/1078-0432.CCR-18-0078
Published: 04 September 2018
View article titled, Comprehensive Molecular Profiling of Intrahepatic and Extrahepatic Cholangiocarcinomas: Potential Targets for Intervention
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Includes: Supplementary data
Journal Articles

Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype

Maeve A. Lowery, Emmet J. Jordan, Olca Basturk, Ryan N. Ptashkin, Ahmet Zehir, Michael F. Berger, Tanisha Leach, Brian Herbst, Gokce Askan, Hannah Maynard, Danielle Glassman, Christina Covington, Nikolaus Schultz, Ghassan K. Abou-Alfa, James J. Harding, David S. Klimstra, Jaclyn F. Hechtman, David M. Hyman, Peter J. Allen, William R. Jarnagin, Vinod P. Balachandran, Anna M. Varghese, Mark A. Schattner, Kenneth H. Yu, Leonard B. Saltz, David B. Solit, Christine A. Iacobuzio-Donahue, Steven D. Leach, Eileen M. O'Reilly
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (20): 6094–6100.
https://doi.org/10.1158/1078-0432.CCR-17-0899
Published: 12 October 2017
View article titled, Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype
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Journal Articles

Clinical Features and Outcomes of Patients with Colorectal Cancers Harboring NRAS Mutations

Andrea Cercek, Maria Ignez Braghiroli, Joanne F. Chou, Jaclyn F. Hechtman, Nancy Kemeny, Leonard Saltz, Marinela Capanu, Rona Yaeger
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (16): 4753–4760.
https://doi.org/10.1158/1078-0432.CCR-17-0400
Published: 14 August 2017
View article titled, Clinical Features and Outcomes of Patients with Colorectal Cancers Harboring NRAS Mutations
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Includes: Supplementary data
Journal Articles

A Novel Crizotinib-Resistant Solvent-Front Mutation Responsive to Cabozantinib Therapy in a Patient with ROS1-Rearranged Lung Cancer

Alexander Drilon, Romel Somwar, Jacob P. Wagner, Nadeem A. Vellore, Christopher A. Eide, Matthew S. Zabriskie, Maria E. Arcila, Jaclyn F. Hechtman, Lu Wang, Roger S. Smith, Mark G. Kris, Gregory J. Riely, Brian J. Druker, Thomas O'Hare, Marc Ladanyi, Monika A. Davare
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (10): 2351–2358.
https://doi.org/10.1158/1078-0432.CCR-15-2013
Published: 12 May 2016
View article titled, A Novel Crizotinib-Resistant Solvent-Front Mutation Responsive to Cabozantinib Therapy in a Patient with <em>ROS1</em>-Rearranged Lung Cancer
Open the PDF for A Novel Crizotinib-Resistant Solvent-Front Mutation Responsive to Cabozantinib Therapy in a Patient with <em>ROS1</em>-Rearranged Lung Cancer in another window
Includes: Supplementary data