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Journal Articles

Phase I/II Study of the Aurora Kinase A Inhibitor Alisertib and Pembrolizumab in Refractory, Rb-Deficient Head and Neck Squamous Cell Carcinomas

Faye M. Johnson, Madison P. O’Hara, Lacin Yapindi, Peixin Jiang, Hai T. Tran, Alexandre Reuben, Weihong Xiao, Maura L. Gillison, Xiaowen Sun, Alexander Khalaf, J. Jack Lee, Jagannadha K. Sastry, Soma Ghosh
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (3): 479–490.
https://doi.org/10.1158/1078-0432.CCR-24-2290
Published: 03 February 2025
View article titled, Phase I/II Study of the Aurora Kinase A Inhibitor Alisertib and Pembrolizumab in Refractory, Rb-Deficient Head and Neck Squamous Cell Carcinomas
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Includes: Supplementary data
Journal Articles

IL6 Mediates Suppression of T- and NK-cell Function in EMT-associated TKI-resistant EGFR-mutant NSCLC

Sonia A. Patel, Monique B. Nilsson, Yan Yang, Xiuning Le, Hai T. Tran, Yasir Y. Elamin, Xiaoxing Yu, Fahao Zhang, Alissa Poteete, Xiaoyang Ren, Li Shen, Jing Wang, Seyed Javad Moghaddam, Tina Cascone, Michael Curran, Don L. Gibbons, John V. Heymach
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (7): 1292–1304.
https://doi.org/10.1158/1078-0432.CCR-22-3379
Published: 03 April 2023
View article titled, IL6 Mediates Suppression of T- and NK-cell Function in EMT-associated TKI-resistant EGFR-mutant NSCLC
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Includes: Supplementary data
Journal Articles

Evolution of Genomic and T-cell Repertoire Heterogeneity of Malignant Pleural Mesothelioma Under Dasatinib Treatment

Runzhe Chen, Won-Chul Lee, Junya Fujimoto, Jun Li, Xin Hu, Reza Mehran, David Rice, Stephen G. Swisher, Boris Sepesi, Hai T. Tran, Chi-Wan Chow, Latasha D. Little, Curtis Gumbs, Cara Haymaker, John V. Heymach, Ignacio I. Wistuba, J. Jack Lee, P. Andrew Futreal, Jianhua Zhang, Alexandre Reuben, Anne S. Tsao, Jianjun Zhang
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (20): 5477–5486.
https://doi.org/10.1158/1078-0432.CCR-20-1767
Published: 15 October 2020
View article titled, Evolution of Genomic and T-cell Repertoire Heterogeneity of Malignant Pleural Mesothelioma Under Dasatinib Treatment
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Includes: Supplementary data
Journal Articles

The HGF/c-MET Pathway Is a Driver and Biomarker of VEGFR-inhibitor Resistance and Vascular Remodeling in Non–Small Cell Lung Cancer

Tina Cascone, Li Xu, Heather Y. Lin, Wenbin Liu, Hai T. Tran, Yuan Liu, Kathryn Howells, Vincent Haddad, Emer Hanrahan, Monique B. Nilsson, Maria A. Cortez, Uma Giri, Humam Kadara, Babita Saigal, Yun-Yong Park, Weiyi Peng, Ju-Seog Lee, Anderson J. Ryan, Juliane M. Jüergensmeier, Roy S. Herbst, Jing Wang, Robert R. Langley, Ignacio I. Wistuba, Jack J. Lee, John V. Heymach
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (18): 5489–5501.
https://doi.org/10.1158/1078-0432.CCR-16-3216
Published: 14 September 2017
View article titled, The HGF/c-MET Pathway Is a Driver and Biomarker of VEGFR-inhibitor Resistance and Vascular Remodeling in Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Detection of T790M, the Acquired Resistance EGFR Mutation, by Tumor Biopsy versus Noninvasive Blood-Based Analyses

Tilak K. Sundaresan, Lecia V. Sequist, John V. Heymach, Gregory J. Riely, Pasi A. Jänne, Walter H. Koch, James P. Sullivan, Douglas B. Fox, Robert Maher, Alona Muzikansky, Andrew Webb, Hai T. Tran, Uma Giri, Martin Fleisher, Helena A. Yu, Wen Wei, Bruce E. Johnson, Thomas A. Barber, John R. Walsh, Jeffrey A. Engelman, Shannon L. Stott, Ravi Kapur, Shyamala Maheswaran, Mehmet Toner, Daniel A. Haber
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (5): 1103–1110.
https://doi.org/10.1158/1078-0432.CCR-15-1031
Published: 29 February 2016
View article titled, Detection of T790M, the Acquired Resistance <em>EGFR</em> Mutation, by Tumor Biopsy versus Noninvasive Blood-Based Analyses
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Includes: Supplementary data
Journal Articles

Comprehensive Biomarker Analysis and Final Efficacy Results of Sorafenib in the BATTLE Trial

George R. Blumenschein, Jr, Pierre Saintigny, Suyu Liu, Edward S. Kim, Anne S. Tsao, Roy S. Herbst, Christine Alden, J. Jack Lee, Ximing Tang, David J. Stewart, Merrill S. Kies, Frank V. Fossella, Hai T. Tran, L. Mao, Marshall E. Hicks, Jeremy Erasmus, Jr, Sanjay Gupta, Luc Girard, Michael Peyton, Lixia Diao, Jing Wang, Suzanne E. Davis, John D. Minna, Ignacio Wistuba, Waun K. Hong, John V. Heymach, Scott M. Lippman
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (24): 6967–6975.
https://doi.org/10.1158/1078-0432.CCR-12-1818
Published: 16 December 2013
View article titled, Comprehensive Biomarker Analysis and Final Efficacy Results of Sorafenib in the BATTLE Trial
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Includes: Supplementary data
Journal Articles

Phase I Study of the Farnesyltransferase Inhibitor BMS-214662 Given Weekly in Patients with Solid Tumors

Vali Papadimitrakopoulou, Sofia Agelaki, Hai T. Tran, Merrill Kies, Robert Gagel, Ralph Zinner, Edward Kim, Gregory Ayers, John Wright, Fadlo Khuri
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (11): 4151–4159.
https://doi.org/10.1158/1078-0432.CCR-04-1659
Published: 01 June 2005
View article titled, Phase I Study of the Farnesyltransferase Inhibitor BMS-214662 Given Weekly in Patients with Solid Tumors
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Journal Articles

Phase I Study of Oral Topotecan in Hematological Malignancies

Miloslav Beran, Susan O’Brien, Deborah A. Thomas, Hai T. Tran, Jorge E. Cortes-Franco, Francis Giles, Elihu Estey, Hagop M. Kantarjian
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (11): 4084–4091.
Published: 30 September 2003
View article titled, Phase I Study of Oral Topotecan in Hematological Malignancies
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Journal Articles

A Phase I/IIA Trial of Continuous Five-Day Infusion of Squalamine Lactate (MSI-1256F) Plus Carboplatin and Paclitaxel in Patients with Advanced Non-Small Cell Lung Cancer

Roy S. Herbst, Lisa A. Hammond, David P. Carbone, Hai T. Tran, Kenneth J. Holroyd, Avinash Desai, Jon I. Williams, B. Nebiyou Bekele, Howard Hait, Victoria Allgood, Stephen Solomon, Joan H. Schiller
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (11): 4108–4115.
Published: 30 September 2003
View article titled, A Phase I/IIA Trial of Continuous Five-Day Infusion of Squalamine Lactate (MSI-1256F) Plus Carboplatin and Paclitaxel in Patients with Advanced Non-Small Cell Lung Cancer
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Journal Articles

Phase I and Pharmacological Study of Oral 9-Aminocamptothecin Colloidal Dispersion (NSC 603071) in Patients with Advanced Solid Tumors

Henry Q. Xiong, Hai T. Tran, Timothy L. Madden, Robert A. Newman, James L. Abbruzzese
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (6): 2066–2071.
Published: 01 June 2003
View article titled, Phase I and Pharmacological Study of Oral 9-Aminocamptothecin Colloidal Dispersion (NSC 603071) in Patients with Advanced Solid Tumors
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Journal Articles

Novel Marine-derived Anticancer Agents: A Phase I Clinical, Pharmacological, and Pharmacodynamic Study of Dolastatin 10 (NSC 376128) in Patients with Advanced Solid Tumors

Timothy Madden, Hai T. Tran, Debrah Beck, Reeves Huie, Robert A. Newman, Lajos Pusztai, John J. Wright, James L. Abbruzzese
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (4): 1293–1301.
Published: 01 April 2000
View article titled, Novel Marine-derived Anticancer Agents: A Phase I Clinical, Pharmacological, and Pharmacodynamic Study of Dolastatin 10 (NSC 376128) in Patients with Advanced Solid Tumors
Open the PDF for Novel Marine-derived Anticancer Agents: A Phase I Clinical, Pharmacological, and Pharmacodynamic Study of Dolastatin 10 (NSC 376128) in Patients with Advanced Solid Tumors in another window