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Gene P. Siegal
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Journal Articles

A Phase I Clinical Trial of Ad5.SSTR/TK.RGD, a Novel Infectivity-Enhanced Bicistronic Adenovirus, in Patients with Recurrent Gynecologic Cancer

Kenneth H. Kim, Igor Dmitriev, Janis P. O'Malley, Minghui Wang, Souheil Saddekni, Zhiying You, Meredith A. Preuss, Raymond D. Harris, Rosemarie Aurigemma, Gene P. Siegal, Kurt R. Zinn, David T. Curiel, Ronald D. Alvarez
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (12): 3440–3451.
https://doi.org/10.1158/1078-0432.CCR-11-2852
Published: 14 June 2012
View article titled, A Phase I Clinical Trial of Ad5.SSTR/TK.RGD, a Novel Infectivity-Enhanced Bicistronic Adenovirus, in Patients with Recurrent Gynecologic Cancer
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Includes: Supplementary data
Journal Articles

Conditionally Replicating Adenovirus Expressing TIMP2 for Ovarian Cancer Therapy

Sherry W. Yang, James J. Cody, Angel A. Rivera, Reinhard Waehler, Minghui Wang, Kristopher J. Kimball, Ronald A. Alvarez, Gene P. Siegal, Joanne T. Douglas, Selvarangan Ponnazhagan
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (3): 538–549.
https://doi.org/10.1158/1078-0432.CCR-10-1628
Published: 01 February 2011
View article titled, Conditionally Replicating Adenovirus Expressing TIMP2 for Ovarian Cancer Therapy
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Journal Articles

A Phase I Study of a Tropism-Modified Conditionally Replicative Adenovirus for Recurrent Malignant Gynecologic Diseases

Kristopher J. Kimball, Meredith A. Preuss, Mack N. Barnes, Minghui Wang, Gene P. Siegal, Wen Wan, Huichien Kuo, Souheil Saddekni, Cecil R. Stockard, William E. Grizzle, Raymond D. Harris, Rosemarie Aurigemma, David T. Curiel, Ronald D. Alvarez
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (21): 5277–5287.
https://doi.org/10.1158/1078-0432.CCR-10-0791
Published: 31 October 2010
View article titled, A Phase I Study of a Tropism-Modified Conditionally Replicative Adenovirus for Recurrent Malignant Gynecologic Diseases
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Journal Articles

Therapeutic Potential of Adult Bone Marrow–Derived Mesenchymal Stem Cells in Prostate Cancer Bone Metastasis

Diptiman Chanda, Tatyana Isayeva, Sanjay Kumar, Jonathan A. Hensel, Anandi Sawant, Girish Ramaswamy, Gene P. Siegal, Matthew S. Beatty, Selvarangan Ponnazhagan
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (23): 7175–7185.
https://doi.org/10.1158/1078-0432.CCR-09-1938
Published: 30 November 2009
View article titled, Therapeutic Potential of Adult Bone Marrow–Derived Mesenchymal Stem Cells in Prostate Cancer Bone Metastasis
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Includes: Supplementary data
Journal Articles

Identifying the Safety Profile of Ad5.SSTR/TK.RGD, a Novel Infectivity-Enhanced Bicistronic Adenovirus, in Anticipation of a Phase I Clinical Trial in Patients with Recurrent Ovarian Cancer

Kellie Matthews, Patricia E. Noker, Baohong Tian, Sheila D. Grimes, Ronna Fulton, Karen Schweikart, Raymond Harris, Rose Aurigemma, Minghui Wang, Mack N. Barnes, Gene P. Siegal, Akseli Hemminki, Kurt Zinn, David T. Curiel, Ronald D. Alvarez
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (12): 4131–4137.
https://doi.org/10.1158/1078-0432.CCR-08-3354
Published: 15 June 2009
View article titled, Identifying the Safety Profile of Ad5.SSTR/TK.RGD, a Novel Infectivity-Enhanced Bicistronic Adenovirus, in Anticipation of a Phase I Clinical Trial in Patients with Recurrent Ovarian Cancer
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Journal Articles

Silencing of Transforming Growth Factor-β1 In situ by RNA Interference for Breast Cancer: Implications for Proliferation and Migration In vitro and Metastasis In vivo

Lakisha D. Moore, Tatyana Isayeva, Gene P. Siegal, Selvarangan Ponnazhagan
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (15): 4961–4970.
https://doi.org/10.1158/1078-0432.CCR-07-4604
Published: 01 August 2008
View article titled, Silencing of Transforming Growth Factor-β1 <em>In situ</em> by RNA Interference for Breast Cancer: Implications for Proliferation and Migration <em>In vitro</em> and Metastasis <em>In vivo</em>
Open the PDF for Silencing of Transforming Growth Factor-β1 <em>In situ</em> by RNA Interference for Breast Cancer: Implications for Proliferation and Migration <em>In vitro</em> and Metastasis <em>In vivo</em> in another window
Includes: Supplementary data
Journal Articles

A Fiber-Modified Mesothelin Promoter–Based Conditionally Replicating Adenovirus for Treatment of Ovarian Cancer

Yuko Tsuruta, Larisa Pereboeva, Martina Breidenbach, Daniel T. Rein, Minghui Wang, Ronald D. Alvarez, Gene P. Siegal, Paul Dent, Paul B. Fisher, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (11): 3582–3588.
https://doi.org/10.1158/1078-0432.CCR-07-5053
Published: 02 June 2008
View article titled, A Fiber-Modified Mesothelin Promoter–Based Conditionally Replicating Adenovirus for Treatment of Ovarian Cancer
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Journal Articles

A Mosaic Fiber Adenovirus Serotype 5 Vector Containing Reovirus σ1 and Adenovirus Serotype 3 Knob Fibers Increases Transduction in an Ovarian Cancer Ex vivo System via a Coxsackie and Adenovirus Receptor–Independent Pathway

Yuko Tsuruta, Larisa Pereboeva, Joel N. Glasgow, Daniel T. Rein, Yosuke Kawakami, Ronald D. Alvarez, Rodney P. Rocconi, Gene P. Siegal, Paul Dent, Paul B. Fisher, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (9): 2777–2783.
https://doi.org/10.1158/1078-0432.CCR-06-2706
Published: 01 May 2007
View article titled, A Mosaic Fiber Adenovirus Serotype 5 Vector Containing Reovirus σ1 and Adenovirus Serotype 3 Knob Fibers Increases Transduction in an Ovarian Cancer <em>Ex vivo</em> System via a Coxsackie and Adenovirus Receptor–Independent Pathway
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Journal Articles

A Fiber-Modified, Secretory Leukoprotease Inhibitor Promoter-Based Conditionally Replicating Adenovirus for Treatment of Ovarian Cancer

Daniel T. Rein, Martina Breidenbach, Tyler O. Kirby, Tie Han, Gene P. Siegal, Gerd J. Bauerschmitz, Minghui Wang, Dirk M. Nettelbeck, Yuko Tsuruta, Masato Yamamoto, Peter Dall, Akseli Hemminki, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (3): 1327–1335.
https://doi.org/10.1158/1078-0432.1327.11.3
Published: 11 February 2005
View article titled, A Fiber-Modified, Secretory Leukoprotease Inhibitor Promoter-Based Conditionally Replicating Adenovirus for Treatment of Ovarian Cancer
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Journal Articles

Intravenous Delivery of Adenovirus-mediated Soluble FLT-1 Results in Liver Toxicity

Parameshwar J. Mahasreshti, Manjula Kataram, Ming H. Wang, Cecil R. Stockard, William E. Grizzle, Delicia Carey, Gene P. Siegal, Hidde J. Haisma, Ronald D. Alvarez, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (7): 2701–2710.
Published: 01 July 2003
View article titled, Intravenous Delivery of Adenovirus-mediated Soluble FLT-1 Results in Liver Toxicity
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Journal Articles

Strategies to Accomplish Targeted Expression of Transgenes in Ovarian Cancer for Molecular Therapeutic Applications

Enrique Casado, Jesus Gomez-Navarro, Masato Yamamoto, Yasuo Adachi, Candace J. Coolidge, Waleed O. Arafat, Shannon D. Barker, Minghui H. Wang, Parameshwar J. Mahasreshti, Akseli Hemminki, Manuel Gonzalez-Baron, Mack N. Barnes, Terri B. Pustilnik, Gene P. Siegal, Ronald D. Alvarez, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (8): 2496–2504.
Published: 01 August 2001
View article titled, Strategies to Accomplish Targeted Expression of Transgenes in Ovarian Cancer for Molecular Therapeutic Applications
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Journal Articles

Adenovirus-mediated Soluble FLT-1 Gene Therapy for Ovarian Carcinoma

Parameshwar J. Mahasreshti, Jesus G. Navarro, Manjula Kataram, Ming H. Wang, Delicia Carey, Gene P. Siegal, Mack N. Barnes, Dirk M. Nettelbeck, Ronald D. Alvarez, Akseli Hemminki, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (7): 2057–2066.
Published: 01 July 2001
View article titled, Adenovirus-mediated Soluble FLT-1 Gene Therapy for Ovarian Carcinoma
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Journal Articles

Genetically Modified CD34+ Cells Exert a Cytotoxic Bystander Effect on Human Endothelial and Cancer Cells

Waleed O. Arafat, Enrique Casado, Minghui Wang, Ronald D. Alvarez, Gene P. Siegal, Joseph C. Glorioso, David T. Curiel, Jesús Gómez-Navarro
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (11): 4442–4448.
Published: 01 November 2000
View article titled, Genetically Modified CD34<sup>+</sup> Cells Exert a Cytotoxic Bystander Effect on Human Endothelial and Cancer Cells
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Journal Articles

A Cancer Gene Therapy Approach Utilizing an Anti-erbB-2 Single-Chain Antibody-encoding Adenovirus (AD21): A Phase I Trial

Ronald D. Alvarez, Mack N. Barnes, Jesus Gomez-Navarro, Minghui Wang, Theresa V. Strong, Waleed Arafat, Ramin B. Arani, Martin R. Johnson, Bruce L. Roberts, Gene P. Siegal, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (8): 3081–3087.
Published: 01 August 2000
View article titled, A Cancer Gene Therapy Approach Utilizing an Anti-erbB-2 Single-Chain Antibody-encoding Adenovirus (AD21): A Phase I Trial
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Journal Articles

Interleukin-6 Modulated Conditionally Replicative Adenovirus as an Antitumor/Cytotoxic Agent for Cancer Therapy

Claudine Rancourt, Alain Piché, Jesús Gomez-Navarro, Minghui Wang, Ronald D. Alvarez, Gene P. Siegal, Gerald M. Fuller, Simon A. Jones, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (1): 43–50.
Published: 01 January 1999
View article titled, Interleukin-6 Modulated Conditionally Replicative Adenovirus as an Antitumor/Cytotoxic Agent for Cancer Therapy
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