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Journal Articles

Results from Phase I Extension Study Assessing Pexidartinib Treatment in Six Cohorts with Solid Tumors including TGCT, and Abnormal CSF1 Transcripts in TGCT

William D. Tap, Arun S. Singh, Stephen Patrick Anthony, Mike Sterba, Chao Zhang, John H. Healey, Bartosz Chmielowski, Allen Lee Cohn, Geoffrey I. Shapiro, Vicki L. Keedy, Zev A. Wainberg, Igor Puzanov, Gregory M. Cote, Andrew J. Wagner, Fadi Braiteh, Eric Sherman, Henry H. Hsu, Charles Peterfy, Heather L. Gelhorn, Xin Ye, Paul Severson, Brian L. West, Paul S. Lin, Sandra Tong-Starksen
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (2): 298–307.
DOI: https://doi.org/10.1158/1078-0432.CCR-21-2007
Published: 19 January 2022
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Neoadjuvant Pembrolizumab and High-Dose IFNα-2b in Resectable Regionally Advanced Melanoma

Yana G. Najjar, Dustin McCurry, Huang Lin, Yan Lin, Yan Zang, Diwakar Davar, Arivarasan Karunamurthy, Joseph J. Drabick, Rogerio I. Neves, Lisa H. Butterfield, Marc S. Ernstoff, Igor Puzanov, Joseph J. Skitzki, Jennifer Bordeaux, IlaSri B. Summit, Jehovana O. Bender, Ju Young Kim, Beiru Chen, Ghanashyam Sarikonda, Anil Pahuja, Jennifer Tsau, Zeni Alfonso, Christian Laing, James F. Pingpank, Matthew P. Holtzman, Cindy Sander, Amy Rose, Hassane M. Zarour, John M. Kirkwood, Ahmad A. Tarhini
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (15): 4195–4204.
DOI: https://doi.org/10.1158/1078-0432.CCR-20-4301
Published: 01 August 2021
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Correction: Angiokines Associated with Outcomes after Sunitinib or Everolimus Treatment in Patients with Non–Clear Cell Renal Cell Carcinoma

Andrew J. Armstrong, Andrew B. Nixon, Andrea Carmack, Qian Yang, Tim Eisen, Walter M. Stadler, Robert J. Jones, Jorge A. Garcia, Ulka N. Vaishampayan, Joel Picus, Robert E. Hawkins, John D. Hainsworth, Christian K. Kollmannsberger, Theodore F. Logan, Igor Puzanov, Lisa M. Pickering, Christopher W. Ryan, Andrew Protheroe, Daniel J. George, Susan Halabi
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (12): 3503.
DOI: https://doi.org/10.1158/1078-0432.CCR-21-1636
Published: 15 June 2021
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Journal Articles

Angiokines Associated with Targeted Therapy Outcomes in Patients with Non–Clear Cell Renal Cell Carcinoma

Andrew J. Armstrong, Andrew B. Nixon, Andrea Carmack, Qian Yang, Tim Eisen, Walter M. Stadler, Robert J. Jones, Jorge A. Garcia, Ulka N. Vaishampayan, Joel Picus, Robert E. Hawkins, John D. Hainsworth, Christian K. Kollmannsberger, Theodore F. Logan, Igor Puzanov, Lisa M. Pickering, Christopher W. Ryan, Andrew Protheroe, Daniel J. George, Susan Halabi
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (12): 3317–3328.
DOI: https://doi.org/10.1158/1078-0432.CCR-20-4504
Published: 15 June 2021
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Phase I Clinical Trial of Combination Propranolol and Pembrolizumab in Locally Advanced and Metastatic Melanoma: Safety, Tolerability, and Preliminary Evidence of Antitumor Activity

Shipra Gandhi, Manu R. Pandey, Kristopher Attwood, Wenyan Ji, Agnieszka K. Witkiewicz, Erik S. Knudsen, Cheryl Allen, Joseph D. Tario, Paul K. Wallace, Carlos D. Cedeno, Maria Levis, Suzanne Stack, Pauline Funchain, Joseph J. Drabick, Mark J. Bucsek, Igor Puzanov, Hemn Mohammadpour, Elizabeth A. Repasky, Marc S. Ernstoff
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (1): 87–95.
DOI: https://doi.org/10.1158/1078-0432.CCR-20-2381
Published: 04 January 2021
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Angiogenic and Immune-Related Biomarkers and Outcomes Following Axitinib/Pembrolizumab Treatment in Patients with Advanced Renal Cell Carcinoma

Jean-François Martini, Elizabeth R. Plimack, Toni K. Choueiri, David F. McDermott, Igor Puzanov, Mayer N. Fishman, Daniel C. Cho, Ulka Vaishampayan, Bradley Rosbrook, Kathrine C. Fernandez, Jamal C. Tarazi, Saby George, Michael B. Atkins
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (21): 5598–5608.
DOI: https://doi.org/10.1158/1078-0432.CCR-20-1408
Published: 02 November 2020
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Extended 5-Year Follow-up Results of a Phase Ib Study (BRIM7) of Vemurafenib and Cobimetinib in BRAF-Mutant Melanoma

Antoni Ribas, Adil Daud, Anna C. Pavlick, Rene Gonzalez, Karl D. Lewis, Omid Hamid, Thomas F. Gajewski, Igor Puzanov, Matthew Wongchenko, Isabelle Rooney, Jessie J. Hsu, Yibing Yan, Erica Park, Grant A. McArthur
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (1): 46–53.
DOI: https://doi.org/10.1158/1078-0432.CCR-18-4180
Published: 03 January 2020
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Prospective Evaluation of Sunitinib-Induced Cardiotoxicity in Patients with Metastatic Renal Cell Carcinoma

Vivek Narayan, Stephen Keefe, Naomi Haas, Le Wang, Igor Puzanov, Mary Putt, Anna Catino, James Fang, Neeraj Agarwal, David Hyman, Amanda M. Smith, Brian S. Finkelman, Hari K. Narayan, Steven Ewer, Chantal ElAmm, Daniel Lenihan, Bonnie Ky
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (14): 3601–3609.
DOI: https://doi.org/10.1158/1078-0432.CCR-16-2869
Published: 13 July 2017
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Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors

Ravi K. Amaravadi, Kathryn E. Hamilton, Xiaohong Ma, Shengfu Piao, Armando Del Portillo, Katherine L. Nathanson, Matteo S. Carlino, Georgina V. Long, Igor Puzanov, Xiaowei Xu, Jennifer J.D. Morrissette, Kenneth Y. Tsai, Keith T. Flaherty, Jeffrey A. Sosman, Grant R. Goodman, Grant A. McArthur, Anil K. Rustgi, David C. Metz, Lynn M. Schuchter, Paul B. Chapman, Antonia R. Sepulveda
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (23): 5215–5221.
DOI: https://doi.org/10.1158/1078-0432.CCR-15-0469
Published: 30 November 2015
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A Phase I Study of Continuous Oral Dosing of OSI-906, a Dual Inhibitor of Insulin-Like Growth Factor-1 and Insulin Receptors, in Patients with Advanced Solid Tumors

Igor Puzanov, Colin R. Lindsay, Laura Goff, Jeff Sosman, Jill Gilbert, Jordan Berlin, Srinivasu Poondru, Ronit Simantov, Rich Gedrich, Andrew Stephens, Emily Chan, T.R. Jeffry Evans
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2015) 21 (4): 701–711.
DOI: https://doi.org/10.1158/1078-0432.CCR-14-0303
Published: 16 February 2015
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BRAF Fusions Define a Distinct Molecular Subset of Melanomas with Potential Sensitivity to MEK Inhibition

Katherine E. Hutchinson, Doron Lipson, Philip J. Stephens, Geoff Otto, Brian D. Lehmann, Pamela L. Lyle, Cindy L. Vnencak-Jones, Jeffrey S. Ross, Jennifer A. Pietenpol, Jeffrey A. Sosman, Igor Puzanov, Vincent A. Miller, William Pao
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2013) 19 (24): 6696–6702.
DOI: https://doi.org/10.1158/1078-0432.CCR-13-1746
Published: 16 December 2013
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γ-H2AX Foci Formation as a Pharmacodynamic Marker of DNA Damage Produced by DNA Cross-Linking Agents: Results from 2 Phase I Clinical Trials of SJG-136 (SG2000)

Jenny Wu, Peter H. Clingen, Victoria J. Spanswick, Maria Mellinas-Gomez, Tim Meyer, Igor Puzanov, Duncan Jodrell, Daniel Hochhauser, John A. Hartley
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (3): 721–730.
DOI: https://doi.org/10.1158/1078-0432.CCR-12-2529
Published: 31 January 2013
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Safety and Pharmacokinetics of Ganitumab (AMG 479) Combined with Sorafenib, Panitumumab, Erlotinib, or Gemcitabine in Patients with Advanced Solid Tumors

Lee S. Rosen, Igor Puzanov, Gregory Friberg, Emily Chan, Yuying C. Hwang, Hongjie Deng, Jill Gilbert, Devalingam Mahalingam, Ian McCaffery, Shaunita A. Michael, Alain C. Mita, Monica M. Mita, Marilyn Mulay, Poornima Shubhakar, Min Zhu, John Sarantopoulos
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (12): 3414–3427.
DOI: https://doi.org/10.1158/1078-0432.CCR-11-3369
Published: 14 June 2012
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Phase I Pharmacokinetic and Pharmacodynamic Study of SJG-136, a Novel DNA Sequence Selective Minor Groove Cross-linking Agent, in Advanced Solid Tumors

Igor Puzanov, Wooin Lee, Alice P. Chen, M. Wade Calcutt, David L. Hachey, Wendy L. Vermeulen, Victoria J. Spanswick, Chih-Yi Liao, John A. Hartley, Jordan D. Berlin, Mace L. Rothenberg
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (11): 3794–3802.
DOI: https://doi.org/10.1158/1078-0432.CCR-10-2056
Published: 01 June 2011
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A Phase I Trial of Bortezomib with Temozolomide in Patients with Advanced Melanoma: Toxicities, Antitumor Effects, and Modulation of Therapeutic Targets

Yingjun Su, Katayoun I. Amiri, Linda W. Horton, Yingchun Yu, Gregory D. Ayers, Elizabeth Koehler, Mark C. Kelley, Igor Puzanov, Ann Richmond, Jeffrey A. Sosman
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (1): 348–357.
DOI: https://doi.org/10.1158/1078-0432.CCR-09-2087
Published: 04 January 2010
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Opportunities and Obstacles to Combination Targeted Therapy in Renal Cell Cancer

Jeffrey A. Sosman, Igor Puzanov, Michael B. Atkins
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (2): 764s–769s.
DOI: https://doi.org/10.1158/1078-0432.CCR-06-1975
Published: 25 January 2007
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Molecular Targets in Melanoma from Angiogenesis to Apoptosis

Jeffrey A. Sosman, Igor Puzanov
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (7): 2376s–2383s.
DOI: https://doi.org/10.1158/1078-0432.CCR-05-2558
Published: 11 April 2006
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