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Journal Articles

CRISPR/Cas9-Engineered Universal CD19/CD22 Dual-Targeted CAR-T Cell Therapy for Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia

Yongxian Hu, Yali Zhou, Mingming Zhang, Wengang Ge, Yi Li, Li Yang, Guoqing Wei, Lu Han, Hao Wang, Shuhui Yu, Yi Chen, Yanbin Wang, Xiaohong He, Xingwang Zhang, Ming Gao, Jingjing Yang, Xiuju Li, Jiangtao Ren, He Huang
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (10): 2764–2772.
https://doi.org/10.1158/1078-0432.CCR-20-3863
Published: 15 May 2021
View article titled, CRISPR/Cas9-Engineered Universal CD19/CD22 Dual-Targeted CAR-T Cell Therapy for Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia
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Includes: Supplementary data
Journal Articles

Randomized Phase II Trial of Sipuleucel-T with or without Radium-223 in Men with Bone-metastatic Castration-resistant Prostate Cancer

Catherine H. Marshall, Wei Fu, Hao Wang, Jong Chul Park, Theodore L. DeWeese, Phuoc T. Tran, Daniel Y. Song, Serina King, Michaella Afful, Julia Hurrelbrink, Charlotte Manogue, Patrick Cotogno, Nancy P. Moldawer, Pedro C. Barata, Charles G. Drake, Edwin M. Posadas, Andrew J. Armstrong, Oliver Sartor, Emmanuel S. Antonarakis
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (6): 1623–1630.
https://doi.org/10.1158/1078-0432.CCR-20-4476
Published: 15 March 2021
View article titled, Randomized Phase II Trial of Sipuleucel-T with or without Radium-223 in Men with Bone-metastatic Castration-resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Abstract IA09: A phase II trial to promote recovery from COVID-19 with endocrine therapy

Catherine H. Marshall, Srinivasan Yegnasubramanian, Hao Wang, Jennifer Durham, Ting Wang, Rachel Damico, Franco R. D'Alessio, Venkataramana K. Sidhaye, Andrew Pekosz, Joseph L. Mankowski, Sabra L. Klein, Sumati Murli, Elizabeth M. Jaffee, Samuel R. Denmeade
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (18_Supplement): IA09.
https://doi.org/10.1158/1557-3265.COVID-19-IA09
Published: 15 September 2020
View article titled, Abstract IA09: A phase II trial to promote recovery from COVID-19 with endocrine therapy
Journal Articles

Tumor Mutational Burden, Toxicity, and Response of Immune Checkpoint Inhibitors Targeting PD(L)1, CTLA-4, and Combination: A Meta-regression Analysis

Arsen Osipov, Su Jin Lim, Aleksandra Popovic, Nilofer S. Azad, Daniel A. Laheru, Lei Zheng, Elizabeth M. Jaffee, Hao Wang, Mark Yarchoan
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (18): 4842–4851.
https://doi.org/10.1158/1078-0432.CCR-20-0458
Published: 15 September 2020
View article titled, Tumor Mutational Burden, Toxicity, and Response of Immune Checkpoint Inhibitors Targeting PD(L)1, CTLA-4, and Combination: A Meta-regression Analysis
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Includes: Supplementary data
Journal Articles

Pan-Tumor Pathologic Scoring of Response to PD-(L)1 Blockade

Julie E. Stein, Evan J. Lipson, Tricia R. Cottrell, Patrick M. Forde, Robert A. Anders, Ashley Cimino-Mathews, Elizabeth D. Thompson, Mohamad E. Allaf, Mark Yarchoan, Josephine Feliciano, Hao Wang, Elizabeth M. Jaffee, Drew M. Pardoll, Suzanne L. Topalian, Janis M. Taube
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (3): 545–551.
https://doi.org/10.1158/1078-0432.CCR-19-2379
Published: 03 February 2020
View article titled, Pan-Tumor Pathologic Scoring of Response to PD-(L)1 Blockade
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Includes: Supplementary data
Journal Articles

Intratumoral Adaptive Immunosuppression and Type 17 Immunity in Mismatch Repair Proficient Colorectal Tumors

Nicolas J. Llosa, Brandon Luber, Ada J. Tam, Kellie N. Smith, Nicholas Siegel, Anas H. Awan, Hongni Fan, Teniola Oke, JiaJia Zhang, Jada Domingue, Elizabeth L. Engle, Charles A. Roberts, Bjarne R. Bartlett, Laveet K. Aulakh, Elizabeth D. Thompson, Janis M. Taube, Jennifer N. Durham, Cynthia L. Sears, Dung T. Le, Luis A. Diaz, Drew M. Pardoll, Hao Wang, Robert A. Anders, Franck Housseau
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (17): 5250–5259.
https://doi.org/10.1158/1078-0432.CCR-19-0114
Published: 03 September 2019
View article titled, Intratumoral Adaptive Immunosuppression and Type 17 Immunity in Mismatch Repair Proficient Colorectal Tumors
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Includes: Supplementary data
Journal Articles

Methylation Biomarker Panel Performance in EsophaCap Cytology Samples for Diagnosing Barrett's Esophagus: A Prospective Validation Study

Zhixiong Wang, Swetha Kambhampati Thiruvengadam, Yulan Cheng, Ke Ma, Cem Simsek, Alan H. Tieu, John M. Abraham, Xi Liu, Vishnu Prasath, Mark Duncan, Alejandro Stark, Alexander Trick, Hua-Ling Tsai, Hao Wang, Yulong He, Mouen A. Khashab, Saowanee Ngamruengphong, Eun J. Shin, Tza-Huei Wang, Stephen J. Meltzer
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (7): 2127–2135.
https://doi.org/10.1158/1078-0432.CCR-18-3696
Published: 01 April 2019
View article titled, Methylation Biomarker Panel Performance in EsophaCap Cytology Samples for Diagnosing Barrett's Esophagus: A Prospective Validation Study
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Includes: Supplementary data
Journal Articles

Correction: Tadalafil Augments Tumor-specific Immunity in Patients with Head and Neck Squamous Cell Carcinoma

Joseph A. Califano, Zubair Khan, Kimberly A. Noonan, Lakshmi Rudraraju, Zhe Zhang, Hao Wang, Steven Goodman, Christine G. Gourin, Patrick K. Ha, Carole Fakhry, John Saunders, Marshall Levine, Mei Tang, Geoffrey Neuner, Jeremy D. Richmon, Ray Blanco, Nishant Agrawal, Wayne M. Koch, Shanthi Marur, Donald T. Weed, Paolo Serafini, Ivan Borrello
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (23): 6100.
https://doi.org/10.1158/1078-0432.CCR-18-3298
Published: 03 December 2018
View article titled, Correction: Tadalafil Augments Tumor-specific Immunity in Patients with Head and Neck Squamous Cell Carcinoma
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Journal Articles

COX-2/PGE2 Axis Regulates HIF2α Activity to Promote Hepatocellular Carcinoma Hypoxic Response and Reduce the Sensitivity of Sorafenib Treatment

Xiao-Feng Dong, Tian-Qi Liu, Xu-Ting Zhi, Jie Zou, Jing-Tao Zhong, Tao Li, Xiang-Lan Mo, Wei Zhou, Wen-Wen Guo, Xia Liu, Yuan-Yuan Chen, Meng-Yang Li, Xiao-Gang Zhong, Ya-Min Han, Zhong-Hao Wang, Zhao-Ru Dong
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (13): 3204–3216.
https://doi.org/10.1158/1078-0432.CCR-17-2725
Published: 01 July 2018
View article titled, COX-2/PGE2 Axis Regulates HIF2α Activity to Promote Hepatocellular Carcinoma Hypoxic Response and Reduce the Sensitivity of Sorafenib Treatment
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Includes: Supplementary data
Journal Articles

Immuno-oncology Trial Endpoints: Capturing Clinically Meaningful Activity

Valsamo Anagnostou, Mark Yarchoan, Aaron R. Hansen, Hao Wang, Franco Verde, Elad Sharon, Deborah Collyar, Laura Q.M. Chow, Patrick M. Forde
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (17): 4959–4969.
https://doi.org/10.1158/1078-0432.CCR-16-3065
Published: 31 August 2017
View article titled, Immuno-oncology Trial Endpoints: Capturing Clinically Meaningful Activity
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Journal Articles

SMAD4 Loss Is Associated with Cetuximab Resistance and Induction of MAPK/JNK Activation in Head and Neck Cancer Cells

Hiroyuki Ozawa, Ruchira S. Ranaweera, Evgeny Izumchenko, Eugene Makarev, Alex Zhavoronkov, Elana J. Fertig, Jason D. Howard, Ana Markovic, Atul Bedi, Rajani Ravi, Jimena Perez, Quynh-Thu Le, Christina S. Kong, Richard C. Jordan, Hao Wang, Hyunseok Kang, Harry Quon, David Sidransky, Christine H. Chung
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (17): 5162–5175.
https://doi.org/10.1158/1078-0432.CCR-16-1686
Published: 31 August 2017
View article titled, SMAD4 Loss Is Associated with Cetuximab Resistance and Induction of MAPK/JNK Activation in Head and Neck Cancer Cells
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Includes: Supplementary data
Journal Articles

Abstract 47: Nucleophosmin/B23 (NPM/B23) and estrogen receptor alpha (ER alpha) in endometrial cancer

Chiao Yun Lin, Angel Chao, Tzu-Hao Wang, Chyong-Huey Lai
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (1_Supplement): 47.
https://doi.org/10.1158/1557-3265.PMSCLINGEN15-47
Published: 03 January 2016
View article titled, Abstract 47: Nucleophosmin/B23 (NPM/B23) and estrogen receptor alpha (ER alpha) in endometrial cancer
Journal Articles

Tadalafil Augments Tumor Specific Immunity in Patients with Head and Neck Squamous Cell Carcinoma

Joseph A. Califano, Zubair Khan, Kimberly A. Noonan, Lakshmi Rudraraju, Zhe Zhang, Hao Wang, Steven Goodman, Christine G. Gourin, Patrick K. Ha, Carole Fakhry, John Saunders, Marshall Levine, Mei Tang, Geoffrey Neuner, Jeremy D. Richmon, Ray Blanco, Nishant Agrawal, Wayne M. Koch, Shanthi Marur, Donald T. Weed, Paolo Serafini, Ivan Borrello
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2015) 21 (1): 30–38.
https://doi.org/10.1158/1078-0432.CCR-14-1716
Published: 05 January 2015
View article titled, Tadalafil Augments Tumor Specific Immunity in Patients with Head and Neck Squamous Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Detection of TIMP3 Promoter Hypermethylation in Salivary Rinse as an Independent Predictor of Local Recurrence-Free Survival in Head and Neck Cancer

Wenyue Sun, David Zaboli, Hao Wang, Yan Liu, Demetri Arnaoutakis, Tanbir Khan, Zubair Khan, Wayne M. Koch, Joseph A. Califano
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (4): 1082–1091.
https://doi.org/10.1158/1078-0432.CCR-11-2392
Published: 14 February 2012
View article titled, Detection of <em>TIMP3</em> Promoter Hypermethylation in Salivary Rinse as an Independent Predictor of Local Recurrence-Free Survival in Head and Neck Cancer
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Includes: Supplementary data
Journal Articles

Targeted Delivery of Tumor Antigens to Activated Dendritic Cells via CD11c Molecules Induces Potent Antitumor Immunity in Mice

Huafeng Wei, Suhui Wang, Dapeng Zhang, Sheng Hou, Weizhu Qian, Bohua Li, Huaizu Guo, Geng Kou, Jinqiu He, Hao Wang, Yajun Guo
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (14): 4612–4621.
https://doi.org/10.1158/1078-0432.CCR-08-3321
Published: 15 July 2009
View article titled, Targeted Delivery of Tumor Antigens to Activated Dendritic Cells via CD11c Molecules Induces Potent Antitumor Immunity in Mice
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Includes: Supplementary data
Journal Articles

Genetically Targeted T Cells Eradicate Established Breast Cancer in Syngeneic Mice

Hao Wang, Huafeng Wei, Ruiping Zhang, Sheng Hou, Bohua Li, Weizhu Qian, Dapeng Zhang, Gen Kou, Jianxin Dai, Yajun Guo
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (3): 943–950.
https://doi.org/10.1158/1078-0432.CCR-08-2381
Published: 02 February 2009
View article titled, Genetically Targeted T Cells Eradicate Established Breast Cancer in Syngeneic Mice
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Includes: Supplementary data
Journal Articles

Methylation of Tip30 Promoter Is Associated with Poor Prognosis in Human Hepatocellular Carcinoma

Bin Lu, Yunchao Ma, Guobin Wu, Xin Tong, Huaizu Guo, Anmin Liang, Wenming Cong, Chang Liu, Hao Wang, Mengchao Wu, Jian Zhao, Yajun Guo
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (22): 7405–7412.
https://doi.org/10.1158/1078-0432.CCR-08-0409
Published: 14 November 2008
View article titled, Methylation of <em>Tip30</em> Promoter Is Associated with Poor Prognosis in Human Hepatocellular Carcinoma
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Includes: Supplementary data
Journal Articles

In vivo Generation of Angiostatin Isoforms by Administration of a Plasminogen Activator and a Free Sulfhydryl Donor: A Phase I Study of an Angiostatic Cocktail of Tissue Plasminogen Activator and Mesna

Gerald A. Soff, Hao Wang, Deborah L. Cundiff, Keyi Jiang, Brenda Martone, Alfred W. Rademaker, Jennifer A. Doll, Timothy M. Kuzel
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (17): 6218–6225.
https://doi.org/10.1158/1078-0432.CCR-04-1514
Published: 06 September 2005
View article titled, <em>In vivo</em> Generation of Angiostatin Isoforms by Administration of a Plasminogen Activator and a Free Sulfhydryl Donor: A Phase I Study of an Angiostatic Cocktail of Tissue Plasminogen Activator and Mesna
Open the PDF for <em>In vivo</em> Generation of Angiostatin Isoforms by Administration of a Plasminogen Activator and a Free Sulfhydryl Donor: A Phase I Study of an Angiostatic Cocktail of Tissue Plasminogen Activator and Mesna in another window
Journal Articles

UGT1A7 and UGT1A9 Polymorphisms Predict Response and Toxicity in Colorectal Cancer Patients Treated with Capecitabine/Irinotecan

Leslie E. Carlini, Neal J. Meropol, John Bever, Michael L. Andria, Todd Hill, Philip Gold, Andre Rogatko, Hao Wang, Rebecca L. Blanchard
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (3): 1226–1236.
https://doi.org/10.1158/1078-0432.1226.11.3
Published: 11 February 2005
View article titled, UGT1A7 and UGT1A9 Polymorphisms Predict Response and Toxicity in Colorectal Cancer Patients Treated with Capecitabine/Irinotecan
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Journal Articles

Patient Characteristics Compete with Dose as Predictors of Acute Treatment Toxicity in Early Phase Clinical Trials

André Rogatko, James S. Babb, Hao Wang, Michael J. Slifker, Gary R. Hudes
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (14): 4645–4651.
https://doi.org/10.1158/1078-0432.CCR-03-0535
Published: 21 July 2004
View article titled, Patient Characteristics Compete with Dose as Predictors of Acute Treatment Toxicity in Early Phase Clinical Trials
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