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Ignacio Melero
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Journal Articles

Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps

Alvaro Teijeira, Saray Garasa, Maria C. Ochoa, Sandra Sanchez-Gregorio, Gabriel Gomis, Carlos Luri-Rey, Rafael Martinez-Monge, Beatrice Pinci, Karmele Valencia, Belen Palencia, Benigno Barbés, Elixabet Bolaños, Arantza Azpilikueta, Marina García-Cardosa, Javier Burguete, Iñaki Eguren-Santamaría, Eneko Garate-Soraluze, Pedro Berraondo, Jose L. Perez-Gracia, Carlos E. de Andrea, Maria E. Rodriguez-Ruiz, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (18): 4131–4142.
https://doi.org/10.1158/1078-0432.CCR-23-3860
Published: 13 September 2024
View article titled, Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
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Includes: Multimedia, Supplementary data
Journal Articles

CD137 (4-1BB) and T-Lymphocyte Exhaustion

Paula Molero-Glez, Arantza Azpilikueta, Laura Mosteo, Javier Glez-Vaz, Belen Palencia, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (18): 3971–3973.
https://doi.org/10.1158/1078-0432.CCR-24-1568
Published: 13 September 2024
View article titled, CD137 (4-1BB) and T-Lymphocyte Exhaustion
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Journal Articles

Double-Stranded RNA to Mimic Viral Infection for Cancer Immunotherapy

Ana Martínez-Riaño, Laura Mosteo, Paula Molero-Glez, Iván Márquez-Rodas, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (16): 3355–3357.
https://doi.org/10.1158/1078-0432.CCR-24-0938
Published: 15 August 2024
View article titled, Double-Stranded RNA to Mimic Viral Infection for Cancer Immunotherapy
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Journal Articles

Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity from a Phase I Study of Simlukafusp Alfa (FAP-IL2v) in Advanced/Metastatic Solid Tumors

Neeltje Steeghs, Carlos Gomez-Roca, Kristoffer S. Rohrberg, Morten Mau-Sørensen, Debbie Robbrecht, Josep Tabernero, Samreen Ahmed, Maria E. Rodríguez-Ruiz, Caroline Ardeshir, Daniela Schmid, Nassim Sleiman, Carl Watson, Hanna Piper-Lepoutre, David Dejardin, Stefan Evers, Christophe Boetsch, Jehad Charo, Volker Teichgräber, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (13): 2693–2701.
https://doi.org/10.1158/1078-0432.CCR-23-3567
Published: 01 July 2024
View article titled, Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity from a Phase I Study of Simlukafusp Alfa (FAP-IL2v) in Advanced/Metastatic Solid Tumors
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Includes: Supplementary data
Journal Articles

Obinutuzumab Pretreatment as a Novel Approach to Mitigate Formation of Anti-Drug Antibodies Against Cergutuzumab Amunaleukin in Patients with Solid Tumors

Solange Peters, Eric Angevin, Teresa Alonso-Gordoa, Kristoffer Rohrberg, Ignacio Melero, Begoña Mellado, Jose-Luis Perez-Gracia, Josep Tabernero, Celine Adessi, Christophe Boetsch, Carl Watson, Joseph Dal Porto, David Dejardin, Christopher Del Nagro, Valeria Nicolini, Stefan Evers, Christian Klein, Barbara Leutgeb, Pavel Pisa, Eva Rossmann, José Saro, Pablo Umana, Jehad Charo, Volker Teichgräber, Neeltje Steeghs
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (8): 1630–1641.
https://doi.org/10.1158/1078-0432.CCR-23-2658
Published: 15 April 2024
View article titled, Obinutuzumab Pretreatment as a Novel Approach to Mitigate Formation of Anti-Drug Antibodies Against Cergutuzumab Amunaleukin in Patients with Solid Tumors
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Includes: Supplementary data
Journal Articles

Facts and Hopes on Neutralization of Protumor Inflammatory Mediators in Cancer Immunotherapy

Irene Olivera, Carlos Luri-Rey, Alvaro Teijeira, Iñaki Eguren-Santamaria, Gabriel Gomis, Belen Palencia, Pedro Berraondo, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (23): 4711–4727.
https://doi.org/10.1158/1078-0432.CCR-22-3653
Published: 01 December 2023
View article titled, Facts and Hopes on Neutralization of Protumor Inflammatory Mediators in Cancer Immunotherapy
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Journal Articles

Druggable Targets in Cytokine Release Syndromes

Carlos Luri-Rey, Iñaki Eguren-Santamaria, Ignacio Matos, Pedro Berraondo, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (21): 4320–4322.
https://doi.org/10.1158/1078-0432.CCR-23-1975
Published: 01 November 2023
View article titled, Druggable Targets in Cytokine Release Syndromes
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Journal Articles

Revisiting Intracavitary Immunotherapy of Cancer

Fernando Aranda, Iñaki Eguren-Santamaria, Ángela Bella, Pedro Berraondo, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (10): 1993–1995.
https://doi.org/10.1158/1078-0432.CCR-22-0201
Published: 13 May 2022
View article titled, Revisiting Intracavitary Immunotherapy of Cancer
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Journal Articles

Consolidating Radiotherapy with Immunotherapy

Maria E. Rodriguez-Ruiz, Miguel F. Sanmamed, Irantzu Serrano-Mendioroz, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (20): 5443–5445.
https://doi.org/10.1158/1078-0432.CCR-21-2335
Published: 15 October 2021
View article titled, Consolidating Radiotherapy with Immunotherapy
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Journal Articles

An Fc-free EGFR-specific 4-1BB-agonistic Trimerbody Displays Broad Antitumor Activity in Humanized Murine Cancer Models without Toxicity

Marta Compte, Seandean L. Harwood, Ainhoa Erce-Llamazares, Antonio Tapia-Galisteo, Eduardo Romero, Irene Ferrer, Eva M. Garrido-Martin, Ana B. Enguita, Maria C. Ochoa, Belén Blanco, Marta Oteo, Nekane Merino, Daniel Nehme-Álvarez, Oana Hangiu, Carmen Domínguez-Alonso, Manuela Zonca, Angel Ramírez-Fernández, Francisco J. Blanco, Miguel A. Morcillo, Ines G. Muñoz, Ignacio Melero, José L. Rodriguez-Peralto, Luis Paz-Ares, Laura Sanz, Luis Alvarez-Vallina
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (11): 3167–3177.
https://doi.org/10.1158/1078-0432.CCR-20-4625
Published: 01 June 2021
View article titled, An Fc-free EGFR-specific 4-1BB-agonistic Trimerbody Displays Broad Antitumor Activity in Humanized Murine Cancer Models without Toxicity
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Includes: Supplementary data
Journal Articles

IL8, Neutrophils, and NETs in a Collusion against Cancer Immunity and Immunotherapy

Alvaro Teijeira, Saray Garasa, Maria C. Ochoa, Maria Villalba, Irene Olivera, Assunta Cirella, Iñaki Eguren-Santamaria, Pedro Berraondo, Kurt A. Schalper, Carlos E. de Andrea, Miguel F. Sanmamed, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (9): 2383–2393.
https://doi.org/10.1158/1078-0432.CCR-20-1319
Published: 01 May 2021
View article titled, IL8, Neutrophils, and NETs in a Collusion against Cancer Immunity and Immunotherapy
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Journal Articles

OX40 Agonist BMS-986178 Alone or in Combination With Nivolumab and/or Ipilimumab in Patients With Advanced Solid Tumors

Martin Gutierrez, Victor Moreno, Kimberley M. Heinhuis, Anthony J. Olszanski, Anna Spreafico, Michael Ong, Quincy Chu, Richard D. Carvajal, José Trigo, Maria Ochoa de Olza, Mariano Provencio, Filip Yves De Vos, Filippo De Braud, Stephen Leong, Deanne Lathers, Rui Wang, Palani Ravindran, Yan Feng, Praveen Aanur, Ignacio Melero
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (2): 460–472.
https://doi.org/10.1158/1078-0432.CCR-20-1830
Published: 19 January 2021
View article titled, OX40 Agonist BMS-986178 Alone or in Combination With Nivolumab and/or Ipilimumab in Patients With Advanced Solid Tumors
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Includes: Supplementary data
Journal Articles

Interleukin-12 Message in a Bottle

Assunta Cirella, Pedro Berraondo, Claudia Augusta Di Trani, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (23): 6080–6082.
https://doi.org/10.1158/1078-0432.CCR-20-3250
Published: 01 December 2020
View article titled, Interleukin-12 Message in a Bottle
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Journal Articles

Exploiting TCR Recognition of Shared Hotspot Oncogene-encoded Neoantigens

Irene Olivera, Iñaki Etxeberria, Elixabet Bolaños, María Gato-Cañas, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (6): 1203–1204.
https://doi.org/10.1158/1078-0432.CCR-19-3813
Published: 13 March 2020
View article titled, Exploiting TCR Recognition of Shared Hotspot Oncogene-encoded Neoantigens
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Journal Articles

An Integrative Approach to Inform Optimal Administration of OX40 Agonist Antibodies in Patients with Advanced Solid Tumors

Rui Wang, Chan Gao, Megan Raymond, Gennaro Dito, Dominic Kabbabe, Xiao Shao, Ed Hilt, Yongliang Sun, Irene Pak, Martin Gutierrez, Ignacio Melero, Anna Spreafico, Richard D. Carvajal, Michael Ong, Anthony J. Olszanski, Christina Milburn, Kent Thudium, Zheng Yang, Yan Feng, Paula M. Fracasso, Alan J. Korman, Praveen Aanur, Shih-Min A. Huang, Michael Quigley
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (22): 6709–6720.
https://doi.org/10.1158/1078-0432.CCR-19-0526
Published: 15 November 2019
View article titled, An Integrative Approach to Inform Optimal Administration of OX40 Agonist Antibodies in Patients with Advanced Solid Tumors
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Includes: Supplementary data
Journal Articles

Vaccination for Pancreatic Ductal Adenocarcinoma: A Hard Nut to Crack

Diego Salas-Benito, Ignacio Melero, Mariano Ponz-Sarvise
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (18): 5435–5437.
https://doi.org/10.1158/1078-0432.CCR-19-1753
Published: 13 September 2019
View article titled, Vaccination for Pancreatic Ductal Adenocarcinoma: A Hard Nut to Crack
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Journal Articles

Immunotherapy in Non–Small Cell Lung Cancer: Facts and Hopes

Deborah B. Doroshow, Miguel F. Sanmamed, Katherine Hastings, Katerina Politi, David L. Rimm, Lieping Chen, Ignacio Melero, Kurt A. Schalper, Roy S. Herbst
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (15): 4592–4602.
https://doi.org/10.1158/1078-0432.CCR-18-1538
Published: 01 August 2019
View article titled, Immunotherapy in Non–Small Cell Lung Cancer: Facts and Hopes
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Journal Articles

Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non–Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis

Ila Datar, Miguel F. Sanmamed, Jun Wang, Brian S. Henick, Jungmin Choi, Ti Badri, Weilai Dong, Nikita Mani, Maria Toki, Luis D. Mejías, Maria D. Lozano, Jose Luis Perez-Gracia, Vamsidhar Velcheti, Matthew D. Hellmann, Justin F. Gainor, Kristen McEachern, David Jenkins, Konstantinos Syrigos, Katerina Politi, Scott Gettinger, David L. Rimm, Roy S. Herbst, Ignacio Melero, Lieping Chen, Kurt A. Schalper
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (15): 4663–4673.
https://doi.org/10.1158/1078-0432.CCR-18-4142
Published: 01 August 2019
View article titled, Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non–Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis
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Includes: Supplementary data
Journal Articles

For Whom the Cell Tolls? Intratumoral Treatment Links Innate and Adaptive Immunity

Ivan Marquez-Rodas, María Angela Aznar, Antonio Calles, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (4): 1127–1129.
https://doi.org/10.1158/1078-0432.CCR-18-2690
Published: 15 February 2019
View article titled, For Whom the Cell Tolls? Intratumoral Treatment Links Innate and Adaptive Immunity
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Journal Articles

Revisiting Interleukin-12 as a Cancer Immunotherapy Agent

Pedro Berraondo, Iñaki Etxeberria, Mariano Ponz-Sarvise, Ignacio Melero
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (12): 2716–2718.
https://doi.org/10.1158/1078-0432.CCR-18-0381
Published: 14 June 2018
View article titled, Revisiting Interleukin-12 as a Cancer Immunotherapy Agent
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