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Francesco Forconi
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Journal Articles

Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells

Adam J. Linley, Laura I. Karydis, Anil K. Mondru, Annalisa D'Avola, Humood Al Shmrany, Silvia Cicconi, Rebecca Griffin, Francesco Forconi, Andrew R. Pettitt, Nagesh Kalakonda, Andrew C. Rawstron, Peter Hillmen, Andrew J. Steele, David J. MacEwan, Graham Packham, Ian A. Prior, Joseph R. Slupsky
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (20): 5647–5659.
https://doi.org/10.1158/1078-0432.CCR-21-0161
Published: 15 October 2021
View article titled, Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells
Open the PDF for Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells in another window
Includes: Supplementary data
Journal Articles

Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells

Elizabeth A. Lemm, Beatriz Valle-Argos, Lindsay D. Smith, Johanna Richter, Yohannes Gebreselassie, Matthew J. Carter, Jana Karolova, Michael Svaton, Karel Helman, Nicola J. Weston-Bell, Laura Karydis, Chris T. Williamson, Georg Lenz, Jeremy Pettigrew, Curtis Harwig, Freda K. Stevenson, Mark Cragg, Francesco Forconi, Andrew J. Steele, Jennifer Cross, Lloyd Mackenzie, Pavel Klener, Graham Packham
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (7): 1700–1711.
https://doi.org/10.1158/1078-0432.CCR-19-2202
Published: 01 April 2020
View article titled, Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells
Open the PDF for Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells in another window
Includes: Supplementary data
Journal Articles

Ibrutinib Therapy Releases Leukemic Surface IgM from Antigen Drive in Chronic Lymphocytic Leukemia Patients

Samantha Drennan, Giorgia Chiodin, Annalisa D'Avola, Ian Tracy, Peter W. Johnson, Livio Trentin, Andrew J. Steele, Graham Packham, Freda K. Stevenson, Francesco Forconi
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (8): 2503–2512.
https://doi.org/10.1158/1078-0432.CCR-18-1286
Published: 15 April 2019
View article titled, Ibrutinib Therapy Releases Leukemic Surface IgM from Antigen Drive in Chronic Lymphocytic Leukemia Patients
Open the PDF for Ibrutinib Therapy Releases Leukemic Surface IgM from Antigen Drive in Chronic Lymphocytic Leukemia Patients in another window
Includes: Supplementary data
Journal Articles

The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia

Matthew D. Blunt, Stefan Koehrer, Rachel C. Dobson, Marta Larrayoz, Sarah Wilmore, Alice Hayman, Jack Parnell, Lindsay D. Smith, Andrew Davies, Peter W.M. Johnson, Pamela B. Conley, Anjali Pandey, Jonathan C. Strefford, Freda K. Stevenson, Graham Packham, Francesco Forconi, Greg P. Coffey, Jan A. Burger, Andrew J. Steele
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (9): 2313–2324.
https://doi.org/10.1158/1078-0432.CCR-16-1662
Published: 30 April 2017
View article titled, The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia
Open the PDF for The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia in another window
Includes: Supplementary data
Journal Articles

Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing

Marina Parry, Matthew J.J. Rose-Zerilli, Viktor Ljungström, Jane Gibson, Jun Wang, Renata Walewska, Helen Parker, Anton Parker, Zadie Davis, Anne Gardiner, Neil McIver-Brown, Christina Kalpadakis, Aliki Xochelli, Achilles Anagnostopoulos, Claudia Fazi, David Gonzalez de Castro, Claire Dearden, Guy Pratt, Richard Rosenquist, Margaret Ashton-Key, Francesco Forconi, Andrew Collins, Paolo Ghia, Estella Matutes, Gerassimos Pangalis, Kostas Stamatopoulos, David Oscier, Jonathan C. Strefford
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (18): 4174–4183.
https://doi.org/10.1158/1078-0432.CCR-14-2759
Published: 14 September 2015
View article titled, Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing
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Includes: Supplementary data
Journal Articles

Expression of Mutated IGHV3-23 Genes in Chronic Lymphocytic Leukemia Identifies a Disease Subset with Peculiar Clinical and Biological Features

Riccardo Bomben, Michele Dal-Bo, Dania Benedetti, Daniela Capello, Francesco Forconi, Daniela Marconi, Francesco Bertoni, Rossana Maffei, Luca Laurenti, Davide Rossi, Maria Ilaria Del Principe, Fabrizio Luciano, Elisa Sozzi, Ilaria Cattarossi, Antonella Zucchetto, Francesca Maria Rossi, Pietro Bulian, Emanuele Zucca, Milena S. Nicoloso, Massimo Degan, Roberto Marasca, Dimitar G. Efremov, Giovanni Del Poeta, Gianluca Gaidano, Valter Gattei
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (2): 620–628.
https://doi.org/10.1158/1078-0432.CCR-09-1638
Published: 14 January 2010
View article titled, Expression of Mutated <em>IGHV3-23</em> Genes in Chronic Lymphocytic Leukemia Identifies a Disease Subset with Peculiar Clinical and Biological Features
Open the PDF for Expression of Mutated <em>IGHV3-23</em> Genes in Chronic Lymphocytic Leukemia Identifies a Disease Subset with Peculiar Clinical and Biological Features in another window
Includes: Supplementary data
Journal Articles

Stereotyped B-Cell Receptor Is an Independent Risk Factor of Chronic Lymphocytic Leukemia Transformation to Richter Syndrome

Davide Rossi, Valeria Spina, Michaela Cerri, Silvia Rasi, Clara Deambrogi, Lorenzo De Paoli, Luca Laurenti, Rossana Maffei, Francesco Forconi, Francesco Bertoni, Emanuele Zucca, Claudio Agostinelli, Antonello Cabras, Marco Lucioni, Maurizio Martini, Michele Magni, Silvia Deaglio, Marco Ladetto, Josep F. Nomdedeu, Caroline Besson, Antonio Ramponi, Vincenzo Canzonieri, Marco Paulli, Roberto Marasca, Luigi M. Larocca, Antonino Carbone, Stefano A. Pileri, Valter Gattei, Gianluca Gaidano
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (13): 4415–4422.
https://doi.org/10.1158/1078-0432.CCR-08-3266
Published: 01 July 2009
View article titled, Stereotyped B-Cell Receptor Is an Independent Risk Factor of Chronic Lymphocytic Leukemia Transformation to Richter Syndrome
Open the PDF for Stereotyped B-Cell Receptor Is an Independent Risk Factor of Chronic Lymphocytic Leukemia Transformation to Richter Syndrome in another window
Includes: Supplementary data
Journal Articles

The Prognostic Value of TP53 Mutations in Chronic Lymphocytic Leukemia Is Independent of Del17p13: Implications for Overall Survival and Chemorefractoriness

Davide Rossi, Michaela Cerri, Clara Deambrogi, Elisa Sozzi, Stefania Cresta, Silvia Rasi, Lorenzo De Paoli, Valeria Spina, Valter Gattei, Daniela Capello, Francesco Forconi, Francesco Lauria, Gianluca Gaidano
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (3): 995–1004.
https://doi.org/10.1158/1078-0432.CCR-08-1630
Published: 02 February 2009
View article titled, The Prognostic Value of <em>TP53</em> Mutations in Chronic Lymphocytic Leukemia Is Independent of Del17p13: Implications for Overall Survival and Chemorefractoriness
Open the PDF for The Prognostic Value of <em>TP53</em> Mutations in Chronic Lymphocytic Leukemia Is Independent of Del17p13: Implications for Overall Survival and Chemorefractoriness in another window
Includes: Supplementary data