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Giuseppe Giaccone
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Journal Articles

Sex-Based Dimorphism of Anticancer Immune Response and Molecular Mechanisms of Immune Evasion

Fabio Conforti, Laura Pala, Eleonora Pagan, Vincenzo Bagnardi, Tommaso De Pas, Paola Queirolo, Elisabetta Pennacchioli, Chiara Catania, Emilia Cocorocchio, Pier Francesco Ferrucci, Maristella Saponara, Gianmarco Orsolini, Paola Zagami, Eleonora Nicoló, Filippo De Marinis, Giampaolo Tortora, Emilio Bria, Saverio Minucci, Hadine Joffe, Paolo Veronesi, Jennifer Wargo, Rachel Rosenthal, Charles Swanton, Alberto Mantovani, Richard D. Gelber, Giuseppe Viale, Aron Goldhirsch, Giuseppe Giaccone
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (15): 4311–4324.
https://doi.org/10.1158/1078-0432.CCR-21-0136
Published: 01 August 2021
View articletitled, Sex-Based Dimorphism of Anticancer Immune Response and Molecular Mechanisms of Immune Evasion
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Includes: Supplementary data
Journal Articles

A Phase I, Dose Escalation Study of Oral ASP8273 in Patients with Non–small Cell Lung Cancers with Epidermal Growth Factor Receptor Mutations

Helena A. Yu, Alexander Spira, Leora Horn, Jared Weiss, Howard West, Giuseppe Giaccone, Tracey Evans, Ronan J. Kelly, Bhardwaj Desai, Andrew Krivoshik, Diarmuid Moran, Srinivasu Poondru, Fei Jie, Kouji Aoyama, Anne Keating, Geoffrey R. Oxnard
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (24): 7467–7473.
https://doi.org/10.1158/1078-0432.CCR-17-1447
Published: 14 December 2017
View articletitled, A Phase I, Dose Escalation Study of Oral ASP8273 in Patients with Non–small Cell Lung Cancers with Epidermal Growth Factor Receptor Mutations
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Includes: Supplementary data
Journal Articles

Molecular Pathways: Anticancer Activity by Inhibition of Nucleocytoplasmic Shuttling

Fabio Conforti, Yisong Wang, Jose A. Rodriguez, Anna Teresa Alberobello, Yu-Wen Zhang, Giuseppe Giaccone
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (20): 4508–4513.
https://doi.org/10.1158/1078-0432.CCR-15-0408
Published: 14 October 2015
View articletitled, Molecular Pathways: Anticancer Activity by Inhibition of Nucleocytoplasmic Shuttling
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Journal Articles

Next-Generation Sequencing: Targeting Targeted Therapies

Justine N. McCutcheon, Giuseppe Giaccone
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (16): 3584–3585.
https://doi.org/10.1158/1078-0432.CCR-15-0407
Published: 13 August 2015
View articletitled, Next-Generation Sequencing: Targeting Targeted Therapies
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Journal Articles

A Phase I/II Trial of Belinostat in Combination with Cisplatin, Doxorubicin, and Cyclophosphamide in Thymic Epithelial Tumors: A Clinical and Translational Study

Anish Thomas, Arun Rajan, Eva Szabo, Yusuke Tomita, Corey A. Carter, Barbara Scepura, Ariel Lopez-Chavez, Min-Jung Lee, Christophe E. Redon, Ari Frosch, Cody J. Peer, Yuanbin Chen, Richard Piekarz, Seth M. Steinberg, Jane B. Trepel, William D. Figg, David S. Schrump, Giuseppe Giaccone
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (21): 5392–5402.
https://doi.org/10.1158/1078-0432.CCR-14-0968
Published: 30 October 2014
View articletitled, A Phase I/II Trial of Belinostat in Combination with Cisplatin, Doxorubicin, and Cyclophosphamide in Thymic Epithelial Tumors: A Clinical and Translational Study
Open the PDF for A Phase I/II Trial of Belinostat in Combination with Cisplatin, Doxorubicin, and Cyclophosphamide in Thymic Epithelial Tumors: A Clinical and Translational Study in another window
Includes: Supplementary data
Journal Articles

The Janus Kinases Inhibitor AZD1480 Attenuates Growth of Small Cell Lung Cancers In Vitro and In Vivo

Jih-Hsiang Lee, Kang-Seo Park, Anna Teresa Alberobello, Bhaskar Kallakury, Meng-Tzu Weng, Yisong Wang, Giuseppe Giaccone
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (24): 6777–6786.
https://doi.org/10.1158/1078-0432.CCR-13-1110
Published: 16 December 2013
View articletitled, The Janus Kinases Inhibitor AZD1480 Attenuates Growth of Small Cell Lung Cancers In Vitro and In Vivo
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Includes: Supplementary data
Journal Articles

Copy Number Aberrations of Genes Regulating Normal Thymus Development in Thymic Epithelial Tumors

Iacopo Petrini, Yisong Wang, Paolo A. Zucali, Hye Seung Lee, Trung Pham, Donna Voeller, Paul S. Meltzer, Giuseppe Giaccone
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (8): 1960–1971.
https://doi.org/10.1158/1078-0432.CCR-12-3260
Published: 15 April 2013
View articletitled, Copy Number Aberrations of Genes Regulating Normal Thymus Development in Thymic Epithelial Tumors
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Includes: Supplementary data
Journal Articles

18F-Fluorodeoxyglucose Positron Emission Tomography in the Management of Patients with Thymic Epithelial Tumors

Anish Thomas, Esther Mena, Karen Kurdziel, David Venzon, Sean Khozin, Arlene W. Berman, Peter Choyke, Eva Szabo, Arun Rajan, Giuseppe Giaccone
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (6): 1487–1493.
https://doi.org/10.1158/1078-0432.CCR-12-2929
Published: 14 March 2013
View articletitled, 18F-Fluorodeoxyglucose Positron Emission Tomography in the Management of Patients with Thymic Epithelial Tumors
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Includes: Supplementary data
Journal Articles

Phase II Study of Single-Agent Navitoclax (ABT-263) and Biomarker Correlates in Patients with Relapsed Small Cell Lung Cancer

Charles M. Rudin, Christine L. Hann, Edward B. Garon, Moacyr Ribeiro de Oliveira, Philip D. Bonomi, D. Ross Camidge, Quincy Chu, Giuseppe Giaccone, Divis Khaira, Suresh S. Ramalingam, Malcolm R. Ranson, Caroline Dive, Evelyn M. McKeegan, Brenda J. Chyla, Barry L. Dowell, Arunava Chakravartty, Cathy E. Nolan, Niki Rudersdorf, Todd A. Busman, Mack H. Mabry, Andrew P. Krivoshik, Rod A. Humerickhouse, Geoffrey I. Shapiro, Leena Gandhi
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (11): 3163–3169.
https://doi.org/10.1158/1078-0432.CCR-11-3090
Published: 31 May 2012
View articletitled, Phase II Study of Single-Agent Navitoclax (ABT-263) and Biomarker Correlates in Patients with Relapsed Small Cell Lung Cancer
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Journal Articles

A Phase I Combination Study of Olaparib with Cisplatin and Gemcitabine in Adults with Solid Tumors

Arun Rajan, Corey A. Carter, Ronan J. Kelly, Martin Gutierrez, Shivaani Kummar, Eva Szabo, Mary Ann Yancey, Jiuping Ji, Baskar Mannargudi, Sukyung Woo, Shawn Spencer, William Douglas Figg, Giuseppe Giaccone
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (8): 2344–2351.
https://doi.org/10.1158/1078-0432.CCR-11-2425
Published: 16 April 2012
View articletitled, A Phase I Combination Study of Olaparib with Cisplatin and Gemcitabine in Adults with Solid Tumors
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Includes: Supplementary data
Journal Articles

Sorafenib Is an Inhibitor of UGT1A1 but Is Metabolized by UGT1A9: Implications of Genetic Variants on Pharmacokinetics and Hyperbilirubinemia

Cody J. Peer, Tristan M. Sissung, AeRang Kim, Lokesh Jain, Sukyung Woo, Erin R. Gardner, C. Tyler Kirkland, Sarah M. Troutman, Bevin C. English, Emily D. Richardson, Joel Federspiel, David Venzon, William Dahut, Elise Kohn, Shivaani Kummar, Robert Yarchoan, Giuseppe Giaccone, Brigitte Widemann, William D. Figg
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (7): 2099–2107.
https://doi.org/10.1158/1078-0432.CCR-11-2484
Published: 01 April 2012
View articletitled, Sorafenib Is an Inhibitor of UGT1A1 but Is Metabolized by UGT1A9: Implications of Genetic Variants on Pharmacokinetics and Hyperbilirubinemia
Open the PDF for Sorafenib Is an Inhibitor of UGT1A1 but Is Metabolized by UGT1A9: Implications of Genetic Variants on Pharmacokinetics and Hyperbilirubinemia in another window
Includes: Supplementary data
Journal Articles

Loss of 18q22.3 Involving the Carboxypeptidase of Glutamate-like Gene Is Associated with Poor Prognosis in Resected Pancreatic Cancer

Jih-Hsiang Lee, Elisa Giovannetti, Jin-Hyeok Hwang, Iacopo Petrini, Qiuyan Wang, Johannes Voortman, Yonghong Wang, Seth M. Steinberg, Niccola Funel, Paul S. Meltzer, Yisong Wang, Giuseppe Giaccone
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (2): 524–533.
https://doi.org/10.1158/1078-0432.CCR-11-1903
Published: 16 January 2012
View articletitled, Loss of 18q22.3 Involving the Carboxypeptidase of Glutamate-like Gene Is Associated with Poor Prognosis in Resected Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Drug Development: Portals of Discovery

Susan E. Bates, Laleh Amiri-Kordestani, Giuseppe Giaccone
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (1): 23–32.
https://doi.org/10.1158/1078-0432.CCR-11-1001
Published: 02 January 2012
View articletitled, Drug Development: Portals of Discovery
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Journal Articles

A Phase I Study of PF-04929113 (SNX-5422), an Orally Bioavailable Heat Shock Protein 90 Inhibitor, in Patients with Refractory Solid Tumor Malignancies and Lymphomas

Arun Rajan, Ronan J. Kelly, Jane B. Trepel, Yeong Sang Kim, Sylvia V. Alarcon, Shivaani Kummar, Martin Gutierrez, Sonja Crandon, Wadih M. Zein, Lokesh Jain, Baskar Mannargudi, William D. Figg, Brett E. Houk, Michael Shnaidman, Nicoletta Brega, Giuseppe Giaccone
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (21): 6831–6839.
https://doi.org/10.1158/1078-0432.CCR-11-0821
Published: 31 October 2011
View articletitled, A Phase I Study of PF-04929113 (SNX-5422), an Orally Bioavailable Heat Shock Protein 90 Inhibitor, in Patients with Refractory Solid Tumor Malignancies and Lymphomas
Open the PDF for A Phase I Study of PF-04929113 (SNX-5422), an Orally Bioavailable Heat Shock Protein 90 Inhibitor, in Patients with Refractory Solid Tumor Malignancies and Lymphomas in another window
Includes: Supplementary data
Journal Articles

Role and Relevance of TrkB Mutations and Expression in Non–Small Cell Lung Cancer

Taishi Harada, Yasushi Yatabe, Masafumi Takeshita, Takaomi Koga, Tokujiro Yano, Yisong Wang, Giuseppe Giaccone
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (9): 2638–2645.
https://doi.org/10.1158/1078-0432.CCR-10-3034
Published: 01 May 2011
View articletitled, Role and Relevance of TrkB Mutations and Expression in Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Heat Shock Protein 90-Sheltered Overexpression of Insulin-Like Growth Factor 1 Receptor Contributes to Malignancy of Thymic Epithelial Tumors

Marco Breinig, Philipp Mayer, Andreas Harjung, Benjamin Goeppert, Mona Malz, Roland Penzel, Olaf Neumann, Arndt Hartmann, Hendrik Dienemann, Giuseppe Giaccone, Peter Schirmacher, Michael André Kern, Gabriela Chiosis, Ralf Joachim Rieker
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (8): 2237–2249.
https://doi.org/10.1158/1078-0432.CCR-10-1689
Published: 14 April 2011
View articletitled, Heat Shock Protein 90-Sheltered Overexpression of Insulin-Like Growth Factor 1 Receptor Contributes to Malignancy of Thymic Epithelial Tumors
Open the PDF for Heat Shock Protein 90-Sheltered Overexpression of Insulin-Like Growth Factor 1 Receptor Contributes to Malignancy of Thymic Epithelial Tumors in another window
Includes: Supplementary data
Journal Articles

Evaluation of KRAS Mutations, Angiogenic Biomarkers, and DCE-MRI in Patients with Advanced Non–Small-Cell Lung Cancer Receiving Sorafenib

Ronan J. Kelly, Arun Rajan, Jeremy Force, Ariel Lopez-Chavez, Corrine Keen, Liang Cao, Yunkai Yu, Peter Choyke, Baris Turkbey, Mark Raffeld, Liqiang Xi, Seth M. Steinberg, John J. Wright, Shivaani Kummar, Martin Gutierrez, Giuseppe Giaccone
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (5): 1190–1199.
https://doi.org/10.1158/1078-0432.CCR-10-2331
Published: 01 March 2011
View articletitled, Evaluation of KRAS Mutations, Angiogenic Biomarkers, and DCE-MRI in Patients with Advanced Non–Small-Cell Lung Cancer Receiving Sorafenib
Open the PDF for Evaluation of KRAS Mutations, Angiogenic Biomarkers, and DCE-MRI in Patients with Advanced Non–Small-Cell Lung Cancer Receiving Sorafenib in another window
Includes: Supplementary data
Journal Articles

A Phase I Pharmacologic Study of Necitumumab (IMC-11F8), a Fully Human IgG1 Monoclonal Antibody Directed Against EGFR in Patients with Advanced Solid Malignancies

Bart Kuenen, Petronella O. Witteveen, Rita Ruijter, Giuseppe Giaccone, Aruna Dontabhaktuni, Floyd Fox, Terry Katz, Hagop Youssoufian, Junming Zhu, Eric K. Rowinsky, Emile E. Voest
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (6): 1915–1923.
https://doi.org/10.1158/1078-0432.CCR-09-2425
Published: 14 March 2010
View articletitled, A Phase I Pharmacologic Study of Necitumumab (IMC-11F8), a Fully Human IgG1 Monoclonal Antibody Directed Against EGFR in Patients with Advanced Solid Malignancies
Open the PDF for A Phase I Pharmacologic Study of Necitumumab (IMC-11F8), a Fully Human IgG1 Monoclonal Antibody Directed Against EGFR in Patients with Advanced Solid Malignancies in another window
Journal Articles

Impact of Epidermal Growth Factor Receptor and KRAS Mutations on Clinical Outcomes in Previously Untreated Non–Small Cell Lung Cancer Patients: Results of an Online Tumor Registry of Clinical Trials

David M. Jackman, Vincent A. Miller, Leigh-Anne Cioffredi, Beow Y. Yeap, Pasi A. Jänne, Gregory J. Riely, Marielle Gallegos Ruiz, Giuseppe Giaccone, Lecia V. Sequist, Bruce E. Johnson
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (16): 5267–5273.
https://doi.org/10.1158/1078-0432.CCR-09-0888
Published: 12 August 2009
View articletitled, Impact of Epidermal Growth Factor Receptor and KRAS Mutations on Clinical Outcomes in Previously Untreated Non–Small Cell Lung Cancer Patients: Results of an Online Tumor Registry of Clinical Trials
Open the PDF for Impact of Epidermal Growth Factor Receptor and KRAS Mutations on Clinical Outcomes in Previously Untreated Non–Small Cell Lung Cancer Patients: Results of an Online Tumor Registry of Clinical Trials in another window
Journal Articles

An Immune Response Enriched 72-Gene Prognostic Profile for Early-Stage Non–Small-Cell Lung Cancer

Paul Roepman, Jacek Jassem, Egbert F. Smit, Thomas Muley, Jacek Niklinski, Tony van de Velde, Anke T. Witteveen, Witold Rzyman, Arno Floore, Sjaak Burgers, Giuseppe Giaccone, Michael Meister, Hendrik Dienemann, Marcin Skrzypski, Miroslaw Kozlowski, Wolter J. Mooi, Nico van Zandwijk
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (1): 284–290.
https://doi.org/10.1158/1078-0432.CCR-08-1258
Published: 31 December 2008
View articletitled, An Immune Response Enriched 72-Gene Prognostic Profile for Early-Stage Non–Small-Cell Lung Cancer
Open the PDF for An Immune Response Enriched 72-Gene Prognostic Profile for Early-Stage Non–Small-Cell Lung Cancer in another window
Includes: Supplementary data