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J. Silvio Gutkind
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Journal Articles

Abstract PR06: Cooperative HPV and YAP-mediated oncogenic reprogramming of oral progenitors into cancer stem cells at single cell resolution

Farhoud Faraji, Sydney I. Ramirez, Lauren M. Clubb, Kuniaki Sato, Paola Y. Anguiano Quiroz, William M. G. Galloway, Thomas S. Hoang, Kate Medetgul-Ernar, Pauline Marangoni, Alfredo A. Molinolo, Joseph A. Califano, Quinton Smith, Ophir D. Klein, Pablo Tamayo, J. Silvio Gutkind
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (18_Supplement): PR06.
https://doi.org/10.1158/1557-3265.AACRAHNS23-PR06
Published: 15 September 2023
View article titled, Abstract PR06: Cooperative HPV and YAP-mediated oncogenic reprogramming of oral progenitors into cancer stem cells at single cell resolution
Journal Articles

A Randomized Multi-institutional Phase II Trial of Everolimus as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck

Cherie-Ann O. Nathan, D. Neil Hayes, Theodore Karrison, Olivier Harismendy, José M. Flores, Tara Moore-Medlin, Everett E. Vokes, J. Silvio Gutkind, Prakash Neupane, Glenn Mills, Zoukaa Sargi, Tanguy Seiwert, Juneko Grilley-Olson, Terry Day, Maura Gillison, James L. Wade, Lawrence Feldman, Gautam Jha, Mark Kozloff, Miriam O'Leary, Francis P. Worden, Ezra E.W. Cohen
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (23): 5040–5048.
https://doi.org/10.1158/1078-0432.CCR-21-4290
Published: 01 December 2022
View article titled, A Randomized Multi-institutional Phase II Trial of Everolimus as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck
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Includes: Supplementary data
Journal Articles

Correction: Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma

Justine S. Paradis, Monica Acosta, Robert Saddawi-Konefka, Ayush Kishore, Simone Lubrano, Frederico Gomes, Nadia Arang, Manoela Tiago, Silvia Coma, Xingyu Wu, Kyle Ford, Chi-Ping Day, Glenn Merlino, Prashant Mali, Jonathan A. Pachter, Takami Sato, Andrew E. Aplin, J. Silvio Gutkind
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (16): 4664.
https://doi.org/10.1158/1078-0432.CCR-21-2433
Published: 15 August 2021
View article titled, Correction: Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for <em>GNAQ</em>-Driven Uveal Melanoma
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Journal Articles

Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma

Justine S. Paradis, Monica Acosta, Robert Saddawi-Konefka, Ayush Kishore, Simone Lubrano, Frederico Gomes, Nadia Arang, Manoela Tiago, Silvia Coma, Xingyu Wu, Kyle Ford, Chi-Ping Day, Glenn Merlino, Prashant Mali, Jonathan A. Pachter, Takami Sato, Andrew E. Aplin, J. Silvio Gutkind
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (11): 3190–3200.
https://doi.org/10.1158/1078-0432.CCR-20-3363
Published: 01 June 2021
View article titled, Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for <em>GNAQ</em>-Driven Uveal Melanoma
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Includes: Supplementary data
Journal Articles

B Cells Improve Overall Survival in HPV-Associated Squamous Cell Carcinomas and Are Activated by Radiation and PD-1 Blockade

Sangwoo S. Kim, Sarek Shen, Sayuri Miyauchi, P. Dominick Sanders, Ida Franiak-Pietryga, Loren Mell, J. Silvio Gutkind, Ezra E.W. Cohen, Joseph A. Califano, Andrew B. Sharabi
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13): 3345–3359.
https://doi.org/10.1158/1078-0432.CCR-19-3211
Published: 01 July 2020
View article titled, B Cells Improve Overall Survival in HPV-Associated Squamous Cell Carcinomas and Are Activated by Radiation and PD-1 Blockade
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Includes: Supplementary data
Journal Articles

Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation

Chao Liu, Sayed H. Sadat, Koji Ebisumoto, Akihiro Sakai, Bharat A. Panuganti, Shuling Ren, Yusuke Goto, Sunny Haft, Takahito Fukusumi, Mizuo Ando, Yuki Saito, Theresa Guo, Pablo Tamayo, Huwate Yeerna, William Kim, Jacqueline Hubbard, Andrew B. Sharabi, J. Silvio Gutkind, Joseph A. Califano
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (11): 2693–2703.
https://doi.org/10.1158/1078-0432.CCR-18-3301
Published: 01 June 2020
View article titled, Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation
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Includes: Supplementary data
Journal Articles

Targeting mTOR in Head and Neck Cancer—Response

J. Silvio Gutkind, Terry A. Day, Scott M. Lippman, Eva Szabo
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (21): 6555.
https://doi.org/10.1158/1078-0432.CCR-19-2002
Published: 01 November 2019
View article titled, Targeting mTOR in Head and Neck Cancer—Response
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Journal Articles

Immune Modulation of Head and Neck Squamous Cell Carcinoma and the Tumor Microenvironment by Conventional Therapeutics

Sayuri Miyauchi, Sangwoo S. Kim, John Pang, Kathryn A. Gold, J. Silvio Gutkind, Joseph A. Califano, Loren K. Mell, Ezra E.W. Cohen, Andrew B. Sharabi
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (14): 4211–4223.
https://doi.org/10.1158/1078-0432.CCR-18-0871
Published: 15 July 2019
View article titled, Immune Modulation of Head and Neck Squamous Cell Carcinoma and the Tumor Microenvironment by Conventional Therapeutics
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Journal Articles

Inhibition of mTOR Signaling and Clinical Activity of Rapamycin in Head and Neck Cancer in a Window of Opportunity Trial

Terry A. Day, Keisuke Shirai, Paul E. O'Brien, Maria Gisele Matheus, Kristina Godwin, Amit J. Sood, Anvesh Kompelli, Julie A. Vick, Daniel Martin, Lynn Vitale-Cross, Juan Luis Callejas-Varela, Zhiyong Wang, Xingyu Wu, Olivier Harismendy, Alfredo A. Molinolo, Scott M. Lippman, Carter Van Waes, Eva Szabo, J. Silvio Gutkind
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (4): 1156–1164.
https://doi.org/10.1158/1078-0432.CCR-18-2024
Published: 15 February 2019
View article titled, Inhibition of mTOR Signaling and Clinical Activity of Rapamycin in Head and Neck Cancer in a Window of Opportunity Trial
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Includes: Supplementary data
Journal Articles

The NOTCH4–HEY1 Pathway Induces Epithelial–Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma

Takahito Fukusumi, Theresa W. Guo, Akihiro Sakai, Mizuo Ando, Shuling Ren, Sunny Haft, Chao Liu, Panomwat Amornphimoltham, J. Silvio Gutkind, Joseph A. Califano
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (3): 619–633.
https://doi.org/10.1158/1078-0432.CCR-17-1366
Published: 31 January 2018
View article titled, The <em>NOTCH4</em>–<em>HEY1</em> Pathway Induces Epithelial–Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Using global expression changes to determine the function of menin in endocrine tumorigenesis

Youngmi Ji, Vyomesh Patel, J. Silvio Gutkind, Settara Chandrasekharappa
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (19_Supplement): A42.
Published: 15 August 2014
View article titled, Using global expression changes to determine the function of menin in endocrine tumorigenesis
Journal Articles

Rab25 Regulates Invasion and Metastasis in Head and Neck Cancer

Panomwat Amornphimoltham, Kamil Rechache, Jamie Thompson, Andrius Masedunskas, Kantima Leelahavanichkul, Vyomesh Patel, Alfredo Molinolo, J. Silvio Gutkind, Roberto Weigert
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (6): 1375–1388.
https://doi.org/10.1158/1078-0432.CCR-12-2858
Published: 14 March 2013
View article titled, Rab25 Regulates Invasion and Metastasis in Head and Neck Cancer
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Includes: Multimedia, Supplementary data
Journal Articles

Chemopreventive and Chemotherapeutic Actions of mTOR Inhibitor in Genetically Defined Head and Neck Squamous Cell Carcinoma Mouse Model

Zhi-Jun Sun, Lu Zhang, Bradford Hall, Yansong Bian, J. Silvio Gutkind, Ashok B. Kulkarni
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (19): 5304–5313.
https://doi.org/10.1158/1078-0432.CCR-12-1371
Published: 30 September 2012
View article titled, Chemopreventive and Chemotherapeutic Actions of mTOR Inhibitor in Genetically Defined Head and Neck Squamous Cell Carcinoma Mouse Model
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Includes: Supplementary data
Journal Articles

Activation of the mTOR Pathway in Primary Medullary Thyroid Carcinoma and Lymph Node Metastases

Anna Tamburrino, Alfredo A. Molinolo, Paolo Salerno, Rebecca D. Chernock, Mark Raffeld, Liqiang Xi, J. Silvio Gutkind, Jeffrey F. Moley, Samuel A. Wells, Jr., Massimo Santoro
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (13): 3532–3540.
https://doi.org/10.1158/1078-0432.CCR-11-2700
Published: 01 July 2012
View article titled, Activation of the mTOR Pathway in Primary Medullary Thyroid Carcinoma and Lymph Node Metastases
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Includes: Supplementary data
Journal Articles

mTOR as a Molecular Target in HPV-Associated Oral and Cervical Squamous Carcinomas

Alfredo A. Molinolo, Christina Marsh, Mohamed El Dinali, Nitin Gangane, Kaitlin Jennison, Stephen Hewitt, Vyomesh Patel, Tanguy Y. Seiwert, J. Silvio Gutkind
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (9): 2558–2568.
https://doi.org/10.1158/1078-0432.CCR-11-2824
Published: 30 April 2012
View article titled, mTOR as a Molecular Target in HPV-Associated Oral and Cervical Squamous Carcinomas
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Includes: Supplementary data
Journal Articles

Inhibition of Mammalian Target of Rapamycin by Rapamycin Causes the Regression of Carcinogen-Induced Skin Tumor Lesions

Panomwat Amornphimoltham, Kantima Leelahavanichkul, Alfredo Molinolo, Vyomesh Patel, J. Silvio Gutkind
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (24): 8094–8101.
https://doi.org/10.1158/1078-0432.CCR-08-0703
Published: 15 December 2008
View article titled, Inhibition of Mammalian Target of Rapamycin by Rapamycin Causes the Regression of Carcinogen-Induced Skin Tumor Lesions
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Includes: Supplementary data
Journal Articles

RCAS/SCL-TVA Animal Model Allows Targeted Delivery of Polyoma Middle T Oncogene to Vascular Endothelial Progenitors In vivo and Results in Hemangioma Development

Justin Sausville, Alfredo A. Molinolo, Xiangfei Cheng, Jon Frampton, Naoko Takebe, J. Silvio Gutkind, Ricardo A. Feldman
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (12): 3948–3955.
https://doi.org/10.1158/1078-0432.CCR-07-5152
Published: 16 June 2008
View article titled, RCAS/SCL-TVA Animal Model Allows Targeted Delivery of Polyoma Middle T Oncogene to Vascular Endothelial Progenitors <em>In vivo</em> and Results in Hemangioma Development
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Journal Articles

Proteomic Analysis of Laser-Captured Paraffin-Embedded Tissues: A Molecular Portrait of Head and Neck Cancer Progression

Vyomesh Patel, Brian L. Hood, Alfredo A. Molinolo, Norman H. Lee, Thomas P. Conrads, John C. Braisted, David B. Krizman, Timothy D. Veenstra, J. Silvio Gutkind
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (4): 1002–1014.
https://doi.org/10.1158/1078-0432.CCR-07-1497
Published: 15 February 2008
View article titled, Proteomic Analysis of Laser-Captured Paraffin-Embedded Tissues: A Molecular Portrait of Head and Neck Cancer Progression
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Includes: Supplementary data
Journal Articles

Dissecting the Akt/Mammalian Target of Rapamycin Signaling Network: Emerging Results from the Head and Neck Cancer Tissue Array Initiative

Alfredo A. Molinolo, Stephen M. Hewitt, Panomwat Amornphimoltham, Somboon Keelawat, Samraeung Rangdaeng, Abelardo Meneses García, Ana R. Raimondi, Rafael Jufe, María Itoiz, Yan Gao, Dhananjaya Saranath, George S. Kaleebi, George H. Yoo, Lee Leak, Ernest M. Myers, Satoru Shintani, David Wong, H. Davis Massey, W. Andrew Yeudall, Fulvio Lonardo, John Ensley, J. Silvio Gutkind
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (17): 4964–4973.
https://doi.org/10.1158/1078-0432.CCR-07-1041
Published: 04 September 2007
View article titled, Dissecting the Akt/Mammalian Target of Rapamycin Signaling Network: Emerging Results from the Head and Neck Cancer Tissue Array Initiative
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Journal Articles

Combination Chemotherapy and Radiation of Human Squamous Cell Carcinoma of the Head and Neck Augments CTL-Mediated Lysis

Alexander Gelbard, Charlie T. Garnett, Scott I. Abrams, Vyomesh Patel, J. Silvio Gutkind, Claudia Palena, Kwong-Yok Tsang, Jeffrey Schlom, James W. Hodge
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (6): 1897–1905.
https://doi.org/10.1158/1078-0432.CCR-05-1761
Published: 21 March 2006
View article titled, Combination Chemotherapy and Radiation of Human Squamous Cell Carcinoma of the Head and Neck Augments CTL-Mediated Lysis
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