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Journal Articles

Bevacizumab, Atezolizumab, and Acetylsalicylic Acid in Recurrent, Platinum-Resistant Ovarian Cancer: The EORTC 1508-GCG Phase II Study

Susana Banerjee, Eleonora Ghisoni, Anita Wolfer, Petronella Beatrix Ottevanger, Romuald Le Scodan, Apostolos Sarivalasis, Ana Montes, Judith Kroep, Margarita Romeo Marin, Petr Szturz, Matteo Morotti, Julien Dagher, Lana Kandalaft, Fernanda Herrera, Corneel Coens, Denarda Dangaj Laniti, George Coukos
Journal: Clinical Cancer Research
Clin Cancer Res OF1–OF9.
https://doi.org/10.1158/1078-0432.CCR-24-3368
Published: 11 April 2025
View articletitled, Bevacizumab, Atezolizumab, and Acetylsalicylic Acid in Recurrent, Platinum-Resistant Ovarian Cancer: The EORTC 1508-GCG Phase II Study
Open the PDF for Bevacizumab, Atezolizumab, and Acetylsalicylic Acid in Recurrent, Platinum-Resistant Ovarian Cancer: The EORTC 1508-GCG Phase II Study in another window
Includes: Supplementary data
Journal Articles

Trabectedin and Durvalumab Combination Is Feasible and Active in Relapsing Ovarian Cancer

Antonia Digklia, George Coukos, Krisztian Homicsko
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (9): 1745–1747.
https://doi.org/10.1158/1078-0432.CCR-21-4592
Published: 02 May 2022
View articletitled, Trabectedin and Durvalumab Combination Is Feasible and Active in Relapsing Ovarian Cancer
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Journal Articles

Abstract IA06: The Long-Term Ovarian Cancer Survivor Project: A Department of Defense initiative

Michael J. Birrer, Lari Wenzel, Austin Miller, Heather Lankes, Nilsa Ramirez, Giovanni Parmigiani, Samuel Mok, Kenneth Nephew, Thomas Conrads, George Coukos, George L. Maxwell, Giulia Fulci, Mary Scroggins
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13_Supplement): IA06.
https://doi.org/10.1158/1557-3265.OVCA19-IA06
Published: 01 July 2020
View articletitled, Abstract IA06: The Long-Term Ovarian Cancer Survivor Project: A Department of Defense initiative
Journal Articles

Abstract NT-099: NOVEL ANTIBODY DRUG CONJUGATE (ADC) AND COMPANION DIAGNOSTICS AGAINST CD248+ CANCER

Yi Guo, Yujue Wang, Xiaohui Peng, George Coukos, Chunsheng Li
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (22_Supplement): NT-099.
https://doi.org/10.1158/1557-3265.OVCASYMP18-NT-099
Published: 15 November 2019
View articletitled, Abstract NT-099: NOVEL ANTIBODY DRUG CONJUGATE (ADC) AND COMPANION DIAGNOSTICS AGAINST CD248+ CANCER
Journal Articles

High-throughput Screening of Human Tumor Antigen–specific CD4 T Cells, Including Neoantigen-reactive T Cells

Carla Costa-Nunes, Amélie Cachot, Sara Bobisse, Marion Arnaud, Raphael Genolet, Petra Baumgaertner, Daniel E. Speiser, Pedro M. Sousa Alves, Federico Sandoval, Olivier Adotévi, Walter Reith, Maria Pia Protti, George Coukos, Alexandre Harari, Pedro Romero, Camilla Jandus
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (14): 4320–4331.
https://doi.org/10.1158/1078-0432.CCR-18-1356
Published: 15 July 2019
View articletitled, High-throughput Screening of Human Tumor Antigen–specific CD4 T Cells, Including Neoantigen-reactive T Cells
Open the PDF for High-throughput Screening of Human Tumor Antigen–specific CD4 T Cells, Including Neoantigen-reactive T Cells in another window
Includes: Supplementary data
Journal Articles

Tumor Landscapes: β-Catenin Drives Immune Desertification

Denarda Dangaj, David Barras, George Coukos
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (10): 2943–2945.
https://doi.org/10.1158/1078-0432.CCR-19-0188
Published: 15 May 2019
View articletitled, Tumor Landscapes: β-Catenin Drives Immune Desertification
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Journal Articles

Integrative Development of a TLR8 Agonist for Ovarian Cancer Chemoimmunotherapy

Bradley J. Monk, Andrea Facciabene, William E. Brady, Carol A. Aghajanian, Paula M. Fracasso, Joan L. Walker, Heather A. Lankes, Kristi L. Manjarrez, Gwenn-äel H. Danet-Desnoyers, Katherine M. Bell-McGuinn, Carolyn K. McCourt, Alexander Malykhin, Robert M. Hershberg, George Coukos
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (8): 1955–1966.
https://doi.org/10.1158/1078-0432.CCR-16-1453
Published: 13 April 2017
View articletitled, Integrative Development of a TLR8 Agonist for Ovarian Cancer Chemoimmunotherapy
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Includes: Supplementary data
Journal Articles

Abstract AS27: VTX-2337, a TLR8 agonist, plus chemotherapy in recurrent ovarian cancer: preclinical and phase 1 data by the gynecologic oncology group

Bradley J. Monk, William E. Brady, Heather A. Lankes, Andrea Facciabene, Kristi L. Manjarrez, Robert M. Hershberg, Paula M. Fracasso, Katherine M. Bell-McGuinn, Joan L. Walker, Carolyn K. McCourt, Carol Aghajanian, George Coukos
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (16_Supplement): AS27.
https://doi.org/10.1158/1557-3265.OVCASYMP14-AS27
Published: 15 August 2015
View articletitled, Abstract AS27: VTX-2337, a TLR8 agonist, plus chemotherapy in recurrent ovarian cancer: preclinical and phase 1 data by the gynecologic oncology group
Journal Articles

The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28–Costimulated T Cells Prepared for Adoptive Therapy

Emese Zsiros, Priyanka Duttagupta, Denarda Dangaj, Hongzhe Li, Renee Frank, Thomas Garrabrant, Ian S. Hagemann, Bruce L. Levine, Carl H. June, Lin Zhang, Ena Wang, Francesco M. Marincola, Davide Bedognetti, Daniel J. Powell, Jr, Janos Tanyi, Michael D. Feldman, Lana E. Kandalaft, George Coukos
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (12): 2840–2850.
https://doi.org/10.1158/1078-0432.CCR-14-2777
Published: 14 June 2015
View articletitled, The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28–Costimulated T Cells Prepared for Adoptive Therapy
Open the PDF for The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28–Costimulated T Cells Prepared for Adoptive Therapy in another window
Includes: Supplementary data
Journal Articles

In vivo modeling and detection of the ovarian cancer vascular marker TEM1

Chunsheng Li, Jennifer Swails, Kosei Hasegawa, Ann O'brien-Jenkins, Yvette Liu, Wafik El-Deiry, Nathalie Scholler, Chaitanya Divgi, Phyllis Gimotty, George Coukos
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (19_Supplement): A19.
Published: 15 August 2014
View articletitled, In vivo modeling and detection of the ovarian cancer vascular marker TEM1
Journal Articles

miRNome integrative analysis in ovarian cancer

Lin Zhang, Stefano Volinia, Tomas Bonome, George Adrian Calin, Nuo Yang, Vassilis Atlamazoglou, Chang-Gong Liu, Antonis Giannakakis, Joel Greshock, Barbara Weber, Michael Birrer, Artemis Hatzigeorgiou, Carlo Croce, George Coukos
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (19_Supplement): ED02-02.
Published: 15 August 2014
View articletitled, miRNome integrative analysis in ovarian cancer
Journal Articles

Abstract IA27: Combinatorial immunotherapy using whole tumor antigen: Evidence from phase I trials

Lana E. Kandalaft, Janos Tanyi, Cheryl Chiang, George Coukos
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (19_Supplement): IA27.
https://doi.org/10.1158/1078-0432.OVCA13-IA27
Published: 13 May 2014
View articletitled, Abstract IA27: Combinatorial immunotherapy using whole tumor antigen: Evidence from phase I trials
Journal Articles

Abstract IA25: Immunotherapy opportunities and challenges in ovarian cancer

George Coukos
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (19_Supplement): IA25.
https://doi.org/10.1158/1078-0432.OVCA13-IA25
Published: 13 May 2014
View articletitled, Abstract IA25: Immunotherapy opportunities and challenges in ovarian cancer
Journal Articles

Abstract B68: Targeted theranostics of tumor vasculature by multivalent scFv constructs against TEM1

Chunsheng Li, Jia Hu, Ann Marie Chacko, Junying Wang, Aizhi Zhao, Xingmei Duan, Vladimir Muzykantov, George Coukos
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (19_Supplement): B68.
https://doi.org/10.1158/1078-0432.OVCA13-B68
Published: 13 May 2014
View articletitled, Abstract B68: Targeted theranostics of tumor vasculature by multivalent scFv constructs against TEM1
Journal Articles

CD137 Accurately Identifies and Enriches for Naturally Occurring Tumor-Reactive T Cells in Tumor

Qunrui Ye, De-Gang Song, Mathilde Poussin, Tori Yamamoto, Andrew Best, Chunsheng Li, George Coukos, Daniel J. Powell, Jr.
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (1): 44–55.
https://doi.org/10.1158/1078-0432.CCR-13-0945
Published: 05 January 2014
View articletitled, CD137 Accurately Identifies and Enriches for Naturally Occurring Tumor-Reactive T Cells in Tumor
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Includes: Supplementary data
Journal Articles

A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside

Cheryl Lai-Lai Chiang, Lana E. Kandalaft, Janos Tanyi, Andrea R. Hagemann, Gregory T. Motz, Nikolaos Svoronos, Kathleen Montone, Gina M. Mantia-Smaldone, Lori Smith, Harvey L. Nisenbaum, Bruce L. Levine, Michael Kalos, Brian J. Czerniecki, Drew A. Torigian, Daniel J. Powell, Jr, Rosemarie Mick, George Coukos
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (17): 4801–4815.
https://doi.org/10.1158/1078-0432.CCR-13-1185
Published: 02 September 2013
View articletitled, A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside
Open the PDF for A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside in another window
Includes: Supplementary data
Journal Articles

TIE-2 and VEGFR Kinase Activities Drive Immunosuppressive Function of TIE-2–Expressing Monocytes in Human Breast Tumors

Mark Ibberson, Sylvian Bron, Nicolas Guex, Eveline Faes-van't Hull, Assia Ifticene-Treboux, Luc Henry, Hans-Anton Lehr, Jean-François Delaloye, George Coukos, Ioannis Xenarios, Marie-Agnès Doucey
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (13): 3439–3449.
https://doi.org/10.1158/1078-0432.CCR-12-3181
Published: 30 June 2013
View articletitled, TIE-2 and VEGFR Kinase Activities Drive Immunosuppressive Function of TIE-2–Expressing Monocytes in Human Breast Tumors
Open the PDF for TIE-2 and VEGFR Kinase Activities Drive Immunosuppressive Function of TIE-2–Expressing Monocytes in Human Breast Tumors in another window
Includes: Supplementary data
Journal Articles

Endothelin B Receptor, a New Target in Cancer Immune Therapy

Lana E. Kandalaft, Andrea Facciabene, Ron J. Buckanovich, George Coukos
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (14): 4521–4528.
https://doi.org/10.1158/1078-0432.CCR-08-0543
Published: 15 July 2009
View articletitled, Endothelin B Receptor, a New Target in Cancer Immune Therapy
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Journal Articles

Ovarian Cancer Early Detection Claims Are Biased

Martin McIntosh, Garnet Anderson, Charles Drescher, Samir Hanash, Nicole Urban, Pat Brown, Sanjiv Sam Gambhir, George Coukos, Peter W. Laird, Brad Nelson, Chana Palmer
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (22): 7574.
https://doi.org/10.1158/1078-0432.CCR-08-0623
Published: 14 November 2008
View articletitled, Ovarian Cancer Early Detection Claims Are Biased
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Journal Articles

Integrative Genomic Analysis of Phosphatidylinositol 3′-Kinase Family Identifies PIK3R3 as a Potential Therapeutic Target in Epithelial Ovarian Cancer

Lin Zhang, Jia Huang, Nuo Yang, Joel Greshock, Shun Liang, Kosei Hasegawa, Antonis Giannakakis, Nikolaos Poulos, Ann O'Brien-Jenkins, Dionyssios Katsaros, Ralf Butzow, Barbara L. Weber, George Coukos
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (18): 5314–5321.
https://doi.org/10.1158/1078-0432.CCR-06-2660
Published: 17 September 2007
View articletitled, Integrative Genomic Analysis of Phosphatidylinositol 3′-Kinase Family Identifies PIK3R3 as a Potential Therapeutic Target in Epithelial Ovarian Cancer
Open the PDF for Integrative Genomic Analysis of Phosphatidylinositol 3′-Kinase Family Identifies PIK3R3 as a Potential Therapeutic Target in Epithelial Ovarian Cancer in another window