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Eugene Demidenko
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Journal Articles

Estrogen Therapy Induces Receptor-Dependent DNA Damage Enhanced by PARP Inhibition in ER+ Breast Cancer

Nicole A. Traphagen, Gary N. Schwartz, Steven Tau, Alyssa M. Roberts, Amanda Jiang, Sarah R. Hosford, Jonathan D. Marotti, Abigail E. Goen, Bianca A. Romo, Anneka L. Johnson, Emily-Claire K. Duffy, Eugene Demidenko, Paul Heverly, Yaron Mosesson, Shannon M. Soucy, Fred Kolling, Todd W. Miller
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (18): 3717–3728.
https://doi.org/10.1158/1078-0432.CCR-23-0488
Published: 15 September 2023
View articletitled, Estrogen Therapy Induces Receptor-Dependent DNA Damage Enhanced by PARP Inhibition in ER+ Breast Cancer
Open the PDF for Estrogen Therapy Induces Receptor-Dependent DNA Damage Enhanced by PARP Inhibition in ER+ Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Alternating 17β-Estradiol and Aromatase Inhibitor Therapies Is Efficacious in Postmenopausal Women with Advanced Endocrine-Resistant ER+ Breast Cancer

Gary N. Schwartz, Peter A. Kaufman, Karthik V. Giridhar, Jonathan D. Marotti, Mary D. Chamberlin, Bradley A. Arrick, Grace Makari-Judson, Matthew P. Goetz, Shannon M. Soucy, Fred Kolling, Eugene Demidenko, Todd W. Miller
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (15): 2767–2773.
https://doi.org/10.1158/1078-0432.CCR-23-0112
Published: 01 August 2023
View articletitled, Alternating 17β-Estradiol and Aromatase Inhibitor Therapies Is Efficacious in Postmenopausal Women with Advanced Endocrine-Resistant ER+ Breast Cancer
Open the PDF for Alternating 17β-Estradiol and Aromatase Inhibitor Therapies Is Efficacious in Postmenopausal Women with Advanced Endocrine-Resistant ER+ Breast Cancer in another window
Includes: Supplementary data
Journal Articles

AMPK Activation by Metformin Promotes Survival of Dormant ER+ Breast Cancer Cells

Riley A. Hampsch, Jason D. Wells, Nicole A. Traphagen, Charlotte F. McCleery, Jennifer L. Fields, Kevin Shee, Lloye M. Dillon, Darcy B. Pooler, Lionel D. Lewis, Eugene Demidenko, Yina H. Huang, Jonathan D. Marotti, Abigail E. Goen, William B. Kinlaw, Todd W. Miller
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (14): 3707–3719.
https://doi.org/10.1158/1078-0432.CCR-20-0269
Published: 15 July 2020
View articletitled, AMPK Activation by Metformin Promotes Survival of Dormant ER+ Breast Cancer Cells
Open the PDF for AMPK Activation by Metformin Promotes Survival of Dormant ER+ Breast Cancer Cells in another window
Includes: Supplementary data
Journal Articles

A Transcriptionally Definable Subgroup of Triple-Negative Breast and Ovarian Cancer Samples Shows Sensitivity to HSP90 Inhibition

Kevin Shee, Jason D. Wells, Matthew Ung, Riley A. Hampsch, Nicole A. Traphagen, Wei Yang, Stephanie C. Liu, Megan A. Zeldenrust, Liewei Wang, Krishna R. Kalari, Jia Yu, Judy C. Boughey, Eugene Demidenko, Arminja N. Kettenbach, Chao Cheng, Matthew P. Goetz, Todd W. Miller
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (1): 159–170.
https://doi.org/10.1158/1078-0432.CCR-18-2213
Published: 03 January 2020
View articletitled, A Transcriptionally Definable Subgroup of Triple-Negative Breast and Ovarian Cancer Samples Shows Sensitivity to HSP90 Inhibition
Open the PDF for A Transcriptionally Definable Subgroup of Triple-Negative Breast and Ovarian Cancer Samples Shows Sensitivity to HSP90 Inhibition in another window
Includes: Supplementary data
Journal Articles

Combined Inhibition of Both p110α and p110β Isoforms of Phosphatidylinositol 3-Kinase Is Required for Sustained Therapeutic Effect in PTEN-Deficient, ER+ Breast Cancer

Sarah R. Hosford, Lloye M. Dillon, Stephanie J. Bouley, Rachele Rosati, Wei Yang, Vivian S. Chen, Eugene Demidenko, Rocco P. Morra, Jr, Todd W. Miller
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (11): 2795–2805.
https://doi.org/10.1158/1078-0432.CCR-15-2764
Published: 31 May 2017
View articletitled, Combined Inhibition of Both p110α and p110β Isoforms of Phosphatidylinositol 3-Kinase Is Required for Sustained Therapeutic Effect in PTEN-Deficient, ER+ Breast Cancer
Open the PDF for Combined Inhibition of Both p110α and p110β Isoforms of Phosphatidylinositol 3-Kinase Is Required for Sustained Therapeutic Effect in PTEN-Deficient, ER+ Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Strategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize Therapeutic Index in Estrogen Receptor Alpha–Positive, PIK3CA-Mutant Breast Cancer

Wei Yang, Sarah R. Hosford, Lloye M. Dillon, Kevin Shee, Stephanie C. Liu, Jennifer R. Bean, Laurent Salphati, Jodie Pang, Xiaolin Zhang, Michelle A. Nannini, Eugene Demidenko, Darcy Bates, Lionel D. Lewis, Jonathan D. Marotti, Alan R. Eastman, Todd W. Miller
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (9): 2250–2260.
https://doi.org/10.1158/1078-0432.CCR-15-2276
Published: 01 May 2016
View articletitled, Strategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize Therapeutic Index in Estrogen Receptor Alpha–Positive, PIK3CA-Mutant Breast Cancer
Open the PDF for Strategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize Therapeutic Index in Estrogen Receptor Alpha–Positive, PIK3CA-Mutant Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Effect of Tumor Host Microenvironment on Photodynamic Therapy in a Rat Prostate Tumor Model

Bin Chen, Brian W. Pogue, Xiaodong Zhou, Julia A. O'Hara, Nicolas Solban, Eugene Demidenko, P. Jack Hoopes, Tayyaba Hasan
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (2): 720–727.
https://doi.org/10.1158/1078-0432.720.11.2
Published: 08 February 2005
View articletitled, Effect of Tumor Host Microenvironment on Photodynamic Therapy in a Rat Prostate Tumor Model
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Journal Articles

The Combination of a Potent Vitamin D3 Analog, EB 1089, with Ionizing Radiation Reduces Tumor Growth and Induces Apoptosis of MCF-7 Breast Tumor Xenografts in Nude Mice

Sujatha Sundaram, Andrea Sea, Stephanie Feldman, Rendall Strawbridge, P. Jack Hoopes, Eugene Demidenko, Lise Binderup, David A. Gewirtz
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (6): 2350–2356.
Published: 01 June 2003
View articletitled, The Combination of a Potent Vitamin D3 Analog, EB 1089, with Ionizing Radiation Reduces Tumor Growth and Induces Apoptosis of MCF-7 Breast Tumor Xenografts in Nude Mice
Open the PDF for The Combination of a Potent Vitamin D3 Analog, EB 1089, with Ionizing Radiation Reduces Tumor Growth and Induces Apoptosis of MCF-7 Breast Tumor Xenografts in Nude Mice in another window