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Hiroshi Shiku
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Journal Articles

Development of Engineered T Cells Expressing a Chimeric CD16-CD3ζ Receptor to Improve the Clinical Efficacy of Mogamulizumab Therapy Against Adult T-Cell Leukemia

Hiroki Tanaka, Hiroshi Fujiwara, Fumihiro Ochi, Kazushi Tanimoto, Nicholas Casey, Sachiko Okamoto, Junichi Mineno, Kiyotaka Kuzushima, Hiroshi Shiku, Takashi Sugiyama, A. John Barrett, Masaki Yasukawa
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (17): 4405–4416.
https://doi.org/10.1158/1078-0432.CCR-15-2714
Published: 31 August 2016
View article titled, Development of Engineered T Cells Expressing a Chimeric CD16-CD3ζ Receptor to Improve the Clinical Efficacy of Mogamulizumab Therapy Against Adult T-Cell Leukemia
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Includes: Supplementary data
Journal Articles

Adoptive Transfer of MAGE-A4 T-cell Receptor Gene-Transduced Lymphocytes in Patients with Recurrent Esophageal Cancer

Shinichi Kageyama, Hiroaki Ikeda, Yoshihiro Miyahara, Naoko Imai, Mikiya Ishihara, Kanako Saito, Sahoko Sugino, Shugo Ueda, Takeshi Ishikawa, Satoshi Kokura, Hiroaki Naota, Kohshi Ohishi, Taizo Shiraishi, Naoki Inoue, Masashige Tanabe, Tomohide Kidokoro, Hirofumi Yoshioka, Daisuke Tomura, Ikuei Nukaya, Junichi Mineno, Kazutoh Takesako, Naoyuki Katayama, Hiroshi Shiku
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (10): 2268–2277.
https://doi.org/10.1158/1078-0432.CCR-14-1559
Published: 14 May 2015
View article titled, Adoptive Transfer of MAGE-A4 T-cell Receptor Gene-Transduced Lymphocytes in Patients with Recurrent Esophageal Cancer
Open the PDF for Adoptive Transfer of MAGE-A4 T-cell Receptor Gene-Transduced Lymphocytes in Patients with Recurrent Esophageal Cancer in another window
Includes: Supplementary data
Journal Articles

Two Distinct Mechanisms of Augmented Antitumor Activity by Modulation of Immunostimulatory/Inhibitory Signals

Jun Mitsui, Hiroyoshi Nishikawa, Daisuke Muraoka, Linan Wang, Takuro Noguchi, Eiichi Sato, Satoshi Kondo, James P. Allison, Shimon Sakaguchi, Lloyd J. Old, Takuma Kato, Hiroshi Shiku
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (10): 2781–2791.
https://doi.org/10.1158/1078-0432.CCR-09-3243
Published: 13 May 2010
View article titled, Two Distinct Mechanisms of Augmented Antitumor Activity by Modulation of Immunostimulatory/Inhibitory Signals
Open the PDF for Two Distinct Mechanisms of Augmented Antitumor Activity by Modulation of Immunostimulatory/Inhibitory Signals in another window
Includes: Supplementary data
Journal Articles

HER2-Specific T-Cell Immune Responses in Patients Vaccinated with Truncated HER2 Protein Complexed with Nanogels of Cholesteryl Pullulan

Shigehisa Kitano, Shinichi Kageyama, Yasuhiro Nagata, Yoshihiro Miyahara, Atsunori Hiasa, Hiroaki Naota, Satoshi Okumura, Hiroshi Imai, Taizo Shiraishi, Masahiro Masuya, Masakatsu Nishikawa, Junzo Sunamoto, Kazunari Akiyoshi, Takashi Kanematsu, Andrew M. Scott, Roger Murphy, Eric W. Hoffman, Lloyd J. Old, Hiroshi Shiku
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (24): 7397–7405.
https://doi.org/10.1158/1078-0432.CCR-06-1546
Published: 22 December 2006
View article titled, HER2-Specific T-Cell Immune Responses in Patients Vaccinated with Truncated HER2 Protein Complexed with Nanogels of Cholesteryl Pullulan
Open the PDF for HER2-Specific T-Cell Immune Responses in Patients Vaccinated with Truncated HER2 Protein Complexed with Nanogels of Cholesteryl Pullulan in another window
Journal Articles

In vitro Stimulation of CD8 and CD4 T Cells by Dendritic Cells Loaded with a Complex of Cholesterol-Bearing Hydrophobized Pullulan and NY-ESO-1 Protein: Identification of a New HLA-DR15–Binding CD4 T-Cell Epitope

Kosei Hasegawa, Yuji Noguchi, Fumihito Koizumi, Akiko Uenaka, Motoyuki Tanaka, Michihide Shimono, Hideo Nakamura, Hiroshi Shiku, Sacha Gnjatic, Roger Murphy, Yuji Hiramatsu, Lloyd J. Old, Eiichi Nakayama
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (6): 1921–1927.
https://doi.org/10.1158/1078-0432.CCR-05-1900
Published: 21 March 2006
View article titled, <em>In vitro</em> Stimulation of CD8 and CD4 T Cells by Dendritic Cells Loaded with a Complex of Cholesterol-Bearing Hydrophobized Pullulan and NY-ESO-1 Protein: Identification of a New HLA-DR15–Binding CD4 T-Cell Epitope
Open the PDF for <em>In vitro</em> Stimulation of CD8 and CD4 T Cells by Dendritic Cells Loaded with a Complex of Cholesterol-Bearing Hydrophobized Pullulan and NY-ESO-1 Protein: Identification of a New HLA-DR15–Binding CD4 T-Cell Epitope in another window
Journal Articles

Determination of Cellularly Processed HLA-A2402-Restricted Novel CTL Epitopes Derived from Two Cancer Germ Line Genes, MAGE-A4 and SAGE

Yoshihiro Miyahara, Hiroaki Naota, Lijie Wang, Atsunori Hiasa, Megumi Goto, Masato Watanabe, Shigehisa Kitano, Satoshi Okumura, Tetsushi Takemitsu, Atsushi Yuta, Yuichi Majima, François A. Lemonnier, Thierry Boon, Hiroshi Shiku
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (15): 5581–5589.
https://doi.org/10.1158/1078-0432.CCR-04-2585
Published: 01 August 2005
View article titled, Determination of Cellularly Processed HLA-A2402-Restricted Novel CTL Epitopes Derived from Two Cancer Germ Line Genes, <em>MAGE-A4</em> and <em>SAGE</em>
Open the PDF for Determination of Cellularly Processed HLA-A2402-Restricted Novel CTL Epitopes Derived from Two Cancer Germ Line Genes, <em>MAGE-A4</em> and <em>SAGE</em> in another window