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Jack F. Shern
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Journal Articles

Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics

R. Taylor Sundby, Jeffrey J. Szymanski, Alexander C. Pan, Paul A. Jones, Sana Z. Mahmood, Olivia H. Reid, Divya Srihari, Amy E. Armstrong, Stacey Chamberlain, Sanita Burgic, Kara Weekley, Béga Murray, Sneh Patel, Faridi Qaium, Andrea N. Lucas, Margaret Fagan, Anne Dufek, Christian F. Meyer, Natalie B. Collins, Christine A. Pratilas, Eva Dombi, Andrea M. Gross, AeRang Kim, John S.A. Chrisinger, Carina A. Dehner, Brigitte C. Widemann, Angela C. Hirbe, Aadel A. Chaudhuri, Jack F. Shern
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (19): 4363–4376.
https://doi.org/10.1158/1078-0432.CCR-24-0797
Published: 01 October 2024
View article titled, Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics
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Includes: Supplementary data
Journal Articles

Cooperative Armoring of CAR and TCR T Cells by T Cell–Restricted IL15 and IL21 Universally Enhances Solid Tumor Efficacy

Rosa Nguyen, Ekaterina Doubrovina, Charlotte M. Mousset, Benjamin Y. Jin, Reona Okada, Xiyuan Zhang, Arina Clavel, Jeyshka M. Reyes-Gonzalez, Vadim Dyomin, Louis Diaz, Ling Zhang, Shahroze Abbas, Ming Sun, Chao-Ming Hsieh, Mitchell Ho, Jack F. Shern, James L. Gulley, Christian S. Hinrichs
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (8): 1555–1566.
https://doi.org/10.1158/1078-0432.CCR-23-1872
Published: 15 April 2024
View article titled, Cooperative Armoring of CAR and TCR T Cells by T Cell–Restricted IL15 and IL21 Universally Enhances Solid Tumor Efficacy
Open the PDF for Cooperative Armoring of CAR and TCR T Cells by T Cell–Restricted IL15 and IL21 Universally Enhances Solid Tumor Efficacy in another window
Includes: Supplementary data
Journal Articles

Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models

Grace B. McKay-Corkum, Victor J. Collins, Choh Yeung, Takeshi Ito, Sameer H. Issaq, David Holland, Ksenia Vulikh, Yiping Zhang, Unsun Lee, Haiyan Lei, Arnulfo Mendoza, Jack F. Shern, Marielle E. Yohe, Kazutoshi Yamamoto, Kelli Wilson, Jiuping Ji, Baktiar O. Karim, Craig J. Thomas, Murali C. Krishna, Leonard M. Neckers, Christine M. Heske
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (21): 4479–4491.
https://doi.org/10.1158/1078-0432.CCR-23-0200
Published: 01 November 2023
View article titled, Inhibition of NAD<sup>+</sup>-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models
Open the PDF for Inhibition of NAD<sup>+</sup>-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models in another window
Includes: Supplementary data
Journal Articles

Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma

Srivandana Akshintala, R. Taylor Sundby, Donna Bernstein, John W. Glod, Rosandra N. Kaplan, Marielle E. Yohe, Andrea M. Gross, Joanne Derdak, Haiyan Lei, Alexander Pan, Eva Dombi, Isabel Palacio-Yance, Kailey R. Herrera, Markku M. Miettinen, Helen X. Chen, Seth M. Steinberg, Lee J. Helman, Leo Mascarenhas, Brigitte C. Widemann, Fariba Navid, Jack F. Shern, Christine M. Heske
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (17): 3329–3339.
https://doi.org/10.1158/1078-0432.CCR-23-0709
Published: 01 September 2023
View article titled, Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma
Open the PDF for Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma in another window
Includes: Supplementary data
Journal Articles

Predicting Molecular Subtype and Survival of Rhabdomyosarcoma Patients Using Deep Learning of H&E Images: A Report from the Children's Oncology Group

David Milewski, Hyun Jung, G. Thomas Brown, Yanling Liu, Ben Somerville, Curtis Lisle, Marc Ladanyi, Erin R. Rudzinski, Hyoyoung Choo-Wosoba, Donald A. Barkauskas, Tammy Lo, David Hall, Corinne M. Linardic, Jun S. Wei, Hsien-Chao Chou, Stephen X. Skapek, Rajkumar Venkatramani, Peter K. Bode, Seth M. Steinberg, George Zaki, Igor B. Kuznetsov, Douglas S. Hawkins, Jack F. Shern, Jack Collins, Javed Khan
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (2): 364–378.
https://doi.org/10.1158/1078-0432.CCR-22-1663
Published: 17 January 2023
View article titled, Predicting Molecular Subtype and Survival of Rhabdomyosarcoma Patients Using Deep Learning of H&amp;E Images: A Report from the Children's Oncology Group
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Includes: Supplementary data
Journal Articles

The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models

Katie E. Hebron, Xiaolin Wan, Jacob S. Roth, David J. Liewehr, Nancy E. Sealover, William J.E. Frye, Angela Kim, Stacey Stauffer, Olivia L. Perkins, Wenyue Sun, Kristine A. Isanogle, Christina M. Robinson, Amy James, Parirokh Awasthi, Priya Shankarappa, Xiaoling Luo, Haiyan Lei, Donna Butcher, Roberta Smith, Elijah F. Edmondson, Jin-Qiu Chen, Noemi Kedei, Cody J. Peer, Jack F. Shern, W. Douglas Figg, Lu Chen, Matthew D. Hall, Simone Difilippantonio, Frederic G. Barr, Robert L. Kortum, Robert W. Robey, Angelina V. Vaseva, Javed Khan, Marielle E. Yohe
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (2): 472–487.
https://doi.org/10.1158/1078-0432.CCR-22-1646
Published: 17 January 2023
View article titled, The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models
Open the PDF for The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models in another window
Includes: Supplementary data
Journal Articles

Abstract B006: Development of a NF1-MPNST-PDX liquid biopsy model using whole-genome sequencing and quantitative PCR of mouse-derived cell-free DNA

Paul A. Jones, Wenjia Feng, Xiaochun Zhang, Peter K. Harris, Taylor Sundby, Jeffrey J. Szymanski, Divya Srihari, Faridi Qaium, Jack F. Shern, Aadel A. Chaudhuri, Angela C. Hirbe
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (18_Supplement): B006.
https://doi.org/10.1158/1557-3265.SARCOMAS22-B006
Published: 15 September 2022
View article titled, Abstract B006: Development of a NF1-MPNST-PDX liquid biopsy model using whole-genome sequencing and quantitative PCR of mouse-derived cell-free DNA
Journal Articles

Abstract IA023: Therapeutic efficacy of trametinib and ganitumab in RAS-mutated rhabdomyosarcoma

Marielle E. Yohe, Katie E. Hebron, Xiaolin Wan, Jacob S. Roth, David J. Liewehr, Nancy E. Sealover, Stacey Stauffer, Olivia Feehan-Nelson, Wenyue Sun, Kristine A. Isanogle, Christina M. Robinson, Amy James, Parirokh Awasthi, Priya Shankarappa, Xiaoling Liu, Haiyan Lei, Donna Butcher, Roberta Smith, Elijah F. Edmonson, Jin-Qui Chen, Noemi Kedei, Cody S. Peer, Jack F. Shern, W. Douglas Figg, Lu Chen, Matthew D. Hall, Simone Difillipantonio, Frederic G. Barr, Robert L. Kortum, Angelina V. Vaseva, Javed Khan
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (18_Supplement): IA023.
https://doi.org/10.1158/1557-3265.SARCOMAS22-IA023
Published: 15 September 2022
View article titled, Abstract IA023: Therapeutic efficacy of trametinib and ganitumab in RAS-mutated rhabdomyosarcoma
Journal Articles

Anti-GD2 Antibodies Conjugated to IL15 and IL21 Mediate Potent Antitumor Cytotoxicity against Neuroblastoma

Rosa Nguyen, Xiyuan Zhang, Ming Sun, Shahroze Abbas, Charlie Seibert, Michael C. Kelly, Jack F. Shern, Carol J. Thiele
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (17): 3785–3796.
https://doi.org/10.1158/1078-0432.CCR-22-0717
Published: 01 September 2022
View article titled, Anti-GD2 Antibodies Conjugated to IL15 and IL21 Mediate Potent Antitumor Cytotoxicity against Neuroblastoma
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Includes: Supplementary data
Journal Articles

Modulation of Target Antigen Density Improves CAR T-cell Functionality and Persistence

Sneha Ramakrishna, Steven L. Highfill, Zachary Walsh, Sang M. Nguyen, Haiyan Lei, Jack F. Shern, Haiying Qin, Ira L. Kraft, Maryalice Stetler-Stevenson, Constance M. Yuan, Jennifer D. Hwang, Yang Feng, Zhongyu Zhu, Dimiter Dimitrov, Nirali N. Shah, Terry J. Fry
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (17): 5329–5341.
https://doi.org/10.1158/1078-0432.CCR-18-3784
Published: 03 September 2019
View article titled, Modulation of Target Antigen Density Improves CAR T-cell Functionality and Persistence
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Includes: Supplementary data
Journal Articles

Outcomes of Children and Adolescents with Advanced Hereditary Medullary Thyroid Carcinoma Treated with Vandetanib

Ira L. Kraft, Srivandana Akshintala, Yuelin Zhu, Haiyan Lei, Claudia Derse-Anthony, Eva Dombi, Seth M. Steinberg, Maya Lodish, Steven G. Waguespack, Oxana Kapustina, Elizabeth Fox, Frank M. Balis, Maria J. Merino, Paul S. Meltzer, John W. Glod, Jack F. Shern, Brigitte C. Widemann
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (4): 753–765.
https://doi.org/10.1158/1078-0432.CCR-17-2101
Published: 14 February 2018
View article titled, Outcomes of Children and Adolescents with Advanced Hereditary Medullary Thyroid Carcinoma Treated with Vandetanib
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Includes: Supplementary data
Journal Articles

Abstract PR11: SSX-mediated chromatin engagement and targeting of BAF complexes activates oncogenic transcription in synovial sarcoma

Matthew J. McBride, John L. Pulice, Robert T. Nakayama, Nazar Mashtalir, Davis R. Ingram, Jacob D. Jaffe, Jack F. Shern, Javed Khan, Jason L. Hornick, Alexander J. Lazar, Cigall Kadoch
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (2_Supplement): PR11.
https://doi.org/10.1158/1557-3265.SARCOMAS17-PR11
Published: 15 January 2018
View article titled, Abstract PR11: SSX-mediated chromatin engagement and targeting of BAF complexes activates oncogenic transcription in synovial sarcoma
Journal Articles

MultiDimensional ClinOmics for Precision Therapy of Children and Adolescent Young Adults with Relapsed and Refractory Cancer: A Report from the Center for Cancer Research

Wendy Chang, Andrew S. Brohl, Rajesh Patidar, Sivasish Sindiri, Jack F. Shern, Jun S. Wei, Young K. Song, Marielle E. Yohe, Berkley Gryder, Shile Zhang, Kathleen A. Calzone, Nityashree Shivaprasad, Xinyu Wen, Thomas C. Badgett, Markku Miettinen, Kip R. Hartman, James C. League-Pascual, Toby N. Trahair, Brigitte C. Widemann, Melinda S. Merchant, Rosandra N. Kaplan, Jimmy C. Lin, Javed Khan
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (15): 3810–3820.
https://doi.org/10.1158/1078-0432.CCR-15-2717
Published: 31 July 2016
View article titled, MultiDimensional ClinOmics for Precision Therapy of Children and Adolescent Young Adults with Relapsed and Refractory Cancer: A Report from the Center for Cancer Research
Open the PDF for MultiDimensional ClinOmics for Precision Therapy of Children and Adolescent Young Adults with Relapsed and Refractory Cancer: A Report from the Center for Cancer Research in another window
Includes: Supplementary data