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Hirofumi Yamamoto
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Journal Articles

Cancer Stem-like Properties in Colorectal Cancer Cells with Low Proteasome Activity

Koji Munakata, Mamoru Uemura, Shinji Tanaka, Kenji Kawai, Tomohiro Kitahara, Masaaki Miyo, Yoshihiro Kano, Shinpei Nishikawa, Takahito Fukusumi, Yusuke Takahashi, Taishi Hata, Junichi Nishimura, Ichiro Takemasa, Tsunekazu Mizushima, Masakazu Ikenaga, Takeshi Kato, Kohei Murata, John M. Carethers, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (21): 5277–5286.
https://doi.org/10.1158/1078-0432.CCR-15-1945
Published: 31 October 2016
View article titled, Cancer Stem-like Properties in Colorectal Cancer Cells with Low Proteasome Activity
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Includes: Supplementary data
Journal Articles

Micrometastasis Volume in Lymph Nodes Determines Disease Recurrence Rate of Stage II Colorectal Cancer: A Prospective Multicenter Trial

Hirofumi Yamamoto, Kohei Murata, Mutsumi Fukunaga, Tadashi Ohnishi, Shingo Noura, Yasuhiro Miyake, Takeshi Kato, Masahisa Ohtsuka, Yurika Nakamura, Ichiro Takemasa, Tsunekazu Mizushima, Masataka Ikeda, Masayuki Ohue, Mitsugu Sekimoto, Riichiro Nezu, Nariaki Matsuura, Morito Monden, Yuichiro Doki, Masaki Mori
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (13): 3201–3208.
https://doi.org/10.1158/1078-0432.CCR-15-2199
Published: 30 June 2016
View article titled, Micrometastasis Volume in Lymph Nodes Determines Disease Recurrence Rate of Stage II Colorectal Cancer: A Prospective Multicenter Trial
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Includes: Supplementary data
Journal Articles

Jumonji Domain Containing 1A Is a Novel Prognostic Marker for Colorectal Cancer: In vivo Identification from Hypoxic Tumor Cells

Mamoru Uemura, Hirofumi Yamamoto, Ichiro Takemasa, Koshi Mimori, Hideyuki Hemmi, Tsunekazu Mizushima, Masataka Ikeda, Mitsugu Sekimoto, Nariaki Matsuura, Yuichiro Doki, Masaki Mori
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (18): 4636–4646.
https://doi.org/10.1158/1078-0432.CCR-10-0407
Published: 14 September 2010
View article titled, <em>Jumonji Domain Containing 1A</em> Is a Novel Prognostic Marker for Colorectal Cancer: <em>In vivo</em> Identification from Hypoxic Tumor Cells
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Includes: Supplementary data
Journal Articles

Aberrant Expression of Connexin 26 Is Associated with Lung Metastasis of Colorectal Cancer

Koji Ezumi, Hirofumi Yamamoto, Kohei Murata, Masahiko Higashiyama, Bazarragchaa Damdinsuren, Yurika Nakamura, Naganori Kyo, Jiro Okami, Chew Yee Ngan, Ichiro Takemasa, Masataka Ikeda, Mitsugu Sekimoto, Nariaki Matsuura, Hiroshi Nojima, Morito Monden
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (3): 677–684.
https://doi.org/10.1158/1078-0432.CCR-07-1184
Published: 01 February 2008
View article titled, Aberrant Expression of Connexin 26 Is Associated with Lung Metastasis of Colorectal Cancer
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Journal Articles

Stromal Myofibroblasts Predict Disease Recurrence for Colorectal Cancer

Tadashi Tsujino, Iwao Seshimo, Hirofumi Yamamoto, Chew Yee Ngan, Koji Ezumi, Ichiro Takemasa, Masataka Ikeda, Mitsugu Sekimoto, Nariaki Matsuura, Morito Monden
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (7): 2082–2090.
https://doi.org/10.1158/1078-0432.CCR-06-2191
Published: 02 April 2007
View article titled, Stromal Myofibroblasts Predict Disease Recurrence for Colorectal Cancer
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Journal Articles

Antisense to Cyclin D1 Inhibits Vascular Endothelial Growth Factor–Stimulated Growth of Vascular Endothelial Cells: Implication of Tumor Vascularization

Masayoshi Yasui, Hirofumi Yamamoto, Chew Yee Ngan, Bazarragchaa Damdinsuren, Yurika Sugita, Hiroki Fukunaga, Jinyu Gu, Makiko Maeda, Ichiro Takemasa, Masataka Ikeda, Yasushi Fujio, Mitsugu Sekimoto, Nariaki Matsuura, I. Bernard Weinstein, Morito Monden
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (15): 4720–4729.
https://doi.org/10.1158/1078-0432.CCR-05-1213
Published: 09 August 2006
View article titled, Antisense to Cyclin D1 Inhibits Vascular Endothelial Growth Factor–Stimulated Growth of Vascular Endothelial Cells: Implication of Tumor Vascularization
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Journal Articles

Combination of IFN- α and 5-Fluorouracil Induces Apoptosis through IFN-α/β Receptor in Human Hepatocellular Carcinoma Cells

Motoi Kondo, Hiroaki Nagano, Hiroshi Wada, Bazarragchaa Damdinsuren, Hirofumi Yamamoto, Nobuaki Hiraoka, Hidetoshi Eguchi, Atsushi Miyamoto, Tameyoshi Yamamoto, Hideo Ota, Masato Nakamura, Shigeru Marubashi, Keizo Dono, Koji Umeshita, Shoji Nakamori, Masato Sakon, Morito Monden
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (3): 1277–1286.
https://doi.org/10.1158/1078-0432.1277.11.3
Published: 11 February 2005
View article titled, Combination of IFN- α and 5-Fluorouracil Induces Apoptosis through IFN-α/β Receptor in Human Hepatocellular Carcinoma Cells
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Journal Articles

Overexpression of CDC25A Phosphatase Is Associated with Hypergrowth Activity and Poor Prognosis of Human Hepatocellular Carcinomas

Xundi Xu, Hirofumi Yamamoto, Masato Sakon, Masayoshi Yasui, Chew Yee Ngan, Hiroki Fukunaga, Tetsushi Morita, Minoru Ogawa, Hiroaki Nagano, Shoji Nakamori, Mitsugu Sekimoto, Nariaki Matsuura, Morito Monden
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (5): 1764–1772.
Published: 01 May 2003
View article titled, Overexpression of CDC25A Phosphatase Is Associated with Hypergrowth Activity and Poor Prognosis of Human Hepatocellular Carcinomas
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Journal Articles

Immunohistochemical Assessment of Localization and Frequency of Micrometastases in Lymph Nodes of Colorectal Cancer

Shingo Noura, Hirofumi Yamamoto, Yasuhiro Miyake, Byung no Kim, Osamu Takayama, Iwao Seshimo, Masakazu Ikenaga, Masataka Ikeda, Mitsugu Sekimoto, Nariaki Matsuura, Morito Monden
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (3): 759–767.
Published: 01 March 2002
View article titled, Immunohistochemical Assessment of Localization and Frequency of Micrometastases in Lymph Nodes of Colorectal Cancer
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Journal Articles

Extensive Micrometastases to Lymph Nodes as a Marker for Rapid Recurrence of Colorectal Cancer: A Study of Lymphatic Mapping

Yasuhiro Miyake, Hirofumi Yamamoto, Yoshiyuki Fujiwara, Masayuki Ohue, Yurika Sugita, Naohiro Tomita, Mitsugu Sekimoto, Nariaki Matsuura, Hitoshi Shiozaki, Morito Monden
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (5): 1350–1357.
Published: 01 May 2001
View article titled, Extensive Micrometastases to Lymph Nodes as a Marker for Rapid Recurrence of Colorectal Cancer: <subtitle>A Study of Lymphatic Mapping</subtitle>
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Journal Articles

CDC25B and p53 Are Independently Implicated in Radiation Sensitivity for Human Esophageal Cancers

Hiroshi Miyata, Yuichiro Doki, Hitoshi Shiozaki, Msatoshi Inoue, Msahiko Yano, Yoshiyuki Fujiwara, Hirofumi Yamamoto, Kiyonori Nishioka, Kentaro Kishi, Morito Monden
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (12): 4859–4865.
Published: 01 December 2000
View article titled, CDC25B and p53 Are Independently Implicated in Radiation Sensitivity for Human Esophageal Cancers
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Journal Articles

Augmentation of Antitumor Activity of 5-Fluorouracil by Interferon α Is Associated with Up-Regulation of p27Kip1 in Human Hepatocellular Carcinoma Cells

Hidetoshi Eguchi, Hiroaki Nagano, Hirofumi Yamamoto, Atsushi Miyamoto, Motoi Kondo, Keizo Dono, Shoji Nakamori, Koji Umeshita, Masato Sakon, Morito Monden
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (7): 2881–2890.
Published: 01 July 2000
View article titled, Augmentation of Antitumor Activity of 5-Fluorouracil by Interferon α Is Associated with Up-Regulation of p27<sup>Kip1</sup> in Human Hepatocellular Carcinoma Cells
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Journal Articles

Genetic Detection for Micrometastasis in Lymph Node of Biliary Tract Carcinoma

Jiro Okami, Keizo Dohno, Masato Sakon, Kyoko Iwao, Terumasa Yamada, Hirofumi Yamamoto, Yoshiyuki Fujiwara, Hiroaki Nagano, Koji Umeshita, Nariaki Matsuura, Shoji Nakamori, Morito Monden
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (6): 2326–2332.
Published: 01 June 2000
View article titled, Genetic Detection for Micrometastasis in Lymph Node of Biliary Tract Carcinoma
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Journal Articles

Up-Regulation of Cyclooxygenase-2 in Squamous Carcinogenesis of the Esophagus

Awad Shamma, Hirofumi Yamamoto, Yuichiro Doki, Jiro Okami, Motoi Kondo, Yoshiyuki Fujiwara, Masahiko Yano, Masatoshi Inoue, Nariaki Matsuura, Hitoshi Shiozaki, Morito Monden
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (4): 1229–1238.
Published: 01 April 2000
View article titled, Up-Regulation of Cyclooxygenase-2 in Squamous Carcinogenesis of the Esophagus
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Journal Articles

Increased Expression of COX-2 in Nontumor Liver Tissue Is Associated with Shorter Disease-free Survival in Patients with Hepatocellular Carcinoma

Motoi Kondo, Hirofumi Yamamoto, Hiroaki Nagano, Jiro Okami, Yasuhiro Ito, Junzo Shimizu, Hidetoshi Eguchi, Atsushi Miyamoto, Keizo Dono, Koji Umeshita, Nariaki Matsuura, Ken-ichi Wakasa, Shoji Nakamori, Masato Sakon, Morito Monden
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (12): 4005–4012.
Published: 01 December 1999
View article titled, Increased Expression of COX-2 in Nontumor Liver Tissue Is Associated with Shorter Disease-free Survival in Patients with Hepatocellular Carcinoma
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Journal Articles

Overexpression of Cyclooxygenase-2 in Carcinoma of the Pancreas

Jiro Okami, Hirofumi Yamamoto, Yoshiyuki Fujiwara, Masaki Tsujie, Motoi Kondo, Shingo Noura, Satoshi Oshima, Hiroaki Nagano, Keizo Dono, Koji Umeshita, Osamu Ishikawa, Masato Sakon, Nariaki Matsuura, Shoji Nakamori, Morito Monden
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (8): 2018–2024.
Published: 01 August 1999
View article titled, Overexpression of Cyclooxygenase-2 in Carcinoma of the Pancreas
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Journal Articles

Paradoxical Increase in Retinoblastoma Protein in Colorectal Carcinomas May Protect Cells from Apoptosis

Hirofumi Yamamoto, Jae-Won Soh, Takushi Monden, Micheal G. Klein, Li Ming Zhang, Haim Shirin, Nadir Arber, Naohiro Tomita, Ira Schieren, C. A. Stein, I. Bernard Weinstein
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (7): 1805–1815.
Published: 01 July 1999
View article titled, Paradoxical Increase in Retinoblastoma Protein in Colorectal Carcinomas May Protect Cells from Apoptosis
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