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Elizabeth A. Mittendorf
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Journal Articles

A phase II study of atezolizumab, pertuzumab, and high-dose trastuzumab for central nervous system metastases in patients with HER2-positive breast cancer

Antonio Giordano, Priya U. Kumthekar, Qingchun Jin, Busem Binboga Kurt, Siyang Ren, Tianyu Li, Jose Pablo. Leone, Elizabeth A. Mittendorf, Alyssa M. Pereslete, Laura Sharp, Raechel Davis, Molly DiLullo, Nabihah Tayob, Erica L. Mayer, Eric P. Winer, Sara M. Tolaney, Nancy U. Lin
Journal: Clinical Cancer Research
Clin Cancer Res (2024)
https://doi.org/10.1158/1078-0432.CCR-24-1161
Published: 03 September 2024
View article titled, A phase II study of atezolizumab, pertuzumab, and high-dose trastuzumab for central nervous system metastases in patients with HER2-positive breast cancer
Open the PDF for A phase II study of atezolizumab, pertuzumab, and high-dose trastuzumab for central nervous system metastases in patients with HER2-positive breast cancer in another window
Includes: Supplementary data
Journal Articles

Integrative multi-omic profiling of triple-negative breast cancer for identifying suitable therapies

Bojana Jovanovic, Sarah E. Church, Kara M. Gorman, Khrystyna North, Edward T. Richardson, Molly DiLullo, Victoria Attaya, Julie Kasparian, Ayesha Mohammed-Abreu, Gregory Kirkner, Melissa E. Hughes, Nancy U. Lin, Elizabeth A. Mittendorf, Stuart J. Schnitt, Sara M. Tolaney, Shom Goel
Journal: Clinical Cancer Research
Clin Cancer Res (2024)
https://doi.org/10.1158/1078-0432.CCR-23-1242
Published: 13 August 2024
View article titled, Integrative multi-omic profiling of triple-negative breast cancer for identifying suitable therapies
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Includes: Supplementary data
Journal Articles

Tumor Immune Microenvironment Changes by Multiplex Immunofluorescence Staining in a Pilot Study of Neoadjuvant Talazoparib for Early-Stage Breast Cancer Patients with a Hereditary BRCA Mutation

Tapsi Kumar, Evie Hobbs, Fei Yang, Jeffrey T. Chang, Alejandro Contreras, Edwin Roger Parra Cuentas, Haven Garber, Sanghoon Lee, Yiling Lu, Marion E. Scoggins, Beatriz E. Adrada, Gary J. Whitman, Banu K. Arun, Elizabeth A. Mittendorf, Jennifer K. Litton
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (17): 3669–3676.
https://doi.org/10.1158/1078-0432.CCR-21-1278
Published: 01 September 2022
View article titled, Tumor Immune Microenvironment Changes by Multiplex Immunofluorescence Staining in a Pilot Study of Neoadjuvant Talazoparib for Early-Stage Breast Cancer Patients with a Hereditary <em>BRCA</em> Mutation
Open the PDF for Tumor Immune Microenvironment Changes by Multiplex Immunofluorescence Staining in a Pilot Study of Neoadjuvant Talazoparib for Early-Stage Breast Cancer Patients with a Hereditary <em>BRCA</em> Mutation in another window
Includes: Supplementary data
Journal Articles

Molecular Characterization and Prospective Evaluation of Pathologic Response and Outcomes with Neoadjuvant Therapy in Metaplastic Triple-Negative Breast Cancer

Clinton Yam, Nour Abuhadra, Ryan Sun, Beatriz E. Adrada, Qing-Qing Ding, Jason B. White, Elizabeth E. Ravenberg, Alyson R. Clayborn, Vicente Valero, Debu Tripathy, Senthilkumar Damodaran, Banu K. Arun, Jennifer K. Litton, Naoto T. Ueno, Rashmi K. Murthy, Bora Lim, Luis Baez, Xiaoxian Li, Aman U. Buzdar, Gabriel N. Hortobagyi, Alistair M. Thompson, Elizabeth A. Mittendorf, Gaiane M. Rauch, Rosalind P. Candelaria, Lei Huo, Stacy L. Moulder, Jeffrey T. Chang
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (13): 2878–2889.
https://doi.org/10.1158/1078-0432.CCR-21-3100
Published: 01 July 2022
View article titled, Molecular Characterization and Prospective Evaluation of Pathologic Response and Outcomes with Neoadjuvant Therapy in Metaplastic Triple-Negative Breast Cancer
Open the PDF for Molecular Characterization and Prospective Evaluation of Pathologic Response and Outcomes with Neoadjuvant Therapy in Metaplastic Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Immune Phenotype and Response to Neoadjuvant Therapy in Triple-Negative Breast Cancer

Clinton Yam, Er-Yen Yen, Jeffrey T. Chang, Roland L. Bassett, Jr, Gheath Alatrash, Haven Garber, Lei Huo, Fei Yang, Anne V. Philips, Qing-Qing Ding, Bora Lim, Naoto T. Ueno, Kasthuri Kannan, Xiangjie Sun, Baohua Sun, Edwin Roger Parra Cuentas, William Fraser Symmans, Jason B. White, Elizabeth Ravenberg, Sahil Seth, Jennifer L. Guerriero, Gaiane M. Rauch, Senthil Damodaran, Jennifer K. Litton, Jennifer A. Wargo, Gabriel N. Hortobagyi, Andrew Futreal, Ignacio I. Wistuba, Ryan Sun, Stacy L. Moulder, Elizabeth A. Mittendorf
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (19): 5365–5375.
https://doi.org/10.1158/1078-0432.CCR-21-0144
Published: 01 October 2021
View article titled, Immune Phenotype and Response to Neoadjuvant Therapy in Triple-Negative Breast Cancer
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Includes: Supplementary data
Journal Articles

Clinical Efficacy and Molecular Response Correlates of the WEE1 Inhibitor Adavosertib Combined with Cisplatin in Patients with Metastatic Triple-Negative Breast Cancer

Tanya E. Keenan, Tianyu Li, Tuulia Vallius, Jennifer L. Guerriero, Nabihah Tayob, Bose Kochupurakkal, Janae Davis, Ricardo Pastorello, Rie K. Tahara, Leilani Anderson, Jake Conway, Meng X. He, Erin Shannon, Robert E. Godin, Peter K. Sorger, Alan D'Andrea, Beth Overmoyer, Eric P. Winer, Elizabeth A. Mittendorf, Eliezer M. Van Allen, Geoffrey I. Shapiro, Sara M. Tolaney
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (4): 983–991.
https://doi.org/10.1158/1078-0432.CCR-20-3089
Published: 15 February 2021
View article titled, Clinical Efficacy and Molecular Response Correlates of the WEE1 Inhibitor Adavosertib Combined with Cisplatin in Patients with Metastatic Triple-Negative Breast Cancer
Open the PDF for Clinical Efficacy and Molecular Response Correlates of the WEE1 Inhibitor Adavosertib Combined with Cisplatin in Patients with Metastatic Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Results of a Randomized Phase IIb Trial of Nelipepimut-S + Trastuzumab versus Trastuzumab to Prevent Recurrences in Patients with High-Risk HER2 Low-Expressing Breast Cancer

G. Travis Clifton, Diane Hale, Timothy J. Vreeland, Annelies T. Hickerson, Jennifer K. Litton, Gheath Alatrash, Rashmi K. Murthy, Na Qiao, Anne V. Philips, Jason J. Lukas, Jarrod P. Holmes, George E. Peoples, Elizabeth A. Mittendorf
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (11): 2515–2523.
https://doi.org/10.1158/1078-0432.CCR-19-2741
Published: 01 June 2020
View article titled, Results of a Randomized Phase IIb Trial of Nelipepimut-S + Trastuzumab versus Trastuzumab to Prevent Recurrences in Patients with High-Risk HER2 Low-Expressing Breast Cancer
Open the PDF for Results of a Randomized Phase IIb Trial of Nelipepimut-S + Trastuzumab versus Trastuzumab to Prevent Recurrences in Patients with High-Risk HER2 Low-Expressing Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Tumor Mutational Burden and PTEN Alterations as Molecular Correlates of Response to PD-1/L1 Blockade in Metastatic Triple-Negative Breast Cancer

Romualdo Barroso-Sousa, Tanya E. Keenan, Sonia Pernas, Pedro Exman, Esha Jain, Ana C. Garrido-Castro, Melissa Hughes, Brittany Bychkovsky, Renato Umeton, Janet L. Files, Neal I. Lindeman, Laura E. MacConaill, F. Stephen Hodi, Ian E. Krop, Deborah Dillon, Eric P. Winer, Nikhil Wagle, Nancy U. Lin, Elizabeth A. Mittendorf, Eliezer M. Van Allen, Sara M. Tolaney
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (11): 2565–2572.
https://doi.org/10.1158/1078-0432.CCR-19-3507
Published: 01 June 2020
View article titled, Tumor Mutational Burden and <em>PTEN</em> Alterations as Molecular Correlates of Response to PD-1/L1 Blockade in Metastatic Triple-Negative Breast Cancer
Open the PDF for Tumor Mutational Burden and <em>PTEN</em> Alterations as Molecular Correlates of Response to PD-1/L1 Blockade in Metastatic Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

The Immune Microenvironment in Hormone Receptor–Positive Breast Cancer Before and After Preoperative Chemotherapy

Adrienne G. Waks, Daniel G. Stover, Jennifer L. Guerriero, Deborah Dillon, William T. Barry, Evisa Gjini, Christina Hartl, Wesley Lo, Jennifer Savoie, Jane Brock, Robert Wesolowski, Zaibo Li, Adrienne Damicis, Anne V. Philips, Yun Wu, Fei Yang, Amy Sullivan, Patrick Danaher, Heather Ann Brauer, Wafa Osmani, Mikel Lipschitz, Katherine A. Hoadley, Michael Goldberg, Charles M. Perou, Scott Rodig, Eric P. Winer, Ian E. Krop, Elizabeth A. Mittendorf, Sara M. Tolaney
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (15): 4644–4655.
https://doi.org/10.1158/1078-0432.CCR-19-0173
Published: 01 August 2019
View article titled, The Immune Microenvironment in Hormone Receptor–Positive Breast Cancer Before and After Preoperative Chemotherapy
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Includes: Supplementary data
Journal Articles

Efficacy and Safety Analysis of Nelipepimut-S Vaccine to Prevent Breast Cancer Recurrence: A Randomized, Multicenter, Phase III Clinical Trial

Elizabeth A. Mittendorf, Biao Lu, Michelle Melisko, Julie Price Hiller, Igor Bondarenko, Adrian Murray Brunt, Grybach Sergii, Katarina Petrakova, George E. Peoples
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (14): 4248–4254.
https://doi.org/10.1158/1078-0432.CCR-18-2867
Published: 15 July 2019
View article titled, Efficacy and Safety Analysis of Nelipepimut-S Vaccine to Prevent Breast Cancer Recurrence: A Randomized, Multicenter, Phase III Clinical Trial
Open the PDF for Efficacy and Safety Analysis of Nelipepimut-S Vaccine to Prevent Breast Cancer Recurrence: A Randomized, Multicenter, Phase III Clinical Trial in another window
Journal Articles

Fucosylation Enhances the Efficacy of Adoptively Transferred Antigen-Specific Cytotoxic T Lymphocytes

Gheath Alatrash, Na Qiao, Mao Zhang, Madhushree Zope, Alexander A. Perakis, Pariya Sukhumalchandra, Anne V. Philips, Haven R. Garber, Celine Kerros, Lisa S. St. John, Maria R. Khouri, Hiep Khong, Karen Clise-Dwyer, Leonard P. Miller, Steve Wolpe, Willem W. Overwijk, Jeffrey J. Molldrem, Qing Ma, Elizabeth J. Shpall, Elizabeth A. Mittendorf
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (8): 2610–2620.
https://doi.org/10.1158/1078-0432.CCR-18-1527
Published: 15 April 2019
View article titled, Fucosylation Enhances the Efficacy of Adoptively Transferred Antigen-Specific Cytotoxic T Lymphocytes
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Includes: Supplementary data
Journal Articles

Targeting the Leukemia Antigen PR1 with Immunotherapy for the Treatment of Multiple Myeloma

Gheath Alatrash, Alexander A. Perakis, Celine Kerros, Haley L. Peters, Pariya Sukhumalchandra, Mao Zhang, Haroon Jakher, Madhushree Zope, Rebecca Patenia, Anna Sergeeva, Shuhua Yi, Ken H. Young, Anne V. Philips, Amanda M. Cernosek, Haven R. Garber, Na Qiao, Jinsheng Weng, Lisa S. St John, Sijie Lu, Karen Clise-Dwyer, Elizabeth A. Mittendorf, Qing Ma, Jeffrey J. Molldrem
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (14): 3386–3396.
https://doi.org/10.1158/1078-0432.CCR-17-2626
Published: 15 July 2018
View article titled, Targeting the Leukemia Antigen PR1 with Immunotherapy for the Treatment of Multiple Myeloma
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Includes: Supplementary data
Journal Articles

A Novel HLA-A*0201 Restricted Peptide Derived from Cathepsin G Is an Effective Immunotherapeutic Target in Acute Myeloid Leukemia

Mao Zhang, Pariya Sukhumalchandra, Atim A. Enyenihi, Lisa S. St. John, Sally A. Hunsucker, Elizabeth A. Mittendorf, Anna Sergeeva, Kathryn Ruisaard, Zein Al-Atrache, Patricia A. Ropp, Haroon Jakher, Tania Rodriguez-Cruz, Gregory Lizee, Karen Clise-Dwyer, Sijie Lu, Jeffrey J. Molldrem, Gary L. Glish, Paul M. Armistead, Gheath Alatrash
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (1): 247–257.
https://doi.org/10.1158/1078-0432.CCR-12-2753
Published: 02 January 2013
View article titled, A Novel HLA-A*0201 Restricted Peptide Derived from Cathepsin G Is an Effective Immunotherapeutic Target in Acute Myeloid Leukemia
Open the PDF for A Novel HLA-A*0201 Restricted Peptide Derived from Cathepsin G Is an Effective Immunotherapeutic Target in Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Loss of HER2 Amplification Following Trastuzumab-Based Neoadjuvant Systemic Therapy and Survival Outcomes

Elizabeth A. Mittendorf, Yun Wu, Maurizio Scaltriti, Funda Meric-Bernstam, Kelly K. Hunt, Shaheenah Dawood, Francisco J. Esteva, Aman U. Buzdar, Huiqin Chen, Sameena Eksambi, Gabriel N. Hortobagyi, Jose Baselga, Ana M. Gonzalez-Angulo
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (23): 7381–7388.
https://doi.org/10.1158/1078-0432.CCR-09-1735
Published: 30 November 2009
View article titled, Loss of <em>HER2</em> Amplification Following Trastuzumab-Based Neoadjuvant Systemic Therapy and Survival Outcomes
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Journal Articles

The Impact of HER2/neu Expression Level on Response to the E75 Vaccine: From U.S. Military Cancer Institute Clinical Trials Group Study I-01 and I-02

Linda C. Benavides, Jeremy D. Gates, Mark G. Carmichael, Ritesh Patel, Jarrod P. Holmes, Matthew T. Hueman, Elizabeth A. Mittendorf, Dianna Craig, Alexander Stojadinovic, Sathibalan Ponniah, George E. Peoples
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (8): 2895–2904.
https://doi.org/10.1158/1078-0432.CCR-08-1126
Published: 15 April 2009
View article titled, The Impact of HER2/<em>neu</em> Expression Level on Response to the E75 Vaccine: From U.S. Military Cancer Institute Clinical Trials Group Study I-01 and I-02
Open the PDF for The Impact of HER2/<em>neu</em> Expression Level on Response to the E75 Vaccine: From U.S. Military Cancer Institute Clinical Trials Group Study I-01 and I-02 in another window
Journal Articles

Combined Clinical Trial Results of a HER2/neu (E75) Vaccine for the Prevention of Recurrence in High-Risk Breast Cancer Patients: U.S. Military Cancer Institute Clinical Trials Group Study I-01 and I-02

George E. Peoples, Jarrod P. Holmes, Matthew T. Hueman, Elizabeth A. Mittendorf, Asna Amin, Steven Khoo, Zia A. Dehqanzada, Jennifer M. Gurney, Michael M. Woll, Gayle B. Ryan, Catherine E. Storrer, Dianna Craig, Constantin G. Ioannides, Sathibalan Ponniah
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (3): 797–803.
https://doi.org/10.1158/1078-0432.CCR-07-1448
Published: 01 February 2008
View article titled, Combined Clinical Trial Results of a HER2/<em>neu</em> (E75) Vaccine for the Prevention of Recurrence in High-Risk Breast Cancer Patients: U.S. Military Cancer Institute Clinical Trials Group Study I-01 and I-02
Open the PDF for Combined Clinical Trial Results of a HER2/<em>neu</em> (E75) Vaccine for the Prevention of Recurrence in High-Risk Breast Cancer Patients: U.S. Military Cancer Institute Clinical Trials Group Study I-01 and I-02 in another window