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Eileen Dolan
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Journal Articles

Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors

Matthew R. Trendowski, Heather E. Wheeler, Omar El-Charif, Darren R. Feldman, Robert J. Hamilton, David J. Vaughn, Chunkit Fung, Christian Kollmannsberger, Lawrence H. Einhorn, Lois B. Travis, M. Eileen Dolan
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (24): 6550–6558.
https://doi.org/10.1158/1078-0432.CCR-20-2682
Published: 15 December 2020
View article titled, Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors
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Includes: Supplementary data
Journal Articles

Genomic Variants of Cytarabine Sensitivity Associated with Treatment-Related Mortality in Pediatric AML: A Report from the Children's Oncology Group

Christine L. Phillips, Adam Lane, Robert B. Gerbing, Todd A. Alonzo, Alyss Wilkey, Gretchen Radloff, Beverly Lange, Eric R. Gamazon, M. Eileen Dolan, Stella M. Davies
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (12): 2891–2897.
https://doi.org/10.1158/1078-0432.CCR-19-3117
Published: 15 June 2020
View article titled, Genomic Variants of Cytarabine Sensitivity Associated with Treatment-Related Mortality in Pediatric AML: A Report from the Children's Oncology Group
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Includes: Supplementary data
Journal Articles

Clinical and Genome-Wide Analysis of Serum Platinum Levels after Cisplatin-Based Chemotherapy

Matthew R. Trendowski, Omar El-Charif, Mark J. Ratain, Patrick Monahan, Zepeng Mu, Heather E. Wheeler, Paul C. Dinh, Jr, Darren R. Feldman, Shirin Ardeshir-Rouhani-Fard, Robert J. Hamilton, David J. Vaughn, Chunkit Fung, Christian Kollmannsberger, Taisei Mushiroda, Michiaki Kubo, Robyn Hannigan, Frederick Strathmann, Lawrence H. Einhorn, Sophie D. Fossa, Lois B. Travis, M. Eileen Dolan
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (19): 5913–5924.
https://doi.org/10.1158/1078-0432.CCR-19-0113
Published: 01 October 2019
View article titled, Clinical and Genome-Wide Analysis of Serum Platinum Levels after Cisplatin-Based Chemotherapy
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Includes: Supplementary data
Journal Articles

Clinical and Genome-wide Analysis of Cisplatin-induced Tinnitus Implicates Novel Ototoxic Mechanisms

Omar El Charif, Brandon Mapes, Matthew R. Trendowski, Heather E. Wheeler, Claudia Wing, Paul C. Dinh, Jr, Robert D. Frisina, Darren R. Feldman, Robert J. Hamilton, David J. Vaughn, Chunkit Fung, Christian Kollmannsberger, Taisei Mushiroda, Michiaki Kubo, Eric R. Gamazon, Nancy J. Cox, Robert Huddart, Shirin Ardeshir-Rouhani-Fard, Patrick Monahan, Sophie D. Fossa, Lawrence H. Einhorn, Lois B. Travis, M. Eileen Dolan
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (13): 4104–4116.
https://doi.org/10.1158/1078-0432.CCR-18-3179
Published: 01 July 2019
View article titled, Clinical and Genome-wide Analysis of Cisplatin-induced Tinnitus Implicates Novel Ototoxic Mechanisms
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Includes: Supplementary data
Journal Articles

Genetic and Modifiable Risk Factors Contributing to Cisplatin-induced Toxicities

Matthew R. Trendowski, Omar El Charif, Paul C. Dinh, Jr, Lois B. Travis, M. Eileen Dolan
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (4): 1147–1155.
https://doi.org/10.1158/1078-0432.CCR-18-2244
Published: 15 February 2019
View article titled, Genetic and Modifiable Risk Factors Contributing to Cisplatin-induced Toxicities
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Includes: Supplementary data
Journal Articles

Clinical and Genome-Wide Analysis of Cisplatin-Induced Peripheral Neuropathy in Survivors of Adult-Onset Cancer

M. Eileen Dolan, Omar El Charif, Heather E. Wheeler, Eric R. Gamazon, Shirin Ardeshir-Rouhani-Fard, Patrick Monahan, Darren R. Feldman, Robert J. Hamilton, David J. Vaughn, Clair J. Beard, Chunkit Fung, Jeri Kim, Sophie D. Fossa, Daniel L Hertz, Taisei Mushiroda, Michiaki Kubo, Lawrence H. Einhorn, Nancy J. Cox, Lois B. Travis
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (19): 5757–5768.
https://doi.org/10.1158/1078-0432.CCR-16-3224
Published: 01 October 2017
View article titled, Clinical and Genome-Wide Analysis of Cisplatin-Induced Peripheral Neuropathy in Survivors of Adult-Onset Cancer
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Includes: Supplementary data
Journal Articles

Genome-Wide Association Studies of Chemotherapeutic Toxicities: Genomics of Inequality

Brandon Mapes, Omar El Charif, Shereen Al-Sawwaf, M. Eileen Dolan
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (15): 4010–4019.
https://doi.org/10.1158/1078-0432.CCR-17-0429
Published: 01 August 2017
View article titled, Genome-Wide Association Studies of Chemotherapeutic Toxicities: Genomics of Inequality
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Journal Articles

Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity

Heather E. Wheeler, Eric R. Gamazon, Robert D. Frisina, Carlos Perez-Cervantes, Omar El Charif, Brandon Mapes, Sophie D. Fossa, Darren R. Feldman, Robert J. Hamilton, David J. Vaughn, Clair J. Beard, Chunkit Fung, Christian Kollmannsberger, Jeri Kim, Taisei Mushiroda, Michiaki Kubo, Shirin Ardeshir-Rouhani-Fard, Lawrence H. Einhorn, Nancy J. Cox, M. Eileen Dolan, Lois B. Travis
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (13): 3325–3333.
https://doi.org/10.1158/1078-0432.CCR-16-2809
Published: 02 July 2017
View article titled, Variants in <em>WFS1</em> and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity
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Includes: Supplementary data
Journal Articles

Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy

Daniel L. Hertz, Kouros Owzar, Sherrie Lessans, Claudia Wing, Chen Jiang, William Kevin Kelly, Jai Patel, Susan Halabi, Yoichi Furukawa, Heather E. Wheeler, Alexander B. Sibley, Cameron Lassiter, Lois Weisman, Dorothy Watson, Stefanie D. Krens, Flora Mulkey, Cynthia L. Renn, Eric J. Small, Phillip G. Febbo, Ivo Shterev, Deanna L. Kroetz, Paula N. Friedman, John F. Mahoney, Michael A. Carducci, Michael J. Kelley, Yusuke Nakamura, Michiaki Kubo, Susan G. Dorsey, M. Eileen Dolan, Michael J. Morris, Mark J. Ratain, Howard L. McLeod
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (19): 4890–4900.
https://doi.org/10.1158/1078-0432.CCR-15-2823
Published: 02 October 2016
View article titled, Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a <em>VAC14</em> Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy
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Includes: Supplementary data
Journal Articles

Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy

Masaaki Komatsu, Heather E. Wheeler, Suyoun Chung, Siew-Kee Low, Claudia Wing, Shannon M. Delaney, Lidija K. Gorsic, Atsushi Takahashi, Michiaki Kubo, Deanna L. Kroetz, Wei Zhang, Yusuke Nakamura, M. Eileen Dolan
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (19): 4337–4346.
https://doi.org/10.1158/1078-0432.CCR-15-0133
Published: 30 September 2015
View article titled, Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy
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Includes: Supplementary data
Journal Articles

Genes contributing to etoposide-induced cytotoxicity

Rong S. Huang, Shiwei Duan, Wasim K. Bleibel, Wei Zhang, M. Eileen Dolan
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (19_Supplement): PR-3.
Published: 15 August 2014
View article titled, Genes contributing to etoposide-induced cytotoxicity
Journal Articles

Unbiased Cell-Based Models to Identify GeneticVariants Associated with Chemotherapeutic Induced Toxicity

R. Stephanie Huang, Wei Zhang, Sunita Shukla, Shiwei Duan, Wasim Bleibel, Christine Hartford, M. Eileen Dolan
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (22_Supplement): CN01-01.
Published: 15 August 2014
View article titled, Unbiased Cell-Based Models to Identify GeneticVariants Associated with Chemotherapeutic Induced Toxicity
Journal Articles

Integration of Cell Line and Clinical Trial Genome-Wide Analyses Supports a Polygenic Architecture of Paclitaxel-Induced Sensory Peripheral Neuropathy

Heather E. Wheeler, Eric R. Gamazon, Claudia Wing, Uchenna O. Njiaju, Chidiamara Njoku, Robert Michael Baldwin, Kouros Owzar, Chen Jiang, Dorothy Watson, Ivo Shterev, Michiaki Kubo, Hitoshi Zembutsu, Eric P. Winer, Clifford A. Hudis, Lawrence N. Shulman, Yusuke Nakamura, Mark J. Ratain, Deanna L. Kroetz, Nancy J. Cox, Mary Eileen Dolan
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (2): 491–499.
https://doi.org/10.1158/1078-0432.CCR-12-2618
Published: 16 January 2013
View article titled, Integration of Cell Line and Clinical Trial Genome-Wide Analyses Supports a Polygenic Architecture of Paclitaxel-Induced Sensory Peripheral Neuropathy
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Includes: Supplementary data
Journal Articles

Regulatory Polymorphisms in β-Tubulin IIa Are Associated with Paclitaxel-Induced Peripheral Neuropathy

Luis J. Leandro-García, Susanna Leskelä, Carlos Jara, Henrik Gréen, Elisabeth Åvall-Lundqvist, Heather E. Wheeler, M. Eileen Dolan, Lucia Inglada-Perez, Agnieszka Maliszewska, Aguirre A. de Cubas, Iñaki Comino-Méndez, Veronika Mancikova, Alberto Cascón, Mercedes Robledo, Cristina Rodríguez-Antona
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (16): 4441–4448.
https://doi.org/10.1158/1078-0432.CCR-12-1221
Published: 14 August 2012
View article titled, Regulatory Polymorphisms in β-Tubulin IIa Are Associated with Paclitaxel-Induced Peripheral Neuropathy
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Includes: Supplementary data
Journal Articles

Using Germline Genomics to Individualize Pediatric Cancer Treatments

Navin Pinto, Susan L. Cohn, M. Eileen Dolan
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (10): 2791–2800.
https://doi.org/10.1158/1078-0432.CCR-11-1938
Published: 14 May 2012
View article titled, Using Germline Genomics to Individualize Pediatric Cancer Treatments
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Journal Articles

Multicenter Phase II Trial of Temozolomide in Mycosis Fungoides/Sézary Syndrome: Correlation with O6-Methylguanine-DNA Methyltransferase and Mismatch Repair Proteins

Christiane Querfeld, Steven T. Rosen, Joan Guitart, Alfred Rademaker, David S. Pezen, M. Eileen Dolan, Joseph Baron, Daniel B. Yarosh, Francine Foss, Timothy M. Kuzel
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (17): 5748–5754.
https://doi.org/10.1158/1078-0432.CCR-11-0556
Published: 01 September 2011
View article titled, Multicenter Phase II Trial of Temozolomide in Mycosis Fungoides/Sézary Syndrome: Correlation with <em>O</em><sup>6</sup>-Methylguanine-DNA Methyltransferase and Mismatch Repair Proteins
Open the PDF for Multicenter Phase II Trial of Temozolomide in Mycosis Fungoides/Sézary Syndrome: Correlation with <em>O</em><sup>6</sup>-Methylguanine-DNA Methyltransferase and Mismatch Repair Proteins in another window
Journal Articles

Platinum Sensitivity–Related Germline Polymorphism Discovered via a Cell-Based Approach and Analysis of Its Association with Outcome in Ovarian Cancer Patients

R. Stephanie Huang, Sharon E. Johnatty, Eric R. Gamazon, Hae Kyung Im, Dana Ziliak, Shiwei Duan, Wei Zhang, Emily O. Kistner, Peixian Chen, Jonathan Beesley, Shuangli Mi, Peter H. O'Donnell, Yarden S. Fraiman, Soma Das, Nancy J. Cox, Yi Lu, Stuart MacGregor, Ellen L. Goode, Robert A. Vierkant, Brooke L. Fridley, Estrid Hogdall, Susanne K. Kjaer, Allan Jensen, Kirsten B. Moysich, Matthew Grasela, Kunle Odunsi, Robert Brown, Jim Paul, Diether Lambrechts, Evelyn Despierre, Ignace Vergote, Jenny Gross, Beth Y. Karlan, Anna deFazio, Georgia Chenevix-Trench, M. Eileen Dolan
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (16): 5490–5500.
https://doi.org/10.1158/1078-0432.CCR-11-0724
Published: 14 August 2011
View article titled, Platinum Sensitivity–Related Germline Polymorphism Discovered via a Cell-Based Approach and Analysis of Its Association with Outcome in Ovarian Cancer Patients
Open the PDF for Platinum Sensitivity–Related Germline Polymorphism Discovered via a Cell-Based Approach and Analysis of Its Association with Outcome in Ovarian Cancer Patients in another window
Includes: Supplementary data
Journal Articles

Cancer Pharmacoethnicity: Ethnic Differences in Susceptibility to the Effects of Chemotherapy

Peter H. O'Donnell, M. Eileen Dolan
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (15): 4806–4814.
https://doi.org/10.1158/1078-0432.CCR-09-0344
Published: 29 July 2009
View article titled, Cancer Pharmacoethnicity: Ethnic Differences in Susceptibility to the Effects of Chemotherapy
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Journal Articles

Phase II Trial of the O6-Alkylguanine DNA Alkyltransferase Inhibitor O6-Benzylguanine and 1,3-Bis(2-Chloroethyl)-1-Nitrosourea in Advanced Melanoma

Thomas F. Gajewski, Jeffrey Sosman, Stanton L. Gerson, Lili Liu, Eileen Dolan, Shang Lin, Everett E. Vokes
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (21): 7861–7865.
https://doi.org/10.1158/1078-0432.CCR-05-0060
Published: 08 November 2005
View article titled, Phase II Trial of the <em>O</em><sup>6</sup>-Alkylguanine DNA Alkyltransferase Inhibitor <em>O</em><sup>6</sup>-Benzylguanine and 1,3-Bis(2-Chloroethyl)-1-Nitrosourea in Advanced Melanoma
Open the PDF for Phase II Trial of the <em>O</em><sup>6</sup>-Alkylguanine DNA Alkyltransferase Inhibitor <em>O</em><sup>6</sup>-Benzylguanine and 1,3-Bis(2-Chloroethyl)-1-Nitrosourea in Advanced Melanoma in another window
Journal Articles

Irinotecan Activation by Human Carboxylesterases in Colorectal Adenocarcinoma Cells

Michael H. Wu, Bingfang Yan, Rod Humerickhouse, M. Eileen Dolan
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (8): 2696–2700.
Published: 01 August 2002
View article titled, Irinotecan Activation by Human Carboxylesterases in Colorectal Adenocarcinoma Cells
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