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Journal Articles

LDHA in Neuroblastoma Is Associated with Poor Outcome and Its Depletion Decreases Neuroblastoma Growth Independent of Aerobic Glycolysis

Free
Carmen Dorneburg, Matthias Fischer, Thomas F.E. Barth, Wolfgang Mueller-Klieser, Barbara Hero, Judith Gecht, Daniel R. Carter, Katleen de Preter, Benjamin Mayer, Lisa Christner, Frank Speleman, Glenn M. Marshall, Klaus-Michael Debatin, Christian Beltinger
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (22): 5772–5783.
https://doi.org/10.1158/1078-0432.CCR-17-2578
Published: 15 November 2018
View articletitled, LDHA in Neuroblastoma Is Associated with Poor Outcome and Its Depletion Decreases Neuroblastoma Growth Independent of Aerobic Glycolysis
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Includes: Supplementary data
Journal Articles

Shallow Whole Genome Sequencing on Circulating Cell-Free DNA Allows Reliable Noninvasive Copy-Number Profiling in Neuroblastoma Patients

Free
Nadine Van Roy, Malaïka Van Der Linden, Björn Menten, Annelies Dheedene, Charlotte Vandeputte, Jo Van Dorpe, Geneviève Laureys, Marleen Renard, Tom Sante, Tim Lammens, Bram De Wilde, Frank Speleman, Katleen De Preter
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (20): 6305–6314.
https://doi.org/10.1158/1078-0432.CCR-17-0675
Published: 12 October 2017
View articletitled, Shallow Whole Genome Sequencing on Circulating Cell-Free DNA Allows Reliable Noninvasive Copy-Number Profiling in Neuroblastoma Patients
Open the PDF for Shallow Whole Genome Sequencing on Circulating Cell-Free DNA Allows Reliable Noninvasive Copy-Number Profiling in Neuroblastoma Patients in another window
Includes: Supplementary data
Journal Articles

Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition

Free
Anton Henssen, Kristina Althoff, Andrea Odersky, Anneleen Beckers, Richard Koche, Frank Speleman, Simon Schäfers, Emma Bell, Maike Nortmeyer, Frank Westermann, Katleen De Preter, Alexandra Florin, Lukas Heukamp, Annika Spruessel, Kathy Astrahanseff, Sven Lindner, Natalie Sadowski, Alexander Schramm, Lucile Astorgues-Xerri, Maria E. Riveiro, Angelika Eggert, Esteban Cvitkovic, Johannes H. Schulte
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (10): 2470–2481.
https://doi.org/10.1158/1078-0432.CCR-15-1449
Published: 12 May 2016
View articletitled, Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition
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Includes: Supplementary data
Journal Articles

Abstract B05: Transcriptional antagonism between the cooperative oncogenes TLX1 and NOTCH1 in T-cell acute lymphoblastic leukemia.

Free
Kaat Durinck, Wouter Van Loocke, Joni Van der Meulen, Inge Van de Walle, Pieter Rondou, Charles E. De Bock, Bruce Poppe, Jan Cools, Jean Soulier, Tom Taghon, Frank Speleman, Pieter Van Vlierberghe
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (17_Supplement): B05.
https://doi.org/10.1158/1557-3265.HEMMAL14-B05
Published: 19 August 2015
View articletitled, Abstract B05: Transcriptional antagonism between the cooperative oncogenes TLX1 and NOTCH1 in T-cell acute lymphoblastic leukemia.
Journal Articles

Upregulation of MAPK Negative Feedback Regulators and RET in Mutant ALK Neuroblastoma: Implications for Targeted Treatment

Free
Irina Lambertz, Candy Kumps, Shana Claeys, Sven Lindner, Anneleen Beckers, Els Janssens, Daniel R. Carter, Alex Cazes, Belamy B. Cheung, Marilena De Mariano, An De Bondt, Sara De Brouwer, Olivier Delattre, Jay Gibbons, Isabelle Janoueix-Lerosey, Geneviève Laureys, Chris Liang, Glenn M. Marchall, Michael Porcu, Junko Takita, David Camacho Trujillo, Ilse Van Den Wyngaert, Nadine Van Roy, Alan Van Goethem, Tom Van Maerken, Piotr Zabrocki, Jan Cools, Johannes H. Schulte, Jorge Vialard, Frank Speleman, Katleen De Preter
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (14): 3327–3339.
https://doi.org/10.1158/1078-0432.CCR-14-2024
Published: 14 July 2015
View articletitled, Upregulation of MAPK Negative Feedback Regulators and RET in Mutant ALK Neuroblastoma: Implications for Targeted Treatment
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Includes: Supplementary data
Journal Articles

Revised Risk Estimation and Treatment Stratification of Low- and Intermediate-Risk Neuroblastoma Patients by Integrating Clinical and Molecular Prognostic Markers

Free
André Oberthuer, Dilafruz Juraeva, Barbara Hero, Ruth Volland, Carolina Sterz, Rene Schmidt, Andreas Faldum, Yvonne Kahlert, Anne Engesser, Shahab Asgharzadeh, Robert Seeger, Miki Ohira, Akira Nakagawara, Paola Scaruffi, Gian Paolo Tonini, Isabelle Janoueix-Lerosey, Olivier Delattre, Gudrun Schleiermacher, Jo Vandesompele, Frank Speleman, Rosa Noguera, Marta Piqueras, Jean Bénard, Alexander Valent, Smadar Avigad, Isaac Yaniv, Richard G. Grundy, Monika Ortmann, Chunxuan Shao, Manfred Schwab, Roland Eils, Thorsten Simon, Jessica Theissen, Frank Berthold, Frank Westermann, Benedikt Brors, Matthias Fischer
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (8): 1904–1915.
https://doi.org/10.1158/1078-0432.CCR-14-0817
Published: 14 April 2015
View articletitled, Revised Risk Estimation and Treatment Stratification of Low- and Intermediate-Risk Neuroblastoma Patients by Integrating Clinical and Molecular Prognostic Markers
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Includes: Supplementary data
Journal Articles

miRNA Expression Profiling Enables Risk Stratification in Archived and Fresh Neuroblastoma Tumor Samples

Free
Katleen De Preter, Pieter Mestdagh, Joëlle Vermeulen, Fjoralba Zeka, Arlene Naranjo, Isabella Bray, Victoria Castel, Caifu Chen, Elzbieta Drozynska, Angelika Eggert, Michael D. Hogarty, Ewa Iżycka-Swieszewska, Wendy B. London, Rosa Noguera, Marta Piqueras, Kenneth Bryan, Benjamin Schowe, Peter van Sluis, Jan J. Molenaar, Alexander Schramm, Johannes H. Schulte, Raymond L. Stallings, Rogier Versteeg, Geneviève Laureys, Nadine Van Roy, Frank Speleman, Jo Vandesompele
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (24): 7684–7692.
https://doi.org/10.1158/1078-0432.CCR-11-0610
Published: 18 December 2011
View articletitled, miRNA Expression Profiling Enables Risk Stratification in Archived and Fresh Neuroblastoma Tumor Samples
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Includes: Supplementary data
Journal Articles

High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary Neuroblastoma

Free
Johannes H. Schulte, Hagen S. Bachmann, Bent Brockmeyer, Katleen DePreter, André Oberthür, Sandra Ackermann, Yvonne Kahlert, Kristian Pajtler, Jessica Theissen, Frank Westermann, Jo Vandesompele, Frank Speleman, Frank Berthold, Angelika Eggert, Benedikt Brors, Barbara Hero, Alexander Schramm, Matthias Fischer
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (15): 5082–5092.
https://doi.org/10.1158/1078-0432.CCR-10-2809
Published: 31 July 2011
View articletitled, High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary Neuroblastoma
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Includes: Supplementary data
Journal Articles

A Multilocus Technique for Risk Evaluation of Patients with Neuroblastoma

Free
Inge M. Ambros, Bettina Brunner, Gerhard Aigner, Clare Bedwell, Klaus Beiske, Jean Bénard, Nick Bown, Valerie Combaret, Jerome Couturier, Raffaella Defferrari, Nicole Gross, Marta Jeison, John Lunec, Barbara Marques, Tommy Martinsson, Katia Mazzocco, Rosa Noguera, Gudrun Schleiermacher, Frank Speleman, Ray Stallings, Gian Paolo Tonini, Deborah A. Tweddle, Alexander Valent, Ales Vicha, Nadine Van Roy, Eva Villamon, Andrea Ziegler, Sandra Preuner, Mario Drobics, Ruth Ladenstein, Gabriele Amann, Robert J.L. Schuit, Ulrike Pötschger, Peter F. Ambros
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (4): 792–804.
https://doi.org/10.1158/1078-0432.CCR-10-0830
Published: 15 February 2011
View articletitled, A Multilocus Technique for Risk Evaluation of Patients with Neuroblastoma
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Journal Articles

Meta-analysis of Neuroblastomas Reveals a Skewed ALK Mutation Spectrum in Tumors with MYCN Amplification

Free
Sara De Brouwer, Katleen De Preter, Candy Kumps, Piotr Zabrocki, Michaël Porcu, Ellen M. Westerhout, Arjan Lakeman, Jo Vandesompele, Jasmien Hoebeeck, Tom Van Maerken, Anne De Paepe, Geneviève Laureys, Johannes H. Schulte, Alexander Schramm, Caroline Van Den Broecke, Joëlle Vermeulen, Nadine Van Roy, Klaus Beiske, Marleen Renard, Rosa Noguera, Olivier Delattre, Isabelle Janoueix-Lerosey, Per Kogner, Tommy Martinsson, Akira Nakagawara, Miki Ohira, Huib Caron, Angelika Eggert, Jan Cools, Rogier Versteeg, Frank Speleman
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (17): 4353–4362.
https://doi.org/10.1158/1078-0432.CCR-09-2660
Published: 31 August 2010
View articletitled, Meta-analysis of Neuroblastomas Reveals a Skewed ALK Mutation Spectrum in Tumors with MYCN Amplification
Open the PDF for Meta-analysis of Neuroblastomas Reveals a Skewed ALK Mutation Spectrum in Tumors with MYCN Amplification in another window
Includes: Supplementary data
Journal Articles

Chromosomal and MicroRNA Expression Patterns Reveal Biologically Distinct Subgroups of 11q− Neuroblastoma

Free
Patrick G. Buckley, Leah Alcock, Kenneth Bryan, Isabella Bray, Johannes H. Schulte, Alexander Schramm, Angelika Eggert, Pieter Mestdagh, Katleen De Preter, Jo Vandesompele, Frank Speleman, Raymond L. Stallings
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (11): 2971–2978.
https://doi.org/10.1158/1078-0432.CCR-09-3215
Published: 31 May 2010
View articletitled, Chromosomal and MicroRNA Expression Patterns Reveal Biologically Distinct Subgroups of 11q− Neuroblastoma
Open the PDF for Chromosomal and MicroRNA Expression Patterns Reveal Biologically Distinct Subgroups of 11q− Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

Accurate Outcome Prediction in Neuroblastoma across Independent Data Sets Using a Multigene Signature

Free
Katleen De Preter, Joëlle Vermeulen, Benedikt Brors, Olivier Delattre, Angelika Eggert, Matthias Fischer, Isabelle Janoueix-Lerosey, Cinzia Lavarino, John M. Maris, Jaume Mora, Akira Nakagawara, André Oberthuer, Miki Ohira, Gudrun Schleiermacher, Alexander Schramm, Johannes H. Schulte, Qun Wang, Frank Westermann, Frank Speleman, Jo Vandesompele
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (5): 1532–1541.
https://doi.org/10.1158/1078-0432.CCR-09-2607
Published: 28 February 2010
View articletitled, Accurate Outcome Prediction in Neuroblastoma across Independent Data Sets Using a Multigene Signature
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Includes: Supplementary data
Journal Articles

Meta-mining of Neuroblastoma and Neuroblast Gene Expression Profiles Reveals Candidate Therapeutic Compounds

Free
Katleen De Preter, Sara De Brouwer, Tom Van Maerken, Filip Pattyn, Alexander Schramm, Angelika Eggert, Jo Vandesompele, Frank Speleman
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (11): 3690–3696.
https://doi.org/10.1158/1078-0432.CCR-08-2699
Published: 01 June 2009
View articletitled, Meta-mining of Neuroblastoma and Neuroblast Gene Expression Profiles Reveals Candidate Therapeutic Compounds
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Includes: Supplementary data
Journal Articles

Translating Expression Profiling into a Clinically Feasible Test to Predict Neuroblastoma Outcome

Free
Alexander Schramm, Jo Vandesompele, Johannes H. Schulte, Sabine Dreesmann, Lars Kaderali, Benedikt Brors, Roland Eils, Frank Speleman, Angelika Eggert
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (5): 1459–1465.
https://doi.org/10.1158/1078-0432.CCR-06-2032
Published: 01 March 2007
View articletitled, Translating Expression Profiling into a Clinically Feasible Test to Predict Neuroblastoma Outcome
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