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Ernst Lengyel
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Journal Articles

Abstract NT-097: QUANTITATIVE HIGH-THROUGHPUT SCREENING USING AN ORGANOTYPIC MODEL IDENTIFIES TWO KINASE INHIBITORS THAT INHIBIT OVARIAN CANCER METASTASIS

Hilary A. Kenny, Madhu Lal, Min Shen, Dominik Nahotko, Sarah Fazal, Siquan Chen, Chun-Yi Chiang, Betul Kara, S. Diane Yamada, Kyle Brimacombe, Juan Marugan, Marc Ferrer, Ernst Lengyel
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (22_Supplement): NT-097.
https://doi.org/10.1158/1557-3265.OVCASYMP18-NT-097
Published: 15 November 2019
View article titled, Abstract NT-097: QUANTITATIVE HIGH-THROUGHPUT SCREENING USING AN ORGANOTYPIC MODEL IDENTIFIES TWO KINASE INHIBITORS THAT INHIBIT OVARIAN CANCER METASTASIS
Journal Articles

Induction of Neoantigen-Specific Cytotoxic T Cells and Construction of T-cell Receptor–Engineered T Cells for Ovarian Cancer

Tatsuo Matsuda, Matthias Leisegang, Jae-Hyun Park, Lili Ren, Taigo Kato, Yuji Ikeda, Makiko Harada, Kazuma Kiyotani, Ernst Lengyel, Gini F. Fleming, Yusuke Nakamura
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (21): 5357–5367.
https://doi.org/10.1158/1078-0432.CCR-18-0142
Published: 01 November 2018
View article titled, Induction of Neoantigen-Specific Cytotoxic T Cells and Construction of T-cell Receptor–Engineered T Cells for Ovarian Cancer
Open the PDF for Induction of Neoantigen-Specific Cytotoxic T Cells and Construction of T-cell Receptor–Engineered T Cells for Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract IA06: Stromal regulation of metastasis

Ernst Lengyel, Mark Eckert, Iris Romero, Hilary Kenny
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (15_Supplement): IA06.
https://doi.org/10.1158/1557-3265.OVCA17-IA06
Published: 01 August 2018
View article titled, Abstract IA06: Stromal regulation of metastasis
Journal Articles

Abstract A28: Beta-escin inhibits ovarian cancer metastasis by targeting the tumor microenvironment

Hilary A. Kenny, Madhu Lal, Min Shen, Betul Kara, Chun-Yi Chiang, Karen Watters, Peter Hart, Marc Ferrer, Ernst Lengyel
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (15_Supplement): A28.
https://doi.org/10.1158/1557-3265.OVCA17-A28
Published: 01 August 2018
View article titled, Abstract A28: Beta-escin inhibits ovarian cancer metastasis by targeting the tumor microenvironment
Journal Articles

Abstract A15: Fatty acid binding protein 4 is indispensable for ovarian cancer metastasis

Abir Mukherjee, Fabian Coscia, Johannes Fahrmann, Chun-Yi Chiang, Justin Smith, Kristin Nieman, Andras Ladanyi, Iris Romero, Oliver Fiehn, Matthias Mann, Ernst Lengyel
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (15_Supplement): A15.
https://doi.org/10.1158/1557-3265.OVCA17-A15
Published: 01 August 2018
View article titled, Abstract A15: Fatty acid binding protein 4 is indispensable for ovarian cancer metastasis
Journal Articles

Abstract TMEM-118: ROLES OF T-LAK CELL-ORIGINATED KINASE (TOPK) AND THE MICROENVIRONMENT IN DRIVING OVARIAN CANCER PROGRESSION

Mark A. Eckert, Fabian Coscia, Shawn Pan, Chun-Yi Chiang, Stephanie McGregor, Ricardo Lastra, S. Diane Yamada, Matthias Mann, Ernst Lengyel
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (11_Supplement): TMEM-118.
https://doi.org/10.1158/1557-3265.OVCASYMP16-TMEM-118
Published: 31 May 2017
View article titled, Abstract TMEM-118: ROLES OF T-LAK CELL-ORIGINATED KINASE (TOPK) AND THE MICROENVIRONMENT IN DRIVING OVARIAN CANCER PROGRESSION
Journal Articles

Abstract B39: Identification and targeting mediators of chemoresistance using the patient-derived xenograft model of ovarian cancer

Zachary Dobbin, Robert Cornelison, Ashwini K. Katre, David A. Schneider, Karen Watters, Fabian Coscia, Ernst Lengyel, Aaron Buechlein, Fang Fang, Kenneth Nephew, Charles N. Landen, Jr
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16_Supplement): B39.
https://doi.org/10.1158/1557-3265.PDX16-B39
Published: 15 August 2016
View article titled, Abstract B39: Identification and targeting mediators of chemoresistance using the patient-derived xenograft model of ovarian cancer
Journal Articles

Abstract A68: Sphingosine kinase 1 as a mediator and predictor of metformin's protective effect in ovarian cancer.

Tatsuyuki Chiyoda, Xiaojing Liu, Ernst Lengyel, Jason Locasale, Iris Romero
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (2_Supplement): A68.
https://doi.org/10.1158/1557-3265.OVCA15-A68
Published: 15 January 2016
View article titled, Abstract A68: Sphingosine kinase 1 as a mediator and predictor of metformin's protective effect in ovarian cancer.
Journal Articles

Abstract POSTER-CTRL-1217: Human placental lactogen-functionalized bimodal imaging probe for human ovarian cancer detection

Yilin Zhang, Karthik M. Sundaram, Nan-Sheng Li, Joseph A. Piccirilli, Ernst Lengyel
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (16_Supplement): POSTER-CTRL-1217.
https://doi.org/10.1158/1557-3265.OVCASYMP14-POSTER-CTRL-1217
Published: 15 August 2015
View article titled, Abstract POSTER-CTRL-1217: Human placental lactogen-functionalized bimodal imaging probe for human ovarian cancer detection
Journal Articles

Abstract POSTER-THER-1440: Targeted delivery of doxorubicin loaded nanobins to ovarian cancer cells through the urokinase plasminogen activator system

Yilin Zhang, Elden P. Swindell, Patrick L. Hankins, Hilary A. Kenny, Thomas V. O'Halloran, Andrew P. Mazar, Ernst Lengyel
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (16_Supplement): POSTER-THER-1440.
https://doi.org/10.1158/1557-3265.OVCASYMP14-POSTER-THER-1440
Published: 15 August 2015
View article titled, Abstract POSTER-THER-1440: Targeted delivery of doxorubicin loaded nanobins to ovarian cancer cells through the urokinase plasminogen activator system
Journal Articles

Abstract POSTER-BIOL-1305: Lovastatin decreases macrophage IL-6 and CXCL1 production in an ovarian tam-like model reducing ovarian cancer cell invasion

Michael J Bradaric, PhD, Lacey Litchfield, PhD, Alyssa Johnson, BS, Mohammed Habis, MD, Nadia Ismail, BS, Ernst Lengyel, MD, PhD, Iris Romero, MD
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (16_Supplement): POSTER-BIOL-1305.
https://doi.org/10.1158/1557-3265.OVCASYMP14-POSTER-BIOL-1305
Published: 15 August 2015
View article titled, Abstract POSTER-BIOL-1305: Lovastatin decreases macrophage IL-6 and CXCL1 production in an ovarian tam-like model reducing ovarian cancer cell invasion
Journal Articles

Abstract POSTER-TECH-1123: Advancing metformin as therapeutic for ovarian cancer: metabolomic profiling of mouse ovarian tumors identifies metformin-induced global metabolic changes

Iris L. Romero, Xiaojing Liu, Anirban K Mitra, Ernst Lengyel, Jason W. Locasale
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (16_Supplement): POSTER-TECH-1123.
https://doi.org/10.1158/1557-3265.OVCASYMP14-POSTER-TECH-1123
Published: 15 August 2015
View article titled, Abstract POSTER-TECH-1123: Advancing metformin as therapeutic for ovarian cancer: metabolomic profiling of mouse ovarian tumors identifies metformin-induced global metabolic changes
Journal Articles

Molecular Pathways: Trafficking of Metabolic Resources in the Tumor Microenvironment

Iris L. Romero, Abir Mukherjee, Hilary A. Kenny, Lacey M. Litchfield, Ernst Lengyel
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (4): 680–686.
https://doi.org/10.1158/1078-0432.CCR-14-2198
Published: 16 February 2015
View article titled, Molecular Pathways: Trafficking of Metabolic Resources in the Tumor Microenvironment
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Journal Articles

Abstract B32: The role of the glucocorticoid receptor (GR) in inhibiting chemotherapy-induced apoptosis in high-grade serous ovarian carcinoma (HGS-OvCa)

Erica M. Stringer, Maxell N. Skor, Lei Zhao, Katja Gwin, Ernst Lengyel, Gini F. Fleming, Suzanne D. Conzen
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (19_Supplement): B32.
https://doi.org/10.1158/1078-0432.OVCA13-B32
Published: 13 May 2014
View article titled, Abstract B32: The role of the glucocorticoid receptor (GR) in inhibiting chemotherapy-induced apoptosis in high-grade serous ovarian carcinoma (HGS-OvCa)
Journal Articles

Abstract PR11: Ovarian cancer cells activate the mesothelium in the peritoneal microenvironment promoting fibronectin production and the early steps of metastasis

Hilary A. Kenny, Chun-Yi Chiang, Andras Ladanyi, Joshy George, David D. Bowtell, Katja Gwin, Andrew Mazar, Ernst Lengyel
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (19_Supplement): PR11.
https://doi.org/10.1158/1078-0432.OVCA13-PR11
Published: 13 May 2014
View article titled, Abstract PR11: Ovarian cancer cells activate the mesothelium in the peritoneal microenvironment promoting fibronectin production and the early steps of metastasis
Journal Articles

Foretinib (GSK1363089), an Orally Available Multikinase Inhibitor of c-Met and VEGFR-2, Blocks Proliferation, Induces Anoikis, and Impairs Ovarian Cancer Metastasis

Marion Zillhardt, Sun-Mi Park, Iris L. Romero, Kenjiro Sawada, Anthony Montag, Thomas Krausz, S. Diane Yamada, Marcus E. Peter, Ernst Lengyel
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (12): 4042–4051.
https://doi.org/10.1158/1078-0432.CCR-10-3387
Published: 15 June 2011
View article titled, Foretinib (GSK1363089), an Orally Available Multikinase Inhibitor of c-Met and VEGFR-2, Blocks Proliferation, Induces Anoikis, and Impairs Ovarian Cancer Metastasis
Open the PDF for Foretinib (GSK1363089), an Orally Available Multikinase Inhibitor of c-Met and VEGFR-2, Blocks Proliferation, Induces Anoikis, and Impairs Ovarian Cancer Metastasis in another window
Includes: Supplementary data
Journal Articles

Targeting the Urokinase Plasminogen Activator Receptor Inhibits Ovarian Cancer Metastasis

Hilary A. Kenny, Payton Leonhardt, Andras Ladanyi, S. Diane Yamada, Anthony Montag, Hae Kyung Im, Sujatha Jagadeeswaran, David E. Shaw, Andrew P. Mazar, Ernst Lengyel
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (3): 459–471.
https://doi.org/10.1158/1078-0432.CCR-10-2258
Published: 01 February 2011
View article titled, Targeting the Urokinase Plasminogen Activator Receptor Inhibits Ovarian Cancer Metastasis
Open the PDF for Targeting the Urokinase Plasminogen Activator Receptor Inhibits Ovarian Cancer Metastasis in another window
Includes: Supplementary data
Journal Articles

Increased Expression of Matrix Metalloproteinases (MMP)-2, MMP-9, and the Urokinase-Type Plasminogen Activator Is Associated with Progression from Benign to Advanced Ovarian Cancer

Barbara Schmalfeldt, Dieter Prechtel, Kathrin Härting, Kerstin Späthe, Stefan Rutke, Elisabeth Konik, Rafael Fridman, Ursula Berger, Manfred Schmitt, Walther Kuhn, Ernst Lengyel
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (8): 2396–2404.
Published: 01 August 2001
View article titled, Increased Expression of Matrix Metalloproteinases (MMP)-2, MMP-9, and the Urokinase-Type Plasminogen Activator Is Associated with Progression from Benign to Advanced Ovarian Cancer
Open the PDF for Increased Expression of Matrix Metalloproteinases (MMP)-2, MMP-9, and the Urokinase-Type Plasminogen Activator Is Associated with Progression from Benign to Advanced Ovarian Cancer in another window