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Journal Articles

Phase 1/2 Study of the Aurora Kinase A Inhibitor Alisertib and Pembrolizumab in Refractory, Rb-Deficient Head and Neck Squamous Cell Carcinomas

Faye M. Johnson, Madison P. O'Hara, Lacin Yapindi, Peixin Jiang, Hai T. Tran, Alexandre Reuben, Weihong Xiao, Maura Gillison, Xiaowen Sun, Alexander Khalaf, J. Jack. Lee, Jagannadha K. Sastry, Soma Ghosh

Clin Cancer Res (2024)

https://doi.org/10.1158/1078-0432.CCR-24-2290

Published: 26 November 2024

View article titled, Phase 1/2 Study of the Aurora Kinase A Inhibitor Alisertib and Pembrolizumab in Refractory, Rb-Deficient Head and Neck Squamous Cell Carcinomas

Includes: Supplementary data

Journal Articles

Abstract PO-060: Novel combination of TRIP13 and Aurora kinase A inhibition demonstrated extensive DNA damage and immunogenic cell death in RB-deficient cancers

Soma Ghosh, Tuhina Mazumdar, Pragya Sinha, Lacin Yapindi, Jagannadha Sastry, Faye M. Johnson

Clin Cancer Res (2023) 29 (18_Supplement): PO-060.

https://doi.org/10.1158/1557-3265.AACRAHNS23-PO-060

Published: 15 September 2023

View article titled, Abstract PO-060: Novel combination of TRIP13 and Aurora kinase A inhibition demonstrated extensive DNA damage and immunogenic cell death in RB-deficient cancers

Journal Articles

Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus–Driven Cancers

Soma Ghosh, Tuhina Mazumdar, Wei Xu, Reid T. Powell, Clifford Stephan, Li Shen, Pooja A. Shah, Curtis R. Pickering, Jeffery N. Myers, Jing Wang, Mitchell J. Frederick, Faye M. Johnson

Clin Cancer Res (2022) 28 (20): 4479–4493.

https://doi.org/10.1158/1078-0432.CCR-22-1627

Published: 14 October 2022

View article titled, Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus–Driven Cancers

Includes: Supplementary data

Journal Articles

Induction Chemotherapy with or without Erlotinib in Patients with Head and Neck Squamous Cell Carcinoma Amenable for Surgical Resection

Clin Cancer Res (2022) 28 (13): 2796–2806.

https://doi.org/10.1158/1078-0432.CCR-21-3239

Published: 01 July 2022

View article titled, Induction Chemotherapy with or without Erlotinib in Patients with Head and Neck Squamous Cell Carcinoma Amenable for Surgical Resection

Includes: Supplementary data

Journal Articles

Correction: Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

Clin Cancer Res (2022) 28 (8): 1735.

https://doi.org/10.1158/1078-0432.CCR-22-0468

Published: 14 April 2022

View article titled, Correction: Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

Includes: Supplementary data

Journal Articles

Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

Clin Cancer Res (2021) 27 (16): 4557–4565.

https://doi.org/10.1158/1078-0432.CCR-21-0585

Published: 15 August 2021

View article titled, Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

Includes: Supplementary data

Journal Articles

Impact of Neoadjuvant Durvalumab with or without Tremelimumab on CD8⁺ Tumor Lymphocyte Density, Safety, and Efficacy in Patients with Oropharynx Cancer: CIAO Trial Results

Renata Ferrarotto, Diana Bell, Maria L. Rubin, Katherine A. Hutcheson, Jason M. Johnson, Ryan P. Goepfert, Jack Phan, Yasir Y. Elamin, Danice K. Torman, Carla L. Warneke, Amy C. Hessel, Adam S. Garden, Jeffrey N. Myers, Faye M. Johnson, J. Jack Lee, Andrew G. Sikora, Maura L. Gillison, Bonnie S. Glisson, Neil D. Gross

Clin Cancer Res (2020) 26 (13): 3211–3219.

https://doi.org/10.1158/1078-0432.CCR-19-3977

Published: 01 July 2020

View article titled, Impact of Neoadjuvant Durvalumab with or without Tremelimumab on CD8+ Tumor Lymphocyte Density, Safety, and Efficacy in Patients with Oropharynx Cancer: CIAO Trial Results

Includes: Supplementary data

Journal Articles

Abstract B14: Variations in the proteasome activity are associated with human papilloma virus (HPV) gene expression and patient survival in HPV+ oropharyngeal tumors

Frederico O. Gleber-Netto, Meng Gao, Li Shen, Jing Wang, Jeffrey N. Myers, Faye M. Johnson, Curtis R. Pickering

Clin Cancer Res (2020) 26 (12_Supplement_2): B14.

https://doi.org/10.1158/1557-3265.AACRAHNS19-B14

Published: 15 June 2020

View article titled, Abstract B14: Variations in the proteasome activity are associated with human papilloma virus (HPV) gene expression and patient survival in HPV+ oropharyngeal tumors

Journal Articles

PDK1 Mediates NOTCH1-Mutated Head and Neck Squamous Carcinoma Vulnerability to Therapeutic PI3K/mTOR Inhibition

Vaishnavi Sambandam, Mitchell J. Frederick, Li Shen, Pan Tong, Xiayu Rao, Shaohua Peng, Ratnakar Singh, Tuhina Mazumdar, Chenfei Huang, Qiuli Li, Curtis R. Pickering, Jeffery N. Myers, Jing Wang, Faye M. Johnson

Clin Cancer Res (2019) 25 (11): 3329–3340.

https://doi.org/10.1158/1078-0432.CCR-18-3276

Published: 03 June 2019

View article titled, PDK1 Mediates NOTCH1-Mutated Head and Neck Squamous Carcinoma Vulnerability to Therapeutic PI3K/mTOR Inhibition

Includes: Supplementary data

Journal Articles

Differential Sensitivity Analysis for Resistant Malignancies (DISARM) Identifies Common Candidate Therapies across Platinum-Resistant Cancers

Carl M. Gay, Pan Tong, Robert J. Cardnell, Triparna Sen, Xiao Su, Jun Ma, Rasha O. Bara, Faye M. Johnson, Chris Wakefield, John V. Heymach, Jing Wang, Lauren A. Byers

Clin Cancer Res (2019) 25 (1): 346–357.

https://doi.org/10.1158/1078-0432.CCR-18-1129

Published: 03 January 2019

View article titled, Differential Sensitivity Analysis for Resistant Malignancies (DISARM) Identifies Common Candidate Therapies across Platinum-Resistant Cancers

Includes: Supplementary data

Journal Articles

Essential Role of DNA Methyltransferase 1–mediated Transcription of Insulin-like Growth Factor 2 in Resistance to Histone Deacetylase Inhibitors

Hye-Young Min, Su-Chan Lee, Jong Kyu Woo, Hyun Jin Jung, Kwan Hee Park, Hae Min Jeong, Seung Yeob Hyun, Jaebeom Cho, Wooin Lee, Ji Eun Park, So Jung Kwon, Hyo-Jong Lee, Xiao Ni, Young Kee Shin, Faye M. Johnson, Madeleine Duvic, Ho-Young Lee

Clin Cancer Res (2017) 23 (5): 1299–1311.

https://doi.org/10.1158/1078-0432.CCR-16-0534

Published: 28 February 2017

View article titled, Essential Role of DNA Methyltransferase 1–mediated Transcription of Insulin-like Growth Factor 2 in Resistance to Histone Deacetylase Inhibitors

Includes: Supplementary data

Journal Articles

Epithelial–Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor–Mediated Apoptosis in Non–Small Cell Lung Cancer

Renata Ferrarotto, Ruchitha Goonatilake, Suk Young Yoo, Pan Tong, Uma Giri, Shaohua Peng, John Minna, Luc Girard, Yuehong Wang, Liguang Wang, Lerong Li, Lixia Diao, David H. Peng, Don L. Gibbons, Bonnie S. Glisson, John V. Heymach, Jing Wang, Lauren A. Byers, Faye M. Johnson

Clin Cancer Res (2016) 22 (7): 1674–1686.

https://doi.org/10.1158/1078-0432.CCR-14-2890

Published: 31 March 2016

View article titled, Epithelial–Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor–Mediated Apoptosis in Non–Small Cell Lung Cancer

Includes: Supplementary data

Journal Articles

Wee-1 Kinase Inhibition Sensitizes High-Risk HPV⁺ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins

Noriaki Tanaka, Ameeta A. Patel, Jiping Wang, Mitchell J. Frederick, Nene N. Kalu, Mei Zhao, Alison L. Fitzgerald, Tong-xin Xie, Natalie L. Silver, Carlos Caulin, Ge Zhou, Heath D. Skinner, Faye M. Johnson, Jeffrey N. Myers, Abdullah A. Osman

Clin Cancer Res (2015) 21 (21): 4831–4844.

https://doi.org/10.1158/1078-0432.CCR-15-0279

Published: 01 November 2015

View article titled, Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins

Includes: Supplementary data

Journal Articles

Phase I Study of Intermittent Oral Dosing of the Insulin-like Growth Factor-1 and Insulin Receptors Inhibitor OSI-906 in Patients With Advanced Solid Tumors

Robin L. Jones, Edward S. Kim, Pilar Nava-Parada, Salma Alam, Faye M. Johnson, Andrew W. Stephens, Ronit Simantov, Srinivasu Poondru, Rich Gedrich, Scott M. Lippman, Stan B. Kaye, Craig P. Carden

Clin Cancer Res (2015) 21 (4): 693–700.

https://doi.org/10.1158/1078-0432.CCR-14-0265

Published: 16 February 2015

View article titled, Phase I Study of Intermittent Oral Dosing of the Insulin-like Growth Factor-1 and Insulin Receptors Inhibitor OSI-906 in Patients With Advanced Solid Tumors

Includes: Supplementary data

Journal Articles

STAT5A-Mediated SOCS2 Expression Regulates Jak2 and STAT3 Activity Following c-Src Inhibition in Head and Neck Squamous Carcinoma

Banibrata Sen, Shaohua Peng, Denise M. Woods, Ignacio Wistuba, Diana Bell, Adel K. El-Naggar, Stephen Y. Lai, Faye M. Johnson

Clin Cancer Res (2012) 18 (1): 127–139.

https://doi.org/10.1158/1078-0432.CCR-11-1889

Published: 02 January 2012

View article titled, STAT5A-Mediated SOCS2 Expression Regulates Jak2 and STAT3 Activity Following c-Src Inhibition in Head and Neck Squamous Carcinoma

Includes: Supplementary data

Journal Articles

Distinct Interactions Between c-Src and c-Met in Mediating Resistance to c-Src Inhibition in Head and Neck Cancer

Banibrata Sen, Shaohua Peng, Babita Saigal, Michelle D. Williams, Faye M. Johnson

Clin Cancer Res (2011) 17 (3): 514–524.

https://doi.org/10.1158/1078-0432.CCR-10-1617

Published: 01 February 2011

View article titled, Distinct Interactions Between c-Src and c-Met in Mediating Resistance to c-Src Inhibition in Head and Neck Cancer

Includes: Supplementary data

Journal Articles

Reciprocal Regulation of c-Src and STAT3 in Non-Small Cell Lung Cancer

Lauren Averett Byers, Banibrata Sen, Babita Saigal, Lixia Diao, Jing Wang, Meera Nanjundan, Tina Cascone, Gordon B. Mills, John V. Heymach, Faye M. Johnson

Clin Cancer Res (2009) 15 (22): 6852–6861.

https://doi.org/10.1158/1078-0432.CCR-09-0767

Published: 11 November 2009

View article titled, Reciprocal Regulation of c-Src and STAT3 in Non-Small Cell Lung Cancer

Journal Articles

Expression of the Receptor Tyrosine Kinase EphA2 Is Increased in Smokers and Predicts Poor Survival in Non–Small Cell Lung Cancer

Jennifer M. Brannan, Wenli Dong, Ludmila Prudkin, Carmen Behrens, Reuben Lotan, B. Nebiyou Bekele, Ignacio Wistuba, Faye M. Johnson

Clin Cancer Res (2009) 15 (13): 4423–4430.

https://doi.org/10.1158/1078-0432.CCR-09-0473

Published: 01 July 2009

View article titled, Expression of the Receptor Tyrosine Kinase EphA2 Is Increased in Smokers and Predicts Poor Survival in Non–Small Cell Lung Cancer

Journal Articles

Abrogation of Signal Transducer and Activator of Transcription 3 Reactivation after Src Kinase Inhibition Results in Synergistic Antitumor Effects

Faye M. Johnson, Babita Saigal, Hai Tran, Nicholas J. Donato

Clin Cancer Res (2007) 13 (14): 4233–4244.

https://doi.org/10.1158/1078-0432.CCR-06-2981

Published: 18 July 2007

View article titled, Abrogation of Signal Transducer and Activator of Transcription 3 Reactivation after Src Kinase Inhibition Results in Synergistic Antitumor Effects

Journal Articles

Dasatinib (BMS-354825) Tyrosine Kinase Inhibitor Suppresses Invasion and Induces Cell Cycle Arrest and Apoptosis of Head and Neck Squamous Cell Carcinoma and Non–Small Cell Lung Cancer Cells

Faye M. Johnson, Babita Saigal, Moshe Talpaz, Nicholas J. Donato

Clin Cancer Res (2005) 11 (19): 6924–6932.

https://doi.org/10.1158/1078-0432.CCR-05-0757

Published: 03 October 2005

View article titled, Dasatinib (BMS-354825) Tyrosine Kinase Inhibitor Suppresses Invasion and Induces Cell Cycle Arrest and Apoptosis of Head and Neck Squamous Cell Carcinoma and Non–Small Cell Lung Cancer Cells

NARROW

Phase 1/2 Study of the Aurora Kinase A Inhibitor Alisertib and Pembrolizumab in Refractory, Rb-Deficient Head and Neck Squamous Cell Carcinomas

Abstract PO-060: Novel combination of TRIP13 and Aurora kinase A inhibition demonstrated extensive DNA damage and immunogenic cell death in RB-deficient cancers

Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus–Driven Cancers

Induction Chemotherapy with or without Erlotinib in Patients with Head and Neck Squamous Cell Carcinoma Amenable for Surgical Resection

Correction: Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

Impact of Neoadjuvant Durvalumab with or without Tremelimumab on CD8⁺ Tumor Lymphocyte Density, Safety, and Efficacy in Patients with Oropharynx Cancer: CIAO Trial Results

Abstract B14: Variations in the proteasome activity are associated with human papilloma virus (HPV) gene expression and patient survival in HPV+ oropharyngeal tumors

PDK1 Mediates NOTCH1-Mutated Head and Neck Squamous Carcinoma Vulnerability to Therapeutic PI3K/mTOR Inhibition

Differential Sensitivity Analysis for Resistant Malignancies (DISARM) Identifies Common Candidate Therapies across Platinum-Resistant Cancers

Essential Role of DNA Methyltransferase 1–mediated Transcription of Insulin-like Growth Factor 2 in Resistance to Histone Deacetylase Inhibitors

Epithelial–Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor–Mediated Apoptosis in Non–Small Cell Lung Cancer

Wee-1 Kinase Inhibition Sensitizes High-Risk HPV⁺ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins

Phase I Study of Intermittent Oral Dosing of the Insulin-like Growth Factor-1 and Insulin Receptors Inhibitor OSI-906 in Patients With Advanced Solid Tumors

STAT5A-Mediated SOCS2 Expression Regulates Jak2 and STAT3 Activity Following c-Src Inhibition in Head and Neck Squamous Carcinoma

Distinct Interactions Between c-Src and c-Met in Mediating Resistance to c-Src Inhibition in Head and Neck Cancer

Reciprocal Regulation of c-Src and STAT3 in Non-Small Cell Lung Cancer

Expression of the Receptor Tyrosine Kinase EphA2 Is Increased in Smokers and Predicts Poor Survival in Non–Small Cell Lung Cancer

Abrogation of Signal Transducer and Activator of Transcription 3 Reactivation after Src Kinase Inhibition Results in Synergistic Antitumor Effects

Dasatinib (BMS-354825) Tyrosine Kinase Inhibitor Suppresses Invasion and Induces Cell Cycle Arrest and Apoptosis of Head and Neck Squamous Cell Carcinoma and Non–Small Cell Lung Cancer Cells

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