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Journal Articles

A Phase Ib Open-Label, Dose-Escalation Study of NUC-1031 in Combination with Carboplatin for Recurrent Ovarian Cancer

Farasat Kazmi, Shibani Nicum, Rene L. Roux, Laura Spiers, Chat Gnanaranjan, Ajithkumar Sukumaran, Hani Gabra, Essam Ghazaly, Nigel W. McCracken, David J. Harrison, Sarah P. Blagden
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (11): 3028–3038.
https://doi.org/10.1158/1078-0432.CCR-20-4403
Published: 01 June 2021
View article titled, A Phase Ib Open-Label, Dose-Escalation Study of NUC-1031 in Combination with Carboplatin for Recurrent Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Abstract AP09: COPY-NUMBER SIGNATURES AND MUTATIONAL PROCESSES IN HIGH GRADE SEROUS OVARIAN CARCINOMA

Geoff Macintyre, Teodora E. Goranova, Dilrini De Silva, Darren Ennis, Anna M. Piskorz, Matthew Eldridge, Daoud Sie, Liz-Anne Lewsley, Aishah Hanif, Cheryl Wilson, Suzanne Dowson, Rosalind M. Glasspool, Michelle Lockley, Elly Brockbank, Ana Montes, Axel Walther, Sudha Sundar, Richard Edmondson, Geoff D. Hall, Andrew Clamp, Charlie Gourley, Marcia Hall, Christina Fotopoulou, Hani Gabra, James Paul, Anna Supernat, David Millan, Aoisha Hoyle, Gareth Bryson, Craig Nourse, Laura Mincarelli, Luis Navarro Sanchez, Bauke Ylstra, Mercedes Jimenez-Linan, Luiza Moore, Oliver Hofmann, Florian Markowetz, Iain A. McNeish, James D. Brenton
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (22_Supplement): AP09.
https://doi.org/10.1158/1557-3265.OVCASYMP18-AP09
Published: 15 November 2019
View article titled, Abstract AP09: COPY-NUMBER SIGNATURES AND MUTATIONAL PROCESSES IN HIGH GRADE SEROUS OVARIAN CARCINOMA
Journal Articles

Phase IB Dose Escalation and Expansion Study of AKT Inhibitor Afuresertib with Carboplatin and Paclitaxel in Recurrent Platinum-resistant Ovarian Cancer

Sarah P. Blagden, Anne L. Hamilton, Linda Mileshkin, Shirley Wong, Agnieszka Michael, Marcia Hall, Jeffrey C. Goh, Alla S. Lisyanskaya, Michelle DeSilvio, Eleni Frangou, Euan A. Stronach, Prashanth Gopalakrishna, Tarek M. Meniawy, Hani Gabra
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (5): 1472–1478.
https://doi.org/10.1158/1078-0432.CCR-18-2277
Published: 01 March 2019
View article titled, Phase IB Dose Escalation and Expansion Study of AKT Inhibitor Afuresertib with Carboplatin and Paclitaxel in Recurrent Platinum-resistant Ovarian Cancer
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Includes: Supplementary data
Journal Articles

A Complex Network of Tumor Microenvironment in Human High-Grade Serous Ovarian Cancer

Caroline Kreuzinger, Angelika Geroldinger, Dominiek Smeets, Elena Ioana Braicu, Jalid Sehouli, Julia Koller, Andrea Wolf, Silvia Darb-Esfahani, Korinna Joehrens, Ignace Vergote, Adriaan Vanderstichele, Bram Boeckx, Diether Lambrechts, Hani Gabra, G. Bea A. Wisman, Fabian Trillsch, Georg Heinze, Reinhard Horvat, Stephan Polterauer, Els Berns, Charles Theillet, Dan Cacsire Castillo-Tong
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (24): 7621–7632.
https://doi.org/10.1158/1078-0432.CCR-17-1159
Published: 14 December 2017
View article titled, A Complex Network of Tumor Microenvironment in Human High-Grade Serous Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Platinum-Based Chemotherapy Induces Methylation Changes in Blood DNA Associated with Overall Survival in Patients with Ovarian Cancer

James M. Flanagan, Angela Wilson, Chail Koo, Nahal Masrour, John Gallon, Erick Loomis, Kirsty Flower, Charlotte Wilhelm-Benartzi, Alexander Hergovich, Paula Cunnea, Hani Gabra, Elena Ioana Braicu, Jalid Sehouli, Silvia Darb-Esfahani, Adriaan Vanderstichele, Ignace Vergote, Caroline Kreuzinger, Dan Cacsire Castillo-Tong, G. Bea A. Wisman, Els MJJ Berns, Nadeem Siddiqui, James Paul, Robert Brown
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (9): 2213–2222.
https://doi.org/10.1158/1078-0432.CCR-16-1754
Published: 30 April 2017
View article titled, Platinum-Based Chemotherapy Induces Methylation Changes in Blood DNA Associated with Overall Survival in Patients with Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Abstract POSTER-BIOL-1301: The receptor tyrosine kinase AXL modulates oncogenic signaling and epithelial mesenchymal transition in epithelial ovarian cancer

Jane Antony, Tuan Zea Tan, Andrew Paterson, Chiara Recchi, Hani Gabra, Jean Paul Thiery, Ruby Yun-Ju Huang
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (16_Supplement): POSTER-BIOL-1301.
https://doi.org/10.1158/1557-3265.OVCASYMP14-POSTER-BIOL-1301
Published: 15 August 2015
View article titled, Abstract POSTER-BIOL-1301: The receptor tyrosine kinase AXL modulates oncogenic signaling and epithelial mesenchymal transition in epithelial ovarian cancer
Journal Articles

Abstract PR04: DNA-PK inhibition resensitizes ovarian cancer cells to cisplatin in vivo and is associated with modulation of AKT pathway signaling

Azadeh Cheraghchi-Bashi-Astaneh, Camila H. De Sousa, Elaina Maginn, Yan Dai, Harpreet Wasan, Gordon B. Mills, Hani Gabra, Euan A. Stronach
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (19_Supplement): PR04.
https://doi.org/10.1158/1078-0432.OVCA13-PR04
Published: 13 May 2014
View article titled, Abstract PR04: DNA-PK inhibition resensitizes ovarian cancer cells to cisplatin in vivo and is associated with modulation of AKT pathway signaling
Journal Articles

Abstract IA15: Targeting acquired platinum resistance in ovarian cancer

Hani Gabra
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (19_Supplement): IA15.
https://doi.org/10.1158/1078-0432.OVCA13-IA15
Published: 13 May 2014
View article titled, Abstract IA15: Targeting acquired platinum resistance in ovarian cancer
Journal Articles

Abstract B51: Management of ascites via the alfa-pump closed system in platinum-resistant-ovarian-cancer (PROC): A model of sequential non-invasive tumor-cell sampling through the urinary bladder

Christina Fotopoulou, Laura Spiers, Delali Adjogatse, Emily Pickford, Roberto Dina, Sara Blagden, Nagy Habib, Hani Gabra
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (19_Supplement): B51.
https://doi.org/10.1158/1078-0432.OVCA13-B51
Published: 13 May 2014
View article titled, Abstract B51: Management of ascites via the alfa-pump closed system in platinum-resistant-ovarian-cancer (PROC): A model of sequential non-invasive tumor-cell sampling through the urinary bladder
Journal Articles

Genomic Analysis Reveals the Molecular Heterogeneity of Ovarian Clear Cell Carcinomas

David S.P. Tan, Marjan Iravani, W. Glenn McCluggage, Maryou B.K. Lambros, Fernanda Milanezi, Alan Mackay, Charles Gourley, Felipe C. Geyer, Radost Vatcheva, Joanne Millar, Karen Thomas, Rachael Natrajan, Kay Savage, Kerry Fenwick, Alistair Williams, Charles Jameson, Mona El-Bahrawy, Martin E. Gore, Hani Gabra, Stanley B. Kaye, Alan Ashworth, Jorge S. Reis-Filho
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (6): 1521–1534.
https://doi.org/10.1158/1078-0432.CCR-10-1688
Published: 15 March 2011
View article titled, Genomic Analysis Reveals the Molecular Heterogeneity of Ovarian Clear Cell Carcinomas
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Includes: Supplementary data
Journal Articles

Inhibition of Carboplatin-Induced DNA Interstrand Cross-link Repair by Gemcitabine in Patients Receiving these Drugs for Platinum-Resistant Ovarian Cancer

Jonathan A. Ledermann, Hani Gabra, Gordon C. Jayson, Victoria J. Spanswick, Gordon J.S. Rustin, Mark Jitlal, Lindsay E. James, John A. Hartley
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (19): 4899–4905.
https://doi.org/10.1158/1078-0432.CCR-10-0832
Published: 29 September 2010
View article titled, Inhibition of Carboplatin-Induced DNA Interstrand Cross-link Repair by Gemcitabine in Patients Receiving these Drugs for Platinum-Resistant Ovarian Cancer
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Journal Articles

PPM1D Is a Potential Therapeutic Target in Ovarian Clear Cell Carcinomas

David S.P. Tan, Maryou B.K. Lambros, Sydonia Rayter, Rachael Natrajan, Radost Vatcheva, Qiong Gao, Caterina Marchiò, Felipe C. Geyer, Kay Savage, Suzanne Parry, Kerry Fenwick, Narinder Tamber, Alan Mackay, Tim Dexter, Charles Jameson, W. Glenn McCluggage, Alistair Williams, Ashley Graham, Dana Faratian, Mona El-Bahrawy, Adam J. Paige, Hani Gabra, Martin E. Gore, Marketa Zvelebil, Christopher J. Lord, Stanley B. Kaye, Alan Ashworth, Jorge S. Reis-Filho
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (7): 2269–2280.
https://doi.org/10.1158/1078-0432.CCR-08-2403
Published: 01 April 2009
View article titled, PPM1D Is a Potential Therapeutic Target in Ovarian Clear Cell Carcinomas
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Includes: Supplementary data
Journal Articles

Antiestrogen Therapy Is Active in Selected Ovarian Cancer Cases: The Use of Letrozole in Estrogen Receptor–Positive Patients

John F. Smyth, Charlie Gourley, Graeme Walker, Melanie J. MacKean, Alan Stevenson, Alistair R.W. Williams, Awatif Al Nafussi, Tzyvia Rye, Ron Rye, Moira Stewart, Janet McCurdy, Max Mano, Nick Reed, Tracey McMahon, Paul Vasey, Hani Gabra, Simon P. Langdon
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (12): 3617–3622.
https://doi.org/10.1158/1078-0432.CCR-06-2878
Published: 15 June 2007
View article titled, Antiestrogen Therapy Is Active in Selected Ovarian Cancer Cases: The Use of Letrozole in Estrogen Receptor–Positive Patients
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Journal Articles

Ovarian Carcinomas: CCN Genes Are Aberrantly Expressed and CCN1 Promotes Proliferation of these Cells

Sigal Gery, Dong Xie, Dong Yin, Hani Gabra, Carl Miller, Heming Wang, Diane Scott, William S. Yi, Miriam L. Popoviciu, Johathan W. Said, H. Phillip Koeffler
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (20): 7243–7254.
https://doi.org/10.1158/1078-0432.CCR-05-0231
Published: 20 October 2005
View article titled, Ovarian Carcinomas: CCN Genes Are Aberrantly Expressed and CCN1 Promotes Proliferation of these Cells
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Journal Articles

The IgLON Family in Epithelial Ovarian Cancer: Expression Profiles and Clinicopathologic Correlates

Evangelos Ntougkos, Robert Rush, Diane Scott, Tobias Frankenberg, Hani Gabra, John F. Smyth, Grant C. Sellar
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (16): 5764–5768.
https://doi.org/10.1158/1078-0432.CCR-04-2388
Published: 22 August 2005
View article titled, The IgLON Family in Epithelial Ovarian Cancer: Expression Profiles and Clinicopathologic Correlates
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Journal Articles

CA125 Response Is Associated with Estrogen Receptor Expression in a Phase II Trial of Letrozole in Ovarian Cancer: Identification of an Endocrine-sensitive Subgroup

Angela Bowman, Hani Gabra, Simon P. Langdon, Alastair Lessells, Moira Stewart, Ann Young, John F. Smyth
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (7): 2233–2239.
Published: 01 July 2002
View article titled, CA125 Response Is Associated with Estrogen Receptor Expression in a Phase II Trial of Letrozole in Ovarian Cancer: <subtitle>Identification of an Endocrine-sensitive Subgroup</subtitle>
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Journal Articles

Expression of the Serine Protease Matriptase and Its Inhibitor HAI-1 in Epithelial Ovarian Cancer: Correlation with Clinical Outcome and Tumor Clinicopathological Parameters

Michael D. Oberst, Michael D. Johnson, Robert B. Dickson, Chen-Yong Lin, Baljit Singh, Moira Stewart, Alastair Williams, Awatif al-Nafussi, John F. Smyth, Hani Gabra, Grant C. Sellar
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (4): 1101–1107.
Published: 01 April 2002
View article titled, Expression of the Serine Protease Matriptase and Its Inhibitor HAI-1 in Epithelial Ovarian Cancer: <subtitle>Correlation with Clinical Outcome and Tumor Clinicopathological Parameters</subtitle>
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