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Ezra E.W. Cohen
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Journal Articles

Facts and Hopes in Neoadjuvant Immunotherapy: Current Approvals and Emerging Evidence

Poorva Vaidya, Ezra E.W. Cohen
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (7): 1232–1239.
https://doi.org/10.1158/1078-0432.CCR-23-0583
Published: 01 April 2024
View article titled, Facts and Hopes in Neoadjuvant Immunotherapy: Current Approvals and Emerging Evidence
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Journal Articles

Eganelisib, a First-in-Class PI3Kγ Inhibitor, in Patients with Advanced Solid Tumors: Results of the Phase 1/1b MARIO-1 Trial

David S. Hong, Michael Postow, Bartosz Chmielowski, Ryan Sullivan, Amita Patnaik, Ezra E.W. Cohen, Geoffrey Shapiro, Conor Steuer, Martin Gutierrez, Heather Yeckes-Rodin, Robert Ilaria, Jr, Brenda O'Connell, Joanna Peng, Guangbin Peng, Nora Zizlsperger, Anthony Tolcher, Jedd D. Wolchok
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (12): 2210–2219.
https://doi.org/10.1158/1078-0432.CCR-22-3313
Published: 13 June 2023
View article titled, Eganelisib, a First-in-Class PI3Kγ Inhibitor, in Patients with Advanced Solid Tumors: Results of the Phase 1/1b MARIO-1 Trial
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Includes: Supplementary data
Journal Articles

A Randomized Multi-institutional Phase II Trial of Everolimus as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck

Cherie-Ann O. Nathan, D. Neil Hayes, Theodore Karrison, Olivier Harismendy, José M. Flores, Tara Moore-Medlin, Everett E. Vokes, J. Silvio Gutkind, Prakash Neupane, Glenn Mills, Zoukaa Sargi, Tanguy Seiwert, Juneko Grilley-Olson, Terry Day, Maura Gillison, James L. Wade, Lawrence Feldman, Gautam Jha, Mark Kozloff, Miriam O'Leary, Francis P. Worden, Ezra E.W. Cohen
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (23): 5040–5048.
https://doi.org/10.1158/1078-0432.CCR-21-4290
Published: 01 December 2022
View article titled, A Randomized Multi-institutional Phase II Trial of Everolimus as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck
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Includes: Supplementary data
Journal Articles

Intralesional SD-101 in Combination with Pembrolizumab in Anti-PD-1 Treatment-Naïve Head and Neck Squamous Cell Carcinoma: Results from a Multicenter, Phase II Trial

Ezra E.W. Cohen, Lisle Nabell, Deborah J. Wong, Terry Day, Gregory A. Daniels, Mohammed Milhem, Sanjeev Deva, Michael Jameson, Orlando Guntinas-Lichius, Mohammed Almubarak, Matthew Strother, Eric Whitman, Michael Chisamore, Cynthia Obiozor, Teresa Bagulho, Jose Gomez-Romo, Cristiana Guiducci, Robert Janssen, Erick Gamelin, Alain P. Algazi
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (6): 1157–1166.
https://doi.org/10.1158/1078-0432.CCR-21-1411
Published: 15 March 2022
View article titled, Intralesional SD-101 in Combination with Pembrolizumab in Anti-PD-1 Treatment-Naïve Head and Neck Squamous Cell Carcinoma: Results from a Multicenter, Phase II Trial
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Includes: Supplementary data
Journal Articles

Safety and Efficacy of Pembrolizumab in Combination with Acalabrutinib in Advanced Head and Neck Squamous Cell Carcinoma: Phase 2 Proof-of-Concept Study

Matthew H. Taylor, Courtney B. Betts, Lauren Maloney, Eric Nadler, Alain Algazi, Michael J. Guarino, John Nemunaitis, Antonio Jimeno, Priti Patel, Veerendra Munugalavadla, Lin Tao, Douglas Adkins, Jerome H. Goldschmidt, Jr, Ezra E.W. Cohen, Lisa M. Coussens
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (5): 903–914.
https://doi.org/10.1158/1078-0432.CCR-21-2547
Published: 01 March 2022
View article titled, Safety and Efficacy of Pembrolizumab in Combination with Acalabrutinib in Advanced Head and Neck Squamous Cell Carcinoma: Phase 2 Proof-of-Concept Study
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Includes: Supplementary data
Journal Articles

Inevitable Progress—Relying on the Immune System, Not Chance

Assuntina G. Sacco, Ezra E.W. Cohen
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (3): 435–437.
https://doi.org/10.1158/1078-0432.CCR-21-3739
Published: 01 February 2022
View article titled, Inevitable Progress—Relying on the Immune System, Not Chance
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Journal Articles

Role of B Cells in Responses to Checkpoint Blockade Immunotherapy and Overall Survival of Cancer Patients

Sangwoo S. Kim, Whitney A. Sumner, Sayuri Miyauchi, Ezra E.W. Cohen, Joseph A. Califano, Andrew B. Sharabi
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (22): 6075–6082.
https://doi.org/10.1158/1078-0432.CCR-21-0697
Published: 15 November 2021
View article titled, Role of B Cells in Responses to Checkpoint Blockade Immunotherapy and Overall Survival of Cancer Patients
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Journal Articles

Did Everolimus Break the Rules?

Shumei Kato, Ezra E.W. Cohen
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (14): 3807–3808.
https://doi.org/10.1158/1078-0432.CCR-21-1508
Published: 15 July 2021
View article titled, Did Everolimus Break the Rules?
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Journal Articles

The Changing Landscape of Therapeutic Cancer Vaccines—Novel Platforms and Neoantigen Identification

Jessica Jou, Kevin J. Harrington, Mai-Britt Zocca, Eva Ehrnrooth, Ezra E.W. Cohen
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (3): 689–703.
https://doi.org/10.1158/1078-0432.CCR-20-0245
Published: 01 February 2021
View article titled, The Changing Landscape of Therapeutic Cancer Vaccines—Novel Platforms and Neoantigen Identification
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Journal Articles

Talimogene Laherparepvec and Pembrolizumab in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (MASTERKEY-232): A Multicenter, Phase 1b Study

Kevin J. Harrington, Anthony Kong, Nicolas Mach, Jason A. Chesney, Beatriz Castelo Fernandez, Danny Rischin, Ezra E.W. Cohen, Hoi-Shen Radcliffe, Burak Gumuscu, Jonathan Cheng, Wendy Snyder, Lillian L. Siu
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (19): 5153–5161.
https://doi.org/10.1158/1078-0432.CCR-20-1170
Published: 01 October 2020
View article titled, Talimogene Laherparepvec and Pembrolizumab in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (MASTERKEY-232): A Multicenter, Phase 1b Study
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Includes: Supplementary data
Journal Articles

B Cells Improve Overall Survival in HPV-Associated Squamous Cell Carcinomas and Are Activated by Radiation and PD-1 Blockade

Sangwoo S. Kim, Sarek Shen, Sayuri Miyauchi, P. Dominick Sanders, Ida Franiak-Pietryga, Loren Mell, J. Silvio Gutkind, Ezra E.W. Cohen, Joseph A. Califano, Andrew B. Sharabi
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13): 3345–3359.
https://doi.org/10.1158/1078-0432.CCR-19-3211
Published: 01 July 2020
View article titled, B Cells Improve Overall Survival in HPV-Associated Squamous Cell Carcinomas and Are Activated by Radiation and PD-1 Blockade
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Includes: Supplementary data
Journal Articles

Immune Modulation of Head and Neck Squamous Cell Carcinoma and the Tumor Microenvironment by Conventional Therapeutics

Sayuri Miyauchi, Sangwoo S. Kim, John Pang, Kathryn A. Gold, J. Silvio Gutkind, Joseph A. Califano, Loren K. Mell, Ezra E.W. Cohen, Andrew B. Sharabi
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (14): 4211–4223.
https://doi.org/10.1158/1078-0432.CCR-18-0871
Published: 15 July 2019
View article titled, Immune Modulation of Head and Neck Squamous Cell Carcinoma and the Tumor Microenvironment by Conventional Therapeutics
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Journal Articles

Lenvatinib in Advanced, Radioactive Iodine–Refractory, Differentiated Thyroid Carcinoma

Kay T. Yeung, Ezra E.W. Cohen
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (24): 5420–5426.
https://doi.org/10.1158/1078-0432.CCR-15-0923
Published: 14 December 2015
View article titled, Lenvatinib in Advanced, Radioactive Iodine–Refractory, Differentiated Thyroid Carcinoma
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Journal Articles

Serum C-Telopeptide Collagen Crosslinks and Plasma Soluble VEGFR2 as Pharmacodynamic Biomarkers in a Trial of Sequentially Administered Sunitinib and Cilengitide

Peter H. O'Donnell, Sanja Karovic, Theodore G. Karrison, Linda Janisch, Matthew R. Levine, Pamela J. Harris, Blase N. Polite, Ezra E.W. Cohen, Gini F. Fleming, Mark J. Ratain, Michael L. Maitland
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (22): 5092–5099.
https://doi.org/10.1158/1078-0432.CCR-15-0427
Published: 12 November 2015
View article titled, Serum C-Telopeptide Collagen Crosslinks and Plasma Soluble VEGFR2 as Pharmacodynamic Biomarkers in a Trial of Sequentially Administered Sunitinib and Cilengitide
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Includes: Supplementary data
Journal Articles

Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct HPV and Three Non-HPV Subtypes

Michaela K. Keck, Zhixiang Zuo, Arun Khattri, Thomas P. Stricker, Christopher D. Brown, Matin Imanguli, Damian Rieke, Katharina Endhardt, Petra Fang, Johannes Brägelmann, Rebecca DeBoer, Mohamed El-Dinali, Serdal Aktolga, Zhengdeng Lei, Patrick Tan, Steve G. Rozen, Ravi Salgia, Ralph R. Weichselbaum, Mark W. Lingen, Michael D. Story, K. Kian Ang, Ezra E.W. Cohen, Kevin P. White, Everett E. Vokes, Tanguy Y. Seiwert
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (4): 870–881.
https://doi.org/10.1158/1078-0432.CCR-14-2481
Published: 16 February 2015
View article titled, Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct HPV and Three Non-HPV Subtypes
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Includes: Supplementary data
Journal Articles

Integrative and Comparative Genomic Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas

Tanguy Y. Seiwert, Zhixiang Zuo, Michaela K. Keck, Arun Khattri, Chandra S. Pedamallu, Thomas Stricker, Christopher Brown, Trevor J. Pugh, Petar Stojanov, Juok Cho, Michael S. Lawrence, Gad Getz, Johannes Brägelmann, Rebecca DeBoer, Ralph R. Weichselbaum, Alexander Langerman, Louis Portugal, Elizabeth Blair, Kerstin Stenson, Mark W. Lingen, Ezra E.W. Cohen, Everett E. Vokes, Kevin P. White, Peter S. Hammerman
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (3): 632–641.
https://doi.org/10.1158/1078-0432.CCR-13-3310
Published: 01 February 2015
View article titled, Integrative and Comparative Genomic Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas
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Includes: Supplementary data
Journal Articles

Evaluation of Food Effect on Pharmacokinetics of Vismodegib in Advanced Solid Tumor Patients

Manish R. Sharma, Theodore G. Karrison, Bethany Kell, Kehua Wu, Michelle Turcich, David Geary, Soonmo P. Kang, Naoko Takebe, Richard A. Graham, Michael L. Maitland, Richard L. Schilsky, Mark J. Ratain, Ezra E.W. Cohen
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (11): 3059–3067.
https://doi.org/10.1158/1078-0432.CCR-12-3829
Published: 30 May 2013
View article titled, Evaluation of Food Effect on Pharmacokinetics of Vismodegib in Advanced Solid Tumor Patients
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Journal Articles

Phase I Studies of Sirolimus Alone or in Combination with Pharmacokinetic Modulators in Advanced Cancer Patients

Ezra E.W. Cohen, Kehua Wu, Christine Hartford, Masha Kocherginsky, Kimberly Napoli Eaton, Yuanyuan Zha, Anitha Nallari, Michael L. Maitland, Kammi Fox-Kay, Kristin Moshier, Larry House, Jacqueline Ramirez, Samir D. Undevia, Gini F. Fleming, Thomas F. Gajewski, Mark J. Ratain
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (17): 4785–4793.
https://doi.org/10.1158/1078-0432.CCR-12-0110
Published: 30 August 2012
View article titled, Phase I Studies of Sirolimus Alone or in Combination with Pharmacokinetic Modulators in Advanced Cancer Patients
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Includes: Supplementary data
Journal Articles

A Phase II Study of Lapatinib in Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck

Jonas A. de Souza, Darren W. Davis, Yujian Zhang, Arun Khattri, Tanguy Y. Seiwert, Serdal Aktolga, Stuart J. Wong, Mark F. Kozloff, Sreenivasa Nattam, Mark W. Lingen, Rangesh Kunnavakkam, Kerstin M. Stenson, Elizabeth A. Blair, Jeffrey Bozeman, Janet E. Dancey, Everett E. Vokes, Ezra E.W. Cohen
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (8): 2336–2343.
https://doi.org/10.1158/1078-0432.CCR-11-2825
Published: 16 April 2012
View article titled, A Phase II Study of Lapatinib in Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck
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Journal Articles

Phase II Efficacy and Pharmacogenomic Study of Selumetinib (AZD6244; ARRY-142886) in Iodine-131 Refractory Papillary Thyroid Carcinoma with or without Follicular Elements

D. Neil Hayes, Amy S. Lucas, Tawee Tanvetyanon, Monika K. Krzyzanowska, Christine H. Chung, Barbara A. Murphy, Jill Gilbert, Ranee Mehra, Dominic T. Moore, Arif Sheikh, Janelle Hoskins, Michele C. Hayward, Ni Zhao, Wendi O'Connor, Karen E. Weck, Roger B. Cohen, Ezra E.W. Cohen
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (7): 2056–2065.
https://doi.org/10.1158/1078-0432.CCR-11-0563
Published: 01 April 2012
View article titled, Phase II Efficacy and Pharmacogenomic Study of Selumetinib (AZD6244; ARRY-142886) in Iodine-131 Refractory Papillary Thyroid Carcinoma with or without Follicular Elements
Open the PDF for Phase II Efficacy and Pharmacogenomic Study of Selumetinib (AZD6244; ARRY-142886) in Iodine-131 Refractory Papillary Thyroid Carcinoma with or without Follicular Elements in another window
Includes: Supplementary data