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Frank A. Sinicrope
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Journal Articles

Spatially Resolved, Multiregion Proteomics for Prediction of Immunotherapy Outcome in Deficient Mismatch Repair Metastatic Colorectal Cancer

Bahar Saberzadeh-Ardestani, Zhenglong Liu, Mariam I. Stein, Will A. Sherman, Christy E. Trussoni, Charles W. Abbott, Dongyao Yan, Skyler Smith, Kandavel Shanmugam, Rondell P. Graham, Alos Diallo, Joshua J. Levy, Tamas Ordog, Frank A. Sinicrope
Journal: Clinical Cancer Research
Clin Cancer Res OF1–OF13.
https://doi.org/10.1158/1078-0432.CCR-24-0853
Published: 18 March 2025
View articletitled, Spatially Resolved, Multiregion Proteomics for Prediction of Immunotherapy Outcome in Deficient Mismatch Repair Metastatic Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Identification of Candidate Alterations Mediating KRASG12C Inhibitor Resistance in Advanced Colorectal and Pancreatic Cancers

Khalid Jazieh, Jill Tsai, Sheila Solomon, Mojun Zhu, Frank A. Sinicrope, Katrina S. Pedersen, Martin E. Fernandez-Zapico, Hao Xie
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (5): 899–906.
https://doi.org/10.1158/1078-0432.CCR-24-2948
Published: 03 March 2025
View articletitled, Identification of Candidate Alterations Mediating KRASG12C Inhibitor Resistance in Advanced Colorectal and Pancreatic Cancers
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Includes: Supplementary data
Journal Articles

Improved Risk-Stratification Scheme for Mismatch-Repair Proficient Stage II Colorectal Cancers Using the Digital Pathology Biomarker QuantCRC

Christina Wu, Reetesh K. Pai, Heidi Kosiorek, Imon Banerjee, Ashlyn Pfeiffer, Catherine E. Hagen, Christopher P. Hartley, Rondell P. Graham, Mohamad B. Sonbol, Tanios Bekaii-Saab, Hao Xie, Frank A. Sinicrope, Bhavik Patel, Thomas Westerling-Bui, Sameer Shivji, James Conner, Carol Swallow, Paul Savage, David P. Cyr, Richard Kirsch, Rish K. Pai
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (9): 1811–1821.
https://doi.org/10.1158/1078-0432.CCR-23-3211
Published: 01 May 2024
View articletitled, Improved Risk-Stratification Scheme for Mismatch-Repair Proficient Stage II Colorectal Cancers Using the Digital Pathology Biomarker QuantCRC
Open the PDF for Improved Risk-Stratification Scheme for Mismatch-Repair Proficient Stage II Colorectal Cancers Using the Digital Pathology Biomarker QuantCRC in another window
Includes: Supplementary data
Journal Articles

Immune Marker Spatial Distribution and Clinical Outcome after PD-1 Blockade in Mismatch Repair–deficient, Advanced Colorectal Carcinomas

Bahar Saberzadeh-Ardestani, Rondell P. Graham, Sara McMahon, Eze Ahanonu, Qian Shi, Crystal Williams, Antony Hubbard, Wenjun Zhang, Andrea Muranyi, Dongyao Yan, Zhaohui Jin, Kandavel Shanmugam, Frank A. Sinicrope
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (20): 4268–4277.
https://doi.org/10.1158/1078-0432.CCR-23-1109
Published: 13 October 2023
View articletitled, Immune Marker Spatial Distribution and Clinical Outcome after PD-1 Blockade in Mismatch Repair–deficient, Advanced Colorectal Carcinomas
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Includes: Supplementary data
Journal Articles

Transcriptomic Signatures of MSI-High Metastatic Colorectal Cancer Predict Efficacy of Immune Checkpoint Inhibitors

Claire Gallois, Matteo Landi, Julien Taieb, Marine Sroussi, Bahar Saberzadeh-Ardestani, Antoine Cazelles, Sara Lonardi, Francesca Bergamo, Rossana Intini, Giulia Maddalena, Filippo Pietrantonio, Francesca Corti, Margherita Ambrosini, Antonia Martinetti, Marco Maria Germani, Chiara Boccaccio, Guglielmo Vetere, Sophie Mouillet-Richard, Aurélien de Reynies, Frank A. Sinicrope, Chiara Cremolini, Pierre Laurent-Puig
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (18): 3771–3778.
https://doi.org/10.1158/1078-0432.CCR-22-3964
Published: 15 September 2023
View articletitled, Transcriptomic Signatures of MSI-High Metastatic Colorectal Cancer Predict Efficacy of Immune Checkpoint Inhibitors
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Includes: Supplementary data
Journal Articles

Intertumoral Heterogeneity of CD3+ and CD8+ T-Cell Densities in the Microenvironment of DNA Mismatch-Repair–Deficient Colon Cancers: Implications for Prognosis

Harry H. Yoon, Qian Shi, Erica N. Heying, Andrea Muranyi, Joerg Bredno, Faith Ough, Azita Djalilvand, June Clements, Rebecca Bowermaster, Wen-Wei Liu, Michael Barnes, Steven R. Alberts, Kandavel Shanmugam, Frank A. Sinicrope
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (1): 125–133.
https://doi.org/10.1158/1078-0432.CCR-18-1984
Published: 03 January 2019
View articletitled, Intertumoral Heterogeneity of CD3+ and CD8+ T-Cell Densities in the Microenvironment of DNA Mismatch-Repair–Deficient Colon Cancers: Implications for Prognosis
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Includes: Supplementary data
Journal Articles

Analysis of Molecular Markers by Anatomic Tumor Site in Stage III Colon Carcinomas from Adjuvant Chemotherapy Trial NCCTG N0147 (Alliance)

Frank A. Sinicrope, Michelle R. Mahoney, Harry H. Yoon, Thomas C. Smyrk, Stephen N. Thibodeau, Richard M. Goldberg, Garth D. Nelson, Daniel J. Sargent, Steven R. Alberts
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (23): 5294–5304.
https://doi.org/10.1158/1078-0432.CCR-15-0527
Published: 30 November 2015
View articletitled, Analysis of Molecular Markers by Anatomic Tumor Site in Stage III Colon Carcinomas from Adjuvant Chemotherapy Trial NCCTG N0147 (Alliance)
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Includes: Supplementary data
Journal Articles

Association Study of the let-7 miRNA-Complementary Site Variant in the 3′ Untranslated Region of the KRAS Gene in Stage III Colon Cancer (NCCTG N0147 Clinical Trial)

Dan Sha, Adam M. Lee, Qian Shi, Steven R. Alberts, Daniel J. Sargent, Frank A. Sinicrope, Robert B. Diasio
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (12): 3319–3327.
https://doi.org/10.1158/1078-0432.CCR-14-0069
Published: 12 June 2014
View articletitled, Association Study of the let-7 miRNA-Complementary Site Variant in the 3′ Untranslated Region of the KRAS Gene in Stage III Colon Cancer (NCCTG N0147 Clinical Trial)
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Journal Articles

KRAS Codon 12 and 13 Mutations in Relation to Disease-Free Survival in BRAF–Wild-Type Stage III Colon Cancers from an Adjuvant Chemotherapy Trial (N0147 Alliance)

Harry H. Yoon, David Tougeron, Qian Shi, Steven R. Alberts, Michelle R. Mahoney, Garth D. Nelson, Suresh G. Nair, Stephen N. Thibodeau, Richard M. Goldberg, Daniel J. Sargent, Frank A. Sinicrope, for the Alliance for Clinical Trials in Oncology
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (11): 3033–3043.
https://doi.org/10.1158/1078-0432.CCR-13-3140
Published: 29 May 2014
View articletitled, KRAS Codon 12 and 13 Mutations in Relation to Disease-Free Survival in BRAF–Wild-Type Stage III Colon Cancers from an Adjuvant Chemotherapy Trial (N0147 Alliance)
Open the PDF for KRAS Codon 12 and 13 Mutations in Relation to Disease-Free Survival in BRAF–Wild-Type Stage III Colon Cancers from an Adjuvant Chemotherapy Trial (N0147 Alliance) in another window
Includes: Supplementary data
Journal Articles

Aspirin and Colorectal Cancer: Back to the Future

David Tougeron, Dan Sha, Sashidhar Manthravadi, Frank A. Sinicrope
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (5): 1087–1094.
https://doi.org/10.1158/1078-0432.CCR-13-2563
Published: 02 March 2014
View articletitled, Aspirin and Colorectal Cancer: Back to the Future
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Journal Articles

Aflibercept and Its Role in the Treatment of Colorectal Cancer—Letter

Frank A. Sinicrope, Eric E. Williamson, Daniel D. Borgeson
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (21): 6057.
https://doi.org/10.1158/1078-0432.CCR-13-2056
Published: 31 October 2013
View articletitled, Aflibercept and Its Role in the Treatment of Colorectal Cancer—Letter
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Journal Articles

Molecular Pathways: Microsatellite Instability in Colorectal Cancer: Prognostic, Predictive, and Therapeutic Implications

Frank A. Sinicrope, Daniel J. Sargent
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (6): 1506–1512.
https://doi.org/10.1158/1078-0432.CCR-11-1469
Published: 14 March 2012
View articletitled, Molecular Pathways: Microsatellite Instability in Colorectal Cancer: Prognostic, Predictive, and Therapeutic Implications
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Journal Articles

Association of HER2/ErbB2 Expression and Gene Amplification with Pathologic Features and Prognosis in Esophageal Adenocarcinomas

Harry H. Yoon, Qian Shi, William R. Sukov, Anne E. Wiktor, Maliha Khan, Christopher A. Sattler, Axel Grothey, Tsung-Teh Wu, Robert B. Diasio, Robert B. Jenkins, Frank A. Sinicrope
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (2): 546–554.
https://doi.org/10.1158/1078-0432.CCR-11-2272
Published: 16 January 2012
View articletitled, Association of HER2/ErbB2 Expression and Gene Amplification with Pathologic Features and Prognosis in Esophageal Adenocarcinomas
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Includes: Supplementary data
Journal Articles

Obesity Is an Independent Prognostic Variable in Colon Cancer Survivors

Frank A. Sinicrope, Nathan R. Foster, Daniel J. Sargent, Michael J. O'Connell, Cathryn Rankin
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (6): 1884–1893.
https://doi.org/10.1158/1078-0432.CCR-09-2636
Published: 14 March 2010
View articletitled, Obesity Is an Independent Prognostic Variable in Colon Cancer Survivors
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Journal Articles

BH3 Mimetic Obatoclax Enhances TRAIL-Mediated Apoptosis in Human Pancreatic Cancer Cells

Shengbing Huang, Kenji Okumura, Frank A. Sinicrope
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (1): 150–159.
https://doi.org/10.1158/1078-0432.CCR-08-1575
Published: 31 December 2008
View articletitled, BH3 Mimetic Obatoclax Enhances TRAIL-Mediated Apoptosis in Human Pancreatic Cancer Cells
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Journal Articles

Induction of Noxa Sensitizes Human Colorectal Cancer Cells Expressing Mcl-1 to the Small-Molecule Bcl-2/Bcl-xL Inhibitor, ABT-737

Kenji Okumura, Shengbing Huang, Frank A. Sinicrope
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (24): 8132–8142.
https://doi.org/10.1158/1078-0432.CCR-08-1665
Published: 15 December 2008
View articletitled, Induction of Noxa Sensitizes Human Colorectal Cancer Cells Expressing Mcl-1 to the Small-Molecule Bcl-2/Bcl-xL Inhibitor, ABT-737
Open the PDF for Induction of Noxa Sensitizes Human Colorectal Cancer Cells Expressing Mcl-1 to the Small-Molecule Bcl-2/Bcl-xL Inhibitor, ABT-737 in another window
Includes: Supplementary data
Journal Articles

Prognostic Impact of Bim, Puma, and Noxa Expression in Human Colon Carcinomas

Frank A. Sinicrope, Rafaela L. Rego, Kenji Okumura, Nathan R. Foster, Michael J. O'Connell, Daniel J. Sargent, Harold E. Windschitl
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (18): 5810–5818.
https://doi.org/10.1158/1078-0432.CCR-07-5202
Published: 14 September 2008
View articletitled, Prognostic Impact of Bim, Puma, and Noxa Expression in Human Colon Carcinomas
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Journal Articles

Proapoptotic Bad and Bid Protein Expression Predict Survival in Stages II and III Colon Cancers

Frank A. Sinicrope, Rafaela L. Rego, Nathan R. Foster, Stephen N. Thibodeau, Steven R. Alberts, Harold E. Windschitl, Daniel J. Sargent
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (13): 4128–4133.
https://doi.org/10.1158/1078-0432.CCR-07-5160
Published: 01 July 2008
View articletitled, Proapoptotic Bad and Bid Protein Expression Predict Survival in Stages II and III Colon Cancers
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Journal Articles

Thymidylate Synthase Expression in Colon Carcinomas with Microsatellite Instability

Frank A. Sinicrope, Rafaela L. Rego, Kevin C. Halling, Nathan R. Foster, Daniel J. Sargent, Betsy La Plant, Amy J. French, Carmen J. Allegra, John A. Laurie, Richard M. Goldberg, Thomas E. Witzig, Stephen N. Thibodeau
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (9): 2738–2744.
https://doi.org/10.1158/1078-0432.CCR-06-0178
Published: 04 May 2006
View articletitled, Thymidylate Synthase Expression in Colon Carcinomas with Microsatellite Instability
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Journal Articles

Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis Is Inhibited by Bcl-2 but Restored by the Small Molecule Bcl-2 Inhibitor, HA 14-1, in Human Colon Cancer Cells

Frank A. Sinicrope, Robert C. Penington, Xi Ming Tang
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (24): 8284–8292.
https://doi.org/10.1158/1078-0432.CCR-04-1289
Published: 28 December 2004
View articletitled, Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis Is Inhibited by Bcl-2 but Restored by the Small Molecule Bcl-2 Inhibitor, HA 14-1, in Human Colon Cancer Cells
Open the PDF for Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis Is Inhibited by Bcl-2 but Restored by the Small Molecule Bcl-2 Inhibitor, HA 14-1, in Human Colon Cancer Cells in another window