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Journal Articles

CAR T cells Targeting Human Immunoglobulin Light Chains Eradicate Mature B-cell Malignancies While Sparing a Subset of Normal B Cells

Raghuveer Ranganathan, Peishun Shou, Sarah Ahn, Chuang Sun, John West, Barbara Savoldo, Gianpietro Dotti

Clin Cancer Res (2021) 27 (21): 5951–5960.

https://doi.org/10.1158/1078-0432.CCR-20-2754

Published: 01 November 2021

View article titled, CAR T cells Targeting Human Immunoglobulin Light Chains Eradicate Mature B-cell Malignancies While Sparing a Subset of Normal B Cells

Includes: Supplementary data

Journal Articles

Preclinical Evaluation of B7-H3–specific Chimeric Antigen Receptor T Cells for the Treatment of Acute Myeloid Leukemia

Eben I. Lichtman, Hongwei Du, Peishun Shou, Feifei Song, Kyogo Suzuki, Sarah Ahn, Guangming Li, Soldano Ferrone, Lishan Su, Barbara Savoldo, Gianpietro Dotti

Clin Cancer Res (2021) 27 (11): 3141–3153.

https://doi.org/10.1158/1078-0432.CCR-20-2540

Published: 01 June 2021

View article titled, Preclinical Evaluation of B7-H3–specific Chimeric Antigen Receptor T Cells for the Treatment of Acute Myeloid Leukemia

Includes: Supplementary data

Journal Articles

CSPG4-Specific CAR.CIK Lymphocytes as a Novel Therapy for the Treatment of Multiple Soft-Tissue Sarcoma Histotypes

Clin Cancer Res (2020) 26 (23): 6321–6334.

https://doi.org/10.1158/1078-0432.CCR-20-0357

Published: 01 December 2020

View article titled, CSPG4-Specific CAR.CIK Lymphocytes as a Novel Therapy for the Treatment of Multiple Soft-Tissue Sarcoma Histotypes

Includes: Multimedia, Supplementary data

Journal Articles

Enhancing Chimeric Antigen Receptor T-Cell Efficacy in Solid Tumors

Giovanni Fucà, Loic Reppel, Elisa Landoni, Barbara Savoldo, Gianpietro Dotti

Clin Cancer Res (2020) 26 (11): 2444–2451.

https://doi.org/10.1158/1078-0432.CCR-19-1835

Published: 01 June 2020

View article titled, Enhancing Chimeric Antigen Receptor T-Cell Efficacy in Solid Tumors

Journal Articles

T-Cell Receptor Stimulation Enhances the Expansion and Function of CD19 Chimeric Antigen Receptor–Expressing T Cells

Clin Cancer Res (2019) 25 (24): 7340–7350.

https://doi.org/10.1158/1078-0432.CCR-18-3199

Published: 13 December 2019

View article titled, T-Cell Receptor Stimulation Enhances the Expansion and Function of CD19 Chimeric Antigen Receptor–Expressing T Cells

Includes: Supplementary data

Journal Articles

NKT Cells Coexpressing a GD2-Specific Chimeric Antigen Receptor and IL15 Show Enhanced In Vivo Persistence and Antitumor Activity against Neuroblastoma

Xin Xu, Wei Huang, Andras Heczey, Daofeng Liu, Linjie Guo, Michael Wood, Jingling Jin, Amy N. Courtney, Bin Liu, Erica J. Di Pierro, John Hicks, Gabriel A. Barragan, Ho Ngai, Yuhui Chen, Barbara Savoldo, Gianpietro Dotti, Leonid S. Metelitsa

Clin Cancer Res (2019) 25 (23): 7126–7138.

https://doi.org/10.1158/1078-0432.CCR-19-0421

Published: 02 December 2019

View article titled, NKT Cells Coexpressing a GD2-Specific Chimeric Antigen Receptor and IL15 Show Enhanced In Vivo Persistence and Antitumor Activity against Neuroblastoma

Includes: Supplementary data

Journal Articles

Eradication of Neuroblastoma by T Cells Redirected with an Optimized GD2-Specific Chimeric Antigen Receptor and Interleukin-15

Yuhui Chen, Chuang Sun, Elisa Landoni, Leonid Metelitsa, Gianpietro Dotti, Barbara Savoldo

Clin Cancer Res (2019) 25 (9): 2915–2924.

https://doi.org/10.1158/1078-0432.CCR-18-1811

Published: 01 May 2019

View article titled, Eradication of Neuroblastoma by T Cells Redirected with an Optimized GD2-Specific Chimeric Antigen Receptor and Interleukin-15

Includes: Supplementary data

Journal Articles

A Phase I/IIa Trial Using CD19-Targeted Third-Generation CAR T Cells for Lymphoma and Leukemia

Gunilla Enblad, Hannah Karlsson, Gustav Gammelgård, Jessica Wenthe, Tanja Lövgren, Rose Marie Amini, Kristina I. Wikstrom, Magnus Essand, Barbara Savoldo, Helene Hallböök, Martin Höglund, Gianpietro Dotti, Malcolm K. Brenner, Hans Hagberg, Angelica Loskog

Clin Cancer Res (2018) 24 (24): 6185–6194.

https://doi.org/10.1158/1078-0432.CCR-18-0426

Published: 13 December 2018

View article titled, A Phase I/IIa Trial Using CD19-Targeted Third-Generation CAR T Cells for Lymphoma and Leukemia

Includes: Supplementary data

Journal Articles

T-cell Homing Therapy for Reducing Regulatory T Cells and Preserving Effector T-cell Function in Large Solid Tumors

Jiemiao Hu, Chuang Sun, Chantale Bernatchez, Xueqing Xia, Patrick Hwu, Gianpietro Dotti, Shulin Li

Clin Cancer Res (2018) 24 (12): 2920–2934.

https://doi.org/10.1158/1078-0432.CCR-17-1365

Published: 14 June 2018

View article titled, T-cell Homing Therapy for Reducing Regulatory T Cells and Preserving Effector T-cell Function in Large Solid Tumors

Includes: Supplementary data

Journal Articles

Vaccination Targeting Native Receptors to Enhance the Function and Proliferation of Chimeric Antigen Receptor (CAR)-Modified T Cells

Miyuki Tanaka, Haruko Tashiro, Bilal Omer, Natasha Lapteva, Jun Ando, Minhtran Ngo, Birju Mehta, Gianpietro Dotti, Paul R. Kinchington, Ann M. Leen, Claudia Rossig, Cliona M. Rooney

Clin Cancer Res (2017) 23 (14): 3499–3509.

https://doi.org/10.1158/1078-0432.CCR-16-2138

Published: 13 July 2017

View article titled, Vaccination Targeting Native Receptors to Enhance the Function and Proliferation of Chimeric Antigen Receptor (CAR)-Modified T Cells

Includes: Supplementary data

Journal Articles

K562-Derived Whole-Cell Vaccine Enhances Antitumor Responses of CAR-Redirected Virus-Specific Cytotoxic T Lymphocytes In Vivo

Ignazio Caruana, Gerrit Weber, Brandon C. Ballard, Michael S. Wood, Barbara Savoldo, Gianpietro Dotti

Clin Cancer Res (2015) 21 (13): 2952–2962.

https://doi.org/10.1158/1078-0432.CCR-14-2998

Published: 30 June 2015

View article titled, K562-Derived Whole-Cell Vaccine Enhances Antitumor Responses of CAR-Redirected Virus-Specific Cytotoxic T Lymphocytes In Vivo

Includes: Supplementary data

Journal Articles

T Lymphocytes Redirected against the Chondroitin Sulfate Proteoglycan-4 Control the Growth of Multiple Solid Tumors both In Vitro and In Vivo

Claudia Geldres, Barbara Savoldo, Valentina Hoyos, Ignazio Caruana, Ming Zhang, Eric Yvon, Michele Del Vecchio, Chad J. Creighton, Michael Ittmann, Soldano Ferrone, Gianpietro Dotti

Clin Cancer Res (2014) 20 (4): 962–971.

https://doi.org/10.1158/1078-0432.CCR-13-2218

Published: 16 February 2014

View article titled, T Lymphocytes Redirected against the Chondroitin Sulfate Proteoglycan-4 Control the Growth of Multiple Solid Tumors both In Vitro and In Vivo

Includes: Supplementary data

Journal Articles

Interleukin-7 Mediates Selective Expansion of Tumor-redirected Cytotoxic T Lymphocytes (CTLs) without Enhancement of Regulatory T-cell Inhibition

Serena K. Perna, Daria Pagliara, Aruna Mahendravada, Hao Liu, Malcolm K. Brenner, Barbara Savoldo, Gianpietro Dotti

Clin Cancer Res (2014) 20 (1): 131–139.

https://doi.org/10.1158/1078-0432.CCR-13-1016

Published: 05 January 2014

View article titled, Interleukin-7 Mediates Selective Expansion of Tumor-redirected Cytotoxic T Lymphocytes (CTLs) without Enhancement of Regulatory T-cell Inhibition

Includes: Supplementary data

Journal Articles

Interleukin 15 Provides Relief to CTLs from Regulatory T Cell–Mediated Inhibition: Implications for Adoptive T Cell–Based Therapies for Lymphoma

Serena K. Perna, Biagio De Angelis, Daria Pagliara, Sayyeda T. Hasan, Lan Zhang, Aruna Mahendravada, Helen E. Heslop, Malcolm K. Brenner, Cliona M. Rooney, Gianpietro Dotti, Barbara Savoldo

Clin Cancer Res (2013) 19 (1): 106–117.

https://doi.org/10.1158/1078-0432.CCR-12-2143

Published: 02 January 2013

View article titled, Interleukin 15 Provides Relief to CTLs from Regulatory T Cell–Mediated Inhibition: Implications for Adoptive T Cell–Based Therapies for Lymphoma

Includes: Supplementary data

Journal Articles

Immunotherapy of Metastatic Melanoma Using Genetically Engineered GD2-Specific T cells

Eric Yvon, Michele Del Vecchio, Barbara Savoldo, Valentina Hoyos, Aurélie Dutour, Andrea Anichini, Gianpietro Dotti, Malcolm K. Brenner

Clin Cancer Res (2009) 15 (18): 5852–5860.

https://doi.org/10.1158/1078-0432.CCR-08-3163

Published: 14 September 2009

View article titled, Immunotherapy of Metastatic Melanoma Using Genetically Engineered GD2-Specific T cells

Includes: Supplementary data

Journal Articles

Responses to Human CD40 Ligand/Human Interleukin-2 Autologous Cell Vaccine in Patients with B-Cell Chronic Lymphocytic Leukemia

Ettore Biagi, Raphael Rousseau, Eric Yvon, Mary Schwartz, Gianpietro Dotti, Aaron Foster, Diana Havlik-Cooper, Bambi Grilley, Adrian Gee, Kelty Baker, George Carrum, Lawrence Rice, Michael Andreeff, Uday Popat, Malcolm Brenner

Clin Cancer Res (2005) 11 (19): 6916–6923.

https://doi.org/10.1158/1078-0432.CCR-05-0484

Published: 03 October 2005

View article titled, Responses to Human CD40 Ligand/Human Interleukin-2 Autologous Cell Vaccine in Patients with B-Cell Chronic Lymphocytic Leukemia

NARROW

CAR T cells Targeting Human Immunoglobulin Light Chains Eradicate Mature B-cell Malignancies While Sparing a Subset of Normal B Cells

Preclinical Evaluation of B7-H3–specific Chimeric Antigen Receptor T Cells for the Treatment of Acute Myeloid Leukemia

CSPG4-Specific CAR.CIK Lymphocytes as a Novel Therapy for the Treatment of Multiple Soft-Tissue Sarcoma Histotypes

Enhancing Chimeric Antigen Receptor T-Cell Efficacy in Solid Tumors

T-Cell Receptor Stimulation Enhances the Expansion and Function of CD19 Chimeric Antigen Receptor–Expressing T Cells

NKT Cells Coexpressing a GD2-Specific Chimeric Antigen Receptor and IL15 Show Enhanced In Vivo Persistence and Antitumor Activity against Neuroblastoma

Eradication of Neuroblastoma by T Cells Redirected with an Optimized GD2-Specific Chimeric Antigen Receptor and Interleukin-15

A Phase I/IIa Trial Using CD19-Targeted Third-Generation CAR T Cells for Lymphoma and Leukemia

T-cell Homing Therapy for Reducing Regulatory T Cells and Preserving Effector T-cell Function in Large Solid Tumors

Vaccination Targeting Native Receptors to Enhance the Function and Proliferation of Chimeric Antigen Receptor (CAR)-Modified T Cells

K562-Derived Whole-Cell Vaccine Enhances Antitumor Responses of CAR-Redirected Virus-Specific Cytotoxic T Lymphocytes In Vivo

T Lymphocytes Redirected against the Chondroitin Sulfate Proteoglycan-4 Control the Growth of Multiple Solid Tumors both In Vitro and In Vivo

Interleukin-7 Mediates Selective Expansion of Tumor-redirected Cytotoxic T Lymphocytes (CTLs) without Enhancement of Regulatory T-cell Inhibition

Interleukin 15 Provides Relief to CTLs from Regulatory T Cell–Mediated Inhibition: Implications for Adoptive T Cell–Based Therapies for Lymphoma

Immunotherapy of Metastatic Melanoma Using Genetically Engineered GD2-Specific T cells

Responses to Human CD40 Ligand/Human Interleukin-2 Autologous Cell Vaccine in Patients with B-Cell Chronic Lymphocytic Leukemia

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