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Francesco Sassi
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Journal Articles

Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer

Simonetta M. Leto, Martina Ferri, Francesco Sassi, Eugenia R. Zanella, Francesca Cottino, Valentina Vurchio, Irene Catalano, Alessandro Ferrero, Caterina C. Zingaretti, Caterina Marchiò, Elena Grassi, Livio Trusolino, Andrea Bertotti
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (6): 1102–1113.
https://doi.org/10.1158/1078-0432.CCR-22-2550
Published: 14 March 2023
View article titled, Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer
Open the PDF for Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer

Adam Lafferty, Alice C. O'Farrell, Giorgia Migliardi, Niraj Khemka, Andreas U. Lindner, Francesco Sassi, Eugenia R. Zanella, Manuela Salvucci, Evy Vanderheyden, Elodie Modave, Bram Boeckx, Luise Halang, Johannes Betge, Matthias P.A. Ebert, Patrick Dicker, Guillem Argilés, Josep Tabernero, Rodrigo Dienstmann, Enzo Medico, Diether Lambrechts, Andrea Bertotti, Claudio Isella, Livio Trusolino, Jochen H.M. Prehn, Annette T. Byrne
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (21): 5979–5992.
https://doi.org/10.1158/1078-0432.CCR-21-0818
Published: 01 November 2021
View article titled, Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer
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Includes: Supplementary data
Journal Articles

A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem–Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy

Paolo Luraghi, Viola Bigatto, Elia Cipriano, Gigliola Reato, Francesca Orzan, Francesco Sassi, Francesca De Bacco, Claudio Isella, Sara E. Bellomo, Enzo Medico, Paolo M. Comoglio, Andrea Bertotti, Livio Trusolino, Carla Boccaccio
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (4): 807–820.
https://doi.org/10.1158/1078-0432.CCR-17-2151
Published: 14 February 2018
View article titled, A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem–Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy
Open the PDF for A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem–Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy in another window
Includes: Supplementary data
Journal Articles

Cytokine-Induced Killer Cells Kill Chemo-surviving Melanoma Cancer Stem Cells

Loretta Gammaitoni, Lidia Giraudo, Marco Macagno, Valeria Leuci, Giulia Mesiano, Ramona Rotolo, Francesco Sassi, Martina Sanlorenzo, Alessandro Zaccagna, Alberto Pisacane, Rebecca Senetta, Michela Cangemi, Giulia Cattaneo, Valentina Martin, Valentina Coha, Susanna Gallo, Ymera Pignochino, Anna Sapino, Giovanni Grignani, Fabrizio Carnevale-Schianca, Massimo Aglietta, Dario Sangiolo
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (9): 2277–2288.
https://doi.org/10.1158/1078-0432.CCR-16-1524
Published: 30 April 2017
View article titled, Cytokine-Induced Killer Cells Kill Chemo-surviving Melanoma Cancer Stem Cells
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Includes: Supplementary data
Journal Articles

Abstract B17: Xenospheres: a comprehensive patient-derived in vitro model to study response and resistance to targeted therapies in metastatic colorectal cancer

Paolo Luraghi, Viola Bigatto, Gigliola Reato, Elia Cipriano, Francesco Sassi, Claudio Isella, Andrea Bertotti, Livio Trusolino, Paolo Maria Comoglio, Carla Boccaccio
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16_Supplement): B17.
https://doi.org/10.1158/1557-3265.PDX16-B17
Published: 15 August 2016
View article titled, Abstract B17: Xenospheres: a comprehensive patient-derived in vitro model to study response and resistance to targeted therapies in metastatic colorectal cancer
Journal Articles

Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2-Amplified Gastrointestinal Carcinomas

Simonetta M. Leto, Francesco Sassi, Irene Catalano, Valter Torri, Giorgia Migliardi, Eugenia R. Zanella, Mark Throsby, Andrea Bertotti, Livio Trusolino
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2015) 21 (24): 5519–5531.
https://doi.org/10.1158/1078-0432.CCR-14-3066
Published: 14 December 2015
View article titled, Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of <em>HER2</em>-Amplified Gastrointestinal Carcinomas
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Includes: Supplementary data
Journal Articles

Molecular Pathways: Sensitivity and Resistance to Anti-EGFR Antibodies

Andrea Bertotti, Francesco Sassi
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (15): 3377–3383.
https://doi.org/10.1158/1078-0432.CCR-14-0848
Published: 02 August 2015
View article titled, Molecular Pathways: Sensitivity and Resistance to Anti-EGFR Antibodies
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Journal Articles

Abstract B43: HER2-amplified gastric and colorectal cancers: Mechanistic insights into HER2 targeting approaches

Simonetta Maria Leto, Francesco Sassi, Giorgia Migliardi, Eugenia Zanella, Irene Catalano, Andrea Bertotti, Livio Trusolino
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (4_Supplement): B43.
https://doi.org/10.1158/1557-3265.PMS14-B43
Published: 13 February 2015
View article titled, Abstract B43: HER2-amplified gastric and colorectal cancers: Mechanistic insights into HER2 targeting approaches
Journal Articles

Inhibition of MEK and PI3K/mTOR Suppresses Tumor Growth but Does Not Cause Tumor Regression in Patient-Derived Xenografts of RAS-Mutant Colorectal Carcinomas

Giorgia Migliardi, Francesco Sassi, Davide Torti, Francesco Galimi, Eugenia R. Zanella, Michela Buscarino, Dario Ribero, Andrea Muratore, Paolo Massucco, Alberto Pisacane, Mauro Risio, Lorenzo Capussotti, Silvia Marsoni, Federica Di Nicolantonio, Alberto Bardelli, Paolo M. Comoglio, Livio Trusolino, Andrea Bertotti
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (9): 2515–2525.
https://doi.org/10.1158/1078-0432.CCR-11-2683
Published: 30 April 2012
View article titled, Inhibition of MEK and PI3K/mTOR Suppresses Tumor Growth but Does Not Cause Tumor Regression in Patient-Derived Xenografts of RAS-Mutant Colorectal Carcinomas
Open the PDF for Inhibition of MEK and PI3K/mTOR Suppresses Tumor Growth but Does Not Cause Tumor Regression in Patient-Derived Xenografts of RAS-Mutant Colorectal Carcinomas in another window
Includes: Supplementary data
Journal Articles

Genetic and Expression Analysis of MET, MACC1, and HGF in Metastatic Colorectal Cancer: Response to Met Inhibition in Patient Xenografts and Pathologic Correlations

Francesco Galimi, Davide Torti, Francesco Sassi, Claudio Isella, Davide Corà, Stefania Gastaldi, Dario Ribero, Andrea Muratore, Paolo Massucco, Dimitrios Siatis, Gianluca Paraluppi, Federica Gonella, Francesca Maione, Alberto Pisacane, Ezio David, Bruno Torchio, Mauro Risio, Mauro Salizzoni, Lorenzo Capussotti, Timothy Perera, Enzo Medico, Maria Flavia Di Renzo, Paolo M. Comoglio, Livio Trusolino, Andrea Bertotti
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (10): 3146–3156.
https://doi.org/10.1158/1078-0432.CCR-10-3377
Published: 15 May 2011
View article titled, Genetic and Expression Analysis of MET, MACC1, and HGF in Metastatic Colorectal Cancer: Response to Met Inhibition in Patient Xenografts and Pathologic Correlations
Open the PDF for Genetic and Expression Analysis of MET, MACC1, and HGF in Metastatic Colorectal Cancer: Response to Met Inhibition in Patient Xenografts and Pathologic Correlations in another window
Includes: Supplementary data