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Giampaolo Tortora
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Journal Articles

Sex-Based Dimorphism of Anticancer Immune Response and Molecular Mechanisms of Immune Evasion

Fabio Conforti, Laura Pala, Eleonora Pagan, Vincenzo Bagnardi, Tommaso De Pas, Paola Queirolo, Elisabetta Pennacchioli, Chiara Catania, Emilia Cocorocchio, Pier Francesco Ferrucci, Maristella Saponara, Gianmarco Orsolini, Paola Zagami, Eleonora Nicoló, Filippo De Marinis, Giampaolo Tortora, Emilio Bria, Saverio Minucci, Hadine Joffe, Paolo Veronesi, Jennifer Wargo, Rachel Rosenthal, Charles Swanton, Alberto Mantovani, Richard D. Gelber, Giuseppe Viale, Aron Goldhirsch, Giuseppe Giaccone
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (15): 4311–4324.
https://doi.org/10.1158/1078-0432.CCR-21-0136
Published: 01 August 2021
View article titled, Sex-Based Dimorphism of Anticancer Immune Response and Molecular Mechanisms of Immune Evasion
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Includes: Supplementary data
Journal Articles

Homeobox B9 Mediates Resistance to Anti-VEGF Therapy in Colorectal Cancer Patients

Carmine Carbone, Geny Piro, Francesca Simionato, Francesca Ligorio, Chiara Cremolini, Fotios Loupakis, Greta Alì, Daniele Rossini, Valeria Merz, Raffaela Santoro, Camilla Zecchetto, Marco Zanotto, Federica Di Nicolantonio, Alberto Bardelli, Gabriella Fontanini, Giampaolo Tortora, Davide Melisi
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (15): 4312–4322.
https://doi.org/10.1158/1078-0432.CCR-16-3153
Published: 01 August 2017
View article titled, Homeobox B9 Mediates Resistance to Anti-VEGF Therapy in Colorectal Cancer Patients
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Includes: Supplementary data
Journal Articles

An FGFR3 Autocrine Loop Sustains Acquired Resistance to Trastuzumab in Gastric Cancer Patients

Geny Piro, Carmine Carbone, Ivana Cataldo, Federica Di Nicolantonio, Simone Giacopuzzi, Giuseppe Aprile, Francesca Simionato, Federico Boschi, Marco Zanotto, Maria Mihaela Mina, Raffaela Santoro, Valeria Merz, Andrea Sbarbati, Giovanni de Manzoni, Aldo Scarpa, Giampaolo Tortora, Davide Melisi
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (24): 6164–6175.
https://doi.org/10.1158/1078-0432.CCR-16-0178
Published: 15 December 2016
View article titled, An FGFR3 Autocrine Loop Sustains Acquired Resistance to Trastuzumab in Gastric Cancer Patients
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Includes: Supplementary data
Journal Articles

Abstract 26: Biomarker analysis of a male breast cancer patient with prolonged stable disease under mTOR/PI3K inhibitors BEZ235/RAD001

A. Rose Brannron, Davide Melisi, Jennifer Hummel, Carmine Carbone, Melissa Frizziero, Wing Cheung, Parul Patel, Jorge Gallo, Giampaolo Tortora, Michael Morrissey, David Chen
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (1_Supplement): 26.
https://doi.org/10.1158/1557-3265.PMSCLINGEN15-26
Published: 03 January 2016
View article titled, Abstract 26: Biomarker analysis of a male breast cancer patient with prolonged stable disease under mTOR/PI3K inhibitors BEZ235/RAD001
Journal Articles

Toll-like Receptor 9 Agonist IMO Cooperates with Cetuximab in K-Ras Mutant Colorectal and Pancreatic Cancers

Roberta Rosa, Davide Melisi, Vincenzo Damiano, Roberto Bianco, Sonia Garofalo, Teresa Gelardi, Sudhir Agrawal, Federica Di Nicolantonio, Aldo Scarpa, Alberto Bardelli, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (20): 6531–6541.
https://doi.org/10.1158/1078-0432.CCR-10-3376
Published: 14 October 2011
View article titled, Toll-like Receptor 9 Agonist IMO Cooperates with Cetuximab in <em>K</em>-<em>Ras</em> Mutant Colorectal and Pancreatic Cancers
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Includes: Supplementary data
Journal Articles

A Novel Toll-Like Receptor 9 Agonist Cooperates with Trastuzumab in Trastuzumab-Resistant Breast Tumors through Multiple Mechanisms of Action

Vincenzo Damiano, Sonia Garofalo, Roberta Rosa, Roberto Bianco, Rosa Caputo, Teresa Gelardi, Gerardina Merola, Luigi Racioppi, Corrado Garbi, Ekambar R. Kandimalla, Sudhir Agrawal, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (22): 6921–6930.
https://doi.org/10.1158/1078-0432.CCR-09-1599
Published: 11 November 2009
View article titled, A Novel Toll-Like Receptor 9 Agonist Cooperates with Trastuzumab in Trastuzumab-Resistant Breast Tumors through Multiple Mechanisms of Action
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Journal Articles

Gefitinib Induction of In vivo Detectable Signals by Bcl-2/Bcl-xL Modulation of Inositol Trisphosphate Receptor Type 3

Antonella Zannetti, Francesca Iommelli, Rosa Fonti, Angela Papaccioli, Jvana Sommella, Anna Lettieri, Giuseppe Pirozzi, Roberto Bianco, Giampaolo Tortora, Marco Salvatore, Silvana Del Vecchio
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (16): 5209–5219.
https://doi.org/10.1158/1078-0432.CCR-08-0374
Published: 12 August 2008
View article titled, Gefitinib Induction of <em>In vivo</em> Detectable Signals by Bcl-2/Bcl-x<sub>L</sub> Modulation of Inositol Trisphosphate Receptor Type 3
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Journal Articles

Vascular Endothelial Growth Factor Receptor-1 Contributes to Resistance to Anti–Epidermal Growth Factor Receptor Drugs in Human Cancer Cells

Roberto Bianco, Roberta Rosa, Vincenzo Damiano, Gennaro Daniele, Teresa Gelardi, Sonia Garofalo, Valeria Tarallo, Sandro De Falco, Davide Melisi, Roberto Benelli, Adriana Albini, Anderson Ryan, Fortunato Ciardiello, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (16): 5069–5080.
https://doi.org/10.1158/1078-0432.CCR-07-4905
Published: 12 August 2008
View article titled, Vascular Endothelial Growth Factor Receptor-1 Contributes to Resistance to Anti–Epidermal Growth Factor Receptor Drugs in Human Cancer Cells
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Includes: Supplementary data
Journal Articles

Synergistic Antitumor Activity of ZD6474, An Inhibitor of Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor Signaling, with Gemcitabine and Ionizing Radiation against Pancreatic Cancer

Cataldo Bianco, Elisa Giovannetti, Fortunato Ciardiello, Valentina Mey, Sara Nannizzi, Giampaolo Tortora, Teresa Troiani, Francesco Pasqualetti, Gail Eckhardt, Mario de Liguoro, Simona Ricciardi, Mario Del Tacca, David Raben, Luca Cionini, Romano Danesi
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (23): 7099–7107.
https://doi.org/10.1158/1078-0432.CCR-06-0833
Published: 04 December 2006
View article titled, Synergistic Antitumor Activity of ZD6474, An Inhibitor of Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor Signaling, with Gemcitabine and Ionizing Radiation against Pancreatic Cancer
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Journal Articles

Novel Toll-Like Receptor 9 Agonist Induces Epidermal Growth Factor Receptor (EGFR) Inhibition and Synergistic Antitumor Activity with EGFR Inhibitors

Vincenzo Damiano, Rosa Caputo, Roberto Bianco, Francesco P. D'Armiento, Antonio Leonardi, Sabino De Placido, A. Raffaele Bianco, Sudhir Agrawal, Fortunato Ciardiello, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (2): 577–583.
https://doi.org/10.1158/1078-0432.CCR-05-1943
Published: 20 January 2006
View article titled, Novel Toll-Like Receptor 9 Agonist Induces Epidermal Growth Factor Receptor (EGFR) Inhibition and Synergistic Antitumor Activity with EGFR Inhibitors
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Journal Articles

Cooperative Antitumor Effect of Multitargeted Kinase Inhibitor ZD6474 and Ionizing Radiation in Glioblastoma

Vincenzo Damiano, Davide Melisi, Cataldo Bianco, David Raben, Rosa Caputo, Gabriella Fontanini, Roberto Bianco, Anderson Ryan, A. Raffaele Bianco, Sabino De Placido, Fortunato Ciardiello, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (15): 5639–5644.
https://doi.org/10.1158/1078-0432.CCR-05-0174
Published: 01 August 2005
View article titled, Cooperative Antitumor Effect of Multitargeted Kinase Inhibitor ZD6474 and Ionizing Radiation in Glioblastoma
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Journal Articles

A Meta-Analysis on the Interaction between HER-2 Expression and Response to Endocrine Treatment in Advanced Breast Cancer

Michele De Laurentiis, Grazia Arpino, Erminia Massarelli, Angela Ruggiero, Chiara Carlomagno, Fortunato Ciardiello, Giampaolo Tortora, Diego D'Agostino, Francesca Caputo, Giuseppe Cancello, Emilia Montagna, Luca Malorni, Luigia Zinno, Rossella Lauria, Angelo Raffaele Bianco, Sabino De Placido
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (13): 4741–4748.
https://doi.org/10.1158/1078-0432.CCR-04-2569
Published: 06 July 2005
View article titled, A Meta-Analysis on the Interaction between HER-2 Expression and Response to Endocrine Treatment in Advanced Breast Cancer
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Journal Articles

Antitumor Activity of ZD6474, a Vascular Endothelial Growth Factor-2 and Epidermal Growth Factor Receptor Small Molecule Tyrosine Kinase Inhibitor, in Combination with SC-236, a Cyclooxygenase-2 Inhibitor

Concetta Tuccillo, Marco Romano, Teresa Troiani, Erika Martinelli, Floriana Morgillo, Ferdinando De Vita, Roberto Bianco, Gabriella Fontanini, Raffaele A. Bianco, Giampaolo Tortora, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (3): 1268–1276.
https://doi.org/10.1158/1078-0432.1268.11.3
Published: 11 February 2005
View article titled, Antitumor Activity of ZD6474, a Vascular Endothelial Growth Factor-2 and Epidermal Growth Factor Receptor Small Molecule Tyrosine Kinase Inhibitor, in Combination with SC-236, a Cyclooxygenase-2 Inhibitor
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Journal Articles

Combined Targeting of Epidermal Growth Factor Receptor and MDM2 by Gefitinib and Antisense MDM2 Cooperatively Inhibit Hormone-Independent Prostate Cancer

Roberto Bianco, Roberta Caputo, Rosa Caputo, Vincenzo Damiano, Sabino De Placido, Corrado Ficorella, Sudhir Agrawal, A. Raffaele Bianco, Fortunato Ciardiello, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (14): 4858–4864.
https://doi.org/10.1158/1078-0432.CCR-03-0497
Published: 21 July 2004
View article titled, Combined Targeting of Epidermal Growth Factor Receptor and MDM2 by Gefitinib and Antisense MDM2 Cooperatively Inhibit Hormone-Independent Prostate Cancer
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Journal Articles

Antitumor Activity of ZD6474, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Human Cancer Cells with Acquired Resistance to Antiepidermal Growth Factor Receptor Therapy

Fortunato Ciardiello, Roberto Bianco, Roberta Caputo, Rosa Caputo, Vincenzo Damiano, Teresa Troiani, Davide Melisi, Ferdinando De Vita, Sabino De Placido, A. Raffaele Bianco, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (2): 784–793.
https://doi.org/10.1158/1078-0432.CCR-1100-03
Published: 03 February 2004
View article titled, Antitumor Activity of ZD6474, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Human Cancer Cells with Acquired Resistance to Antiepidermal Growth Factor Receptor Therapy
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Journal Articles

Helicobacter pylori VacA Toxin Up-Regulates Vascular Endothelial Growth Factor Expression in MKN 28 Gastric Cells through an Epidermal Growth Factor Receptor-, Cyclooxygenase-2-dependent Mechanism

Rosa Caputo, Concetta Tuccillo, Barbara A. Manzo, Raffaele Zarrilli, Giampaolo Tortora, Camillo Del Vecchio Blanco, Vittorio Ricci, Fortunato Ciardiello, Marco Romano
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (6): 2015–2021.
Published: 01 June 2003
View article titled, <em>Helicobacter pylori</em> VacA Toxin Up-Regulates Vascular Endothelial Growth Factor Expression in MKN 28 Gastric Cells through an Epidermal Growth Factor Receptor-, Cyclooxygenase-2-dependent Mechanism
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Journal Articles

Antitumor Effects of ZD6474, a Small Molecule Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, with Additional Activity against Epidermal Growth Factor Receptor Tyrosine Kinase

Fortunato Ciardiello, Rosa Caputo, Vincenzo Damiano, Roberta Caputo, Teresa Troiani, Donatella Vitagliano, Francesca Carlomagno, Bianca Maria Veneziani, Gabriella Fontanini, A. Raffaele Bianco, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (4): 1546–1556.
Published: 01 April 2003
View article titled, Antitumor Effects of ZD6474, a Small Molecule Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, with Additional Activity against Epidermal Growth Factor Receptor Tyrosine Kinase
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Journal Articles

Combination of a Selective Cyclooxygenase-2 Inhibitor with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 and Protein Kinase A Antisense Causes Cooperative Antitumor and Antiangiogenic Effect

Giampaolo Tortora, Rosa Caputo, Vincenzo Damiano, Davide Melisi, Roberto Bianco, Gabriella Fontanini, Bianca Maria Veneziani, Sabino De Placido, A. Raffaele Bianco, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (4): 1566–1572.
Published: 01 April 2003
View article titled, Combination of a Selective Cyclooxygenase-2 Inhibitor with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 and Protein Kinase A Antisense Causes Cooperative Antitumor and Antiangiogenic Effect
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Journal Articles

Combined Targeted Inhibition of bcl -2, bcl -XL, Epidermal Growth Factor Receptor, and Protein Kinase A Type I Causes Potent Antitumor, Apoptotic, and Antiangiogenic Activity

Giampaolo Tortora, Rosa Caputo, Vincenzo Damiano, Roberta Caputo, Teresa Troiani, Bianca Maria Veneziani, Sabino De Placido, Angelo Raffaele Bianco, Uwe Zangemeister-Wittke, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (2): 866–871.
Published: 01 February 2003
View article titled, Combined Targeted Inhibition of <em>bcl</em> -2, <em>bcl</em> -XL, Epidermal Growth Factor Receptor, and Protein Kinase A Type I Causes Potent Antitumor, Apoptotic, and Antiangiogenic Activity
Open the PDF for Combined Targeted Inhibition of <em>bcl</em> -2, <em>bcl</em> -XL, Epidermal Growth Factor Receptor, and Protein Kinase A Type I Causes Potent Antitumor, Apoptotic, and Antiangiogenic Activity in another window
Journal Articles

Expression of Epidermal Growth Factor Receptor Correlates with Disease Relapse and Progression to Androgen-independence in Human Prostate Cancer

Giuseppe Di Lorenzo, Giampaolo Tortora, Francesco P. D’Armiento, Gaetano De Rosa, Stefania Staibano, Riccardo Autorino, Massimo D’Armiento, Michele De Laurentiis, Sabino De Placido, Giuseppe Catalano, A. Raffaele Bianco, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (11): 3438–3444.
Published: 01 November 2002
View article titled, Expression of Epidermal Growth Factor Receptor Correlates with Disease Relapse and Progression to Androgen-independence in Human Prostate Cancer
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