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Emmanuel S. Antonarakis
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Journal Articles

Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer

Matthew C. Dallos, Aleksandar Z. Obradovic, Patrick McCann, Nivedita Chowdhury, Aditya Pratapa, David H. Aggen, Christopher Gaffney, Karen A. Autio, Renu K. Virk, Angelo M. De Marzo, Emmanuel S. Antonarakis, Howard I. Scher, Charles G. Drake, Dana E. Rathkopf
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (22): 5218–5230.
https://doi.org/10.1158/1078-0432.CCR-24-0060
Published: 15 November 2024
View article titled, Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer
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Includes: Supplementary data
Journal Articles

Abiraterone, Olaparib, or Abiraterone + Olaparib in First-Line Metastatic Castration-Resistant Prostate Cancer with DNA Repair Defects (BRCAAway)

Maha Hussain, Masha Kocherginsky, Neeraj Agarwal, Nabil Adra, Jingsong Zhang, Channing J. Paller, Joel Picus, Zachery R. Reichert, Russell Z. Szmulewitz, Scott T. Tagawa, Timothy M. Kuzel, Latifa A. Bazzi, Stephanie Daignault-Newton, Young E. Whang, Robert Dreicer, Ryan D. Stephenson, Matthew B. Rettig, Daniel Shevrin, Travis Gerke, Arul M. Chinnaiyan, Emmanuel S. Antonarakis
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (19): 4318–4328.
https://doi.org/10.1158/1078-0432.CCR-24-1402
Published: 01 October 2024
View article titled, Abiraterone, Olaparib, or Abiraterone + Olaparib in First-Line Metastatic Castration-Resistant Prostate Cancer with DNA Repair Defects (BRCAAway)
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Includes: Supplementary data
Journal Articles

Evaluating Immune Checkpoint Blockade in Metastatic Castration-Resistant Prostate Cancers with Deleterious CDK12 Alterations in the Phase 2 IMPACT Trial

Charles B. Nguyen, Melissa A. Reimers, Chamila Perera, Wassim Abida, Jonathan Chou, Felix Y. Feng, Emmanuel S. Antonarakis, Rana R. McKay, Russell K. Pachynski, Jingsong Zhang, Zachery R. Reichert, Phillip L. Palmbos, Megan E.V. Caram, Ulka N. Vaishampayan, Elisabeth I. Heath, Alexander C. Hopkins, Marcin P. Cieslik, Yi-Mi Wu, Dan R. Robinson, Veerabhadran Baladandayuthapani, Arul M. Chinnaiyan, Ajjai S. Alva
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (15): 3200–3210.
https://doi.org/10.1158/1078-0432.CCR-24-0400
Published: 01 August 2024
View article titled, Evaluating Immune Checkpoint Blockade in Metastatic Castration-Resistant Prostate Cancers with Deleterious <em>CDK12</em> Alterations in the Phase 2 IMPACT Trial
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Includes: Supplementary data
Journal Articles

The Impact of Circulating Tumor Cell HOXB13 RNA Detection in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Treated with Abiraterone or Enzalutamide

Susan Halabi, Siyuan Guo, Joseph J. Park, David M. Nanus, Daniel J. George, Emmanuel S. Antonarakis, Daniel Costin Danila, Russell Zelig Szmulewitz, Donald P. McDonnell, John D. Norris, Changxue Lu, Jun Luo, Andrew J. Armstrong
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (6): 1152–1159.
https://doi.org/10.1158/1078-0432.CCR-23-3017
Published: 15 March 2024
View article titled, The Impact of Circulating Tumor Cell HOXB13 RNA Detection in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Treated with Abiraterone or Enzalutamide
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Includes: Supplementary data
Journal Articles

Unique Spectrum of Activating BRAF Alterations in Prostate Cancer

Alex Chehrazi-Raffle, Hanna Tukachinsky, Eamon Toye, Smruthy Sivakumar, Alexa B. Schrock, Hannah E. Bergom, Hedyeh Ebrahimi, Sumanta Pal, Tanya Dorff, Neeraj Agarwal, Brandon A. Mahal, Geoffrey R. Oxnard, Justin Hwang, Emmanuel S. Antonarakis
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (19): 3948–3957.
https://doi.org/10.1158/1078-0432.CCR-23-1393
Published: 02 October 2023
View article titled, Unique Spectrum of Activating <em>BRAF</em> Alterations in Prostate Cancer
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Includes: Supplementary data
Journal Articles

Metastatic Prostate Cancers with BRCA2 versus ATM Mutations Exhibit Divergent Molecular Features and Clinical Outcomes

Justin Hwang, Xiaolei Shi, Andrew Elliott, Taylor E. Arnoff, Julie McGrath, Joanne Xiu, Phillip Walker, Hannah E. Bergom, Abderrahman Day, Shihab Ahmed, Sydney Tape, Allison Makovec, Atef Ali, Rami M. Shaker, Eamon Toye, Rachel Passow, John R. Lozada, Jinhua Wang, Emil Lou, Kent W. Mouw, Benedito A. Carneiro, Elisabeth I. Heath, Rana R. McKay, W. Michael Korn, Chadi Nabhan, Charles J. Ryan, Emmanuel S. Antonarakis
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (14): 2702–2713.
https://doi.org/10.1158/1078-0432.CCR-22-3394
Published: 14 July 2023
View article titled, Metastatic Prostate Cancers with <em>BRCA2</em> versus <em>ATM</em> Mutations Exhibit Divergent Molecular Features and Clinical Outcomes
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Includes: Supplementary data
Journal Articles

Combination Treatment with Sipuleucel-T and Abiraterone Acetate or Enzalutamide for Metastatic Castration-Resistant Prostate Cancer: STAMP and STRIDE Trials

Emmanuel S. Antonarakis, Sumit K. Subudhi, Christopher M. Pieczonka, Lawrence I. Karsh, David I. Quinn, Jason M. Hafron, Helen M. Wilfehrt, Matthew Harmon, Nadeem A. Sheikh, Neal D. Shore, Daniel P. Petrylak
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (13): 2426–2434.
https://doi.org/10.1158/1078-0432.CCR-22-3832
Published: 05 July 2023
View article titled, Combination Treatment with Sipuleucel-T and Abiraterone Acetate or Enzalutamide for Metastatic Castration-Resistant Prostate Cancer: STAMP and STRIDE Trials
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Includes: Supplementary data
Journal Articles

PSMA-positive Circulating Tumor Cell Detection and Outcomes with Abiraterone or Enzalutamide Treatment in Men with Metastatic Castrate-resistant Prostate Cancer

Santosh Gupta, Susan Halabi, Qian Yang, Akash Roy, Alisa Tubbs, Yamini Gore, Daniel J. George, David M. Nanus, Emmanuel S. Antonarakis, Daniel C. Danila, Russell Z. Szmulewitz, Richard Wenstrup, Andrew J. Armstrong
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (10): 1929–1937.
https://doi.org/10.1158/1078-0432.CCR-22-3233
Published: 15 May 2023
View article titled, PSMA-positive Circulating Tumor Cell Detection and Outcomes with Abiraterone or Enzalutamide Treatment in Men with Metastatic Castrate-resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

SPOP Mutations as a Predictive Biomarker for Androgen Receptor Axis–Targeted Therapy in De Novo Metastatic Castration-Sensitive Prostate Cancer

Umang Swami, Ryon P. Graf, Roberto H. Nussenzveig, Virginia Fisher, Hanna Tukachinsky, Alexa B. Schrock, Gerald Li, Jeffrey S. Ross, Nicolas Sayegh, Nishita Tripathi, Vinay Mathew Thomas, Geoffrey R. Oxnard, Emmanuel S. Antonarakis, Neeraj Agarwal
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (22): 4917–4925.
https://doi.org/10.1158/1078-0432.CCR-22-2228
Published: 14 November 2022
View article titled, SPOP Mutations as a Predictive Biomarker for Androgen Receptor Axis–Targeted Therapy in <em>De Novo</em> Metastatic Castration-Sensitive Prostate Cancer
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Includes: Supplementary data
Journal Articles

A Phase Ib/II Study of Sabizabulin, a Novel Oral Cytoskeleton Disruptor, in Men with Metastatic Castration-resistant Prostate Cancer with Progression on an Androgen Receptor–targeting Agent

Mark C. Markowski, Ronald Tutrone, Christopher Pieczonka, K. Gary Barnette, Robert H. Getzenberg, Domingo Rodriguez, Mitchell S. Steiner, Daniel R. Saltzstein, Mario A. Eisenberger, Emmanuel S. Antonarakis
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (13): 2789–2795.
https://doi.org/10.1158/1078-0432.CCR-22-0162
Published: 01 July 2022
View article titled, A Phase Ib/II Study of Sabizabulin, a Novel Oral Cytoskeleton Disruptor, in Men with Metastatic Castration-resistant Prostate Cancer with Progression on an Androgen Receptor–targeting Agent
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Includes: Supplementary data
Journal Articles

Circulating Tumor Cell Chromosomal Instability and Neuroendocrine Phenotype by Immunomorphology and Poor Outcomes in Men with mCRPC Treated with Abiraterone or Enzalutamide

Landon C. Brown, Susan Halabi, Joseph D. Schonhoft, Qian Yang, Jun Luo, David M. Nanus, Paraskevi Giannakakou, Russell Z. Szmulewitz, Daniel C. Danila, Ethan S. Barnett, Emily A. Carbone, Jimmy L. Zhao, Patrick Healy, Monika Anand, Audrey Gill, Adam Jendrisak, William R. Berry, Santosh Gupta, Simon G. Gregory, Richard Wenstrup, Emmanuel S. Antonarakis, Daniel J. George, Howard I. Scher, Andrew J. Armstrong
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (14): 4077–4088.
https://doi.org/10.1158/1078-0432.CCR-20-3471
Published: 15 July 2021
View article titled, Circulating Tumor Cell Chromosomal Instability and Neuroendocrine Phenotype by Immunomorphology and Poor Outcomes in Men with mCRPC Treated with Abiraterone or Enzalutamide
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Includes: Supplementary data
Journal Articles

A Randomized Phase II Study of Androgen Deprivation Therapy with or without Palbociclib in RB-positive Metastatic Hormone-Sensitive Prostate Cancer

Phillip L. Palmbos, Stephanie Daignault-Newton, Scott A. Tomlins, Neeraj Agarwal, Przemyslaw Twardowski, Alicia K. Morgans, Wm. Kevin Kelly, Vivek K. Arora, Emmanuel S. Antonarakis, Javed Siddiqui, Jon A. Jacobson, Matthew S. Davenport, Dan R. Robinson, Arul M. Chinnaiyan, Karen E. Knudsen, Maha Hussain
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (11): 3017–3027.
https://doi.org/10.1158/1078-0432.CCR-21-0024
Published: 01 June 2021
View article titled, A Randomized Phase II Study of Androgen Deprivation Therapy with or without Palbociclib in RB-positive Metastatic Hormone-Sensitive Prostate Cancer
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Journal Articles

Randomized Phase II Trial of Sipuleucel-T with or without Radium-223 in Men with Bone-metastatic Castration-resistant Prostate Cancer

Catherine H. Marshall, Wei Fu, Hao Wang, Jong Chul Park, Theodore L. DeWeese, Phuoc T. Tran, Daniel Y. Song, Serina King, Michaella Afful, Julia Hurrelbrink, Charlotte Manogue, Patrick Cotogno, Nancy P. Moldawer, Pedro C. Barata, Charles G. Drake, Edwin M. Posadas, Andrew J. Armstrong, Oliver Sartor, Emmanuel S. Antonarakis
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (6): 1623–1630.
https://doi.org/10.1158/1078-0432.CCR-20-4476
Published: 15 March 2021
View article titled, Randomized Phase II Trial of Sipuleucel-T with or without Radium-223 in Men with Bone-metastatic Castration-resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

CDK12 Deficiency and the Immune Microenvironment in Prostate Cancer

Tamara L. Lotan, Emmanuel S. Antonarakis
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (2): 380–382.
https://doi.org/10.1158/1078-0432.CCR-20-3877
Published: 19 January 2021
View article titled, <em>CDK12</em> Deficiency and the Immune Microenvironment in Prostate Cancer
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Journal Articles

Reimagining Vaccines for Prostate Cancer: Back to the Future

Eugene Shenderov, Emmanuel S. Antonarakis
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (19): 5056–5058.
https://doi.org/10.1158/1078-0432.CCR-20-2257
Published: 01 October 2020
View article titled, Reimagining Vaccines for Prostate Cancer: Back to the Future
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Journal Articles

Genomic and Clinicopathologic Characterization of ATM-deficient Prostate Cancer

Harsimar Kaur, Daniela C. Salles, Sanjana Murali, Jessica L. Hicks, Minh Nguyen, Colin C. Pritchard, Angelo M. De Marzo, Jerry S. Lanchbury, Bruce J. Trock, William B. Isaacs, Kirsten M. Timms, Emmanuel S. Antonarakis, Tamara L. Lotan
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (18): 4869–4881.
https://doi.org/10.1158/1078-0432.CCR-20-0764
Published: 15 September 2020
View article titled, Genomic and Clinicopathologic Characterization of <em>ATM</em>-deficient Prostate Cancer
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Includes: Supplementary data
Journal Articles

T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer

Aleksandar Z. Obradovic, Matthew C. Dallos, Marianna L. Zahurak, Alan W. Partin, Edward M. Schaeffer, Ashley E. Ross, Mohamad E. Allaf, Thomas R. Nirschl, David Liu, Carolyn G. Chapman, Tanya O'Neal, Haiyi Cao, Jennifer N. Durham, Gunes Guner, Javier A. Baena-Del Valle, Onur Ertunc, Angelo M. De Marzo, Emmanuel S. Antonarakis, Charles G. Drake
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13): 3182–3192.
https://doi.org/10.1158/1078-0432.CCR-19-3372
Published: 01 July 2020
View article titled, T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer
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Includes: Supplementary data
Journal Articles

Clinical Significance of AR-V567es in Prostate Cancer—Response

Scott T. Tagawa, Emmanuel S. Antonarakis, Ada Gjyrezi, Giuseppe Galletti, Paraskevi Giannakakou
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (19): 6010–6011.
https://doi.org/10.1158/1078-0432.CCR-19-1820
Published: 01 October 2019
View article titled, Clinical Significance of AR-V567es in Prostate Cancer—Response
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Journal Articles

Expression of AR-V7 and ARv567es in Circulating Tumor Cells Correlates with Outcomes to Taxane Therapy in Men with Metastatic Prostate Cancer Treated in TAXYNERGY

Scott T. Tagawa, Emmanuel S. Antonarakis, Ada Gjyrezi, Giuseppe Galletti, Seaho Kim, Daniel Worroll, John Stewart, Atef Zaher, Ted P. Szatrowski, Karla V. Ballman, Katsuhiro Kita, Shinsuke Tasaki, Yang Bai, Luigi Portella, Brian J. Kirby, Fred Saad, Mario A. Eisenberger, David M. Nanus, Paraskevi Giannakakou
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (6): 1880–1888.
https://doi.org/10.1158/1078-0432.CCR-18-0320
Published: 15 March 2019
View article titled, Expression of AR-V7 and ARv<sup>567es</sup> in Circulating Tumor Cells Correlates with Outcomes to Taxane Therapy in Men with Metastatic Prostate Cancer Treated in TAXYNERGY
Open the PDF for Expression of AR-V7 and ARv<sup>567es</sup> in Circulating Tumor Cells Correlates with Outcomes to Taxane Therapy in Men with Metastatic Prostate Cancer Treated in TAXYNERGY in another window
Includes: Supplementary data
Journal Articles

Antigen-Specific CD8 Lytic Phenotype Induced by Sipuleucel-T in Hormone-Sensitive or Castration-Resistant Prostate Cancer and Association with Overall Survival

Emmanuel S. Antonarakis, Eric J. Small, Daniel P. Petrylak, David I. Quinn, Adam S. Kibel, Nancy N. Chang, Erica Dearstyne, Matt Harmon, Dwayne Campogan, Heather Haynes, Tuyen Vu, Nadeem A. Sheikh, Charles G. Drake
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (19): 4662–4671.
https://doi.org/10.1158/1078-0432.CCR-18-0638
Published: 01 October 2018
View article titled, Antigen-Specific CD8 Lytic Phenotype Induced by Sipuleucel-T in Hormone-Sensitive or Castration-Resistant Prostate Cancer and Association with Overall Survival
Open the PDF for Antigen-Specific CD8 Lytic Phenotype Induced by Sipuleucel-T in Hormone-Sensitive or Castration-Resistant Prostate Cancer and Association with Overall Survival in another window
Includes: Supplementary data