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Francis P. Worden
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Journal Articles

Combination Targeted Therapy with Pembrolizumab and Lenvatinib in Progressive, Radioiodine-Refractory Differentiated Thyroid Cancers

Jena D. French, Bryan R. Haugen, Francis P. Worden, Daniel W. Bowles, Andrew G. Gianoukakis, Bhavana Konda, Ramona Dadu, Eric J. Sherman, Shaylene McCue, Nathan R. Foster, Yuri E. Nikiforov, Ticiana D.J. Farias, Paul J. Norman, Lori J. Wirth
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (17): 3757–3767.
https://doi.org/10.1158/1078-0432.CCR-23-3417
Published: 03 September 2024
View article titled, Combination Targeted Therapy with Pembrolizumab and Lenvatinib in Progressive, Radioiodine-Refractory Differentiated Thyroid Cancers
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Includes: Supplementary data
Journal Articles

Upfront Neck Dissection for Treatment Selection and Improvement in Quality of Life as a Novel Treatment Paradigm for Deintensification in HPV+ OPSCC

Paul L. Swiecicki, Emily Bellile, Aleksandar F. Dragovic, Jonathan McHugh, Aaron Udager, Michelle Lynn Mierzwa, Jennifer Shah, Molly Heft-Neal, Andrew Rosko, Kelly M. Malloy, Keith Casper, Steven Bennett Chinn, Andrew G. Shuman, Chaz Stucken, Douglas B. Chepeha, Gregory T. Wolf, Carol Rossier Bradford, Avraham Eisbruch, Mark E. Prince, Francis P. Worden, Matthew E. Spector
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (11): 2393–2401.
https://doi.org/10.1158/1078-0432.CCR-23-3247
Published: 03 June 2024
View article titled, Upfront Neck Dissection for Treatment Selection and Improvement in Quality of Life as a Novel Treatment Paradigm for Deintensification in HPV<sup>+</sup> OPSCC
Open the PDF for Upfront Neck Dissection for Treatment Selection and Improvement in Quality of Life as a Novel Treatment Paradigm for Deintensification in HPV<sup>+</sup> OPSCC in another window
Includes: Supplementary data
Journal Articles

A Randomized Multi-institutional Phase II Trial of Everolimus as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck

Cherie-Ann O. Nathan, D. Neil Hayes, Theodore Karrison, Olivier Harismendy, José M. Flores, Tara Moore-Medlin, Everett E. Vokes, J. Silvio Gutkind, Prakash Neupane, Glenn Mills, Zoukaa Sargi, Tanguy Seiwert, Juneko Grilley-Olson, Terry Day, Maura Gillison, James L. Wade, Lawrence Feldman, Gautam Jha, Mark Kozloff, Miriam O'Leary, Francis P. Worden, Ezra E.W. Cohen
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (23): 5040–5048.
https://doi.org/10.1158/1078-0432.CCR-21-4290
Published: 01 December 2022
View article titled, A Randomized Multi-institutional Phase II Trial of Everolimus as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck
Open the PDF for A Randomized Multi-institutional Phase II Trial of Everolimus as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck in another window
Includes: Supplementary data
Journal Articles

Randomized Phase II Study of Physiologic MRI-Directed Adaptive Radiation Boost in Poor Prognosis Head and Neck Cancer

Michelle L. Mierzwa, Madhava Aryal, Choonik Lee, Matthew Schipper, Monica VanTil, Krystal Morales, Paul L. Swiecicki, Keith A. Casper, Kelly M. Malloy, Matthew E. Spector, Andrew G. Shuman, Steven B. Chinn, Mark E.P. Prince, Chaz L. Stucken, Andrew J. Rosko, Theodore S. Lawrence, J. Chad Brenner, Benjamin Rosen, Caitlin A. Schonewolf, Jennifer Shah, Avraham Eisbruch, Francis P. Worden, Yue Cao
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (23): 5049–5057.
https://doi.org/10.1158/1078-0432.CCR-22-1522
Published: 01 December 2022
View article titled, Randomized Phase II Study of Physiologic MRI-Directed Adaptive Radiation Boost in Poor Prognosis Head and Neck Cancer
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Includes: Supplementary data
Journal Articles

Phase II Clinical Trial of Neoadjuvant and Adjuvant Pembrolizumab in Resectable Local–Regionally Advanced Head and Neck Squamous Cell Carcinoma

Trisha M. Wise-Draper, Shuchi Gulati, Sarah Palackdharry, Benjamin H. Hinrichs, Francis P. Worden, Matthew O. Old, Neal E. Dunlap, John M. Kaczmar, Yash Patil, Muhammed Kashif Riaz, Alice Tang, Jonathan Mark, Chad Zender, Ann M. Gillenwater, Diana Bell, Nicky Kurtzweil, Maria Mathews, Casey L. Allen, Michelle L. Mierzwa, Keith Casper, Roman Jandarov, Mario Medvedovic, J. Jack Lee, Nusrat Harun, Vinita Takiar, Maura Gillison
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (7): 1345–1352.
https://doi.org/10.1158/1078-0432.CCR-21-3351
Published: 01 April 2022
View article titled, Phase II Clinical Trial of Neoadjuvant and Adjuvant Pembrolizumab in Resectable Local–Regionally Advanced Head and Neck Squamous Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Early HPV ctDNA Kinetics and Imaging Biomarkers Predict Therapeutic Response in p16+ Oropharyngeal Squamous Cell Carcinoma

Yue Cao, Catherine T. Haring, Collin Brummel, Chandan Bhambhani, Madhava Aryal, Choonik Lee, Molly Heft Neal, Apurva Bhangale, Wenjin Gu, Keith Casper, Kelly Malloy, Yilun Sun, Andrew Shuman, Mark E. Prince, Matthew E. Spector, Steven Chinn, Jennifer Shah, Caitlin Schonewolf, Jonathan B. McHugh, Ryan E. Mills, Muneesh Tewari, Francis P. Worden, Paul L. Swiecicki, Michelle Mierzwa, J. Chad Brenner
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (2): 350–359.
https://doi.org/10.1158/1078-0432.CCR-21-2338
Published: 19 January 2022
View article titled, Early HPV ctDNA Kinetics and Imaging Biomarkers Predict Therapeutic Response in p16+ Oropharyngeal Squamous Cell Carcinoma
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Includes: Supplementary data
Journal Articles

E6 and E7 Antibody Levels Are Potential Biomarkers of Recurrence in Patients with Advanced-Stage Human Papillomavirus–Positive Oropharyngeal Squamous Cell Carcinoma

Matthew E. Spector, Assuntina G. Sacco, Emily Bellile, Jeremy M.G. Taylor, Tamara Jones, Kan Sun, William C. Brown, Andrew C. Birkeland, Carol R. Bradford, Gregory T. Wolf, Mark E. Prince, Jeffrey S. Moyer, Kelly Malloy, Paul Swiecicki, Avraham Eisbruch, Jonathan B. McHugh, Douglas B. Chepeha, Laura Rozek, Francis P. Worden
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (11): 2723–2729.
https://doi.org/10.1158/1078-0432.CCR-16-1617
Published: 31 May 2017
View article titled, E6 and E7 Antibody Levels Are Potential Biomarkers of Recurrence in Patients with Advanced-Stage Human Papillomavirus–Positive Oropharyngeal Squamous Cell Carcinoma
Open the PDF for E6 and E7 Antibody Levels Are Potential Biomarkers of Recurrence in Patients with Advanced-Stage Human Papillomavirus–Positive Oropharyngeal Squamous Cell Carcinoma in another window
Journal Articles

Inactivation or Loss of TTP Promotes Invasion in Head and Neck Cancer via Transcript Stabilization and Secretion of MMP9, MMP2, and IL-6

Elizabeth A. Van Tubergen, Rajat Banerjee, Min Liu, Robert Vander Broek, Emily Light, Shiuhyang Kuo, Stephen E. Feinberg, Amanda L. Willis, Gregory Wolf, Thomas Carey, Carol Bradford, Mark Prince, Francis P. Worden, Keith L. Kirkwood, Nisha J. D'Silva
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (5): 1169–1179.
https://doi.org/10.1158/1078-0432.CCR-12-2927
Published: 03 March 2013
View article titled, Inactivation or Loss of TTP Promotes Invasion in Head and Neck Cancer via Transcript Stabilization and Secretion of MMP9, MMP2, and IL-6
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Includes: Supplementary data
Journal Articles

Tobacco Use in Human Papillomavirus–Positive Advanced Oropharynx Cancer Patients Related to Increased Risk of Distant Metastases and Tumor Recurrence

Jessica H. Maxwell, Bhavna Kumar, Felix Y. Feng, Francis P. Worden, Julia S. Lee, Avraham Eisbruch, Gregory T. Wolf, Mark E. Prince, Jeffrey S. Moyer, Theodoros N. Teknos, Douglas B. Chepeha, Jonathan B. McHugh, Susan G. Urba, Jay Stoerker, Heather M. Walline, David M. Kurnit, Kitrina G. Cordell, Samantha J. Davis, Preston D. Ward, Carol R. Bradford, Thomas E. Carey
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (4): 1226–1235.
https://doi.org/10.1158/1078-0432.CCR-09-2350
Published: 15 February 2010
View article titled, Tobacco Use in Human Papillomavirus–Positive Advanced Oropharynx Cancer Patients Related to Increased Risk of Distant Metastases and Tumor Recurrence
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