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Henk M. Lokhorst
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Journal Articles

Combined CD28 and 4-1BB Costimulation Potentiates Affinity-tuned Chimeric Antigen Receptor–engineered T Cells

Esther Drent, Renée Poels, Ruud Ruiter, Niels W.C.J. van de Donk, Sonja Zweegman, Huipin Yuan, Joost de Bruijn, Michel Sadelain, Henk M. Lokhorst, Richard W.J. Groen, Tuna Mutis, Maria Themeli
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (13): 4014–4025.
https://doi.org/10.1158/1078-0432.CCR-18-2559
Published: 01 July 2019
View article titled, Combined CD28 and 4-1BB Costimulation Potentiates Affinity-tuned Chimeric Antigen Receptor–engineered T Cells
Open the PDF for Combined CD28 and 4-1BB Costimulation Potentiates Affinity-tuned Chimeric Antigen Receptor–engineered T Cells in another window
Includes: Supplementary data
Journal Articles

Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab

Jakub Krejcik, Kris A. Frerichs, Inger S. Nijhof, Berris van Kessel, Jeroen F. van Velzen, Andries C. Bloem, Marloes E.C. Broekmans, Sonja Zweegman, Johan van Meerloo, René J.P. Musters, Pino J. Poddighe, Richard W.J. Groen, Christopher Chiu, Torben Plesner, Henk M. Lokhorst, A. Kate Sasser, Tuna Mutis, Niels W.C.J. van de Donk
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (24): 7498–7511.
https://doi.org/10.1158/1078-0432.CCR-17-2027
Published: 14 December 2017
View article titled, Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab
Open the PDF for Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab in another window
Includes: Supplementary data
Journal Articles

Abstract A12: Combination of the anti-CD38 monoclonal antibody daratumumab and all-trans retinoic acid.

Inger S. Nijhof, Henk M. Lokhorst, Berris van Kessel, Parul Doshi, Kate Sasser, Tuna Mutis, Niels WCJ van de Donk
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (17_Supplement): A12.
https://doi.org/10.1158/1557-3265.HEMMAL14-A12
Published: 19 August 2015
View article titled, Abstract A12: Combination of the anti-CD38 monoclonal antibody daratumumab and all-trans retinoic acid.
Journal Articles

Preclinical Evidence for the Therapeutic Potential of CD38-Targeted Immuno-Chemotherapy in Multiple Myeloma Patients Refractory to Lenalidomide and Bortezomib

Inger S. Nijhof, Richard W.J. Groen, Willy A. Noort, Berris van Kessel, Regina de Jong-Korlaar, Joost Bakker, Jeroen J.L. van Bueren, Paul W.H.I. Parren, Henk M. Lokhorst, Niels W.C.J. van de Donk, Anton C.M. Martens, Tuna Mutis
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (12): 2802–2810.
https://doi.org/10.1158/1078-0432.CCR-14-1813
Published: 14 June 2015
View article titled, Preclinical Evidence for the Therapeutic Potential of CD38-Targeted Immuno-Chemotherapy in Multiple Myeloma Patients Refractory to Lenalidomide and Bortezomib
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Journal Articles

Accessory Cells of the Microenvironment Protect Multiple Myeloma from T-Cell Cytotoxicity through Cell Adhesion-Mediated Immune Resistance

Sanne J. de Haart, Niels W.C.J. van de Donk, Monique C. Minnema, Julie H. Huang, Tineke Aarts-Riemens, Niels Bovenschen, Huipin Yuan, Richard W.J. Groen, Douglas W. McMillin, Jana Jakubikova, Henk M. Lokhorst, Anton C. Martens, Constantine S. Mitsiades, Tuna Mutis
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (20): 5591–5601.
https://doi.org/10.1158/1078-0432.CCR-12-3676
Published: 14 October 2013
View article titled, Accessory Cells of the Microenvironment Protect Multiple Myeloma from T-Cell Cytotoxicity through Cell Adhesion-Mediated Immune Resistance
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Includes: Supplementary data
Journal Articles

Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells

Teun Guichelaar, Maarten E. Emmelot, Henk Rozemuller, Bianka Martini, Richard W.J. Groen, Gert Storm, Henk M. Lokhorst, Anton C. Martens, Tuna Mutis
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (6): 1467–1475.
https://doi.org/10.1158/1078-0432.CCR-12-2177
Published: 14 March 2013
View article titled, Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells
Open the PDF for Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells in another window
Includes: Supplementary data
Journal Articles

Eradication of Medullary Multiple Myeloma by CD4+ Cytotoxic Human T Lymphocytes Directed at a Single Minor Histocompatibility Antigen

Robbert M. Spaapen, Richard W.J. Groen, Kelly van den Oudenalder, Teun Guichelaar, Maureen van Elk, Tineke Aarts-Riemens, Andries C. Bloem, Gert Storm, Anton C. Martens, Henk M. Lokhorst, Tuna Mutis
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (22): 5481–5488.
https://doi.org/10.1158/1078-0432.CCR-10-1340
Published: 14 November 2010
View article titled, Eradication of Medullary Multiple Myeloma by CD4<sup>+</sup> Cytotoxic Human T Lymphocytes Directed at a Single Minor Histocompatibility Antigen
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Journal Articles

Rapid Identification of Clinical Relevant Minor Histocompatibility Antigens via Genome-Wide Zygosity-Genotype Correlation Analysis

Robbert M. Spaapen, Ron A.L. de Kort, Kelly van den Oudenalder, Maureen van Elk, Andries C. Bloem, Henk M. Lokhorst, Tuna Mutis
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (23): 7137–7143.
https://doi.org/10.1158/1078-0432.CCR-09-1914
Published: 30 November 2009
View article titled, Rapid Identification of Clinical Relevant Minor Histocompatibility Antigens via Genome-Wide Zygosity-Genotype Correlation Analysis
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Journal Articles

Geranylgeranylated Proteins are Involved in the Regulation of Myeloma Cell Growth

Niels W.C.J. van de Donk, Henk M. Lokhorst, Evert H.J. Nijhuis, Marloes M.J. Kamphuis, Andries C. Bloem
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (2): 429–439.
https://doi.org/10.1158/1078-0432.429.11.2
Published: 08 February 2005
View article titled, Geranylgeranylated Proteins are Involved in the Regulation of Myeloma Cell Growth
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Journal Articles

Protein Geranylgeranylation Is Critical for the Regulation of Survival and Proliferation of Lymphoma Tumor Cells

Niels W. C. J. van de Donk, Diana Schotte, Marloes M. J. Kamphuis, Ariënne M. W. van Marion, Berris van Kessel, Andries C. Bloem, Henk M. Lokhorst
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (15): 5735–5748.
Published: 03 December 2003
View article titled, Protein Geranylgeranylation Is Critical for the Regulation of Survival and Proliferation of Lymphoma Tumor Cells
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