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Gosse J. Adema
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Journal Articles

Mitochondria Targeting of Oxidative Phosphorylation Inhibitors to Alleviate Hypoxia and Enhance Anticancer Treatment Efficacy

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Anne P.M. Beerkens, Sandra Heskamp, Flavia V. Reinema, Gosse J. Adema, Paul N. Span, Johan Bussink
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (7): 1186–1193.
https://doi.org/10.1158/1078-0432.CCR-24-3296
Published: 01 April 2025
View articletitled, Mitochondria Targeting of Oxidative Phosphorylation Inhibitors to Alleviate Hypoxia and Enhance Anticancer Treatment Efficacy
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Journal Articles

Targeting Oxidative Phosphorylation to Increase the Efficacy of Radio- and Immune-Combination Therapy

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Daan F. Boreel, Paul N. Span, Sandra Heskamp, Gosse J. Adema, Johan Bussink
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (11): 2970–2978.
https://doi.org/10.1158/1078-0432.CCR-20-3913
Published: 01 June 2021
View articletitled, Targeting Oxidative Phosphorylation to Increase the Efficacy of Radio- and Immune-Combination Therapy
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Journal Articles

Targeting of 111In-Labeled Dendritic Cell Human Vaccines Improved by Reducing Number of Cells

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Erik H.J.G. Aarntzen, Mangala Srinivas, Fernando Bonetto, Luis J. Cruz, Pauline Verdijk, Gerty Schreibelt, Mandy van de Rakt, W. Joost Lesterhuis, Maichel van Riel, Cornelius J.A. Punt, Gosse J. Adema, Arend Heerschap, Carl G. Figdor, Wim J. Oyen, I. Jolanda M. de Vries
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (6): 1525–1533.
https://doi.org/10.1158/1078-0432.CCR-12-1879
Published: 14 March 2013
View articletitled, Targeting of 111In-Labeled Dendritic Cell Human Vaccines Improved by Reducing Number of Cells
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Includes: Supplementary data
Journal Articles

Vaccination with mRNA-Electroporated Dendritic Cells Induces Robust Tumor Antigen-Specific CD4+ and CD8+ T Cells Responses in Stage III and IV Melanoma Patients

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Erik H. J. G. Aarntzen, Gerty Schreibelt, Kalijn Bol, W. Joost Lesterhuis, Alexandra J. Croockewit, Johannes H. W. de Wilt, Michelle M. van Rossum, Willeke A. M. Blokx, Joannes F. M. Jacobs, Tjitske Duiveman-de Boer, Danita H. Schuurhuis, Roel Mus, Kris Thielemans, I. Jolanda M. de Vries, Carl G. Figdor, Cornelis J. A. Punt, Gosse J. Adema
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (19): 5460–5470.
https://doi.org/10.1158/1078-0432.CCR-11-3368
Published: 30 September 2012
View articletitled, Vaccination with mRNA-Electroporated Dendritic Cells Induces Robust Tumor Antigen-Specific CD4+ and CD8+ T Cells Responses in Stage III and IV Melanoma Patients
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Includes: Supplementary data
Journal Articles

Route of Administration Modulates the Induction of Dendritic Cell Vaccine–Induced Antigen-Specific T Cells in Advanced Melanoma Patients

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W. Joost Lesterhuis, I. Jolanda M. de Vries, Gerty Schreibelt, Annechien J.A. Lambeck, Erik H.J.G. Aarntzen, Joannes F.M. Jacobs, Nicole M. Scharenborg, Mandy W.M.M. van de Rakt, Annemiek J. de Boer, Sandra Croockewit, Michelle M. van Rossum, Roel Mus, Wim J.G. Oyen, Otto C. Boerman, Sophie Lucas, Gosse J. Adema, Cornelis J.A. Punt, Carl G. Figdor
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (17): 5725–5735.
https://doi.org/10.1158/1078-0432.CCR-11-1261
Published: 01 September 2011
View articletitled, Route of Administration Modulates the Induction of Dendritic Cell Vaccine–Induced Antigen-Specific T Cells in Advanced Melanoma Patients
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Includes: Supplementary data
Journal Articles

Frequency of Circulating Tregs with Demethylated FOXP3 Intron 1 in Melanoma Patients Receiving Tumor Vaccines and Potentially Treg-Depleting Agents

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I. Jolanda M. de Vries, Chiara Castelli, Caroline Huygens, Joannes F.M. Jacobs, Julie Stockis, Beatrice Schuler-Thurner, Gosse J. Adema, Cornelis J.A. Punt, Licia Rivoltini, Gerold Schuler, Pierre G. Coulie, Sophie Lucas
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (4): 841–848.
https://doi.org/10.1158/1078-0432.CCR-10-2227
Published: 15 February 2011
View articletitled, Frequency of Circulating Tregs with Demethylated FOXP3 Intron 1 in Melanoma Patients Receiving Tumor Vaccines and Potentially Treg-Depleting Agents
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Includes: Supplementary data
Journal Articles

Dendritic Cell Vaccination in Combination with Anti-CD25 Monoclonal Antibody Treatment: A Phase I/II Study in Metastatic Melanoma Patients

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Joannes F.M. Jacobs, Cornelis J.A. Punt, W. Joost Lesterhuis, Roger P.M. Sutmuller, H. Mary-lène H. Brouwer, Nicole M. Scharenborg, Ina S. Klasen, Luuk B. Hilbrands, Carl G. Figdor, I. Jolanda M. de Vries, Gosse J. Adema
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (20): 5067–5078.
https://doi.org/10.1158/1078-0432.CCR-10-1757
Published: 13 October 2010
View articletitled, Dendritic Cell Vaccination in Combination with Anti-CD25 Monoclonal Antibody Treatment: A Phase I/II Study in Metastatic Melanoma Patients
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Journal Articles

Intratumoral Recombinant Human Interleukin-12 Administration in Head and Neck Squamous Cell Carcinoma Patients Modifies Locoregional Lymph Node Architecture and Induces Natural Killer Cell Infiltration in the Primary Tumor

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Carla M.L. van Herpen, Jeroen A.W.M. van der Laak, I. Jolanda M. de Vries, Johan H. van Krieken, Peter C. de Wilde, Michiel G.J. Balvers, Gosse J. Adema, Pieter H.M. De Mulder
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (5): 1899–1909.
https://doi.org/10.1158/1078-0432.CCR-04-1524
Published: 08 March 2005
View articletitled, Intratumoral Recombinant Human Interleukin-12 Administration in Head and Neck Squamous Cell Carcinoma Patients Modifies Locoregional Lymph Node Architecture and Induces Natural Killer Cell Infiltration in the Primary Tumor
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Journal Articles

Intratumoral Administration of Recombinant Human Interleukin 12 in Head and Neck Squamous Cell Carcinoma Patients Elicits a T-Helper 1 Profile in the Locoregional Lymph Nodes

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Carla M. van Herpen, Maaike Looman, Marijke Zonneveld, Nicole Scharenborg, Peter C. de Wilde, Louis van de Locht, Matthias A. W. Merkx, Gosse J. Adema, Pieter H. De Mulder
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (8): 2626–2635.
https://doi.org/10.1158/1078-0432.CCR-03-0304
Published: 20 April 2004
View articletitled, Intratumoral Administration of Recombinant Human Interleukin 12 in Head and Neck Squamous Cell Carcinoma Patients Elicits a T-Helper 1 Profile in the Locoregional Lymph Nodes
Open the PDF for Intratumoral Administration of Recombinant Human Interleukin 12 in Head and Neck Squamous Cell Carcinoma Patients Elicits a T-Helper 1 Profile in the Locoregional Lymph Nodes in another window
Journal Articles

Maturation of Dendritic Cells Is a Prerequisite for Inducing Immune Responses in Advanced Melanoma Patients

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I. Jolanda M. de Vries, W. Joost Lesterhuis, Nicole M. Scharenborg, Linda P. H. Engelen, Dirk J. Ruiter, Marie-Jeanne P. Gerritsen, Sandra Croockewit, Cedrik M. Britten, Ruurd Torensma, Gosse J. Adema, Carl G. Figdor, Cornelis J. A. Punt
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (14): 5091–5100.
Published: 12 November 2003
View articletitled, Maturation of Dendritic Cells Is a Prerequisite for Inducing Immune Responses in Advanced Melanoma Patients
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Journal Articles

Pharmacokinetics and Immunological Aspects of a Phase Ib Study with Intratumoral Administration of Recombinant Human Interleukin-12 in Patients with Head and Neck Squamous Cell Carcinoma: A Decrease of T-bet in Peripheral Blood Mononuclear Cells

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Carla M. van Herpen, Richard Huijbens, Maaike Looman, Jolanda de Vries, Henri Marres, Johanna van de Ven, Rob Hermsen, Gosse J. Adema, Pieter H. De Mulder
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (8): 2950–2956.
Published: 11 August 2003
View articletitled, Pharmacokinetics and Immunological Aspects of a Phase Ib Study with Intratumoral Administration of Recombinant Human Interleukin-12 in Patients with Head and Neck Squamous Cell Carcinoma: A Decrease of T-bet in Peripheral Blood Mononuclear Cells
Open the PDF for Pharmacokinetics and Immunological Aspects of a Phase Ib Study with Intratumoral Administration of Recombinant Human Interleukin-12 in Patients with Head and Neck Squamous Cell Carcinoma: A Decrease of T-bet in Peripheral Blood Mononuclear Cells in another window