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Edward M. Schaeffer
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Journal Articles

T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer

Aleksandar Z. Obradovic, Matthew C. Dallos, Marianna L. Zahurak, Alan W. Partin, Edward M. Schaeffer, Ashley E. Ross, Mohamad E. Allaf, Thomas R. Nirschl, David Liu, Carolyn G. Chapman, Tanya O'Neal, Haiyi Cao, Jennifer N. Durham, Gunes Guner, Javier A. Baena-Del Valle, Onur Ertunc, Angelo M. De Marzo, Emmanuel S. Antonarakis, Charles G. Drake
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13): 3182–3192.
https://doi.org/10.1158/1078-0432.CCR-19-3372
Published: 01 July 2020
View article titled, T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer
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Includes: Supplementary data
Journal Articles

CDKN1B Deletions are Associated with Metastasis in African American Men with Clinically Localized, Surgically Treated Prostate Cancer

Farzana A. Faisal, Sanjana Murali, Harsimar Kaur, Thiago Vidotto, Liana B. Guedes, Daniela Correia Salles, Vishal Kothari, Jeffrey J. Tosoian, Sumin Han, Daniel H. Hovelson, Kevin Hu, Daniel E. Spratt, Alexander S. Baras, Scott A. Tomlins, Edward M. Schaeffer, Tamara L. Lotan
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (11): 2595–2602.
https://doi.org/10.1158/1078-0432.CCR-19-1669
Published: 01 June 2020
View article titled, <em>CDKN1B</em> Deletions are Associated with Metastasis in African American Men with Clinically Localized, Surgically Treated Prostate Cancer
Open the PDF for <em>CDKN1B</em> Deletions are Associated with Metastasis in African American Men with Clinically Localized, Surgically Treated Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Transcriptomic Heterogeneity of Androgen Receptor Activity Defines a de novo low AR-Active Subclass in Treatment Naïve Primary Prostate Cancer

Daniel E. Spratt, Mohammed Alshalalfa, Nick Fishbane, Adam B. Weiner, Rohit Mehra, Brandon A. Mahal, Jonathan Lehrer, Yang Liu, Shuang G. Zhao, Corey Speers, Todd M. Morgan, Adam P. Dicker, Stephen J. Freedland, R. Jeffery Karnes, Sheila Weinmann, Elai Davicioni, Ashley E. Ross, Robert B. Den, Paul L. Nguyen, Felix Y. Feng, Tamara L. Lotan, Arul M. Chinnaiyan, Edward M. Schaeffer
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (22): 6721–6730.
https://doi.org/10.1158/1078-0432.CCR-19-1587
Published: 15 November 2019
View article titled, Transcriptomic Heterogeneity of Androgen Receptor Activity Defines a <em>de novo</em> low AR-Active Subclass in Treatment Naïve Primary Prostate Cancer
Open the PDF for Transcriptomic Heterogeneity of Androgen Receptor Activity Defines a <em>de novo</em> low AR-Active Subclass in Treatment Naïve Primary Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

DNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway

Vishal Kothari, Jonathan F. Goodwin, Shuang G. Zhao, Justin M. Drake, Yi Yin, S. Laura Chang, Joseph R. Evans, Kari Wilder-Romans, Kristina Gabbara, Emanuela Dylgjeri, Jonathan Chou, Grace Sun, Scott A. Tomlins, Rohit Mehra, Kristen Hege, Ellen H. Filvaroff, Edward M. Schaeffer, R. Jeffrey Karnes, David A. Quigley, Dana E. Rathkopf, Housheng H. He, Corey Speers, Daniel E. Spratt, Luke A. Gilbert, Alan Ashworth, Arul M. Chinnaiyan, Ganesh V. Raj, Karen E. Knudsen, Felix Y. Feng
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (18): 5608–5622.
https://doi.org/10.1158/1078-0432.CCR-18-2387
Published: 13 September 2019
View article titled, DNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway
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Journal Articles

Development and Validation of a Prostate Cancer Genomic Signature that Predicts Early ADT Treatment Response Following Radical Prostatectomy

R. Jeffrey Karnes, Vidit Sharma, Voleak Choeurng, Hussam Al-Deen Ashab, Nicholas Erho, Mohammed Alshalalfa, Bruce Trock, Ashley Ross, Kasra Yousefi, Harrison Tsai, Shuang G. Zhao, Jeffrey J. Tosoian, Zaid Haddad, Mandeep Takhar, S. Laura Chang, Daniel E. Spratt, Firas Abdollah, Robert B. Jenkins, Eric A. Klein, Paul L. Nguyen, Adam P. Dicker, Robert B. Den, Elai Davicioni, Felix Y. Feng, Tamara L. Lotan, Edward M. Schaeffer
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (16): 3908–3916.
https://doi.org/10.1158/1078-0432.CCR-17-2745
Published: 14 August 2018
View article titled, Development and Validation of a Prostate Cancer Genomic Signature that Predicts Early ADT Treatment Response Following Radical Prostatectomy
Open the PDF for Development and Validation of a Prostate Cancer Genomic Signature that Predicts Early ADT Treatment Response Following Radical Prostatectomy in another window
Includes: Supplementary data
Journal Articles

TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup

David P. Labbé, Christopher J. Sweeney, Myles Brown, Phillip Galbo, Spencer Rosario, Kristine M. Wadosky, Sheng-Yu Ku, Martin Sjöström, Mohammed Alshalalfa, Nicholas Erho, Elai Davicioni, R. Jeffrey Karnes, Edward M. Schaeffer, Robert B. Jenkins, Robert B. Den, Ashley E. Ross, Michaela Bowden, Ying Huang, Kathryn P. Gray, Felix Y. Feng, Daniel E. Spratt, David W. Goodrich, Kevin H. Eng, Leigh Ellis
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (22): 7072–7083.
https://doi.org/10.1158/1078-0432.CCR-17-0413
Published: 14 November 2017
View article titled, TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup
Open the PDF for TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup in another window
Includes: Supplementary data
Journal Articles

Analytic, Preanalytic, and Clinical Validation of p53 IHC for Detection of TP53 Missense Mutation in Prostate Cancer

Liana B. Guedes, Fawaz Almutairi, Michael C. Haffner, Gaurav Rajoria, Zach Liu, Szczepan Klimek, Roberto Zoino, Kasra Yousefi, Rajni Sharma, Angelo M. De Marzo, George J. Netto, William B. Isaacs, Ashley E. Ross, Edward M. Schaeffer, Tamara L. Lotan
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (16): 4693–4703.
https://doi.org/10.1158/1078-0432.CCR-17-0257
Published: 14 August 2017
View article titled, Analytic, Preanalytic, and Clinical Validation of p53 IHC for Detection of <em>TP53</em> Missense Mutation in Prostate Cancer
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Includes: Supplementary data
Journal Articles

The Landscape of Prognostic Outlier Genes in High-Risk Prostate Cancer

Shuang G. Zhao, Joseph R. Evans, Vishal Kothari, Grace Sun, Ashley Larm, Victor Mondine, Edward M. Schaeffer, Ashley E. Ross, Eric A. Klein, Robert B. Den, Adam P. Dicker, R. Jeffrey Karnes, Nicholas Erho, Paul L. Nguyen, Elai Davicioni, Felix Y. Feng
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (7): 1777–1786.
https://doi.org/10.1158/1078-0432.CCR-15-1250
Published: 31 March 2016
View article titled, The Landscape of Prognostic Outlier Genes in High-Risk Prostate Cancer
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Includes: Supplementary data
Journal Articles

Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer

Paula J. Hurley, Debasish Sundi, Brian Shinder, Brian W. Simons, Robert M. Hughes, Rebecca M. Miller, Benjamin Benzon, Sheila F. Faraj, George J. Netto, Ismael A. Vergara, Nicholas Erho, Elai Davicioni, R. Jeffrey Karnes, Guifang Yan, Charles Ewing, Sarah D. Isaacs, David M. Berman, Jennifer R. Rider, Kristina M. Jordahl, Lorelei A. Mucci, Jessie Huang, Steven S. An, Ben H. Park, William B. Isaacs, Luigi Marchionni, Ashley E. Ross, Edward M. Schaeffer
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (2): 448–458.
https://doi.org/10.1158/1078-0432.CCR-15-0256
Published: 14 January 2016
View article titled, Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer
Open the PDF for Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Cyclin D1 Loss Distinguishes Prostatic Small-Cell Carcinoma from Most Prostatic Adenocarcinomas

Harrison Tsai, Carlos L. Morais, Mohammed Alshalalfa, Hsueh-Li Tan, Zaid Haddad, Jessica Hicks, Nilesh Gupta, Jonathan I. Epstein, George J. Netto, William B. Isaacs, Jun Luo, Rohit Mehra, Robert L. Vessella, R. Jeffrey Karnes, Edward M. Schaeffer, Elai Davicioni, Angelo M. De Marzo, Tamara L. Lotan
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (24): 5619–5629.
https://doi.org/10.1158/1078-0432.CCR-15-0744
Published: 14 December 2015
View article titled, Cyclin D1 Loss Distinguishes Prostatic Small-Cell Carcinoma from Most Prostatic Adenocarcinomas
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Includes: Supplementary data