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Minimal Residual Disease in Myeloma: Application for Clinical Care and New Drug Registration

Clin Cancer Res (2021) 27 (19): 5195–5212.

DOI: https://doi.org/10.1158/1078-0432.CCR-21-1059

Published: 01 October 2021

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Journal Articles

Abstract IA10: Liquid biopsies as biomarkers of disease progression in multiple myeloma

Irene M. Ghobrial

Clin Cancer Res (2020) 26 (11_Supplement): IA10.

DOI: https://doi.org/10.1158/1557-3265.LiqBiop20-IA10

Published: 01 June 2020

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Journal Articles

Abstract A38: A novel clinical-grade liquid biopsy platform for multiple myeloma

Mark W. Bustoros, Carrie Cibulskis, Teni Dowdell, Svetlana Gavrilov, Cody Boehner, Jennifer Yesil, Steven E. Labkoff, Shaadi Mehr, Jihye Park, Romanos Sklavenitis Pistofidis, Salomon Manier, Annette S. Kim, Keith L. Ligon, Niall Lennon, Viktor Adalsteinsson, Jane Wilkinson, Irene M. Ghobrial, Daniel Auclair

Clin Cancer Res (2020) 26 (11_Supplement): A38.

DOI: https://doi.org/10.1158/1557-3265.LiqBiop20-A38

Published: 01 June 2020

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Journal Articles

A Phase Ib/II Trial of the First-in-Class Anti-CXCR4 Antibody Ulocuplumab in Combination with Lenalidomide or Bortezomib Plus Dexamethasone in Relapsed Multiple Myeloma

Irene M. Ghobrial, Chia-Jen Liu, Robert A. Redd, Raymond P. Perez, Rachid Baz, Oksana Zavidij, Romanos Sklavenitis-Pistofidis, Paul G. Richardson, Kenneth C. Anderson, Jacob Laubach, Patrick Henrick, Alexandra Savell, Kaitlen Reyes, Kalvis Hornburg, Stacey Chuma, Peter Sabbatini, Michael D. Robbins, Pamela S. Becker

Clin Cancer Res (2020) 26 (2): 344–353.

DOI: https://doi.org/10.1158/1078-0432.CCR-19-0647

Published: 15 January 2020

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Includes: Supplementary data

Journal Articles

A Phase Ib/II Study of Oprozomib in Patients with Advanced Multiple Myeloma and Waldenström Macroglobulinemia

Irene M. Ghobrial, Ravi Vij, David Siegel, Ashraf Badros, Jonathan Kaufman, Noopur Raje, Andrzej Jakubowiak, Michael R. Savona, Mihaela Obreja, Jesus G. Berdeja

Clin Cancer Res (2019) 25 (16): 4907–4916.

DOI: https://doi.org/10.1158/1078-0432.CCR-18-3728

Published: 15 August 2019

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Includes: Supplementary data

Journal Articles

Correction: Resveratrol Exerts Antiproliferative Activity and Induces Apoptosis in Waldenström Macroglobulinemia

Aldo M. Roccaro, Xavier Leleu, Antonio Sacco, Anne-Sophie Moreau, Evdoxia Hatjiharissi, Xiaoying Jia, Lian Xu, Bryan Ciccarelli, Christopher J. Patterson, Hai T. Ngo, Domenico Russo, Angelo Vacca, Franco Dammacco, Kenneth C. Anderson, Irene M. Ghobrial, Steven P. Treon

Clin Cancer Res (2019) 25 (15): 4860.

DOI: https://doi.org/10.1158/1078-0432.CCR-19-2051

Published: 01 August 2019

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Journal Articles

A Phase I/II Study of Evofosfamide, A Hypoxia-activated Prodrug with or without Bortezomib in Subjects with Relapsed/Refractory Multiple Myeloma

Clin Cancer Res (2019) 25 (2): 478–486.

DOI: https://doi.org/10.1158/1078-0432.CCR-18-1325

Published: 15 January 2019

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Journal Articles

Platelets Enhance Multiple Myeloma Progression via IL-1β Upregulation

Satoshi Takagi, Shokichi Tsukamoto, Jihye Park, Kelly E. Johnson, Yawara Kawano, Michele Moschetta, Chia-Jen Liu, Yuji Mishima, Katsutoshi Kokubun, Salomon Manier, Karma Z. Salem, Daisy Huynh, Antonio Sacco, Jodi Forward, Aldo M. Roccaro, Elisabeth M. Battinelli, Irene M. Ghobrial

Clin Cancer Res (2018) 24 (10): 2430–2439.

DOI: https://doi.org/10.1158/1078-0432.CCR-17-2003

Published: 14 May 2018

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Includes: Supplementary data

Journal Articles

Prospective, Multicenter Clinical Trial of Everolimus as Primary Therapy in Waldenstrom Macroglobulinemia (WMCTG 09-214)

Steven P. Treon, Kirsten Meid, Christina Tripsas, Leonard T. Heffner, Herbert Eradat, Ashraf Z. Badros, Lian Xu, Zachary R. Hunter, Guang Yang, Christopher J. Patterson, Joshua Gustine, Jorge J. Castillo, Jeffrey Matous, Irene M. Ghobrial

Clin Cancer Res (2017) 23 (10): 2400–2404.

DOI: https://doi.org/10.1158/1078-0432.CCR-16-1918

Published: 14 May 2017

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Journal Articles

Myeloma Cell Dynamics in Response to Treatment Supports a Model of Hierarchical Differentiation and Clonal Evolution

Min Tang, Rui Zhao, Helgi van de Velde, Jennifer G. Tross, Constantine Mitsiades, Suzanne Viselli, Rachel Neuwirth, Dixie-Lee Esseltine, Kenneth Anderson, Irene M. Ghobrial, Jesús F. San Miguel, Paul G. Richardson, Michael H. Tomasson, Franziska Michor

Clin Cancer Res (2016) 22 (16): 4206–4214.

DOI: https://doi.org/10.1158/1078-0432.CCR-15-2793

Published: 14 August 2016

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Includes: Supplementary data

Journal Articles

Team Work Matters: Dual Inhibition Puts Non-Hodgkin Lymphoma Under Siege

Giada Bianchi, Irene M. Ghobrial

Clin Cancer Res (2014) 20 (23): 5863–5865.

DOI: https://doi.org/10.1158/1078-0432.CCR-14-2055

Published: 30 November 2014

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Journal Articles

Biomarkers of Bone Remodeling in Multiple Myeloma Patients to Tailor Bisphosphonate Therapy

Chirayu G. Patel, Andrew J. Yee, Tyler A. Scullen, Neeharika Nemani, Loredana Santo, Paul G. Richardson, Jacob P. Laubach, Irene M. Ghobrial, Robert L. Schlossman, Nikhil C. Munshi, Kenneth C. Anderson, Noopur S. Raje

Clin Cancer Res (2014) 20 (15): 3955–3961.

DOI: https://doi.org/10.1158/1078-0432.CCR-14-0434

Published: 31 July 2014

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Journal Articles

Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma: A Review of the Current Understanding of Epidemiology, Biology, Risk Stratification, and Management of Myeloma Precursor Disease

Amit Agarwal, Irene M. Ghobrial

Clin Cancer Res (2013) 19 (5): 985–994.

DOI: https://doi.org/10.1158/1078-0432.CCR-12-2922

Published: 03 March 2013

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Includes: Supplementary data

Journal Articles

Mechanisms of Activity of the TORC1 Inhibitor Everolimus in Waldenstrom Macroglobulinemia

Aldo M. Roccaro, Antonio Sacco, Xiaojing Jia, Ranjit Banwait, Patricia Maiso, Feda Azab, Ludmila Flores, Salomon Manier, Abdel Kareem Azab, Irene M. Ghobrial

Clin Cancer Res (2012) 18 (24): 6609–6622.

DOI: https://doi.org/10.1158/1078-0432.CCR-12-1532

Published: 16 December 2012

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Includes: Supplementary data

Journal Articles

A Multicenter Phase II Study of Single-Agent Enzastaurin in Previously Treated Waldenström Macroglobulinemia

Irene M. Ghobrial, Philippe Moreau, Brianna Harris, Tiffany Poon, Eric Jourdan, Hervé Maisonneuve, Karim A. Benhadji, Anwar M. Hossain, Tuan S. Nguyen, James E. Wooldridge, Veronique Leblond

Clin Cancer Res (2012) 18 (18): 5043–5050.

DOI: https://doi.org/10.1158/1078-0432.CCR-12-0181

Published: 16 September 2012

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Journal Articles

Multiple Myeloma Mesenchymal Stem Cells: Characterization, Origin, and Tumor-Promoting Effects

Michaela R. Reagan, Irene M. Ghobrial

Clin Cancer Res (2012) 18 (2): 342–349.

DOI: https://doi.org/10.1158/1078-0432.CCR-11-2212

Published: 16 January 2012

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Journal Articles

Eph-B2/Ephrin-B2 Interaction Plays a Major Role in the Adhesion and Proliferation of Waldenstrom's Macroglobulinemia

Feda Azab, Abdel Kareem Azab, Patricia Maiso, Teresa Calimeri, Ludmila Flores, Yang Liu, Phong Quang, Aldo M. Roccaro, Antonio Sacco, Hai T. Ngo, Yong Zhang, Brittany L. Morgan, Ruben D. Carrasco, Irene M. Ghobrial

Clin Cancer Res (2012) 18 (1): 91–104.

DOI: https://doi.org/10.1158/1078-0432.CCR-11-0111

Published: 02 January 2012

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Journal Articles

FGFR3 Is Overexpressed Waldenström Macroglobulinemia and Its Inhibition by Dovitinib Induces Apoptosis and Overcomes Stroma-Induced Proliferation

Abdel Kareem Azab, Feda Azab, Phong Quang, Patricia Maiso, Antonio Sacco, Hai T. Ngo, Yang Liu, Yong Zhang, Brittany L. Morgan, Aldo M. Roccaro, Irene M. Ghobrial

Clin Cancer Res (2011) 17 (13): 4389–4399.

DOI: https://doi.org/10.1158/1078-0432.CCR-10-2772

Published: 05 July 2011

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Journal Articles

The Role of Serum Immunoglobulin Free Light Chain in Response and Progression in Waldenstrom Macroglobulinemia

Xavier Leleu, Wanling Xie, Meghan Bagshaw, Ranjit Banwait, Renee Leduc, Nitin Roper, Edie Weller, Irene M. Ghobrial

Clin Cancer Res (2011) 17 (9): 3013–3018.

DOI: https://doi.org/10.1158/1078-0432.CCR-10-2954

Published: 01 May 2011

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Includes: Supplementary data

Journal Articles

Carfilzomib-Dependent Selective Inhibition of the Chymotrypsin-like Activity of the Proteasome Leads to Antitumor Activity in Waldenstrom's Macroglobulinemia

Antonio Sacco, Monette Aujay, Brittany Morgan, Abdel Kareem Azab, Patricia Maiso, Yang Liu, Yong Zhang, Feda Azab, Hai T. Ngo, Ghayas C. Issa, Phong Quang, Aldo M. Roccaro, Irene M. Ghobrial

Clin Cancer Res (2011) 17 (7): 1753–1764.

DOI: https://doi.org/10.1158/1078-0432.CCR-10-2130

Published: 31 March 2011

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Includes: Supplementary data

NARROW

Minimal Residual Disease in Myeloma: Application for Clinical Care and New Drug Registration

Abstract IA10: Liquid biopsies as biomarkers of disease progression in multiple myeloma

Abstract A38: A novel clinical-grade liquid biopsy platform for multiple myeloma

A Phase Ib/II Trial of the First-in-Class Anti-CXCR4 Antibody Ulocuplumab in Combination with Lenalidomide or Bortezomib Plus Dexamethasone in Relapsed Multiple Myeloma

A Phase Ib/II Study of Oprozomib in Patients with Advanced Multiple Myeloma and Waldenström Macroglobulinemia

Correction: Resveratrol Exerts Antiproliferative Activity and Induces Apoptosis in Waldenström Macroglobulinemia

A Phase I/II Study of Evofosfamide, A Hypoxia-activated Prodrug with or without Bortezomib in Subjects with Relapsed/Refractory Multiple Myeloma

Platelets Enhance Multiple Myeloma Progression via IL-1β Upregulation

Prospective, Multicenter Clinical Trial of Everolimus as Primary Therapy in Waldenstrom Macroglobulinemia (WMCTG 09-214)

Myeloma Cell Dynamics in Response to Treatment Supports a Model of Hierarchical Differentiation and Clonal Evolution

Team Work Matters: Dual Inhibition Puts Non-Hodgkin Lymphoma Under Siege

Biomarkers of Bone Remodeling in Multiple Myeloma Patients to Tailor Bisphosphonate Therapy

Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma: A Review of the Current Understanding of Epidemiology, Biology, Risk Stratification, and Management of Myeloma Precursor Disease

Mechanisms of Activity of the TORC1 Inhibitor Everolimus in Waldenstrom Macroglobulinemia

A Multicenter Phase II Study of Single-Agent Enzastaurin in Previously Treated Waldenström Macroglobulinemia

Multiple Myeloma Mesenchymal Stem Cells: Characterization, Origin, and Tumor-Promoting Effects

Eph-B2/Ephrin-B2 Interaction Plays a Major Role in the Adhesion and Proliferation of Waldenstrom's Macroglobulinemia

FGFR3 Is Overexpressed Waldenström Macroglobulinemia and Its Inhibition by Dovitinib Induces Apoptosis and Overcomes Stroma-Induced Proliferation

The Role of Serum Immunoglobulin Free Light Chain in Response and Progression in Waldenstrom Macroglobulinemia

Carfilzomib-Dependent Selective Inhibition of the Chymotrypsin-like Activity of the Proteasome Leads to Antitumor Activity in Waldenstrom's Macroglobulinemia

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