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Eric H. Rubin
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Journal Articles

A Biomarker-enriched, Randomized Phase II Trial of Adavosertib (AZD1775) Plus Paclitaxel and Carboplatin for Women with Platinum-sensitive TP53-mutant Ovarian Cancer

Amit M. Oza, Maria Estevez-Diz, Eva-Maria Grischke, Marcia Hall, Frederik Marmé, Diane Provencher, Denise Uyar, Johanne I. Weberpals, Robert M. Wenham, Naomi Laing, Michael Tracy, Tomoko Freshwater, Mark A. Lee, Ji Liu, Jingjun Qiu, Shelonitda Rose, Eric H. Rubin, Kathleen Moore
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (18): 4767–4776.
https://doi.org/10.1158/1078-0432.CCR-20-0219
Published: 15 September 2020
View article titled, A Biomarker-enriched, Randomized Phase II Trial of Adavosertib (AZD1775) Plus Paclitaxel and Carboplatin for Women with Platinum-sensitive <em>TP53</em>-mutant Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Challenges with Novel Clinical Trial Designs: Master Protocols

Michael Cecchini, Eric H. Rubin, Gideon M. Blumenthal, Kassa Ayalew, Howard A. Burris, Michele Russell-Einhorn, Hildy Dillon, H. Kim Lyerly, Gregory H. Reaman, Scott Boerner, Patricia M. LoRusso
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (7): 2049–2057.
https://doi.org/10.1158/1078-0432.CCR-18-3544
Published: 01 April 2019
View article titled, Challenges with Novel Clinical Trial Designs: Master Protocols
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Journal Articles

From Famine to Feast: Developing Early-Phase Combination Immunotherapy Trials Wisely

Daphne Day, Arta M. Monjazeb, Elad Sharon, S. Percy Ivy, Eric H. Rubin, Gary L. Rosner, Marcus O. Butler
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (17): 4980–4991.
https://doi.org/10.1158/1078-0432.CCR-16-3064
Published: 31 August 2017
View article titled, From Famine to Feast: Developing Early-Phase Combination Immunotherapy Trials Wisely
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Journal Articles

Immuno-oncology Clinical Trial Design: Limitations, Challenges, and Opportunities

Christina S. Baik, Eric H. Rubin, Patrick M. Forde, Janice M. Mehnert, Deborah Collyar, Marcus O. Butler, Erica L. Dixon, Laura Q.M. Chow
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (17): 4992–5002.
https://doi.org/10.1158/1078-0432.CCR-16-3066
Published: 31 August 2017
View article titled, Immuno-oncology Clinical Trial Design: Limitations, Challenges, and Opportunities
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Journal Articles

Rendering the 3 + 3 Design to Rest: More Efficient Approaches to Oncology Dose-Finding Trials in the Era of Targeted Therapy

Lei Nie, Eric H. Rubin, Nitin Mehrotra, José Pinheiro, Laura L. Fernandes, Amit Roy, Stuart Bailey, Dinesh P. de Alwis
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (11): 2623–2629.
https://doi.org/10.1158/1078-0432.CCR-15-2644
Published: 31 May 2016
View article titled, Rendering the 3 + 3 Design to Rest: More Efficient Approaches to Oncology Dose-Finding Trials in the Era of Targeted Therapy
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Journal Articles

Advancing Clinical Trials to Streamline Drug Development

Susan E. Bates, Donald A. Berry, Sanjeeve Balasubramaniam, Stuart Bailey, Patricia M. LoRusso, Eric H. Rubin
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (20): 4527–4535.
https://doi.org/10.1158/1078-0432.CCR-15-0039
Published: 14 October 2015
View article titled, Advancing Clinical Trials to Streamline Drug Development
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Journal Articles

Antitumor Activity in RAS-Driven Tumors by Blocking AKT and MEK

Anthony W. Tolcher, Khurum Khan, Michael Ong, Udai Banerji, Vassiliki Papadimitrakopoulou, David R. Gandara, Amita Patnaik, Richard D. Baird, David Olmos, Christopher R. Garrett, Jeffrey M. Skolnik, Eric H. Rubin, Paul D. Smith, Pearl Huang, Maria Learoyd, Keith A. Shannon, Anne Morosky, Ernestina Tetteh, Ying-Ming Jou, Kyriakos P. Papadopoulos, Victor Moreno, Brianne Kaiser, Timothy A. Yap, Li Yan, Johann S. de Bono
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (4): 739–748.
https://doi.org/10.1158/1078-0432.CCR-14-1901
Published: 16 February 2015
View article titled, Antitumor Activity in <em>RAS</em>-Driven Tumors by Blocking AKT and MEK
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Includes: Supplementary data
Journal Articles

AACR Cancer Progress Report 2014

Carlos L. Arteaga, Peter C. Adamson, Jeffrey A. Engelman, Margaret Foti, Richard B. Gaynor, Susan G. Hilsenbeck, Paul J. Limburg, Scott W. Lowe, Elaine R. Mardis, Scott Ramsey, Timothy R. Rebbeck, Andrea L. Richardson, Eric H. Rubin, George J. Weiner
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (19_Supplement): S1–S112.
https://doi.org/10.1158/1078-0432.CCR-14-2123
Published: 01 October 2014
View article titled, AACR Cancer Progress Report 2014
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Includes: Supplementary data
Journal Articles

Developing Precision Medicine in a Global World

Eric H. Rubin, Jeffrey D. Allen, Jan A. Nowak, Susan E. Bates
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (6): 1419–1427.
https://doi.org/10.1158/1078-0432.CCR-14-0091
Published: 13 March 2014
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Journal Articles

Reports from the 2010 Clinical and Translational Cancer Research Think Tank Meeting: Design Strategies for Personalized Therapy Trials

Donald A. Berry, Roy S. Herbst, Eric H. Rubin
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (3): 638–644.
https://doi.org/10.1158/1078-0432.CCR-11-2018
Published: 31 January 2012
View article titled, Reports from the 2010 Clinical and Translational Cancer Research Think Tank Meeting: Design Strategies for Personalized Therapy Trials
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Journal Articles

Adaptive Clinical Trial Designs for Simultaneous Testing of Matched Diagnostics and Therapeutics

Howard I. Scher, Shelley Fuld Nasso, Eric H. Rubin, Richard Simon
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (21): 6634–6640.
https://doi.org/10.1158/1078-0432.CCR-11-1105
Published: 31 October 2011
View article titled, Adaptive Clinical Trial Designs for Simultaneous Testing of Matched Diagnostics and Therapeutics
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Journal Articles

Introducing New Strategies in...

James L. Abbruzzese, M.D., Alexander M.M. Eggermont, M.D., Ph.D., Eric H. Rubin, M.D.
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (5): 1347.
https://doi.org/10.1158/1078-0432.CCR-10-0236
Published: 28 February 2010
View article titled, Introducing <em>New Strategies in...</em>
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Includes: Supplementary data
Journal Articles

Finding the Right Dose for Cancer Therapeutics—Can We Do Better?

Eric H. Rubin, Keaven M. Anderson
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (4): 1085–1087.
https://doi.org/10.1158/1078-0432.CCR-09-3246
Published: 15 February 2010
View article titled, Finding the Right Dose for Cancer Therapeutics—Can We Do Better?
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Includes: Supplementary data
Journal Articles

A Single Supratherapeutic Dose of Vorinostat Does Not Prolong the QTc Interval in Patients with Advanced Cancer

Pamela N. Munster, Eric H. Rubin, Simon Van Belle, Evan Friedman, Jaclyn K. Patterson, Kristien Van Dyck, Xiadong Li, Wendy Comisar, Jeffery A. Chodakewitz, John A. Wagner, Marian Iwamoto
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (22): 7077–7084.
https://doi.org/10.1158/1078-0432.CCR-09-1214
Published: 11 November 2009
View article titled, A Single Supratherapeutic Dose of Vorinostat Does Not Prolong the QTc Interval in Patients with Advanced Cancer
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Includes: Supplementary data
Journal Articles

Phase I Study of Eribulin Mesylate Administered Once Every 21 Days in Patients with Advanced Solid Tumors

Antoinette R. Tan, Eric H. Rubin, Diana C. Walton, Dale E. Shuster, Y. Nancy Wong, Fang Fang, Simon Ashworth, Lee S. Rosen
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (12): 4213–4219.
https://doi.org/10.1158/1078-0432.CCR-09-0360
Published: 15 June 2009
View article titled, Phase I Study of Eribulin Mesylate Administered Once Every 21 Days in Patients with Advanced Solid Tumors
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Includes: Supplementary data
Journal Articles

Pharmacokinetic/Pharmacodynamic Modeling and Simulation of Neutropenia during Phase I Development of Liposome-Entrapped Paclitaxel

Gerald J. Fetterly, Thaddeus H. Grasela, Jeffrey W. Sherman, Jeanne L. Dul, Amy Grahn, Diane Lecomte, Jill Fiedler-Kelly, Nevena Damjanov, Mayer Fishman, Michael P. Kane, Eric H. Rubin, Antoinette R. Tan
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (18): 5856–5863.
https://doi.org/10.1158/1078-0432.CCR-08-1046
Published: 14 September 2008
View article titled, Pharmacokinetic/Pharmacodynamic Modeling and Simulation of Neutropenia during Phase I Development of Liposome-Entrapped Paclitaxel
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Includes: Supplementary data
Journal Articles

Phase I and Pharmacokinetic Study of Imatinib Mesylate (Gleevec) and Gemcitabine in Patients with Refractory Solid Tumors

Yaqoob Ali, Yong Lin, Mecide M. Gharibo, Murugesan K. Gounder, Mark N. Stein, Theodore F. Lagattuta, Merrill J. Egorin, Eric H. Rubin, Elizabeth A. Poplin
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (19): 5876–5882.
https://doi.org/10.1158/1078-0432.CCR-07-0883
Published: 01 October 2007
View article titled, Phase I and Pharmacokinetic Study of Imatinib Mesylate (Gleevec) and Gemcitabine in Patients with Refractory Solid Tumors
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Journal Articles

A Study to Determine the Effects of Food and Multiple Dosing on the Pharmacokinetics of Vorinostat Given Orally to Patients with Advanced Cancer

Eric H. Rubin, Nancy G.B. Agrawal, Evan J. Friedman, Pamela Scott, Kathryn E. Mazina, Linda Sun, Lihong Du, Justin L. Ricker, Stanley R. Frankel, Keith M. Gottesdiener, John A. Wagner, Marian Iwamoto
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (23): 7039–7045.
https://doi.org/10.1158/1078-0432.CCR-06-1802
Published: 04 December 2006
View article titled, A Study to Determine the Effects of Food and Multiple Dosing on the Pharmacokinetics of Vorinostat Given Orally to Patients with Advanced Cancer
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Journal Articles

Pharmacokinetics of Cetuximab After Administration of Escalating Single Dosing and Weekly Fixed Dosing in Patients with Solid Tumors

Antoinette R. Tan, Dirk F. Moore, Manuel Hidalgo, James H. Doroshow, Elizabeth A. Poplin, Susan Goodin, David Mauro, Eric H. Rubin
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (21): 6517–6522.
https://doi.org/10.1158/1078-0432.CCR-06-0705
Published: 03 November 2006
View article titled, Pharmacokinetics of Cetuximab After Administration of Escalating Single Dosing and Weekly Fixed Dosing in Patients with Solid Tumors
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Journal Articles

Sequencing Topotecan and Etoposide Plus Cisplatin to Overcome Topoisomerase I and II Resistance: A Pharmacodynamically Based Phase I Trial

Joseph Aisner, Rita Musanti, Stephanie Beers, Sharon Smith, Stephanie Locsin, Eric H. Rubin
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (7): 2504–2509.
Published: 01 July 2003
View article titled, Sequencing Topotecan and Etoposide Plus Cisplatin to Overcome Topoisomerase I and II Resistance: <subtitle>A Pharmacodynamically Based Phase I Trial</subtitle>
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