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Giovanni Scambia
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Journal Articles

Validation of the Clinical Use of GIScar, an Academic-developed Genomic Instability Score Predicting Sensitivity to Maintenance Olaparib for Ovarian Cancer

Raphaël Leman, Etienne Muller, Angelina Legros, Nicolas Goardon, Imène Chentli, Alexandre Atkinson, Aurore Tranchant, Laurent Castera, Sophie Krieger, Agathe Ricou, Flavie Boulouard, Florence Joly, Romain Boucly, Aurélie Dumont, Noémie Basset, Florence Coulet, Louise-Marie Chevalier, Etienne Rouleau, Katharina Leitner, Antonio González-Martin, Piera Gargiulo, Hans-Joachim Lück, Catherine Genestie, the PAOLA-1 investigators, Gerhard Bogner, Christian Marth, Edgar Petru, Alexander Reinthaller, Christian Schauer, Paul Sevelda, Lionel D'Hondt, Ignace Vergote, Peter Vuylsteke, Sakari Hietanen, Gabriel Lindahl, Johanna Mäenpää, Trine Jakobi Nøttrup, Ulla Puistola, Sophie Abadie-Lacourtoisie, Jérôme Alexandre, Emilie Boissier, Hugues Bourgeois, Annick Chevalier-Place, Pierre Combe, Cristina Costan, Jérôme Dauba, Laure De Cock, Christophe Desauw, Raymond Despax, Nadine Dohollou, Coraline Dubot, Michel Fabbro, Laure Favier, Anne Floquet, Philippe Follana, Claire Garnier Tixidre, Georges Garnier, Laurence Gladieff, Julien Grenier, Cécile Guillemet, Anne-Claire Hardy-Bessard, Florence Joly, Elsa Kalbacher, Marie-Christine Kaminsky, Jean-Emmanuel Kurtz, Rémy Largillier, Claudia Lefeuvre-Plesse, Anne Lesoin, Charles-Briac Levache, Tifenn L'Haridon, Alain Lortholary, Jean-Pierre Lotz, Jérôme Meunier, Mirerille Mousseau, Marie-Ange Mouret-Reynier, Patricia Pautier, Thierry Petit, Magali Provansal, Eric Pujade-Lauraine, Nadia Raban, Isabelle Ray-Coquard, Manuel Rodrigues, Frédéric Selle, Robert Sverdlin, Youssef Tazi, Benoît You, Bahriye Aktas, Dirk Olaf Bauerschlag, Thomas Beck, Antje Belau, Holger Bronger, Stefan Buchholz, Paul Buderath, Alexander Burges, Ulrich Canzler, Nikolaus de Gregorio, Dominik Denschlag, Max Dieterich, Michael Eichbaum, Ahmed El-Balat, Günter Emons, Peter Fasching, Gabriele Feisel-Schwickardi, Matthias Frank, Michael Friedrich, Eva-Maria Grischke, Martina Gropp-Meier, Lars Hanker, Carla Hannig, Philipp Harter, Annette Hasenburg, Martin Hellriegel, Uwe Herwig, Martin Heubner, Joachim Hulde, Christian Jackisch, Matthias Kögel, Peter Krieger, Thorsten Kühn, Clemens Liebrich, Hans-Joachim Lück, Peter Mallmann, Frederik Marmé, Werner Meier, Voker Möbus, Omar Farag Mohamed, Carolin Nestle-Krämling, Tanja Neunhöffer, Gülten Oskay-Özcelik, Tjoung-Won Park-Simon, Beate Rautenberg, Daniel Rein, Wencke Ruhwedel, Ingo Runnebaum, Jacqueline Sagasser, Barbara Schmalfeldt, Andreas Schneeweiss, Andreas Schnelzer, Heinz Scholz, Jalid Sehouli, Antje Sperfeld, Annette Steckkönig, Hans-Georg Strauß, Oliver Tomé, Jörn Treustedt, Hermann Voß, Arthur Wischnik, Ralf Witteler, Achim Wöckel, Hans-Heinrich Woeltjen, Andreas Zorr, Alessandra Bologna, Nicoletta Colombo, Germana Tognon, Saverio Cinieri, Domenica Lorusso, Anna Maria Mosconi, Sandro Pignata, Antonella Savarese, Giovanni Scambia, Roberto Sorio, Claudio Zamagni, Keiichi Fujiwara, Hiroyuki Fujiwara, Hiroaki Kobayashi, Takashi Matsumoto, Shoji Nagao, Toyomi Satoh, Kan Yonemori, Hiroyuki Yoshida, Raquel Bratos, Cristina Caballero, Yolanda Garica, Antonio González-Martín, Eva Maria Guerra Alia, Susana Hernando, Ana Herrero, Nuria Lainez, Luis Manso, Cristina Martin, Eleonor Murata, Eugenia Ortega, Isabel Palacio, Andres Poveda, Ignacio Romero, Maria Jesús Rubio, Isabelle Ray-Coquard, Eric Pujade-Lauraine, Dominique Vaur
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (21): 4419–4429.
https://doi.org/10.1158/1078-0432.CCR-23-0898
Published: 01 November 2023
View article titled, Validation of the Clinical Use of GIScar, an Academic-developed Genomic Instability Score Predicting Sensitivity to Maintenance Olaparib for Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Abstract PR06: ARIEL3: A phase 3, randomized, double-blind study of rucaparib vs placebo following response to platinum-based chemotherapy for recurrent ovarian cancer (OC)

Robert L. Coleman, Amit M. Oza, Domenica Lorusso, Carol Aghajanian, Ana Oaknin, Andrew Dean, Nicoletta Colombo, Johanne I. Weberpals, Andrew Clamp, Giovanni Scambia, Alexandra Leary, Robert W. Holloway, David M. O’Malley, Terri Cameron, Lara Maloney, Sandra Goble, Kevin Lin, James Sun, Heidi Giordano, Jonathan A. Ledermann
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (15_Supplement): PR06.
https://doi.org/10.1158/1557-3265.OVCA17-PR06
Published: 01 August 2018
View article titled, Abstract PR06: ARIEL3: A phase 3, randomized, double-blind study of rucaparib vs placebo following response to platinum-based chemotherapy for recurrent ovarian cancer (OC)
Journal Articles

Gender Influences the Class III and V β-Tubulin Ability to Predict Poor Outcome in Colorectal Cancer

Marisa Mariani, Gian Franco Zannoni, Stefano Sioletic, Steven Sieber, Candice Martino, Enrica Martinelli, Claudio Coco, Giovanni Scambia, Shohreh Shahabi, Cristiano Ferlini
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (10): 2964–2975.
https://doi.org/10.1158/1078-0432.CCR-11-2318
Published: 14 May 2012
View article titled, Gender Influences the Class III and V β-Tubulin Ability to Predict Poor Outcome in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Cells with Characteristics of Cancer Stem/Progenitor Cells Express the CD133 Antigen in Human Endometrial Tumors

Sergio Rutella, Giuseppina Bonanno, Annabella Procoli, Andrea Mariotti, Maria Corallo, Maria Grazia Prisco, Adriana Eramo, Chiara Napoletano, Daniela Gallo, Alessandro Perillo, Marianna Nuti, Luca Pierelli, Ugo Testa, Giovanni Scambia, Gabriella Ferrandina
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (13): 4299–4311.
https://doi.org/10.1158/1078-0432.CCR-08-1883
Published: 01 July 2009
View article titled, Cells with Characteristics of Cancer Stem/Progenitor Cells Express the CD133 Antigen in Human Endometrial Tumors
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Includes: Supplementary data
Journal Articles

The Retinoblastoma Family Member pRb2/p130 Is an Independent Predictor of Survival in Human Soft Tissue Sarcomas

Valeria Masciullo, Ester Berardengo, Antonella Boglione, Alessandro Sgambato, Amelia Bernardi, Marco Forni, Alessandra Linari, Letizia Cito, Giovanni Scambia, Alessandro Comandone, Antonio Giordano
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (15): 4775–4779.
https://doi.org/10.1158/1078-0432.CCR-07-4055
Published: 01 August 2008
View article titled, The Retinoblastoma Family Member pRb2/p130 Is an Independent Predictor of Survival in Human Soft Tissue Sarcomas
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Journal Articles

Class III β-Tubulin Overexpression Is a Marker of Poor Clinical Outcome in Advanced Ovarian Cancer Patients

Gabriella Ferrandina, Gian Franco Zannoni, Enrica Martinelli, Amelia Paglia, Valerio Gallotta, Simona Mozzetti, Giovanni Scambia, Cristiano Ferlini
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (9): 2774–2779.
https://doi.org/10.1158/1078-0432.CCR-05-2715
Published: 04 May 2006
View article titled, Class III β-Tubulin Overexpression Is a Marker of Poor Clinical Outcome in Advanced Ovarian Cancer Patients
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Journal Articles

Celecoxib Up-Regulates the Expression of the ζ Chain of T Cell Receptor Complex in Tumor-Infiltrating Lymphocytes in Human Cervical Cancer

Gabriella Ferrandina, Franco Oreste Ranelletti, Francesco Legge, Vanda Salutari, Enrica Martinelli, Andrea Fattorossi, Domenica Lorusso, Gianfranco Zannoni, Valerio Vellone, Amelia Paglia, Giovanni Scambia
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (7): 2055–2060.
https://doi.org/10.1158/1078-0432.CCR-05-2530
Published: 11 April 2006
View article titled, Celecoxib Up-Regulates the Expression of the ζ Chain of T Cell Receptor Complex in Tumor-Infiltrating Lymphocytes in Human Cervical Cancer
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Journal Articles

Class III β-Tubulin Overexpression Is a Prominent Mechanism of Paclitaxel Resistance in Ovarian Cancer Patients

Simona Mozzetti, Cristiano Ferlini, Paola Concolino, Flavia Filippetti, Giuseppina Raspaglio, Silvia Prislei, Daniela Gallo, Enrica Martinelli, Franco Oreste Ranelletti, Gabriella Ferrandina, Giovanni Scambia
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (1): 298–305.
https://doi.org/10.1158/1078-0432.298.11.1
Published: 21 January 2005
View article titled, Class III β-Tubulin Overexpression Is a Prominent Mechanism of Paclitaxel Resistance in Ovarian Cancer Patients
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Journal Articles

Cell Cycle Genes in Ovarian Cancer: Steps Toward Earlier Diagnosis and Novel Therapies

Giuseppina D’Andrilli, Christine Kumar, Giovanni Scambia, Antonio Giordano
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (24): 8132–8141.
https://doi.org/10.1158/1078-0432.CCR-04-0886
Published: 28 December 2004
View article titled, Cell Cycle Genes in Ovarian Cancer: <subtitle>Steps Toward Earlier Diagnosis and Novel Therapies</subtitle>
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Journal Articles

pRb2/p130 Decreases Sensitivity to Apoptosis Induced by Camptothecin and Doxorubicin but not by Taxol

Tiziana Tonini, Chiara Gabellini, Luigi Bagella, Giuseppina D’Andrilli, Valeria Masciullo, Gaetano Romano, Giovanni Scambia, Gabriella Zupi, Antonio Giordano
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (23): 8085–8093.
https://doi.org/10.1158/1078-0432.CCR-04-0996
Published: 07 December 2004
View article titled, pRb2/p130 Decreases Sensitivity to Apoptosis Induced by Camptothecin and Doxorubicin but not by Taxol
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Journal Articles

Frequent Loss of pRb2/p130 in Human Ovarian Carcinoma

Giuseppina D’Andrilli, Valeria Masciullo, Luigi Bagella, Tiziana Tonini, Corrado Minimo, Gian Franco Zannoni, Robert L. Giuntoli, II, John A. Carlson, Jr., Dianne Robert Soprano, Kenneth J. Soprano, Giovanni Scambia, Antonio Giordano
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (9): 3098–3103.
https://doi.org/10.1158/1078-0432.CCR-03-0524
Published: 06 May 2004
View article titled, Frequent Loss of pRb2/p130 in Human Ovarian Carcinoma
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Journal Articles

Prognostic Role of the Ratio between Cyclooxygenase-2 in Tumor and Stroma Compartments in Cervical Cancer

Gabriella Ferrandina, Franco Oreste Ranelletti, Francesco Legge, Marco Gessi, Vanda Salutari, Maria Grazia Distefano, Libero Lauriola, Gian Franco Zannoni, Enrica Martinelli, Giovanni Scambia
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (9): 3117–3123.
https://doi.org/10.1158/1078-0432.CCR-1090-3
Published: 06 May 2004
View article titled, Prognostic Role of the Ratio between Cyclooxygenase-2 in Tumor and Stroma Compartments in Cervical Cancer
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Journal Articles

Frequent Loss of Expression of the Cyclin-Dependent Kinase Inhibitor p27Kip1 in Estrogen-Related Endometrial Adenocarcinomas

Valeria Masciullo, Tommaso Susini, Alessandra Zamparelli, Alessandro Bovicelli, Corrado Minimo, Daniela Massi, Gianluigi Taddei, Nicola Maggiano, Pierandrea De Iaco, Marcello Ceccaroni, Luciano Bovicelli, Gianni Amunni, Salvatore Mancuso, Giovanni Scambia, Antonio Giordano
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (14): 5332–5338.
Published: 12 November 2003
View article titled, Frequent Loss of Expression of the Cyclin-Dependent Kinase Inhibitor p27<sup>Kip1</sup> in Estrogen-Related Endometrial Adenocarcinomas
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Journal Articles

Celecoxib Modulates the Expression of Cyclooxygenase-2, Ki67, Apoptosis-Related Marker, and Microvessel Density in Human Cervical Cancer: A Pilot Study

Gabriella Ferrandina, Franco O. Ranelletti, Francesco Legge, Libero Lauriola, Vanda Salutari, Marco Gessi, Antonia C. Testa, Ulrike Werner, Pierluigi Navarra, Giuseppe Tringali, Alessandra Battaglia, Giovanni Scambia
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (12): 4324–4331.
Published: 10 October 2003
View article titled, Celecoxib Modulates the Expression of Cyclooxygenase-2, Ki67, Apoptosis-Related Marker, and Microvessel Density in Human Cervical Cancer: <subtitle>A Pilot Study</subtitle>
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Journal Articles

Lymphocyte Recovery in Advanced Ovarian Cancer Patients after High-Dose Chemotherapy and Peripheral Blood Stem Cell Plus Growth Factor Support: Clinical Implications

Gabriella Ferrandina, Luca Pierelli, Alessandro Perillo, Sergio Rutella, Manuela Ludovisi, Giuseppe Leone, Salvatore Mancuso, Giovanni Scambia
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (1): 195–200.
Published: 01 January 2003
View article titled, Lymphocyte Recovery in Advanced Ovarian Cancer Patients after High-Dose Chemotherapy and Peripheral Blood Stem Cell Plus Growth Factor Support: <subtitle>Clinical Implications</subtitle>
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Journal Articles

Human Papillomavirus Infection and Epidermal Growth Factor Receptor Expression in Primary Laryngeal Squamous Cell Carcinoma

Giovanni Almadori, Gabriella Cadoni, Paola Cattani, Jacopo Galli, Francesco Bussu, Gabriella Ferrandina, Giovanni Scambia, Giovanni Fadda, Maurizio Maurizi
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (12): 3988–3993.
Published: 01 December 2001
View article titled, Human Papillomavirus Infection and Epidermal Growth Factor Receptor Expression in Primary Laryngeal Squamous Cell Carcinoma
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Journal Articles

Tamoxifen Modulates the Expression of Ki67, Apoptosis, and Microvessel Density in Cervical Cancer

Gabriella Ferrandina, Franco O. Ranelletti, Luigi M. Larocca, Nicola Maggiano, Erika Fruscella, Francesco Legge, Giuseppe Santeusanio, Alessandro Bombonati, Salvatore Mancuso, Giovanni Scambia
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (9): 2656–2661.
Published: 01 September 2001
View article titled, Tamoxifen Modulates the Expression of Ki67, Apoptosis, and Microvessel Density in Cervical Cancer
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Journal Articles

p27Kip1 Expression Is Associated with Clinical Outcome in Advanced Epithelial Ovarian Cancer: Multivariate Analysis

Valeria Masciullo, Gabriella Ferrandina, Bruna Pucci, Francesco Fanfani, Silvia Lovergine, Juan Palazzo, Gianfranco Zannoni, Salvatore Mancuso, Giovanni Scambia, Antonio Giordano
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (12): 4816–4822.
Published: 01 December 2000
View article titled, p27<sup>Kip1</sup> Expression Is Associated with Clinical Outcome in Advanced Epithelial Ovarian Cancer: Multivariate Analysis
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