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Hilary Calvert
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Journal Articles

Performing Phase I Clinical Trials of Anticancer Agents: Perspectives from within the European Union and Japan

Martin D. Forster, Nagahiro Saijo, Lesley Seymour, Hilary Calvert
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (6): 1737–1744.
https://doi.org/10.1158/1078-0432.CCR-09-2228
Published: 14 March 2010
View article titled, Performing Phase I Clinical Trials of Anticancer Agents: Perspectives from within the European Union and Japan
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Journal Articles

Phase I Study of MG98, an Oligonucleotide Antisense Inhibitor of Human DNA Methyltransferase 1, Given as a 7-Day Infusion in Patients with Advanced Solid Tumors

Ruth Plummer, Laura Vidal, Melanie Griffin, Mark Lesley, Johann de Bono, Sally Coulthard, Julieann Sludden, Lillian L. Siu, Eric X. Chen, Amit M. Oza, Gregory K. Reid, A. Robert McLeod, Jeffrey M. Besterman, Chooi Lee, Ian Judson, Hilary Calvert, Alan V. Boddy
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (9): 3177–3183.
https://doi.org/10.1158/1078-0432.CCR-08-2859
Published: 30 April 2009
View article titled, Phase I Study of MG98, an Oligonucleotide Antisense Inhibitor of Human DNA Methyltransferase 1, Given as a 7-Day Infusion in Patients with Advanced Solid Tumors
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Journal Articles

Phase I Study of the Poly(ADP-Ribose) Polymerase Inhibitor, AG014699, in Combination with Temozolomide in Patients with Advanced Solid Tumors

Ruth Plummer, Christopher Jones, Mark Middleton, Richard Wilson, Jeffrey Evans, Anna Olsen, Nicola Curtin, Alan Boddy, Peter McHugh, David Newell, Adrian Harris, Patrick Johnson, Heidi Steinfeldt, Raz Dewji, Diane Wang, Lesley Robson, Hilary Calvert
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (23): 7917–7923.
https://doi.org/10.1158/1078-0432.CCR-08-1223
Published: 01 December 2008
View article titled, Phase I Study of the Poly(ADP-Ribose) Polymerase Inhibitor, AG014699, in Combination with Temozolomide in Patients with Advanced Solid Tumors
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Journal Articles

The Development of Phase I Cancer Trial Methodologies: the Use of Pharmacokinetic and Pharmacodynamic End Points Sets the Scene for Phase 0 Cancer Clinical Trials

A. Hilary Calvert, Ruth Plummer
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (12): 3664–3669.
https://doi.org/10.1158/1078-0432.CCR-07-4559
Published: 16 June 2008
View article titled, The Development of Phase I Cancer Trial Methodologies: the Use of Pharmacokinetic and Pharmacodynamic End Points Sets the Scene for Phase 0 Cancer Clinical Trials
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Journal Articles

Mechanisms of Chemoresistance to Alkylating Agents in Malignant Glioma

Jann N. Sarkaria, Gaspar J. Kitange, C. David James, Ruth Plummer, Hilary Calvert, Michael Weller, Wolfgang Wick
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (10): 2900–2908.
https://doi.org/10.1158/1078-0432.CCR-07-1719
Published: 15 May 2008
View article titled, Mechanisms of Chemoresistance to Alkylating Agents in Malignant Glioma
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Journal Articles

Targeting Poly(ADP-Ribose) Polymerase: A Two-Armed Strategy for Cancer Therapy

Elizabeth Ruth Plummer, Hilary Calvert
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (21): 6252–6256.
https://doi.org/10.1158/1078-0432.CCR-07-0617
Published: 01 November 2007
View article titled, Targeting Poly(ADP-Ribose) Polymerase: A Two-Armed Strategy for Cancer Therapy
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Journal Articles

Population Pharmacokinetics and Pharmacodynamics of Paclitaxel and Carboplatin in Ovarian Cancer Patients: A Study by the European Organization for Research and Treatment of Cancer-Pharmacology and Molecular Mechanisms Group and New Drug Development Group

Markus Joerger, Alwin D.R. Huitema, Dick J. Richel, Christian Dittrich, Nikolas Pavlidis, Evangelos Briasoulis, Jan B. Vermorken, Elena Strocchi, Andrea Martoni, Roberto Sorio, Henk P. Sleeboom, Miguel A. Izquierdo, Duncan I. Jodrell, Hilary Calvert, Alan V. Boddy, Harry Hollema, Regine Féty, Wjf J.F. Van der Vijgh, Georg Hempel, Etienne Chatelut, Mats Karlsson, Justin Wilkins, Brigitte Tranchand, Ad H.G.J. Schrijvers, Christian Twelves, Jos H. Beijnen, Jan H.M. Schellens
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (21): 6410–6418.
https://doi.org/10.1158/1078-0432.CCR-07-0064
Published: 01 November 2007
View article titled, Population Pharmacokinetics and Pharmacodynamics of Paclitaxel and Carboplatin in Ovarian Cancer Patients: A Study by the European Organization for Research and Treatment of Cancer-Pharmacology and Molecular Mechanisms Group and New Drug Development Group
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Journal Articles

Phase 1 and Pharmacokinetic Study of Lexatumumab in Patients with Advanced Cancers

Ruth Plummer, Gerhardt Attard, Simon Pacey, Louise Li, Albiruni Razak, Rebecca Perrett, Mary Barrett, Ian Judson, Stan Kaye, Norma Lynn Fox, Wendy Halpern, Alfred Corey, Hilary Calvert, Johann de Bono
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (20): 6187–6194.
https://doi.org/10.1158/1078-0432.CCR-07-0950
Published: 18 October 2007
View article titled, Phase 1 and Pharmacokinetic Study of Lexatumumab in Patients with Advanced Cancers
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Journal Articles

A Phase I and Pharmacokinetic Study of Paclitaxel Poliglumex (XYOTAX), Investigating Both 3-Weekly and 2-Weekly Schedules

Alan V. Boddy, E. Ruth Plummer, Radha Todd, Julieann Sludden, Melanie Griffin, Lesley Robson, James Cassidy, Donald Bissett, Alberto Bernareggi, Mark W. Verrill, A. Hilary Calvert
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (21): 7834–7840.
https://doi.org/10.1158/1078-0432.CCR-05-0803
Published: 08 November 2005
View article titled, A Phase I and Pharmacokinetic Study of Paclitaxel Poliglumex (XYOTAX), Investigating Both 3-Weekly and 2-Weekly Schedules
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Journal Articles

Temozolomide Pharmacodynamics in Patients with Metastatic Melanoma: DNA Damage and Activity of Repair Enzymes O6-Alkylguanine Alkyltransferase and Poly(ADP-Ribose) Polymerase-1

E. Ruth Plummer, Mark R. Middleton, Christopher Jones, Anna Olsen, Ian Hickson, Peter McHugh, Geoffrey P. Margison, Gail McGown, Mary Thorncroft, Amanda J. Watson, Alan V. Boddy, A. Hilary Calvert, Adrian L. Harris, David R. Newell, Nicola J. Curtin
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (9): 3402–3409.
https://doi.org/10.1158/1078-0432.CCR-04-2353
Published: 02 May 2005
View article titled, Temozolomide Pharmacodynamics in Patients with Metastatic Melanoma: DNA Damage and Activity of Repair Enzymes <em>O</em><sup>6</sup>-Alkylguanine Alkyltransferase and Poly(ADP-Ribose) Polymerase-1
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Journal Articles

Phase I and Pharmacokinetic Study of E7070, a Chloroindolyl-Sulfonamide Anticancer Agent, Administered on a Weekly Schedule to Patients with Solid Tumors

Christian Dittrich, Herlinde Dumez, Hilary Calvert, Axel Hanauske, Marije Faber, Jantien Wanders, Murray Yule, Miroslav Ravic, Pierre Fumoleau
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (14): 5195–5204.
Published: 12 November 2003
View article titled, Phase I and Pharmacokinetic Study of E7070, a Chloroindolyl-Sulfonamide Anticancer Agent, Administered on a Weekly Schedule to Patients with Solid Tumors
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Journal Articles

Improvements in Quality of Life and Disease-related Symptoms in Phase I Trials of the Selective Oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 in Non-Small Cell Lung Cancer and Other Solid Tumors

Patricia M. LoRusso, Roy S. Herbst, Danny Rischin, Malcolm Ranson, Hilary Calvert, Eric Raymond, Dirk Kieback, Stan Kaye, Luca Gianni, Adrian Harris, Thomas Bjork, Anne-Marie Maddox, Mace L. Rothenberg, Eric J. Small, Eric H. Rubin, Andrea Feyereislova, Anne Heyes, Steven D. Averbuch, Judith Ochs, José Baselga
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (6): 2040–2048.
Published: 01 June 2003
View article titled, Improvements in Quality of Life and Disease-related Symptoms in Phase I Trials of the Selective Oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 in Non-Small Cell Lung Cancer and Other Solid Tumors
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Journal Articles

A Phase I Trial of ZD9331, a Water-Soluble, Nonpolyglutamatable, Thymidylate Synthase Inhibitor

Ruth Plummer, Charlotte Rees, Andrew Hughes, Philip Beale, Martin Highley, Jose Trigo, Sathyarathnarn Gokul, Ian Judson, Hilary Calvert, Ann Jackman, Fraser Mitchell, Robert Smith, Edwin Douglass
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (4): 1313–1322.
Published: 01 April 2003
View article titled, A Phase I Trial of ZD9331, a Water-Soluble, Nonpolyglutamatable, Thymidylate Synthase Inhibitor
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Journal Articles

Phase I and Pharmacokinetic Study of the New Taxane Analog BMS-184476 Given Weekly in Patients with Advanced Malignancies

Ruth Plummer, Michele Ghielmini, Paula Calvert, Maurizio Voi, Josette Renard, Gilles Gallant, Elora Gupta, Hilary Calvert, Cristiana Sessa
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (9): 2788–2797.
Published: 01 September 2002
View article titled, Phase I and Pharmacokinetic Study of the New Taxane Analog BMS-184476 Given Weekly in Patients with Advanced Malignancies
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Journal Articles

Patterns of Elevation of Plasma 2′-Deoxyuridine, a Surrogate Marker of Thymidylate Synthase (TS) Inhibition, after Administration of Two Different Schedules of 5-Fluorouracil and the Specific TS Inhibitors Raltitrexed (Tomudex) and ZD9331

Hugo E. R. Ford, Fraser Mitchell, David Cunningham, David C. Farrugia, Mark E. Hill, Charlotte Rees, A. Hilary Calvert, Ian R. Judson, Ann L. Jackman
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (1): 103–109.
Published: 01 January 2002
View article titled, Patterns of Elevation of Plasma 2′-Deoxyuridine, a Surrogate Marker of Thymidylate Synthase (TS) Inhibition, after Administration of Two Different Schedules of 5-Fluorouracil and the Specific TS Inhibitors Raltitrexed (Tomudex) and ZD9331
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Journal Articles

In Vitro and in Vivo Properties of Novel Nucleoside Transport Inhibitors with Improved Pharmacological Properties That Potentiate Antifolate Activity

Peter G. Smith, Huw D. Thomas, Hannah C. Barlow, Roger J. Griffin, Bernard T. Golding, A. Hilary Calvert, David R. Newell, Nicola J. Curtin
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (7): 2105–2113.
Published: 01 July 2001
View article titled, <em>In Vitro</em> and <em>in Vivo</em> Properties of Novel Nucleoside Transport Inhibitors with Improved Pharmacological Properties That Potentiate Antifolate Activity
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Journal Articles

Potentiation of Temozolomide and Topotecan Growth Inhibition and Cytotoxicity by Novel Poly(adenosine Diphosphoribose) Polymerase Inhibitors in a Panel of Human Tumor Cell Lines

Carol A. Delaney, Lan-Z Wang, Suzanne Kyle, Alex W. White, A. Hilary Calvert, Nicola J. Curtin, Barbara W. Durkacz, Zdenek Hostomsky, David R. Newell
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (7): 2860–2867.
Published: 01 July 2000
View article titled, Potentiation of Temozolomide and Topotecan Growth Inhibition and Cytotoxicity by Novel Poly(adenosine Diphosphoribose) Polymerase Inhibitors in a Panel of Human Tumor Cell Lines
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Journal Articles

Temozolomide and Treatment of Malignant Glioma

Henry S. Friedman, Tracy Kerby, Hilary Calvert
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (7): 2585–2597.
Published: 01 July 2000
View article titled, Temozolomide and Treatment of Malignant Glioma
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Journal Articles

Phase I Studies with the Nonclassical Antifolate Nolatrexed Dihydrochloride (AG337, THYMITAQ) Administered Orally for 5 Days

Andy N. Hughes, Imran Rafi, Melanie J. Griffin, A. Hilary Calvert, David R. Newell, Joanne A. Calvete, Amanda Johnston, Neil Clendeninn, Alan V. Boddy
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (1): 111–118.
Published: 01 January 1999
View article titled, Phase I Studies with the Nonclassical Antifolate Nolatrexed Dihydrochloride (AG337, THYMITAQ) Administered Orally for 5 Days
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