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Haiyan Lei
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Journal Articles

Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models

Grace B. McKay-Corkum, Victor J. Collins, Choh Yeung, Takeshi Ito, Sameer H. Issaq, David Holland, Ksenia Vulikh, Yiping Zhang, Unsun Lee, Haiyan Lei, Arnulfo Mendoza, Jack F. Shern, Marielle E. Yohe, Kazutoshi Yamamoto, Kelli Wilson, Jiuping Ji, Baktiar O. Karim, Craig J. Thomas, Murali C. Krishna, Leonard M. Neckers, Christine M. Heske
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (21): 4479–4491.
https://doi.org/10.1158/1078-0432.CCR-23-0200
Published: 01 November 2023
View article titled, Inhibition of NAD<sup>+</sup>-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models
Open the PDF for Inhibition of NAD<sup>+</sup>-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models in another window
Includes: Supplementary data
Journal Articles

Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma

Srivandana Akshintala, R. Taylor Sundby, Donna Bernstein, John W. Glod, Rosandra N. Kaplan, Marielle E. Yohe, Andrea M. Gross, Joanne Derdak, Haiyan Lei, Alexander Pan, Eva Dombi, Isabel Palacio-Yance, Kailey R. Herrera, Markku M. Miettinen, Helen X. Chen, Seth M. Steinberg, Lee J. Helman, Leo Mascarenhas, Brigitte C. Widemann, Fariba Navid, Jack F. Shern, Christine M. Heske
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (17): 3329–3339.
https://doi.org/10.1158/1078-0432.CCR-23-0709
Published: 01 September 2023
View article titled, Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma
Open the PDF for Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma in another window
Includes: Supplementary data
Journal Articles

A Phase II Trial of Guadecitabine in Children and Adults with SDH-Deficient GIST, Pheochromocytoma, Paraganglioma, and HLRCC-Associated Renal Cell Carcinoma

John A. Ligon, R. Taylor Sundby, Mary F. Wedekind, Fernanda I. Arnaldez, Jaydira Del Rivero, Lori Wiener, Ramaprasad Srinivasan, Melissa Spencer, Amanda Carbonell, Haiyan Lei, John Shern, Seth M. Steinberg, William D. Figg, Cody J. Peer, Sara Zimmerman, Josquin Moraly, Xia Xu, Stephen Fox, King Chan, Michael I. Barbato, Thorkell Andresson, Naomi Taylor, Karel Pacak, J. Keith Killian, Eva Dombi, W. Marston Linehan, Markku Miettinen, Richard Piekarz, Lee J. Helman, Paul Meltzer, Brigitte Widemann, John Glod
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (2): 341–348.
https://doi.org/10.1158/1078-0432.CCR-22-2168
Published: 17 January 2023
View article titled, A Phase II Trial of Guadecitabine in Children and Adults with SDH-Deficient GIST, Pheochromocytoma, Paraganglioma, and HLRCC-Associated Renal Cell Carcinoma
Open the PDF for A Phase II Trial of Guadecitabine in Children and Adults with SDH-Deficient GIST, Pheochromocytoma, Paraganglioma, and HLRCC-Associated Renal Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models

Katie E. Hebron, Xiaolin Wan, Jacob S. Roth, David J. Liewehr, Nancy E. Sealover, William J.E. Frye, Angela Kim, Stacey Stauffer, Olivia L. Perkins, Wenyue Sun, Kristine A. Isanogle, Christina M. Robinson, Amy James, Parirokh Awasthi, Priya Shankarappa, Xiaoling Luo, Haiyan Lei, Donna Butcher, Roberta Smith, Elijah F. Edmondson, Jin-Qiu Chen, Noemi Kedei, Cody J. Peer, Jack F. Shern, W. Douglas Figg, Lu Chen, Matthew D. Hall, Simone Difilippantonio, Frederic G. Barr, Robert L. Kortum, Robert W. Robey, Angelina V. Vaseva, Javed Khan, Marielle E. Yohe
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (2): 472–487.
https://doi.org/10.1158/1078-0432.CCR-22-1646
Published: 17 January 2023
View article titled, The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models
Open the PDF for The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models in another window
Includes: Supplementary data
Journal Articles

Abstract IA023: Therapeutic efficacy of trametinib and ganitumab in RAS-mutated rhabdomyosarcoma

Marielle E. Yohe, Katie E. Hebron, Xiaolin Wan, Jacob S. Roth, David J. Liewehr, Nancy E. Sealover, Stacey Stauffer, Olivia Feehan-Nelson, Wenyue Sun, Kristine A. Isanogle, Christina M. Robinson, Amy James, Parirokh Awasthi, Priya Shankarappa, Xiaoling Liu, Haiyan Lei, Donna Butcher, Roberta Smith, Elijah F. Edmonson, Jin-Qui Chen, Noemi Kedei, Cody S. Peer, Jack F. Shern, W. Douglas Figg, Lu Chen, Matthew D. Hall, Simone Difillipantonio, Frederic G. Barr, Robert L. Kortum, Angelina V. Vaseva, Javed Khan
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (18_Supplement): IA023.
https://doi.org/10.1158/1557-3265.SARCOMAS22-IA023
Published: 15 September 2022
View article titled, Abstract IA023: Therapeutic efficacy of trametinib and ganitumab in RAS-mutated rhabdomyosarcoma
Journal Articles

Modulation of Target Antigen Density Improves CAR T-cell Functionality and Persistence

Sneha Ramakrishna, Steven L. Highfill, Zachary Walsh, Sang M. Nguyen, Haiyan Lei, Jack F. Shern, Haiying Qin, Ira L. Kraft, Maryalice Stetler-Stevenson, Constance M. Yuan, Jennifer D. Hwang, Yang Feng, Zhongyu Zhu, Dimiter Dimitrov, Nirali N. Shah, Terry J. Fry
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (17): 5329–5341.
https://doi.org/10.1158/1078-0432.CCR-18-3784
Published: 03 September 2019
View article titled, Modulation of Target Antigen Density Improves CAR T-cell Functionality and Persistence
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Includes: Supplementary data
Journal Articles

Outcomes of Children and Adolescents with Advanced Hereditary Medullary Thyroid Carcinoma Treated with Vandetanib

Ira L. Kraft, Srivandana Akshintala, Yuelin Zhu, Haiyan Lei, Claudia Derse-Anthony, Eva Dombi, Seth M. Steinberg, Maya Lodish, Steven G. Waguespack, Oxana Kapustina, Elizabeth Fox, Frank M. Balis, Maria J. Merino, Paul S. Meltzer, John W. Glod, Jack F. Shern, Brigitte C. Widemann
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (4): 753–765.
https://doi.org/10.1158/1078-0432.CCR-17-2101
Published: 14 February 2018
View article titled, Outcomes of Children and Adolescents with Advanced Hereditary Medullary Thyroid Carcinoma Treated with Vandetanib
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Includes: Supplementary data