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Howard L. McLeod
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Journal Articles

Genomic Analysis of Germline Variation Associated with Survival of Patients with Colorectal Cancer Treated with Chemotherapy Plus Biologics in CALGB/SWOG 80405 (Alliance)

Federico Innocenti, Alexander B. Sibley, Sushant A. Patil, Amy S. Etheridge, Chen Jiang, Fang-Shu Ou, Stefanie D. Howell, Sarah J. Plummer, Graham Casey, Monica M. Bertagnolli, Howard L. McLeod, James T. Auman, Charles D. Blanke, Yoichi Furukawa, Alan P. Venook, Michiaki Kubo, Heinz-Josef Lenz, Joel S. Parker, Mark J. Ratain, Kouros Owzar
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (1): 267–275.
https://doi.org/10.1158/1078-0432.CCR-20-2021
Published: 04 January 2021
View article titled, Genomic Analysis of Germline Variation Associated with Survival of Patients with Colorectal Cancer Treated with Chemotherapy Plus Biologics in CALGB/SWOG 80405 (Alliance)
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Includes: Supplementary data
Journal Articles

The Genomic Landscape of Merkel Cell Carcinoma and Clinicogenomic Biomarkers of Response to Immune Checkpoint Inhibitor Therapy

Todd C. Knepper, Meagan Montesion, Jeffery S. Russell, Ethan S. Sokol, Garrett M. Frampton, Vincent A. Miller, Lee A. Albacker, Howard L. McLeod, Zeynep Eroglu, Nikhil I. Khushalani, Vernon K. Sondak, Jane L. Messina, Michael J. Schell, James A. DeCaprio, Kenneth Y. Tsai, Andrew S. Brohl
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (19): 5961–5971.
https://doi.org/10.1158/1078-0432.CCR-18-4159
Published: 01 October 2019
View article titled, The Genomic Landscape of Merkel Cell Carcinoma and Clinicogenomic Biomarkers of Response to Immune Checkpoint Inhibitor Therapy
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Includes: Supplementary data
Journal Articles

Identification of a Genomic Region between SLC29A1 and HSP90AB1 Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance)

Megan Li, Flora Mulkey, Chen Jiang, Bert H. O’Neil, Bryan P. Schneider, Fei Shen, Paula N. Friedman, Yukihide Momozawa, Michiaki Kubo, Donna Niedzwiecki, Howard S. Hochster, Heinz-Josef Lenz, James N. Atkins, Hope S. Rugo, Susan Halabi, William Kevin Kelly, Howard L. McLeod, Federico Innocenti, Mark J. Ratain, Alan P. Venook, Kouros Owzar, Deanna L. Kroetz
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (19): 4734–4744.
https://doi.org/10.1158/1078-0432.CCR-17-1523
Published: 01 October 2018
View article titled, Identification of a Genomic Region between <em>SLC29A1</em> and <em>HSP90AB1</em> Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance)
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Includes: Supplementary data
Journal Articles

Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy

Daniel L. Hertz, Kouros Owzar, Sherrie Lessans, Claudia Wing, Chen Jiang, William Kevin Kelly, Jai Patel, Susan Halabi, Yoichi Furukawa, Heather E. Wheeler, Alexander B. Sibley, Cameron Lassiter, Lois Weisman, Dorothy Watson, Stefanie D. Krens, Flora Mulkey, Cynthia L. Renn, Eric J. Small, Phillip G. Febbo, Ivo Shterev, Deanna L. Kroetz, Paula N. Friedman, John F. Mahoney, Michael A. Carducci, Michael J. Kelley, Yusuke Nakamura, Michiaki Kubo, Susan G. Dorsey, M. Eileen Dolan, Michael J. Morris, Mark J. Ratain, Howard L. McLeod
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (19): 4890–4900.
https://doi.org/10.1158/1078-0432.CCR-15-2823
Published: 02 October 2016
View article titled, Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a <em>VAC14</em> Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy
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Includes: Supplementary data
Journal Articles

Using Pharmacogene Polymorphism Panels to Detect Germline Pharmacodynamic Markers in Oncology

Daniel L. Hertz, Howard L. McLeod
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (10): 2530–2540.
https://doi.org/10.1158/1078-0432.CCR-13-2780
Published: 14 May 2014
View article titled, Using Pharmacogene Polymorphism Panels to Detect Germline Pharmacodynamic Markers in Oncology
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Journal Articles

Cumulative Genetic Risk Predicts Platinum/Taxane-Induced Neurotoxicity

Sarah McWhinney-Glass, Stacey J. Winham, Daniel L. Hertz, Jane Yen Revollo, Jim Paul, Yijing He, Robert Brown, Alison A. Motsinger-Reif, Howard L. McLeod, For the Scottish Gynaecological Clinical Trials Group
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (20): 5769–5776.
https://doi.org/10.1158/1078-0432.CCR-13-0774
Published: 14 October 2013
View article titled, Cumulative Genetic Risk Predicts Platinum/Taxane-Induced Neurotoxicity
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Includes: Supplementary data
Journal Articles

A Genome-Wide Association Study Identifies Novel Loci for Paclitaxel-Induced Sensory Peripheral Neuropathy in CALGB 40101

R. Michael Baldwin, Kouros Owzar, Hitoshi Zembutsu, Aparna Chhibber, Michiaki Kubo, Chen Jiang, Dorothy Watson, Rachel J. Eclov, Joel Mefford, Howard L. McLeod, Paula N. Friedman, Clifford A. Hudis, Eric P. Winer, Eric M. Jorgenson, John S. Witte, Lawrence N. Shulman, Yusuke Nakamura, Mark J. Ratain, Deanna L. Kroetz
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (18): 5099–5109.
https://doi.org/10.1158/1078-0432.CCR-12-1590
Published: 16 September 2012
View article titled, A Genome-Wide Association Study Identifies Novel Loci for Paclitaxel-Induced Sensory Peripheral Neuropathy in CALGB 40101
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Includes: Supplementary data
Journal Articles

A Genome-Wide Association Study of Overall Survival in Pancreatic Cancer Patients Treated with Gemcitabine in CALGB 80303

Federico Innocenti, Kouros Owzar, Nancy L. Cox, Patrick Evans, Michiaki Kubo, Hitoshi Zembutsu, Chen Jiang, Donna Hollis, Taisei Mushiroda, Liang Li, Paula Friedman, Liewei Wang, Dylan Glubb, Herbert Hurwitz, Kathleen M. Giacomini, Howard L. McLeod, Richard M. Goldberg, Richard L. Schilsky, Hedy L. Kindler, Yusuke Nakamura, Mark J. Ratain
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (2): 577–584.
https://doi.org/10.1158/1078-0432.CCR-11-1387
Published: 16 January 2012
View article titled, A Genome-Wide Association Study of Overall Survival in Pancreatic Cancer Patients Treated with Gemcitabine in CALGB 80303
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Includes: Supplementary data
Journal Articles

Irinotecan Pharmacogenetics: Influence of Pharmacodynamic Genes

Janelle M. Hoskins, Eugenio Marcuello, Albert Altes, Sharon Marsh, Taylor Maxwell, Derek J. Van Booven, Laia Paré, Robert Culverhouse, Howard L. McLeod, Montserrat Baiget
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (6): 1788–1796.
https://doi.org/10.1158/1078-0432.CCR-07-1472
Published: 17 March 2008
View article titled, Irinotecan Pharmacogenetics: Influence of Pharmacodynamic Genes
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Includes: Supplementary data
Journal Articles

Can Inhibiting Dihydropyrimidine Dehydrogenase Limit Hand-Foot Syndrome Caused by Fluoropyrimidines?

Jane L. Yen-Revollo, Richard M. Goldberg, Howard L. McLeod
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (1): 8–13.
https://doi.org/10.1158/1078-0432.CCR-07-1225
Published: 02 January 2008
View article titled, Can Inhibiting Dihydropyrimidine Dehydrogenase Limit Hand-Foot Syndrome Caused by Fluoropyrimidines?
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Journal Articles

Hoosier Oncology Group Randomized Phase II Study of Docetaxel, Vinorelbine, and Estramustine in Combination in Hormone-Refractory Prostate Cancer with Pharmacogenetic Survival Analysis

Noah M. Hahn, Sharon Marsh, William Fisher, Robert Langdon, Robin Zon, Mark Browning, Cynthia S. Johnson, Tiffany J. Scott-Horton, Lang Li, Howard L. McLeod, Christopher J. Sweeney
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (20): 6094–6099.
https://doi.org/10.1158/1078-0432.CCR-06-1188
Published: 24 October 2006
View article titled, Hoosier Oncology Group Randomized Phase II Study of Docetaxel, Vinorelbine, and Estramustine in Combination in Hormone-Refractory Prostate Cancer with Pharmacogenetic Survival Analysis
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Journal Articles

DNA Repair Pathway Profiling and Microsatellite Instability in Colorectal Cancer

Jinsheng Yu, Mary A. Mallon, Wanghai Zhang, Robert R. Freimuth, Sharon Marsh, Mark A. Watson, Paul J. Goodfellow, Howard L. McLeod
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (17): 5104–5111.
https://doi.org/10.1158/1078-0432.CCR-06-0547
Published: 01 September 2006
View article titled, DNA Repair Pathway Profiling and Microsatellite Instability in Colorectal Cancer
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Journal Articles

ABCB1 2677G>T/A Genotype and Paclitaxel Pharmacogenetics in Ovarian Cancer

Sharon Marsh, Cristi R. King, Howard L. McLeod, Jim Paul, Gillian Gifford, Robert Brown
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (13): 4127–4129.
https://doi.org/10.1158/1078-0432.CCR-06-0461
Published: 03 July 2006
View article titled, ABCB1 2677G&gt;T/A Genotype and Paclitaxel Pharmacogenetics in Ovarian Cancer
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Journal Articles

Methylation of the DPYD Promoter and Dihydropyrimidine Dehydrogenase Deficiency

Jinsheng Yu, Howard L. McLeod
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (12): 3864.
https://doi.org/10.1158/1078-0432.CCR-06-0549
Published: 15 June 2006
View article titled, Methylation of the DPYD Promoter and Dihydropyrimidine Dehydrogenase Deficiency
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Journal Articles

The Cancer and Leukemia Group B Pharmacology and Experimental Therapeutics Committee: A Historical Perspective

Mark J. Ratain, Antonius A. Miller, Howard L. McLeod, Alan P. Venook, Merrill J. Egorin, Richard L. Schilsky
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (11): 3612s–3616s.
https://doi.org/10.1158/1078-0432.CCR-06-9008
Published: 01 June 2006
View article titled, The Cancer and Leukemia Group B Pharmacology and Experimental Therapeutics Committee: A Historical Perspective
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Journal Articles

Association of CYP2C8, CYP3A4, CYP3A5, and ABCB1 Polymorphisms with the Pharmacokinetics of Paclitaxel

Anja Henningsson, Sharon Marsh, Walter J. Loos, Mats O. Karlsson, Adam Garsa, Klaus Mross, Stephan Mielke, Lucia Viganò, Alberta Locatelli, Jaap Verweij, Alex Sparreboom, Howard L. McLeod
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (22): 8097–8104.
https://doi.org/10.1158/1078-0432.CCR-05-1152
Published: 18 November 2005
View article titled, Association of <em>CYP2C8, CYP3A4, CYP3A5</em>, and <em>ABCB1</em> Polymorphisms with the Pharmacokinetics of Paclitaxel
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Journal Articles

Variance in the Expression of 5-Fluorouracil Pathway Genes in Colorectal Cancer

Elizabeth A. Kidd, Jinsheng Yu, Xia Li, William D. Shannon, Mark A. Watson, Howard L. McLeod
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (7): 2612–2619.
https://doi.org/10.1158/1078-0432.CCR-04-1258
Published: 06 April 2005
View article titled, Variance in the Expression of 5-Fluorouracil Pathway Genes in Colorectal Cancer
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Journal Articles

Gene Expression Profiling of the Irinotecan Pathway in Colorectal Cancer

Jinsheng Yu, William D. Shannon, Mark A. Watson, Howard L. McLeod
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (5): 2053–2062.
https://doi.org/10.1158/1078-0432.CCR-04-1254
Published: 08 March 2005
View article titled, Gene Expression Profiling of the Irinotecan Pathway in Colorectal Cancer
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Journal Articles

ABCG2 Pharmacogenetics: Ethnic Differences in Allele Frequency and Assessment of Influence on Irinotecan Disposition

Floris A. de Jong, Sharon Marsh, Ron H. J. Mathijssen, Cristi King, Jaap Verweij, Alex Sparreboom, Howard L. McLeod
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (17): 5889–5894.
https://doi.org/10.1158/1078-0432.CCR-04-0144
Published: 08 September 2004
View article titled, ABCG2 Pharmacogenetics: <subtitle>Ethnic Differences in Allele Frequency and Assessment of Influence on Irinotecan Disposition</subtitle>
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Journal Articles

Therapeutic Synergy Between Irinotecan and 5-Fluorouracil against Human Tumor Xenografts

Rami G. Azrak, Shousong Cao, Harry K. Slocum, Károly Tóth, Farukh A. Durrani, Ming-biao Yin, Lakshmi Pendyala, Wanghai Zhang, Howard L. McLeod, Youcef M. Rustum
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (3): 1121–1129.
https://doi.org/10.1158/1078-0432.CCR-0913-3
Published: 10 February 2004
View article titled, Therapeutic Synergy Between Irinotecan and 5-Fluorouracil against Human Tumor Xenografts
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