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Journal Articles

Abstract P5-05-12: Real-world outcome of patients with HER2-positive metastatic breast cancer who were treated with inetetamab-containing regimens: A multicenter retrospective analysis conducted in China

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Huihui Li, Dongdong Zhou, Zhiyong Yu, Changping Shan, Chongsheng Xia, Lihua Song, Baoxuan Zhang, Shu Fang, Hongjian Wang, Fan Yang, Ling Qiang, Guohua Ren, Jiale Zhang, Lingyu Kong, Jingfen Wang, Guozhu Liu
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): P5-05-12.
https://doi.org/10.1158/1557-3265.SABCS24-P5-05-12
Published: 13 June 2025
View article titled, Abstract P5-05-12: Real-world outcome of patients with HER2-positive metastatic breast cancer who were treated with inetetamab-containing regimens: A multicenter retrospective analysis conducted in China
Journal Articles

Abstract P5-09-29: Trastuzumab Combined with Pyrotinib and Capecitabine as Postoperative Adjuvant Therapy in Non-Pathological Complete Response HER2-Positive Early Breast Cancer Following Neoadjuvant Therapy: A Multicenter Phase II Study

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Chuan Wang, Fangmeng Fu, Shunguo Lin, Zhenchuan Song, Zhong Ouyang, Xiangjin Chen, Mengbo Lin, Guozhong Cui, Guohui Han, Wenhui Guo, Xia Chen, Lining Jia, Chuangui Song, Sumei Yang, Ruizhen Luo, Yu Yan, Yi Zeng, Debo Chen, Jianqing Lin, Fan Yang, Ruixue Huang, Yili Wang, Zhechao Zeng, Zhe Zhang
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): P5-09-29.
https://doi.org/10.1158/1557-3265.SABCS24-P5-09-29
Published: 13 June 2025
View article titled, Abstract P5-09-29: Trastuzumab Combined with Pyrotinib and Capecitabine as Postoperative Adjuvant Therapy in Non-Pathological Complete Response HER2-Positive Early Breast Cancer Following Neoadjuvant Therapy: A Multicenter Phase II Study
Journal Articles

Amplification of Extrachromosomal MYC Paralogs Shapes Immunosuppressive Tumor Microenvironment in Small Cell Lung Cancer

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Jingwei Zhang, Yueqi Jin, Haodong Lin, Jiaming Deng, Yan Ju, Xueyan Hu, Jianqi She, Zhijian Liang, Kongxu Dai, Mantang Qiu, Kunkun Sun, Jun Wang, Fan Yang, Jian Chen, Ence Yang, Xiao Li
Journal: Clinical Cancer Research
Clin Cancer Res OF1–OF14.
https://doi.org/10.1158/1078-0432.CCR-24-3399
Published: 13 May 2025
View article titled, Amplification of Extrachromosomal MYC Paralogs Shapes Immunosuppressive Tumor Microenvironment in Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Genomic Profiling and Immune Phenotyping of Neuroendocrine Bladder Cancer

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Jingyu Zang, Akezhouli Shahatiaili, Mei-Chun Cai, Di Jin, Peiye Shen, Lei Qian, Lu Zhang, Tianxiang Zhang, Yuchen Wu, Fan Yang, Zheng Wu, Yanli Hou, Yongrui Bai, Jun Xia, Liang Cheng, Ruiyun Zhang, Guanglei Zhuang, Haige Chen
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (21): 4920–4931.
https://doi.org/10.1158/1078-0432.CCR-24-1277
Published: 01 November 2024
View article titled, Genomic Profiling and Immune Phenotyping of Neuroendocrine Bladder Cancer
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Includes: Supplementary data
Journal Articles

Single-Cell Transcriptomics Reveals Immune Reconstitution in Patients with R/R T-ALL/LBL Treated with Donor-Derived CD7 CAR-T Therapy

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Wei Chen, Hui Shi, Zhuojun Liu, Fan Yang, Jia Liu, Leqiang Zhang, Yajin Wu, Yuanshi Xia, Yuxuan Ou, Ruiting Li, Ting Zhang, Jiecheng Zhang, Xiaoyan Ke, Kai Hu, Jian Yu
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (8): 1484–1495.
https://doi.org/10.1158/1078-0432.CCR-22-2924
Published: 14 April 2023
View article titled, Single-Cell Transcriptomics Reveals Immune Reconstitution in Patients with R/R T-ALL/LBL Treated with Donor-Derived CD7 CAR-T Therapy
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Includes: Supplementary data
Journal Articles

Neoadjuvant Trastuzumab and Pyrotinib for Locally Advanced HER2-Positive Breast Cancer (NeoATP): Primary Analysis of a Phase II Study

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Wenjin Yin, Yaohui Wang, Ziping Wu, Yumei Ye, Liheng Zhou, Shuguang Xu, Yanping Lin, Yueyao Du, Tingting Yan, Fan Yang, Jie Zhang, Qiang Liu, Jinsong Lu
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (17): 3677–3685.
https://doi.org/10.1158/1078-0432.CCR-22-0446
Published: 01 September 2022
View article titled, Neoadjuvant Trastuzumab and Pyrotinib for Locally Advanced HER2-Positive Breast Cancer (NeoATP): Primary Analysis of a Phase II Study
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Includes: Supplementary data
Journal Articles

Development and Validation of Machine Learning–based Model for the Prediction of Malignancy in Multiple Pulmonary Nodules: Analysis from Multicentric Cohorts

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Kezhong Chen, Yuntao Nie, Samina Park, Kai Zhang, Yangming Zhang, Yuan Liu, Bengang Hui, Lixin Zhou, Xun Wang, Qingyi Qi, Hao Li, Guannan Kang, Yuqing Huang, Yingtai Chen, Jiabao Liu, Jian Cui, Mingru Li, In Kyu Park, Chang Hyun Kang, Haifeng Shen, Yingshun Yang, Tian Guan, Yaxiao Zhang, Fan Yang, Young Tae Kim, Jun Wang
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (8): 2255–2265.
https://doi.org/10.1158/1078-0432.CCR-20-4007
Published: 15 April 2021
View article titled, Development and Validation of Machine Learning–based Model for the Prediction of Malignancy in Multiple Pulmonary Nodules: Analysis from Multicentric Cohorts
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Includes: Supplementary data
Journal Articles

Analysis of Tumor Genomic Pathway Alterations Using Broad-Panel Next-Generation Sequencing in Surgically Resected Lung Adenocarcinoma

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Jian Zhou, Francisco Sanchez-Vega, Raul Caso, Kay See Tan, Whitney S. Brandt, Gregory D. Jones, Shi Yan, Prasad S. Adusumilli, Matthew Bott, James Huang, James M. Isbell, Smita Sihag, Daniela Molena, Valerie W. Rusch, Walid K. Chatila, Natasha Rekhtman, Fan Yang, Marc Ladanyi, David B. Solit, Michael F. Berger, Nikolaus Schultz, David R. Jones
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (24): 7475–7484.
https://doi.org/10.1158/1078-0432.CCR-19-1651
Published: 13 December 2019
View article titled, Analysis of Tumor Genomic Pathway Alterations Using Broad-Panel Next-Generation Sequencing in Surgically Resected Lung Adenocarcinoma
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Includes: Supplementary data
Journal Articles

Perioperative Dynamic Changes in Circulating Tumor DNA in Patients with Lung Cancer (DYNAMIC)

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Kezhong Chen, Heng Zhao, Yanbin Shi, Fan Yang, Lien Tu Wang, Guannan Kang, Yuntao Nie, Jun Wang
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (23): 7058–7067.
https://doi.org/10.1158/1078-0432.CCR-19-1213
Published: 02 December 2019
View article titled, Perioperative Dynamic Changes in Circulating Tumor DNA in Patients with Lung Cancer (DYNAMIC)
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Includes: Supplementary data
Journal Articles

Genetic Polymorphisms Predisposing the Interleukin 6–Induced APOBEC3B-UNG Imbalance Increase HCC Risk via Promoting the Generation of APOBEC-Signature HBV Mutations

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Wenbin Liu, Jianfeng Wu, Fan Yang, Longteng Ma, Chong Ni, Xiaomei Hou, Ling Wang, Aijing Xu, Jiahui Song, Yang Deng, Linfeng Xian, Zixiong Li, Shuo Wang, Xi Chen, Jianhua Yin, Xue Han, Chengzhong Li, Jun Zhao, Guangwen Cao
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (18): 5525–5536.
https://doi.org/10.1158/1078-0432.CCR-18-3083
Published: 13 September 2019
View article titled, Genetic Polymorphisms Predisposing the Interleukin 6–Induced APOBEC3B-UNG Imbalance Increase HCC Risk via Promoting the Generation of APOBEC-Signature HBV Mutations
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Includes: Supplementary data
Journal Articles

A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma

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Jezabel Rodriguez-Blanco, Bin Li, Jun Long, Chen Shen, Fan Yang, Darren Orton, Sara Collins, Noriyuki Kasahara, Nagi G. Ayad, Heather J. McCrea, Martine F. Roussel, William A. Weiss, Anthony J. Capobianco, David J. Robbins
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (4): 1379–1388.
https://doi.org/10.1158/1078-0432.CCR-18-1319
Published: 15 February 2019
View article titled, A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma
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Includes: Supplementary data
Journal Articles

Brain-Derived Neurotrophic Factor Promotes Tumorigenesis via Induction of Neovascularization: Implication in Hepatocellular Carcinoma

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Chi-Tat Lam, Zhen-Fan Yang, Chi-Keung Lau, Ka-Ho Tam, Sheung-Tat Fan, Ronnie T.P. Poon
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (10): 3123–3133.
https://doi.org/10.1158/1078-0432.CCR-10-2802
Published: 15 May 2011
View article titled, Brain-Derived Neurotrophic Factor Promotes Tumorigenesis via Induction of Neovascularization: Implication in Hepatocellular Carcinoma
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Includes: Supplementary data
Journal Articles

MEK-Independent Survival of B-RAFV600E Melanoma Cells Selected for Resistance to Apoptosis Induced by the RAF Inhibitor PLX4720

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Chen Chen Jiang, Fritz Lai, Rick F. Thorne, Fan Yang, Hao Liu, Peter Hersey, Xu Dong Zhang
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (4): 721–730.
https://doi.org/10.1158/1078-0432.CCR-10-2225
Published: 15 February 2011
View article titled, MEK-Independent Survival of B-RAFV600E Melanoma Cells Selected for Resistance to Apoptosis Induced by the RAF Inhibitor PLX4720
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Journal Articles

CXCR2 Promotes Ovarian Cancer Growth through Dysregulated Cell Cycle, Diminished Apoptosis, and Enhanced Angiogenesis

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Gong Yang, Daniel G. Rosen, Guangzhi Liu, Fan Yang, Xiaoqing Guo, Xue Xiao, Fengxia Xue, Imelda Mercado-Uribe, Jiaoti Huang, Sue-Hwa Lin, Gordon B. Mills, Jinsong Liu
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (15): 3875–3886.
https://doi.org/10.1158/1078-0432.CCR-10-0483
Published: 28 July 2010
View article titled, CXCR2 Promotes Ovarian Cancer Growth through Dysregulated Cell Cycle, Diminished Apoptosis, and Enhanced Angiogenesis
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Includes: Supplementary data
Journal Articles

Aurora Kinase A Promotes Ovarian Tumorigenesis through Dysregulation of the Cell Cycle and Suppression of BRCA2

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Gong Yang, Bin Chang, Fan Yang, Xiaoqing Guo, Kathy Qi Cai, Xue (Sherry) Xiao, Huamin Wang, Subrata Sen, Mien-Chie Hung, Gordon B. Mills, Sandy Chang, Asha S. Multani, Imelda Mercado-Uribe, Jinsong Liu
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (12): 3171–3181.
https://doi.org/10.1158/1078-0432.CCR-09-3171
Published: 14 June 2010
View article titled, Aurora Kinase A Promotes Ovarian Tumorigenesis through Dysregulation of the Cell Cycle and Suppression of BRCA2
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Includes: Supplementary data
Journal Articles

An Akt/Hypoxia-Inducible Factor-1α/Platelet-Derived Growth Factor-BB Autocrine Loop Mediates Hypoxia-Induced Chemoresistance in Liver Cancer Cells and Tumorigenic Hepatic Progenitor Cells

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Chi Keung Lau, Zhen Fan Yang, David W. Ho, Michael N. Ng, George C.T. Yeoh, Ronnie T.P. Poon, Sheung Tat Fan
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (10): 3462–3471.
https://doi.org/10.1158/1078-0432.CCR-08-2127
Published: 18 May 2009
View article titled, An Akt/Hypoxia-Inducible Factor-1α/Platelet-Derived Growth Factor-BB Autocrine Loop Mediates Hypoxia-Induced Chemoresistance in Liver Cancer Cells and Tumorigenic Hepatic Progenitor Cells
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Includes: Supplementary data
Journal Articles

Rac Activation Is Associated with Hepatocellular Carcinoma Metastasis by Up-regulation of Vascular Endothelial Growth Factor Expression

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Terence K. Lee, Ronnie T.P. Poon, Anthony P. Yuen, Kwan Man, Zhen Fan Yang, Xin Yuan Guan, Sheung Tat Fan
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (17): 5082–5089.
https://doi.org/10.1158/1078-0432.CCR-05-2794
Published: 01 September 2006
View article titled, Rac Activation Is Associated with Hepatocellular Carcinoma Metastasis by Up-regulation of Vascular Endothelial Growth Factor Expression
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