1-13 of 13
Hiroyuki Mano
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Phase II Trial of Nivolumab in Metastatic Rare Cancer with dMMR or MSI-H and Relation with Immune Phenotypic Analysis (the ROCK Trial)

Hitomi S. Okuma, Keisuke Watanabe, Kenji Tsuchihashi, Ryunosuke Machida, Ryo Sadachi, Akihiro Hirakawa, Hiroshi Ariyama, Masashi Kanai, Masahisa Kamikura, Kenta Anjo, Akari Hiramitsu, Shigeki Sekine, Natsuko Okita, Hiroyuki Mano, Hiroyoshi Nishikawa, Kenichi Nakamura, Kan Yonemori
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (24): 5079–5086.
https://doi.org/10.1158/1078-0432.CCR-23-1807
Published: 15 December 2023
View article titled, Phase II Trial of Nivolumab in Metastatic Rare Cancer with dMMR or MSI-H and Relation with Immune Phenotypic Analysis (the ROCK Trial)
Open the PDF for Phase II Trial of Nivolumab in Metastatic Rare Cancer with dMMR or MSI-H and Relation with Immune Phenotypic Analysis (the ROCK Trial) in another window
Includes: Supplementary data
Journal Articles

HSP90 Inhibition Overcomes Resistance to Molecular Targeted Therapy in BRAFV600E-mutant High-grade Glioma

Jo Sasame, Naoki Ikegaya, Masahito Kawazu, Manabu Natsumeda, Takahiro Hayashi, Masataka Isoda, Kaishi Satomi, Arata Tomiyama, Akito Oshima, Hirokuni Honma, Yohei Miyake, Katsuhiro Takabayashi, Taishi Nakamura, Toshihide Ueno, Yuko Matsushita, Hiromichi Iwashita, Yu Kanemaru, Hidetoshi Murata, Akihide Ryo, Keita Terashima, Shoji Yamanaka, Yukihiko Fujii, Hiroyuki Mano, Takashi Komori, Koichi Ichimura, Daniel P. Cahill, Hiroaki Wakimoto, Tetsuya Yamamoto, Kensuke Tateishi
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (11): 2425–2439.
https://doi.org/10.1158/1078-0432.CCR-21-3622
Published: 01 June 2022
View article titled, HSP90 Inhibition Overcomes Resistance to Molecular Targeted Therapy in <em>BRAF<sup>V600E</sup></em>-mutant High-grade Glioma
Open the PDF for HSP90 Inhibition Overcomes Resistance to Molecular Targeted Therapy in <em>BRAF<sup>V600E</sup></em>-mutant High-grade Glioma in another window
Includes: Supplementary data
Journal Articles

Transcriptomic Profiling of MSI-H/dMMR Gastrointestinal Tumors to Identify Determinants of Responsiveness to Anti–PD-1 Therapy

Keigo Chida, Akihito Kawazoe, Toshihiro Suzuki, Masahito Kawazu, Toshihide Ueno, Kazumasa Takenouchi, Yoshiaki Nakamura, Yasutoshi Kuboki, Daisuke Kotani, Takashi Kojima, Hideaki Bando, Saori Mishima, Takeshi Kuwata, Naoya Sakamoto, Jun Watanabe, Hiroyuki Mano, Masafumi Ikeda, Kohei Shitara, Itaru Endo, Tetsuya Nakatsura, Takayuki Yoshino
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (10): 2110–2117.
https://doi.org/10.1158/1078-0432.CCR-22-0041
Published: 13 May 2022
View article titled, Transcriptomic Profiling of MSI-H/dMMR Gastrointestinal Tumors to Identify Determinants of Responsiveness to Anti–PD-1 Therapy
Open the PDF for Transcriptomic Profiling of MSI-H/dMMR Gastrointestinal Tumors to Identify Determinants of Responsiveness to Anti–PD-1 Therapy in another window
Includes: Supplementary data
Journal Articles

A Low Tumor Mutational Burden and PTEN Mutations Are Predictors of a Negative Response to PD-1 Blockade in MSI-H/dMMR Gastrointestinal Tumors

Keigo Chida, Akihito Kawazoe, Masahito Kawazu, Toshihiro Suzuki, Yoshiaki Nakamura, Tetsuya Nakatsura, Takeshi Kuwata, Toshihide Ueno, Yasutoshi Kuboki, Daisuke Kotani, Takashi Kojima, Hiroya Taniguchi, Hiroyuki Mano, Masafumi Ikeda, Kohei Shitara, Itaru Endo, Takayuki Yoshino
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (13): 3714–3724.
https://doi.org/10.1158/1078-0432.CCR-21-0401
Published: 01 July 2021
View article titled, A Low Tumor Mutational Burden and <em>PTEN</em> Mutations Are Predictors of a Negative Response to PD-1 Blockade in MSI-H/dMMR Gastrointestinal Tumors
Open the PDF for A Low Tumor Mutational Burden and <em>PTEN</em> Mutations Are Predictors of a Negative Response to PD-1 Blockade in MSI-H/dMMR Gastrointestinal Tumors in another window
Includes: Supplementary data
Journal Articles

Multicenter Phase I/II Trial of Napabucasin and Pembrolizumab in Patients with Metastatic Colorectal Cancer (EPOC1503/SCOOP Trial)

Akihito Kawazoe, Yasutoshi Kuboki, Eiji Shinozaki, Hiroki Hara, Tomohiro Nishina, Yoshito Komatsu, Satoshi Yuki, Masashi Wakabayashi, Shogo Nomura, Akihiro Sato, Takeshi Kuwata, Masahito Kawazu, Hiroyuki Mano, Yosuke Togashi, Hiroyoshi Nishikawa, Takayuki Yoshino
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (22): 5887–5894.
https://doi.org/10.1158/1078-0432.CCR-20-1803
Published: 13 November 2020
View article titled, Multicenter Phase I/II Trial of Napabucasin and Pembrolizumab in Patients with Metastatic Colorectal Cancer (EPOC1503/SCOOP Trial)
Open the PDF for Multicenter Phase I/II Trial of Napabucasin and Pembrolizumab in Patients with Metastatic Colorectal Cancer (EPOC1503/SCOOP Trial) in another window
Includes: Supplementary data
Journal Articles

Fusion Kinases Identified by Genomic Analyses of Sporadic Microsatellite Instability–High Colorectal Cancers

Kazuhito Sato, Masahito Kawazu, Yoko Yamamoto, Toshihide Ueno, Shinya Kojima, Genta Nagae, Hiroyuki Abe, Manabu Soda, Takafumi Oga, Shinji Kohsaka, Eirin Sai, Yoshihiro Yamashita, Hisae Iinuma, Masashi Fukayama, Hiroyuki Aburatani, Toshiaki Watanabe, Hiroyuki Mano
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (1): 378–389.
https://doi.org/10.1158/1078-0432.CCR-18-1574
Published: 03 January 2019
View article titled, Fusion Kinases Identified by Genomic Analyses of Sporadic Microsatellite Instability–High Colorectal Cancers
Open the PDF for Fusion Kinases Identified by Genomic Analyses of Sporadic Microsatellite Instability–High Colorectal Cancers in another window
Includes: Supplementary data
Journal Articles

High-Throughput Functional Evaluation of Variants of Unknown Significance in ERBB2

Masaaki Nagano, Shinji Kohsaka, Toshihide Ueno, Shinya Kojima, Kanju Saka, Hirotaro Iwase, Masahito Kawazu, Hiroyuki Mano
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (20): 5112–5122.
https://doi.org/10.1158/1078-0432.CCR-18-0991
Published: 15 October 2018
View article titled, High-Throughput Functional Evaluation of Variants of Unknown Significance in <em>ERBB2</em>
Open the PDF for High-Throughput Functional Evaluation of Variants of Unknown Significance in <em>ERBB2</em> in another window
Includes: Supplementary data
Journal Articles

A Prospective PCR-Based Screening for the EML4-ALK Oncogene in Non–Small Cell Lung Cancer

Manabu Soda, Kazutoshi Isobe, Akira Inoue, Makoto Maemondo, Satoshi Oizumi, Yuka Fujita, Akihiko Gemma, Yoshihiro Yamashita, Toshihide Ueno, Kengo Takeuchi, Young Lim Choi, Hitoshi Miyazawa, Tomoaki Tanaka, Koichi Hagiwara, Hiroyuki Mano, for the North-East Japan Study Group and the ALK Lung Cancer Study Group
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (20): 5682–5689.
https://doi.org/10.1158/1078-0432.CCR-11-2947
Published: 14 October 2012
View article titled, A Prospective PCR-Based Screening for the <em>EML4-ALK</em> Oncogene in Non–Small Cell Lung Cancer
Open the PDF for A Prospective PCR-Based Screening for the <em>EML4-ALK</em> Oncogene in Non–Small Cell Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Paracrine Receptor Activation by Microenvironment Triggers Bypass Survival Signals and ALK Inhibitor Resistance in EML4-ALK Lung Cancer Cells

Tadaaki Yamada, Shinji Takeuchi, Junya Nakade, Kenji Kita, Takayuki Nakagawa, Shigeki Nanjo, Takahiro Nakamura, Kunio Matsumoto, Manabu Soda, Hiroyuki Mano, Toshimitsu Uenaka, Seiji Yano
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (13): 3592–3602.
https://doi.org/10.1158/1078-0432.CCR-11-2972
Published: 01 July 2012
View article titled, Paracrine Receptor Activation by Microenvironment Triggers Bypass Survival Signals and ALK Inhibitor Resistance in EML4-ALK Lung Cancer Cells
Open the PDF for Paracrine Receptor Activation by Microenvironment Triggers Bypass Survival Signals and ALK Inhibitor Resistance in EML4-ALK Lung Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Pulmonary Inflammatory Myofibroblastic Tumor Expressing a Novel Fusion, PPFIBP1–ALK: Reappraisal of Anti-ALK Immunohistochemistry as a Tool for Novel ALK Fusion Identification

Kengo Takeuchi, Manabu Soda, Yuki Togashi, Emiko Sugawara, Satoko Hatano, Reimi Asaka, Sakae Okumura, Ken Nakagawa, Hiroyuki Mano, Yuichi Ishikawa
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (10): 3341–3348.
https://doi.org/10.1158/1078-0432.CCR-11-0063
Published: 15 May 2011
View article titled, Pulmonary Inflammatory Myofibroblastic Tumor Expressing a Novel Fusion, PPFIBP1–ALK: Reappraisal of Anti-ALK Immunohistochemistry as a Tool for Novel ALK Fusion Identification
Open the PDF for Pulmonary Inflammatory Myofibroblastic Tumor Expressing a Novel Fusion, PPFIBP1–ALK: Reappraisal of Anti-ALK Immunohistochemistry as a Tool for Novel ALK Fusion Identification in another window
Includes: Supplementary data
Journal Articles

EML4-ALK Fusion Gene Assessment Using Metastatic Lymph Node Samples Obtained by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration

Yuichi Sakairi, Takahiro Nakajima, Kazuhiro Yasufuku, Dai Ikebe, Hajime Kageyama, Manabu Soda, Kengo Takeuchi, Makiko Itami, Toshihiko Iizasa, Ichiro Yoshino, Hiroyuki Mano, Hideki Kimura
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (20): 4938–4945.
https://doi.org/10.1158/1078-0432.CCR-10-0099
Published: 13 October 2010
View article titled, <em>EML4-ALK</em> Fusion Gene Assessment Using Metastatic Lymph Node Samples Obtained by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration
Open the PDF for <em>EML4-ALK</em> Fusion Gene Assessment Using Metastatic Lymph Node Samples Obtained by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in another window
Includes: Supplementary data
Journal Articles

KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancer

Kengo Takeuchi, Young Lim Choi, Yuki Togashi, Manabu Soda, Satoko Hatano, Kentaro Inamura, Shuji Takada, Toshihide Ueno, Yoshihiro Yamashita, Yukitoshi Satoh, Sakae Okumura, Ken Nakagawa, Yuichi Ishikawa, Hiroyuki Mano
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (9): 3143–3149.
https://doi.org/10.1158/1078-0432.CCR-08-3248
Published: 30 April 2009
View article titled, KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancer
Open the PDF for KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Multiplex Reverse Transcription-PCR Screening for EML4-ALK Fusion Transcripts

Kengo Takeuchi, Young Lim Choi, Manabu Soda, Kentaro Inamura, Yuki Togashi, Satoko Hatano, Munehiro Enomoto, Shuji Takada, Yoshihiro Yamashita, Yukitoshi Satoh, Sakae Okumura, Ken Nakagawa, Yuichi Ishikawa, Hiroyuki Mano
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (20): 6618–6624.
https://doi.org/10.1158/1078-0432.CCR-08-1018
Published: 16 October 2008
View article titled, Multiplex Reverse Transcription-PCR Screening for <em>EML4-ALK</em> Fusion Transcripts
Open the PDF for Multiplex Reverse Transcription-PCR Screening for <em>EML4-ALK</em> Fusion Transcripts in another window
Includes: Supplementary data