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Journal Articles

STK11/LKB1 Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition

Piyada Sitthideatphaiboon, Ana Galan-Cobo, Marcelo V. Negrao, Xiao Qu, Alissa Poteete, Fahao Zhang, Diane D. Liu, Whitney E. Lewis, Haley N. Kemp, Jeff Lewis, Waree Rinsurongkawong, Uma Giri, J. Jack Lee, Jianjun Zhang, Jack A. Roth, Stephen Swisher, John V. Heymach
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (6): 1720–1733.
https://doi.org/10.1158/1078-0432.CCR-20-2859
Published: 15 March 2021
View article titled, <em>STK11</em>/LKB1 Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition
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Includes: Supplementary data
Journal Articles

The Prognostic and Therapeutic Role of Genomic Subtyping by Sequencing Tumor or Cell-Free DNA in Pulmonary Large-Cell Neuroendocrine Carcinoma

Minglei Zhuo, Yanfang Guan, Xue Yang, Lingzhi Hong, Yuqi Wang, Zhongwu Li, Runzhe Chen, Hussein A. Abbas, Lianpeng Chang, Yuhua Gong, Nan Wu, Jia Zhong, Wenting Chen, Hanxiao Chen, Zhi Dong, Xiang Zhu, Jianjie Li, Yuyan Wang, Tongtong An, Meina Wu, Ziping Wang, Jiayin Wang, Emily B. Roarty, Waree Rinsurongkawong, Jeff Lewis, Jack A. Roth, Stephen G. Swisher, J. Jack Lee, John V. Heymach, Ignacio I. Wistuba, Neda Kalhor, Ling Yang, Xin Yi, P. Andrew Futreal, Bonnie S. Glisson, Xuefeng Xia, Jianjun Zhang, Jun Zhao
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (4): 892–901.
https://doi.org/10.1158/1078-0432.CCR-19-0556
Published: 14 February 2020
View article titled, The Prognostic and Therapeutic Role of Genomic Subtyping by Sequencing Tumor or Cell-Free DNA in Pulmonary Large-Cell Neuroendocrine Carcinoma
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Includes: Supplementary data
Journal Articles

Validation of the 12-gene Predictive Signature for Adjuvant Chemotherapy Response in Lung Cancer

Yang Xie, Wei Lu, Shidan Wang, Ximing Tang, Hao Tang, Yunyun Zhou, Cesar Moran, Carmen Behrens, Jack A. Roth, Qinghua Zhou, David H. Johnson, Stephen G. Swisher, John V. Heymach, Vassiliki A. Papadimitrakopoulou, Guanghua Xiao, John D. Minna, Ignacio I. Wistuba
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (1): 150–157.
https://doi.org/10.1158/1078-0432.CCR-17-2543
Published: 03 January 2019
View article titled, Validation of the 12-gene Predictive Signature for Adjuvant Chemotherapy Response in Lung Cancer
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Includes: Supplementary data
Journal Articles

Landscape of EGFR-Dependent and -Independent Resistance Mechanisms to Osimertinib and Continuation Therapy Beyond Progression in EGFR-Mutant NSCLC

Xiuning Le, Sonam Puri, Marcelo V. Negrao, Monique B. Nilsson, Jacqulyne Robichaux, Theresa Boyle, J. Kevin Hicks, Katherine L. Lovinger, Emily Roarty, Waree Rinsurongkawong, Ming Tang, Huiying Sun, Yasir Elamin, Lara C. Lacerda, Jeff Lewis, Jack A. Roth, Stephen G. Swisher, J. Jack Lee, William N. William, Jr, Bonnie S. Glisson, Jianjun Zhang, Vassiliki A. Papadimitrakopoulou, Jhanelle E. Gray, John V. Heymach
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (24): 6195–6203.
https://doi.org/10.1158/1078-0432.CCR-18-1542
Published: 13 December 2018
View article titled, Landscape of EGFR-Dependent and -Independent Resistance Mechanisms to Osimertinib and Continuation Therapy Beyond Progression in <em>EGFR</em>-Mutant NSCLC
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Includes: Supplementary data
Journal Articles

Predictors of Survival in Never-Smokers with Non–Small Cell Lung Cancer: A Large-Scale, Two-Phase Genetic Study

Xia Pu, Yuanqing Ye, Margaret R. Spitz, Liang Wang, Jian Gu, Scott M. Lippman, Michelle A.T. Hildebrandt, Waun Ki Hong, John D. Minna, Jack A. Roth, Ping Yang, Xifeng Wu
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (21): 5983–5991.
https://doi.org/10.1158/1078-0432.CCR-12-0774
Published: 06 November 2012
View article titled, Predictors of Survival in Never-Smokers with Non–Small Cell Lung Cancer: A Large-Scale, Two-Phase Genetic Study
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Includes: Supplementary data
Journal Articles

Genetic Variations in Epigenetic Genes Are Predictors of Recurrence in Stage I or II Non–Small Cell Lung Cancer Patients

Klaus W. Wagner, Yuanqing Ye, Jie Lin, Ara A. Vaporciyan, Jack A. Roth, Xifeng Wu
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (2): 585–592.
https://doi.org/10.1158/1078-0432.CCR-11-2087
Published: 16 January 2012
View article titled, Genetic Variations in Epigenetic Genes Are Predictors of Recurrence in Stage I or II Non–Small Cell Lung Cancer Patients
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Journal Articles

Prognostic Significance of RNA-Dependent Protein Kinase on Non–Small Cell Lung Cancer Patients

Abujiang Pataer, Maria Gabriela Raso, Arlene M. Correa, Carmen Behrens, Koji Tsuta, Luisa Solis, Bingliang Fang, Jack A. Roth, Ignacio I. Wistuba, Stephen G. Swisher
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (22): 5522–5528.
https://doi.org/10.1158/1078-0432.CCR-10-0753
Published: 14 November 2010
View article titled, Prognostic Significance of RNA-Dependent Protein Kinase on Non–Small Cell Lung Cancer Patients
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Journal Articles

Genetically Abnormal Circulating Cells in Lung Cancer Patients: An Antigen-Independent Fluorescence In situ Hybridization–Based Case-Control Study

Ruth L. Katz, Weigong He, Abha Khanna, Ricardo L. Fernandez, Tanweer M. Zaidi, Matthew Krebs, Nancy P. Caraway, Hua-Zhong Zhang, Feng Jiang, Margaret R. Spitz, David P. Blowers, Carlos A. Jimenez, Reza J. Mehran, Stephen G. Swisher, Jack A. Roth, Jeffrey S. Morris, Carol J. Etzel, Randa El-Zein
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (15): 3976–3987.
https://doi.org/10.1158/1078-0432.CCR-09-3358
Published: 28 July 2010
View article titled, Genetically Abnormal Circulating Cells in Lung Cancer Patients: An Antigen-Independent Fluorescence <em>In situ</em> Hybridization–Based Case-Control Study
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Includes: Supplementary data
Journal Articles

Targeted Cytosine Deaminase-Uracil Phosphoribosyl Transferase Suicide Gene Therapy Induces Small Cell Lung Cancer–Specific Cytotoxicity and Tumor Growth Delay

Camilla L. Christensen, Torben Gjetting, Thomas T. Poulsen, Frederik Cramer, Jack A. Roth, Hans S. Poulsen
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (8): 2308–2319.
https://doi.org/10.1158/1078-0432.CCR-09-3057
Published: 14 April 2010
View article titled, Targeted Cytosine Deaminase-Uracil Phosphoribosyl Transferase Suicide Gene Therapy Induces Small Cell Lung Cancer–Specific Cytotoxicity and Tumor Growth Delay
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Journal Articles

Biomarkers Predict p53 Gene Therapy Efficacy in Recurrent Squamous Cell Carcinoma of the Head and Neck

John Nemunaitis, Gary Clayman, Sanjiv S. Agarwala, William Hrushesky, James R. Wells, Charles Moore, John Hamm, George Yoo, Jose Baselga, Barbara A. Murphy, Kerstin A. Menander, Laura L. Licato, Sunil Chada, Robert D. Gibbons, Magali Olivier, Pierre Hainaut, Jack A. Roth, Robert E. Sobol, W. Jarrard Goodwin
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (24): 7719–7725.
https://doi.org/10.1158/1078-0432.CCR-09-1044
Published: 14 December 2009
View article titled, Biomarkers Predict <em>p53</em> Gene Therapy Efficacy in Recurrent Squamous Cell Carcinoma of the Head and Neck
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Journal Articles

Loss and Reduction of Fus1 Protein Expression is a Frequent Phenomenon in the Pathogenesis of Lung Cancer

Ludmila Prudkin, Carmen Behrens, Diane D. Liu, Xian Zhou, Natalie C. Ozburn, B. Nebiyou Bekele, John D. Minna, Cesar Moran, Jack A. Roth, Lin Ji, Ignacio I. Wistuba
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (1): 41–47.
https://doi.org/10.1158/1078-0432.CCR-07-1252
Published: 02 January 2008
View article titled, Loss and Reduction of Fus1 Protein Expression is a Frequent Phenomenon in the Pathogenesis of Lung Cancer
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Includes: Supplementary data
Journal Articles

The Double-Stranded RNA-Activated Protein Kinase Mediates Radiation Resistance in Mouse Embryo Fibroblasts through Nuclear Factor κB and Akt Activation

Urs von Holzen, Abujiang Pataer, Uma Raju, Dora Bocangel, Stephan A. Vorburger, Yanna Liu, Xiaolin Lu, Jack A. Roth, Bharat B. Aggarwal, Glen N. Barber, Khandan Keyomarsi, Kelly K. Hunt, Stephen G. Swisher
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (20): 6032–6039.
https://doi.org/10.1158/1078-0432.CCR-06-2932
Published: 18 October 2007
View article titled, The Double-Stranded RNA-Activated Protein Kinase Mediates Radiation Resistance in Mouse Embryo Fibroblasts through Nuclear Factor κB and Akt Activation
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Journal Articles

Aberrant Promoter Methylation Profile and Association with Survival in Patients with Non–Small Cell Lung Cancer

Jian Gu, David Berman, Charles Lu, Ignacio I. Wistuba, Jack A. Roth, Marsha Frazier, Margaret R. Spitz, Xifeng Wu
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (24): 7329–7338.
https://doi.org/10.1158/1078-0432.CCR-06-0894
Published: 22 December 2006
View article titled, Aberrant Promoter Methylation Profile and Association with Survival in Patients with Non–Small Cell Lung Cancer
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Journal Articles

Current Status of Gene Therapy for Lung Cancer and Head and Neck Cancer

Chulso Moon, Yun Oh, Jack A. Roth
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (14): 5055–5067.
Published: 12 November 2003
View article titled, Current Status of Gene Therapy for Lung Cancer and Head and Neck Cancer
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Journal Articles

Epidermal Growth Factor Receptor, Cyclooxygenase-2, and BAX Expression in the Primary Non-Small Cell Lung Cancer and Brain Metastases

Ivan Milas, Ritsuko Komaki, Tsutomu Hachiya, Robbin S. Bubb, Jae Y. Ro, Lauren Langford, Raymond Sawaya, Joe B. Putnam, Pamela Allen, James D. Cox, Timothy J. McDonnell, William Brock, Waun Ki Hong, Jack A. Roth, Luka Milas
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (3): 1070–1076.
Published: 01 March 2003
View article titled, Epidermal Growth Factor Receptor, Cyclooxygenase-2, and BAX Expression in the Primary Non-Small Cell Lung Cancer and Brain Metastases
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Journal Articles

Induction of p53-regulated Genes and Tumor Regression in Lung Cancer Patients after Intratumoral Delivery of Adenoviral p53 (INGN 201) and Radiation Therapy

Stephen G. Swisher, Jack A. Roth, Ritsuko Komaki, Jian Gu, J. Jack Lee, Marshall Hicks, Jae Y. Ro, Waun K. Hong, James A. Merritt, Kamaran Ahrar, N. Edward Atkinson, Arlene M. Correa, Marcelo Dolormente, Linda Dreiling, Adel K. El-Naggar, Frank Fossella, Rhodette Francisco, Bonnie Glisson, Susan Grammer, Roy Herbst, Armando Huaringa, Bonnie Kemp, Fadlo R. Khuri, Jonathan M. Kurie, Zhongxio Liao, Timothy J. McDonnell, Rudolfo Morice, Frank Morello, Reginald Munden, Vassiliki Papadimitrakopoulou, Katherine M. W. Pisters, Joe B. Putnam, Jr., Arcenio J. Sarabia, Thomas Shelton, Craig Stevens, Daniel M. Shin, William R. Smythe, Ara A. Vaporciyan, Garrett L. Walsh, Min Yin
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (1): 93–101.
Published: 01 January 2003
View article titled, Induction of p53-regulated Genes and Tumor Regression in Lung Cancer Patients after Intratumoral Delivery of Adenoviral p53 (INGN 201) and Radiation Therapy
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Journal Articles

Mebendazole Elicits a Potent Antitumor Effect on Human Cancer Cell Lines Both in Vitro and in Vivo

Tapas Mukhopadhyay, Ji-ichiro Sasaki, Rajagopal Ramesh, Jack A. Roth
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (9): 2963–2969.
Published: 01 September 2002
View article titled, Mebendazole Elicits a Potent Antitumor Effect on Human Cancer Cell Lines Both <em>in Vitro</em> and <em>in Vivo</em>
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Journal Articles

Synergistic Inhibition of Human Lung Cancer Cell Growth by Adenovirus-mediated Wild-Type p53 Gene Transfer in Combination with Docetaxel and Radiation Therapeutics in Vitro and in Vivo

Masahiko Nishizaki, Raymond E. Meyn, Lawrence B. Levy, Edward N. Atkinson, R. Allen White, Jack A. Roth, Lin Ji
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (9): 2887–2897.
Published: 01 September 2001
View article titled, Synergistic Inhibition of Human Lung Cancer Cell Growth by Adenovirus-mediated Wild-Type <em>p53</em> Gene Transfer in Combination with Docetaxel and Radiation Therapeutics <em>in Vitro</em> and <em>in Vivo</em>
Open the PDF for Synergistic Inhibition of Human Lung Cancer Cell Growth by Adenovirus-mediated Wild-Type <em>p53</em> Gene Transfer in Combination with Docetaxel and Radiation Therapeutics <em>in Vitro</em> and <em>in Vivo</em> in another window
Journal Articles

Deficiency of Caspase-3 in MCF7 Cells Blocks Bax-mediated Nuclear Fragmentation but not Cell Death

Shunsuke Kagawa, Jian Gu, Tsuyoshi Honda, Timothy J. McDonnell, Stephen G. Swisher, Jack A. Roth, Bingliang Fang
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (5): 1474–1480.
Published: 01 May 2001
View article titled, Deficiency of Caspase-3 in MCF7 Cells Blocks Bax-mediated Nuclear Fragmentation but not Cell Death
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Journal Articles

Adenovirus-mediated Antisense Urokinase-Type Plasminogen Activator Receptor Gene Transfer Reduces Tumor Cell Invasion and Metastasis in Non-Small Cell Lung Cancer Cell Lines

Sajani S. Lakka, Ramesh Rajagopal, Mannari K. Rajan, Pamarthi M. Mohan, Yoshiaki Adachi, Dzung H. Dinh, Willaim C. Olivero, Meena Gujrati, Francis Ali-Osman, Jack A. Roth, W. K. Alfred Yung, Athanassios P. Kyritsis, Jasti S. Rao
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (4): 1087–1093.
Published: 01 April 2001
View article titled, Adenovirus-mediated Antisense Urokinase-Type Plasminogen Activator Receptor Gene Transfer Reduces Tumor Cell Invasion and Metastasis in Non-Small Cell Lung Cancer Cell Lines
Open the PDF for Adenovirus-mediated Antisense Urokinase-Type Plasminogen Activator Receptor Gene Transfer Reduces Tumor Cell Invasion and Metastasis in Non-Small Cell Lung Cancer Cell Lines in another window