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Henk-Jan Guchelaar
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Journal Articles

Tamoxifen Metabolism and Efficacy in Breast Cancer: A Prospective Multicenter Trial

Patrick Neven, Lynn Jongen, Anneleen Lintermans, Kathleen Van Asten, Chantal Blomme, Diether Lambrechts, An Poppe, Hans Wildiers, Anne-Sophie Dieudonné, Olivier Brouckaert, Jan Decloedt, Patrick Berteloot, Didier Verhoeven, Markus Joerger, Peter Vuylsteke, Wim Wynendaele, Minne Casteels, Sabine Van Huffel, Willem Lybaert, Johan Van Ginderachter, Robert Paridaens, Ignace Vergote, Vincent Olaf Dezentjé, Ben Van Calster, Henk-Jan Guchelaar
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (10): 2312–2318.
https://doi.org/10.1158/1078-0432.CCR-17-3028
Published: 14 May 2018
View article titled, Tamoxifen Metabolism and Efficacy in Breast Cancer: A Prospective Multicenter Trial
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Includes: Supplementary data
Journal Articles

A Genetic Polymorphism in CTLA-4 Is Associated with Overall Survival in Sunitinib-Treated Patients with Clear Cell Metastatic Renal Cell Carcinoma

Xiaoyan Liu, Jesse J. Swen, Meta H.M. Diekstra, Epie Boven, Daniel Castellano, Hans Gelderblom, Ron H.J. Mathijssen, Sita H. Vermeulen, Egbert Oosterwijk, Kerstin Junker, Max Roessler, Kristin Alexiusdottir, Asgerdur Sverrisdottir, Marius T. Radu, Valentin Ambert, Tim Eisen, Anne Warren, Cristina Rodríguez-Antona, Jesus García-Donas, Stefan Böhringer, Karel K.M. Koudijs, Lambertus A.L.M. Kiemeney, Brian I. Rini, Henk-Jan Guchelaar
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (10): 2350–2356.
https://doi.org/10.1158/1078-0432.CCR-17-2815
Published: 14 May 2018
View article titled, A Genetic Polymorphism in <em>CTLA-4</em> Is Associated with Overall Survival in Sunitinib-Treated Patients with Clear Cell Metastatic Renal Cell Carcinoma
Open the PDF for A Genetic Polymorphism in <em>CTLA-4</em> Is Associated with Overall Survival in Sunitinib-Treated Patients with Clear Cell Metastatic Renal Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

A First Step toward Personalized Medicine in Osteosarcoma: Pharmacogenetics as Predictive Marker of Outcome after Chemotherapy-Based Treatment

Melanie M. Hagleitner, Marieke J.H. Coenen, Hans Gelderblom, Remco R. Makkinje, Hanneke I. Vos, Eveline S.J.M. de Bont, Winette T.A. van der Graaf, H.W. Bart Schreuder, Uta Flucke, Frank N. van Leeuwen, Peter M. Hoogerbrugge, Henk-Jan Guchelaar, Dunja M.W.M te Loo
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (15): 3436–3441.
https://doi.org/10.1158/1078-0432.CCR-14-2638
Published: 02 August 2015
View article titled, A First Step toward Personalized Medicine in Osteosarcoma: Pharmacogenetics as Predictive Marker of Outcome after Chemotherapy-Based Treatment
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Includes: Supplementary data
Journal Articles

Activation of Tumor-Promoting Type 2 Macrophages by EGFR-Targeting Antibody Cetuximab

Jan Pander, Moniek Heusinkveld, Tahar van der Straaten, Ekaterina S. Jordanova, Renée Baak-Pablo, Hans Gelderblom, Hans Morreau, Sjoerd H. van der Burg, Henk-Jan Guchelaar, Thorbald van Hall
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (17): 5668–5673.
https://doi.org/10.1158/1078-0432.CCR-11-0239
Published: 01 September 2011
View article titled, Activation of Tumor-Promoting Type 2 Macrophages by EGFR-Targeting Antibody Cetuximab
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Includes: Supplementary data
Journal Articles

Relationship between Single Nucleotide Polymorphisms and Haplotypes in DPYD and Toxicity and Efficacy of Capecitabine in Advanced Colorectal Cancer

Maarten J. Deenen, Jolien Tol, Artur M Burylo, Valerie D. Doodeman, Anthonius de Boer, Andrew Vincent, Henk-Jan Guchelaar, Paul H.M. Smits, Jos H. Beijnen, Cornelis J.A. Punt, Jan H.M. Schellens, Annemieke Cats
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (10): 3455–3468.
https://doi.org/10.1158/1078-0432.CCR-10-2209
Published: 15 May 2011
View article titled, Relationship between Single Nucleotide Polymorphisms and Haplotypes in <em>DPYD</em> and Toxicity and Efficacy of Capecitabine in Advanced Colorectal Cancer
Open the PDF for Relationship between Single Nucleotide Polymorphisms and Haplotypes in <em>DPYD</em> and Toxicity and Efficacy of Capecitabine in Advanced Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Genetic Polymorphisms Associated with a Prolonged Progression-Free Survival in Patients with Metastatic Renal Cell Cancer Treated with Sunitinib

Astrid A.M. van der Veldt, Karel Eechoute, Hans Gelderblom, Jourik Gietema, Henk-Jan Guchelaar, Nielka P. van Erp, Alfons J.M. van den Eertwegh, John B. Haanen, Ron H.J. Mathijssen, Judith A.M. Wessels
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (3): 620–629.
https://doi.org/10.1158/1078-0432.CCR-10-1828
Published: 01 February 2011
View article titled, Genetic Polymorphisms Associated with a Prolonged Progression-Free Survival in Patients with Metastatic Renal Cell Cancer Treated with Sunitinib
Open the PDF for Genetic Polymorphisms Associated with a Prolonged Progression-Free Survival in Patients with Metastatic Renal Cell Cancer Treated with Sunitinib in another window
Includes: Supplementary data
Journal Articles

Clinical Implications of CYP2D6 Genotyping in Tamoxifen Treatment for Breast Cancer

Vincent O. Dezentjé, Henk-Jan Guchelaar, Johan W.R. Nortier, Cornelis J.H. van de Velde, Hans Gelderblom
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (1): 15–21.
https://doi.org/10.1158/1078-0432.CCR-08-2006
Published: 31 December 2008
View article titled, Clinical Implications of <em>CYP2D6</em> Genotyping in Tamoxifen Treatment for Breast Cancer
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Journal Articles

Effect of Cigarette Smoking on Imatinib in Patients in the Soft Tissue and Bone Sarcoma Group of the EORTC

Nielka van Erp, Hans Gelderblom, Martine van Glabbeke, Allan Van Oosterom, Jaap Verweij, Henk-Jan Guchelaar, Maria Debiec-Rychter, Bin Peng, Jean-Yves Blay, Ian Judson
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (24): 8308–8313.
https://doi.org/10.1158/1078-0432.CCR-08-1303
Published: 15 December 2008
View article titled, Effect of Cigarette Smoking on Imatinib in Patients in the Soft Tissue and Bone Sarcoma Group of the EORTC
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Journal Articles

Influence of CYP3A4 Inhibition on the Steady-State Pharmacokinetics of Imatinib

Nielka P. van Erp, Hans Gelderblom, Mats O. Karlsson, Jing Li, Ming Zhao, Jan Ouwerkerk, Johan W. Nortier, Henk-Jan Guchelaar, Sharyn D. Baker, Alex Sparreboom
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (24): 7394–7400.
https://doi.org/10.1158/1078-0432.CCR-07-0346
Published: 19 December 2007
View article titled, Influence of CYP3A4 Inhibition on the Steady-State Pharmacokinetics of Imatinib
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Journal Articles

Effect of Milk Thistle (Silybum marianum) on the Pharmacokinetics of Irinotecan

Nielka P.H. van Erp, Sharyn D. Baker, Ming Zhao, Michelle A. Rudek, Henk-Jan Guchelaar, Johan W.R. Nortier, Alex Sparreboom, Hans Gelderblom
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (21): 7800–7806.
https://doi.org/10.1158/1078-0432.CCR-05-1288
Published: 08 November 2005
View article titled, Effect of Milk Thistle (<em>Silybum marianum</em>) on the Pharmacokinetics of Irinotecan
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