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Ignacio Melero
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Journal Articles

Druggable Targets in Cytokine Release Syndromes

Carlos Luri-Rey, Iñaki Eguren-Santamaria, Ignacio Matos, Pedro Berraondo, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res OF1–OF3.
https://doi.org/10.1158/1078-0432.CCR-23-1975
Published: 21 September 2023
View article titled, Druggable Targets in Cytokine Release Syndromes
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Journal Articles

Facts and Hopes on Neutralization of Protumor Inflammatory Mediators in Cancer Immunotherapy

Irene Olivera, Carlos Luri-Rey, Alvaro Teijeira, Iñaki Eguren-Santamaria, Gabriel Gomis, Belen Palencia, Pedro Berraondo, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res OF1–OF17.
https://doi.org/10.1158/1078-0432.CCR-22-3653
Published: 07 September 2023
View article titled, Facts and Hopes on Neutralization of Protumor Inflammatory Mediators in Cancer Immunotherapy
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Journal Articles

Revisiting Intracavitary Immunotherapy of Cancer

Fernando Aranda, Iñaki Eguren-Santamaria, Ángela Bella, Pedro Berraondo, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (10): 1993–1995.
https://doi.org/10.1158/1078-0432.CCR-22-0201
Published: 13 May 2022
View article titled, Revisiting Intracavitary Immunotherapy of Cancer
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Journal Articles

Consolidating Radiotherapy with Immunotherapy

Maria E. Rodriguez-Ruiz, Miguel F. Sanmamed, Irantzu Serrano-Mendioroz, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (20): 5443–5445.
https://doi.org/10.1158/1078-0432.CCR-21-2335
Published: 15 October 2021
View article titled, Consolidating Radiotherapy with Immunotherapy
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Journal Articles

An Fc-free EGFR-specific 4-1BB-agonistic Trimerbody Displays Broad Antitumor Activity in Humanized Murine Cancer Models without Toxicity

Marta Compte, Seandean L. Harwood, Ainhoa Erce-Llamazares, Antonio Tapia-Galisteo, Eduardo Romero, Irene Ferrer, Eva M. Garrido-Martin, Ana B. Enguita, Maria C. Ochoa, Belén Blanco, Marta Oteo, Nekane Merino, Daniel Nehme-Álvarez, Oana Hangiu, Carmen Domínguez-Alonso, Manuela Zonca, Angel Ramírez-Fernández, Francisco J. Blanco, Miguel A. Morcillo, Ines G. Muñoz, Ignacio Melero, José L. Rodriguez-Peralto, Luis Paz-Ares, Laura Sanz, Luis Alvarez-Vallina
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (11): 3167–3177.
https://doi.org/10.1158/1078-0432.CCR-20-4625
Published: 01 June 2021
View article titled, An Fc-free EGFR-specific 4-1BB-agonistic Trimerbody Displays Broad Antitumor Activity in Humanized Murine Cancer Models without Toxicity
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Includes: Supplementary data
Journal Articles

IL8, Neutrophils, and NETs in a Collusion against Cancer Immunity and Immunotherapy

Alvaro Teijeira, Saray Garasa, Maria C. Ochoa, Maria Villalba, Irene Olivera, Assunta Cirella, Iñaki Eguren-Santamaria, Pedro Berraondo, Kurt A. Schalper, Carlos E. de Andrea, Miguel F. Sanmamed, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (9): 2383–2393.
https://doi.org/10.1158/1078-0432.CCR-20-1319
Published: 01 May 2021
View article titled, IL8, Neutrophils, and NETs in a Collusion against Cancer Immunity and Immunotherapy
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Journal Articles

OX40 Agonist BMS-986178 Alone or in Combination With Nivolumab and/or Ipilimumab in Patients With Advanced Solid Tumors

Martin Gutierrez, Victor Moreno, Kimberley M. Heinhuis, Anthony J. Olszanski, Anna Spreafico, Michael Ong, Quincy Chu, Richard D. Carvajal, José Trigo, Maria Ochoa de Olza, Mariano Provencio, Filip Yves De Vos, Filippo De Braud, Stephen Leong, Deanne Lathers, Rui Wang, Palani Ravindran, Yan Feng, Praveen Aanur, Ignacio Melero
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (2): 460–472.
https://doi.org/10.1158/1078-0432.CCR-20-1830
Published: 19 January 2021
View article titled, OX40 Agonist BMS-986178 Alone or in Combination With Nivolumab and/or Ipilimumab in Patients With Advanced Solid Tumors
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Includes: Supplementary data
Journal Articles

Interleukin-12 Message in a Bottle

Assunta Cirella, Pedro Berraondo, Claudia Augusta Di Trani, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (23): 6080–6082.
https://doi.org/10.1158/1078-0432.CCR-20-3250
Published: 01 December 2020
View article titled, Interleukin-12 Message in a Bottle
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Journal Articles

Exploiting TCR Recognition of Shared Hotspot Oncogene-encoded Neoantigens

Irene Olivera, Iñaki Etxeberria, Elixabet Bolaños, María Gato-Cañas, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (6): 1203–1204.
https://doi.org/10.1158/1078-0432.CCR-19-3813
Published: 13 March 2020
View article titled, Exploiting TCR Recognition of Shared Hotspot Oncogene-encoded Neoantigens
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Journal Articles

An Integrative Approach to Inform Optimal Administration of OX40 Agonist Antibodies in Patients with Advanced Solid Tumors

Rui Wang, Chan Gao, Megan Raymond, Gennaro Dito, Dominic Kabbabe, Xiao Shao, Ed Hilt, Yongliang Sun, Irene Pak, Martin Gutierrez, Ignacio Melero, Anna Spreafico, Richard D. Carvajal, Michael Ong, Anthony J. Olszanski, Christina Milburn, Kent Thudium, Zheng Yang, Yan Feng, Paula M. Fracasso, Alan J. Korman, Praveen Aanur, Shih-Min A. Huang, Michael Quigley
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (22): 6709–6720.
https://doi.org/10.1158/1078-0432.CCR-19-0526
Published: 15 November 2019
View article titled, An Integrative Approach to Inform Optimal Administration of OX40 Agonist Antibodies in Patients with Advanced Solid Tumors
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Includes: Supplementary data
Journal Articles

Vaccination for Pancreatic Ductal Adenocarcinoma: A Hard Nut to Crack

Diego Salas-Benito, Ignacio Melero, Mariano Ponz-Sarvise
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (18): 5435–5437.
https://doi.org/10.1158/1078-0432.CCR-19-1753
Published: 13 September 2019
View article titled, Vaccination for Pancreatic Ductal Adenocarcinoma: A Hard Nut to Crack
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Journal Articles

Immunotherapy in Non–Small Cell Lung Cancer: Facts and Hopes

Deborah B. Doroshow, Miguel F. Sanmamed, Katherine Hastings, Katerina Politi, David L. Rimm, Lieping Chen, Ignacio Melero, Kurt A. Schalper, Roy S. Herbst
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (15): 4592–4602.
https://doi.org/10.1158/1078-0432.CCR-18-1538
Published: 01 August 2019
View article titled, Immunotherapy in Non–Small Cell Lung Cancer: Facts and Hopes
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Journal Articles

Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non–Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis

Ila Datar, Miguel F. Sanmamed, Jun Wang, Brian S. Henick, Jungmin Choi, Ti Badri, Weilai Dong, Nikita Mani, Maria Toki, Luis D. Mejías, Maria D. Lozano, Jose Luis Perez-Gracia, Vamsidhar Velcheti, Matthew D. Hellmann, Justin F. Gainor, Kristen McEachern, David Jenkins, Konstantinos Syrigos, Katerina Politi, Scott Gettinger, David L. Rimm, Roy S. Herbst, Ignacio Melero, Lieping Chen, Kurt A. Schalper
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (15): 4663–4673.
https://doi.org/10.1158/1078-0432.CCR-18-4142
Published: 01 August 2019
View article titled, Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non–Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis
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Includes: Supplementary data
Journal Articles

For Whom the Cell Tolls? Intratumoral Treatment Links Innate and Adaptive Immunity

Ivan Marquez-Rodas, María Angela Aznar, Antonio Calles, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (4): 1127–1129.
https://doi.org/10.1158/1078-0432.CCR-18-2690
Published: 15 February 2019
View article titled, For Whom the Cell Tolls? Intratumoral Treatment Links Innate and Adaptive Immunity
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Journal Articles

Revisiting Interleukin-12 as a Cancer Immunotherapy Agent

Pedro Berraondo, Iñaki Etxeberria, Mariano Ponz-Sarvise, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (12): 2716–2718.
https://doi.org/10.1158/1078-0432.CCR-18-0381
Published: 14 June 2018
View article titled, Revisiting Interleukin-12 as a Cancer Immunotherapy Agent
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Journal Articles

Introducing a New Series: Immunotherapy Facts and Hopes

Ignacio Melero, Mario Sznol, Marlowe S. Tessmer, Theresa L. Whiteside, Jedd D. Wolchok
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (8): 1773–1774.
https://doi.org/10.1158/1078-0432.CCR-18-0408
Published: 12 April 2018
View article titled, Introducing a New Series: Immunotherapy Facts and Hopes
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Journal Articles

Immunotherapy of Hepatocellular Carcinoma: Facts and Hopes

Mercedes Iñarrairaegui, Ignacio Melero, Bruno Sangro
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (7): 1518–1524.
https://doi.org/10.1158/1078-0432.CCR-17-0289
Published: 02 April 2018
View article titled, Immunotherapy of Hepatocellular Carcinoma: Facts and Hopes
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Journal Articles

Anti-CD137 and PD-1/PD-L1 Antibodies En Route toward Clinical Synergy

Elisabeth Pérez-Ruiz, Iñaki Etxeberria, Maria E. Rodriguez-Ruiz, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (18): 5326–5328.
https://doi.org/10.1158/1078-0432.CCR-17-1799
Published: 14 September 2017
View article titled, Anti-CD137 and PD-1/PD-L1 Antibodies En Route toward Clinical Synergy
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Journal Articles

Results from an Integrated Safety Analysis of Urelumab, an Agonist Anti-CD137 Monoclonal Antibody

Neil H. Segal, Theodore F. Logan, F. Stephen Hodi, David McDermott, Ignacio Melero, Omid Hamid, Henrik Schmidt, Caroline Robert, Vanna Chiarion-Sileni, Paolo A. Ascierto, Michele Maio, Walter J. Urba, Tara C. Gangadhar, Satyendra Suryawanshi, Jaclyn Neely, Maria Jure-Kunkel, Suba Krishnan, Holbrook Kohrt, Mario Sznol, Ronald Levy
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (8): 1929–1936.
https://doi.org/10.1158/1078-0432.CCR-16-1272
Published: 13 April 2017
View article titled, Results from an Integrated Safety Analysis of Urelumab, an Agonist Anti-CD137 Monoclonal Antibody
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Includes: Supplementary data
Journal Articles

Immunotherapy of Cancer Visualized by Live Microscopy: Seeing Is Believing

Alvaro Teijeira, Iñaki Etxeberria, Mariano Ponz-Sarvise, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (17): 4277–4279.
https://doi.org/10.1158/1078-0432.CCR-16-1072
Published: 31 August 2016
View article titled, Immunotherapy of Cancer Visualized by Live Microscopy: Seeing Is Believing
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