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Journal Articles

Antibody–Drug Conjugates in Non–Small Cell Lung Cancer: Where Are the Target and the Biomarker?

Fred R. Hirsch

Clin Cancer Res (2025) 31 (13): 2550–2551.

https://doi.org/10.1158/1078-0432.CCR-25-0839

Published: 01 July 2025

View articletitled, Antibody–Drug Conjugates in Non–Small Cell Lung Cancer: Where Are the Target and the Biomarker?

Journal Articles

Elevated ctDNA Tumor Fraction Is Associated with Improved Mutation Detection but Worse Overall Survival in Advanced Non-Small Cell Lung Cancer: a Lung-MAP Study

Clin Cancer Res (2025)

https://doi.org/10.1158/1078-0432.CCR-24-3658

Published: 04 June 2025

View articletitled, Elevated ctDNA Tumor Fraction Is Associated with Improved Mutation Detection but Worse Overall Survival in Advanced Non-Small Cell Lung Cancer: a Lung-MAP Study

Includes: Supplementary data

Journal Articles

Circulating Tumor DNA Kinetics Predict Progression-Free and Overall Survival in EGFR TKI–Treated Patients with EGFR-Mutant NSCLC (SWOG S1403)

Philip C. Mack, Jieling Miao, Mary W. Redman, James Moon, Sarah B. Goldberg, Roy S. Herbst, Mary Ann Melnick, Zenta Walther, Fred R. Hirsch, Katerina Politi, Karen Kelly, David R. Gandara

Clin Cancer Res (2022) 28 (17): 3752–3760.

https://doi.org/10.1158/1078-0432.CCR-22-0741

Published: 01 September 2022

View articletitled, Circulating Tumor DNA Kinetics Predict Progression-Free and Overall Survival in EGFR TKI–Treated Patients with EGFR-Mutant NSCLC (SWOG S1403)

Includes: Supplementary data

Journal Articles

Abstract S01-02: Assessing vulnerability of patients with lung cancer to SARS-CoV-2 infection based on serological antibody analyses

Amy C. Moore, Paul A Bunn, Jr., Beatriz Fontoura, Adolfo García-Sastre, Jorge Gomez, Florian Krammer, Phillip Mack, John D. Minna, Christian Rolfo, Yu Shyr, Peter Ujhazy, Fred R. Hirsch

Clin Cancer Res (2021) 27 (6_Supplement): S01-02.

https://doi.org/10.1158/1557-3265.COVID-19-21-S01-02

Published: 15 March 2021

View articletitled, Abstract S01-02: Assessing vulnerability of patients with lung cancer to SARS-CoV-2 infection based on serological antibody analyses

Journal Articles

FGFR1 Expression Levels Predict BGJ398 Sensitivity of FGFR1-Dependent Head and Neck Squamous Cell Cancers

Clin Cancer Res (2015) 21 (19): 4356–4364.

https://doi.org/10.1158/1078-0432.CCR-14-3357

Published: 30 September 2015

View articletitled, FGFR1 Expression Levels Predict BGJ398 Sensitivity of FGFR1-Dependent Head and Neck Squamous Cell Cancers

Includes: Supplementary data

Journal Articles

Squamous Cell Lung Cancer: From Tumor Genomics to Cancer Therapeutics

David R. Gandara, Peter S. Hammerman, Martin L. Sos, Primo N. Lara, Jr, Fred R. Hirsch

Clin Cancer Res (2015) 21 (10): 2236–2243.

https://doi.org/10.1158/1078-0432.CCR-14-3039

Published: 14 May 2015

View articletitled, Squamous Cell Lung Cancer: From Tumor Genomics to Cancer Therapeutics

Journal Articles

Lung Master Protocol (Lung-MAP)—A Biomarker-Driven Protocol for Accelerating Development of Therapies for Squamous Cell Lung Cancer: SWOG S1400

Clin Cancer Res (2015) 21 (7): 1514–1524.

https://doi.org/10.1158/1078-0432.CCR-13-3473

Published: 31 March 2015

View articletitled, Lung Master Protocol (Lung-MAP)—A Biomarker-Driven Protocol for Accelerating Development of Therapies for Squamous Cell Lung Cancer: SWOG S1400

Journal Articles

“Companion Diagnostics”: Has Their Time Come and Gone?

Fred R. Hirsch, Paul A. Bunn, Jr, Roy S. Herbst

Clin Cancer Res (2014) 20 (17): 4422–4424.

https://doi.org/10.1158/1078-0432.CCR-14-0932

Published: 01 September 2014

View articletitled, “Companion Diagnostics”: Has Their Time Come and Gone?

Journal Articles

Assessing lung cancer risk in bronchial dysplasia by identification of prognostic gene expression profiles

Christopher D. Coldren, Michio Sugita, Dexiang Gao, York E. Miller, Daniel T. Merrick, Wilbur A. Franklin, Robert L. Keith, Fred R. Hirsch, Mark W. Geraci, Raphael A. Nemenoff

Clin Cancer Res (2010) 16 (19_Supplement): B15.

https://doi.org/10.1158/DIAG-10-B15

Published: 15 August 2014

View articletitled, Assessing lung cancer risk in bronchial dysplasia by identification of prognostic gene expression profiles

Journal Articles

FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies

Clin Cancer Res (2014) 20 (12): 3299–3309.

https://doi.org/10.1158/1078-0432.CCR-13-3060

Published: 12 June 2014

View articletitled, FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies

Includes: Supplementary data

Journal Articles

Is There Clinical Value to Prognostic Signatures in Early-Stage NSCLC?

Paul A. Bunn, Jr, Fred R. Hirsch, Dara L. Aisner

Clin Cancer Res (2014) 20 (7): 1727–1729.

https://doi.org/10.1158/1078-0432.CCR-13-3387

Published: 31 March 2014

View articletitled, Is There Clinical Value to Prognostic Signatures in Early-Stage NSCLC?

Journal Articles

Design of a Phase III Clinical Trial with Prospective Biomarker Validation: SWOG S0819

Mary W. Redman, John J. Crowley, Roy S. Herbst, Fred R. Hirsch, David R. Gandara

Clin Cancer Res (2012) 18 (15): 4004–4012.

https://doi.org/10.1158/1078-0432.CCR-12-0167

Published: 30 July 2012

View articletitled, Design of a Phase III Clinical Trial with Prospective Biomarker Validation: SWOG S0819

Includes: Supplementary data

Journal Articles

Abstract IA14: Cetuximab in NSCLC and predictive markers

Fred R. Hirsch

Clin Cancer Res (2012) 18 (3_Supplement): IA14.

https://doi.org/10.1158/1078-0432.12AACRIASLC-IA14

Published: 01 February 2012

View articletitled, Abstract IA14: Cetuximab in NSCLC and predictive markers

Journal Articles

Abstract A36: Breath Biomarkers in the Post NLST-era for the Discrimination between Malignant from Benign Pulmonary Nodules

Nir Peled, Fred R. Hirsch, Hossam Haick, Meggie Hakim, Ulrike Tisch, Paul A. Bunn, Jr., York E. Miller, Timothy C. Kennedy, Jane Mattei, John D. Mitchell, Michael J. Weyant

Clin Cancer Res (2012) 18 (3_Supplement): A36.

https://doi.org/10.1158/1078-0432.12AACRIASLC-A36

Published: 01 February 2012

View articletitled, Abstract A36: Breath Biomarkers in the Post NLST-era for the Discrimination between Malignant from Benign Pulmonary Nodules

Journal Articles

Abstract B16: Histology and intervention related miRNA expression changes from baseline to follow-up paired bronchial biopsies of patient in the iloprost chemoprevention trial

Celine Mascaux, Robert L. Keith, William J. Feser, Marina T. Lewis, Anna E. Baron, Christopher D. Coldren, Dan T. Merrick, Timothy C. Kennedy, John I. Eckelberger, Wilbur A. Franklin, Paul A. Bunn, Jr., York E. Miller, Fred R. Hirsch

Clin Cancer Res (2012) 18 (3_Supplement): B16.

https://doi.org/10.1158/1078-0432.12AACRIASLC-B16

Published: 01 February 2012

View articletitled, Abstract B16: Histology and intervention related miRNA expression changes from baseline to follow-up paired bronchial biopsies of patient in the iloprost chemoprevention trial

Journal Articles

Abstract B6: Folylpoly-glutamate synthetase and thymidylate synthase are associated with clinical outcome from pemetrexed-based therapy in non-small cell lung cancer (NSCLC)

Daniel C. Christoph, Heike Loewendick, Anja Peglow, Martin Schuler, Wilfried E. Eberhardt, Fred R. Hirsch, Bernadette Reyna Asuncion, Murry W. Wynes, Thomas C. Gauler, Jeremias Wohlschlaeger, Dirk Theegarten, Stefan Welter, Cindy Tran, Biftu Hassan

Clin Cancer Res (2012) 18 (3_Supplement): B6.

https://doi.org/10.1158/1078-0432.12AACRIASLC-B6

Published: 01 February 2012

View articletitled, Abstract B6: Folylpoly-glutamate synthetase and thymidylate synthase are associated with clinical outcome from pemetrexed-based therapy in non-small cell lung cancer (NSCLC)

Journal Articles

EGFR Protein Expression in Non–Small Cell Lung Cancer Predicts Response to an EGFR Tyrosine Kinase Inhibitor—A Novel Antibody for Immunohistochemistry or AQUA Technology

Celine Mascaux, Murry W. Wynes, Yasufumi Kato, Cindy Tran, Bernadette Reyna Asuncion, Jason M. Zhao, Mark Gustavson, Jim Ranger-Moore, Fabien Gaire, Jun Matsubayashi, Toshitaka Nagao, Koichi Yoshida, Tatuso Ohira, Norihiko Ikeda, Fred R. Hirsch

Clin Cancer Res (2011) 17 (24): 7796–7807.

https://doi.org/10.1158/1078-0432.CCR-11-0209

Published: 18 December 2011

View articletitled, EGFR Protein Expression in Non–Small Cell Lung Cancer Predicts Response to an EGFR Tyrosine Kinase Inhibitor—A Novel Antibody for Immunohistochemistry or AQUA Technology

Includes: Supplementary data

Journal Articles

Novel Functional Germline Variants in the VEGF Receptor 2 Gene and Their Effect on Gene Expression and Microvessel Density in Lung Cancer

Dylan M. Glubb, Elisa Cerri, Alexandra Giese, Wei Zhang, Osman Mirza, Emma E. Thompson, Peixian Chen, Soma Das, Jacek Jassem, Witold Rzyman, Mark W. Lingen, Ravi Salgia, Fred R. Hirsch, Rafal Dziadziuszko, Kurt Ballmer-Hofer, Federico Innocenti

Clin Cancer Res (2011) 17 (16): 5257–5267.

https://doi.org/10.1158/1078-0432.CCR-11-0379

Published: 14 August 2011

View articletitled, Novel Functional Germline Variants in the VEGF Receptor 2 Gene and Their Effect on Gene Expression and Microvessel Density in Lung Cancer

Includes: Supplementary data

Journal Articles

The Tissue Is the Issue: Personalized Medicine for Non-Small Cell Lung Cancer

Fred R. Hirsch, Murry W. Wynes, David R. Gandara, Paul A. Bunn, Jr.

Clin Cancer Res (2010) 16 (20): 4909–4911.

https://doi.org/10.1158/1078-0432.CCR-10-2005

Published: 13 October 2010

View articletitled, The Tissue Is the Issue: Personalized Medicine for Non-Small Cell Lung Cancer

Includes: Supplementary data

Journal Articles

Development of an Integrated Genomic Classifier for a Novel Agent in Colorectal Cancer: Approach to Individualized Therapy in Early Development

Todd M. Pitts, Aik Choon Tan, Gillian N. Kulikowski, John J. Tentler, Amy M. Brown, Sara A. Flanigan, Stephen Leong, Christopher D. Coldren, Fred R. Hirsch, Marileila Varella-Garcia, Christopher Korch, S. Gail Eckhardt

Clin Cancer Res (2010) 16 (12): 3193–3204.

https://doi.org/10.1158/1078-0432.CCR-09-3191

Published: 14 June 2010

View articletitled, Development of an Integrated Genomic Classifier for a Novel Agent in Colorectal Cancer: Approach to Individualized Therapy in Early Development

Includes: Supplementary data

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Antibody–Drug Conjugates in Non–Small Cell Lung Cancer: Where Are the Target and the Biomarker?

Elevated ctDNA Tumor Fraction Is Associated with Improved Mutation Detection but Worse Overall Survival in Advanced Non-Small Cell Lung Cancer: a Lung-MAP Study

Circulating Tumor DNA Kinetics Predict Progression-Free and Overall Survival in EGFR TKI–Treated Patients with EGFR-Mutant NSCLC (SWOG S1403)

Abstract S01-02: Assessing vulnerability of patients with lung cancer to SARS-CoV-2 infection based on serological antibody analyses

FGFR1 Expression Levels Predict BGJ398 Sensitivity of FGFR1-Dependent Head and Neck Squamous Cell Cancers

Squamous Cell Lung Cancer: From Tumor Genomics to Cancer Therapeutics

Lung Master Protocol (Lung-MAP)—A Biomarker-Driven Protocol for Accelerating Development of Therapies for Squamous Cell Lung Cancer: SWOG S1400

“Companion Diagnostics”: Has Their Time Come and Gone?

Assessing lung cancer risk in bronchial dysplasia by identification of prognostic gene expression profiles

FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies

Is There Clinical Value to Prognostic Signatures in Early-Stage NSCLC?

Design of a Phase III Clinical Trial with Prospective Biomarker Validation: SWOG S0819

Abstract IA14: Cetuximab in NSCLC and predictive markers

Abstract A36: Breath Biomarkers in the Post NLST-era for the Discrimination between Malignant from Benign Pulmonary Nodules

Abstract B16: Histology and intervention related miRNA expression changes from baseline to follow-up paired bronchial biopsies of patient in the iloprost chemoprevention trial

Abstract B6: Folylpoly-glutamate synthetase and thymidylate synthase are associated with clinical outcome from pemetrexed-based therapy in non-small cell lung cancer (NSCLC)

EGFR Protein Expression in Non–Small Cell Lung Cancer Predicts Response to an EGFR Tyrosine Kinase Inhibitor—A Novel Antibody for Immunohistochemistry or AQUA Technology

Novel Functional Germline Variants in the VEGF Receptor 2 Gene and Their Effect on Gene Expression and Microvessel Density in Lung Cancer

The Tissue Is the Issue: Personalized Medicine for Non-Small Cell Lung Cancer

Development of an Integrated Genomic Classifier for a Novel Agent in Colorectal Cancer: Approach to Individualized Therapy in Early Development

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